MATERIAL SAFETY DATA SHEET
PhytoTechnology
Laboratories
1. CHEMICAL IDENTIFICATION AND COMPANY INFORMATION
PRODUCT NAME: Chloramphenicol, USP Grade
[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-
SYNONYMS:
(4-nitrophenyl)ethyl]acetamide
PRODUCT NUMBER: C252
CAS NO: 56-75-7
NIOSH/RTECS NO: AB6825000
COMPANY INFO: Phyto Technology Laboratories
PO Box 13481 Shawnee Mission, KS 66282-3481
Phone: 1-888-749-8682 or 913-341-5343; Fax: 1-888-449-8682 or 913-341-5442
www.phytotechlab.com
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient CAS Number Purity Hazardous
Chloramphenicol 56-75-7 >97 % No exposure limits established by OSHA or ACGIH
3. PHYSICAL & CHEMICAL PROPERTIES
Product Description: Chloramphenicol, USP Grade
Formula: C11H12Cl2N2O5
Molecular Weight: 323.13
Storage Temperature: RT
pH (0.050 g/L): Under Development (4.5 鈥? 6.5 suspected range)
Vapor Density: N/A
Melting Point: 150-152 C
Specific Gravity: N/A
Solubility: Soluble in Water
Appearance: White to yellow powder
Odor: Mostly odorless
4. HAZARDS IDENTIFICATION
Label Hazard Warnings: May cause sensitization by inhalation or by skin contact. May cause cancer.
Label Precautionary Statements: In case of accident or if you feel unwell, seek medical advice immediately. Wear
suitable protective clothing, gloves, and eye/face protection.
Laboratory Protective Equipment: Safety glasses, protective gloves, lab coat, and appropriate respirator
Personal Protection
HMIS Rating: Health Flammability Reactivity
Equipment
2 0 0 F
NFPA Rating: Health Flammability Reactivity Special Hazards
N/A N/A N/A N/A
Storage and Handling Precautions: Store in a tightly sealed container in a cool, dry place. Avoid all contact with
material. Avoid direct light. Do not breathe dust. Wash thoroughly after handling.
PRODUCT NAME: Chloramphenicol, USP Grade Page #: 1 of 4
PRODUCT NUMBER: C252 Last Revised: 11/30/2004 .
5. POTENTIAL HEALTH HAZARDS/ TOXICOLOGICAL INFORMATION
Toxicity: LD50 (Oral-Rat)(mg/Kg): 2500
LD50 (IV-Rat)(mg/Kg): 171
LD50 (Oral-Mouse)(mg/Kg): 1500
Carcinogenicity: NTP: Group 2
IARC: Group 2A
Z List: No
OSHA Reg: No
Effects of Overexposure: Irritation, itching, gastrointestinal upset, allergic reaction,
dermatitis, nausea, vomiting, possible mutagenic and
tumorigenic effects, effects on reproduction, blood pressure
changes, cancer, anemia, bleeding, bone marrow changes
Target Organs: Liver, kidney, blood
Medical Conditions Aggravated By Exposure: None identified
Routes of Entry: Ingestion, inhalation, skin and eye contact
The to xicological properties of this product have not been thoroughly investigated
6. EMERGENCY AND FIRST AID
Route of Entry Symptoms First Aid Procedures
Ingestion May cause irritation if swallowed If swallowed, wash out mouth with water. Never give anything
by mouth to an unconscious person. Get medical attention.
Inhalation May cause irritation to respiratory Safely remove victim to fresh air. If not breathing, institute
tract cardiopulmonary resuscitation (CPR). If breathing is difficult,
ensure clear airway and give oxygen. Get medical attention.
Eye Contact Direct contact may cause irritation. Flush immediately with large amounts of water for at least 15
May cause redness, tearing, or minutes. Eyelids should be held away from the eyeball to
blurred vision. ensure thorough rinsing. Get medical attention if irritation
persists.
Skin Contact Irritating. May cause reddening, Wash area thoroughly with soap and water. Remove and wash
itching or inflammation. contaminated clothing. Get medical attention if irritation
persists.
7. FIRE HAZARDS & FIRE FIGHTING MEASURES
Flash Point (Closed Cup): N/A
Flammable Limits: Upper 鈥? N/A % Lower 鈥? N/A %
Fire Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, or appropriate foam. Use
extinguishing media suitable for surrounding fire.
Special Fire-Fighting Procedures: In the event of a fire, wear full protective clothing and NIOSH approved self-
contained breathing apparatus. Evacuate the area and fight fire from a safe distance.
Unusual Fire & Explosion Hazards: May emit toxic fumes under fire conditions.
Toxic Gases Produced: Carbon dioxide, carbon monoxide, nitrogen oxides, hydrogen chloride gas, chlorine
PRODUCT NAME: Chloramphenicol, USP Grade Page #: 2 of 4
PRODUCT NUMBER: C252 Last Revised: 11/30/2004 .
8. REACTIVITY & CONDITIONS TO AVOID
Stability: Stable under normal conditions of use
Hazardous Polymerization: Will not occur
Conditions to Avoid: Incompatibles, dust generation, may be sensitive to light
Incompatibles: Strong oxidizing agents, acids, acid chlorides, acid anhydrides
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, hydrogen chloride gas, chlorine
9. SPECIAL PRECAUTIONS/PROTECTIVE EQUIPMENT
Ventilation: Ventilation hood recommended
Respiratory Protection: A NIOSH/MSHA approved air purifying respirator is recommended where airborne
concentrations are expected to exceed exposure limits. Protection provided by purifying
respirators is limited.
Eye/Skin Protection: Have eye-washing facilities readily available where eye contact can occur. Wear
chemical safety goggles. Use appropriate chemical protective gloves when handling.
Showering and changing into street clothes after work is recommended.
10. SPILLS & LEAKS
Spill or Discharge: Wear suitable protective clothing and a self-contained breathing apparatus if available.
Carefully sweep up and remove. Place material in a dry container and cover. Remove
from the area. Flush spill area with water.
Disposal Procedure: Dispose in accordance with all applicable federal, state, and local environmental
regulations.
EPA Hazardous Waste Number: N/A
11. TRASNPORTATION DATA
Domestic (D.O.T.): Proper Shipping Name: CHEMICALS, N.O.S. (NON-REGULATED)
Hazard Class: N/A
UN/NA: N/A
Labels: N/A
International (I.M.O.): Proper Shipping Name: CHEMICALS, N.O.S. (NON-REGULATED)
Hazard Class: N/A
UN/NA: N/A
Labels: N/A
12. REGULATORY INFORMATION
U.S. Federal Regulatory Information
TSCA: Yes
SARA TITLE III:
Section 302 (EHS) Ingredients: No
Section 313 Ingredients: No
Section 304 (EHS/CERCLA) Ingredients: No
PRODUCT NAME: Chloramphenicol, USP Grade Page #: 3 of 4
PRODUCT NUMBER: C252 Last Revised: 11/30/2004 .
SARA TITLE III NOTIFICATION INFORMATION
Acute Health Hazard: No
Chronic Health Hazard: No
Fire Hazard: No
Sudden Release of Pressure Hazard: No
International Regulatory Information
Risk Phrases: 42/43 鈥? May cause sensitization by inhalation or skin contact
45 鈥? May cause cancer
Safety Phrases: 45 鈥? In case of accident or if you feel unwell, seek medical advice immediately
36/37/39 鈥? Wear suitable protective clothing, gloves, and eye/face protection
Phyto Technology Laboratories provides the information contained herein in good faith but makes
no representation as to its comprehensiveness or accuracy. The above information is intended to
be used only as a guide to the appropriate precautionary handling of this material by a properly
trained person. PhytoTechnology Laboratories shall not be held liable for any damage resulting
from handling or from contact with the above product. This product is intended for
LABORATORY USE ONLY. Our products may NOT BE USED as drugs, cosmetics,
agricultural or pesticidal products, food additives, or as household chemicals.
PRODUCT NAME: Chloramphenicol, USP Grade Page #: 4 of 4
PRODUCT NUMBER: C252 Last Revised: 11/30/2004 .
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