MATERIAL SAFETY DATA SHEET
COLISTIN SULFATE
PADDOCK LABORATORIES, INC. EMERGENCY ASSISTANCE:
3940 QUEBEC AVENUE NORTH CHEMTREC 800-424-9300
MINNEAPOLIS, MINNESOTA 55427 202-483-7616
PHONE: (763)-546-4676 PADDOCK TECH. ASST. 800-328-5113
DATE PREPARED: 08/24/92 BY: Patrick L. Johnson
SECTION 1 - PRODUCT IDENTIFICATION AND HAZARDOUS COMPONENTS
PRODUCT NAME: Colistin Sulfate, USP
SYNONYMS: Polymyxin E Sulfate
MOLECULAR FORMULA: C53 H100 O13 N16 MOLECULAR WEIGHT: N/A
CHEMICAL FAMILY: Cyclic peptide antibiotic
INGREDIENT (CAS NUMBER) % OSHA PEL ACGIH TLV
Colistin sulfate (1264-72-8) 100 N/A N/A
SECTION 2 - PHYSICAL AND CHEMICAL CHARACTERISTICS
BOILING POINT: N/A VAPOR PRESSURE: N/A
MELTING POINT: N/A VAPOR DENSITY: N/A
SPECIFIC GRAVITY: N/A EVAPORATION RATE: N/A
(WATER = 1) (BUTYL ACETATE = 1)
WATER SOLUBILITY: Freely soluble. WATER REACTIVE: No
APPEARANCE AND ODOR: Fine, white to slightly yellow, odorless powder.
SECTION 3 - FIRE AND EXPLOSION DATA
FLASH POINT (METHOD): N/A NFPA RATING: N/A
MSDS - Colistin Sulfate Page 2 of 4
AUTOIGNITION TEMPERATURE: N/A
FLAMMABLE LIMITS: LOWER: N/A UPPER: N/A
EXTINGUISHING MEDIA: Water spray, carbon dioxide, dry chemical, or foam as indicated by surrounding fire
conditions.
SPECIAL FIRE FIGHTING PROCEDURES: Fire fighters should wear full protective gear including self-contained
breathing apparatus.
UNUSUAL FIRE AND EXPLOSION HAZARDS: May produce toxic fumes (COx, NOx) if heated to
decomposition.
SECTION 4 - REACTIVITY HAZARD DATA
STABILITY: Stable ( X ) Unstable ( )
INCOMPATIBILITY (MATERIALS TO AVOID): Alkalis, aldehydes, and certain organic acids.
HAZARDOUS DECOMPOSITION PRODUCTS: May produce toxic fumes (COx, NOx) if heated to
decomposition.
HAZARDOUS POLYMERIZATION: May Occur ( ) Will Not Occur ( X )
SECTION 5 - HEALTH HAZARD DATA
TOXICITY: LD50 : Intravenous (mouse) ~5 mg/kg
Oral (mouse) ~300 mg/kg
CARCINOGEN LISTED BY: NTP Yes ( ) No ( X )
IARC Yes ( ) No ( X )
OSHA Yes ( ) No ( X )
Other Yes ( ) No ( X )
ROUTES OF ENTRY: Inhalation, ingestion, absorption.
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
INHALATION: May cause irritation of the respiratory tract.
EYE CONTACT: May cause irritation.
MSDS - Colistin Sulfate Page 3 of 4
SKIN CONTACT: May cause irritation to broken skin.
INGESTION: May cause irritation of the gastrointestinal tract.
CHRONIC EFFECTS OF OVEREXPOSURE: May cause kidney damage evidenced by decreased urine output,
proteinuria, hematuria, and casts in the urine. May cause neurotoxic reactions including dizziness, ataxia (muscle
weakness), sensory disturbances of the face and extremities, blurred vision, and slurred speech. Neuromuscular
blockade causing respiratory paralysis can occur, especially in patients with impaired renal function.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Hypersensitivity to colistin sulfate and
polymyxin b sulfate, impaired renal function, overgrowth of nonsusceptible organisms.
OTHER PRECAUTIONS TO CONSIDER: Safe use of colistin sulfate during pregnancy has not been established.
This product should only be used during pregnancy when the potential benefits justify the possible risks to the fetus.
Persons developing hypersensitivity (anaphylactic) reactions must receive immediate medical attention.
EMERGENCY FIRST AID PROCEDURES:
INHALATION: Remove from exposure. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Seek immediate medical attention.
EYE CONTACT: Flush with water for at least 15 minutes. If irritation persists or develops seek medical
attention.
SKIN CONTACT: Wash thoroughly with soap and water. If irritation persists or develops seek medical
attention.
INGESTION: Seek medical attention or contact a poison control center immediately.
SECTION 6 - CONTROL AND PROTECTIVE MEASURES
RESPIRATORY PROTECTION: NIOSH/MSHA approved respirator.
PROTECTIVE GLOVES: Rubber.
EYE PROTECTION: Safety glasses or goggles. Avoid wearing contact lenses when working with this or any chemical
due to the possibility of increased severity of eye damage.
VENTILATION: General or local exhaust recommended.
OTHER PROTECTIVE EQUIPMENT: Appropriate laboratory apparel.
HYGIENIC WORK PRACTICES: Do not eat, drink or smoke near this material. Wash thoroughly after handling and
wash any contaminated clothing before reuse.
MSDS - Colistin Sulfate Page 4 of 4
SECTION 7 - HANDLING AND STORAGE PRECAUTIONS
HANDLING PRECAUTIONS: Avoid contact with eyes, skin or clothing and avoid breathing dust. Wash thoroughly
after handling and wash any contaminated clothing before reuse.
STORAGE PRECAUTIONS: Store in a tight container in a cool, dry, well ventilated location.
SECTION 8 - SPILL AND DISPOSAL PROCEDURES
STEPS TO BE TAKEN IN CASE OF SPILL OR DISCHARGE: Wear all protective gear including: respirator,
goggles, gloves. Vacuum or sweep up spillage and place in a tight container. Wash and ventilate spill site. Wash
thoroughly or shower after handling and wash all clothing and protective gear before reuse.
WASTE DISPOSAL METHOD: Dispose of in accordance with all applicable local, state, federal, and environmental
regulations.
SECTION 9 - DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources and is believed to
be correct as of the date issued. It is the responsibility of the user to determine the appropriateness and applicability to
their situation. Paddock Laboratories, Inc. disclaims any expressed or implied warranty as to the accuracy of the above
information and shall not be held liable for any direct, incidental, or consequential damages from use or reliance on the
above information.
_________________________________________________________________________________________
DEFINITIONS OF ABBREVIATIONS USED:
ACGIH: American Conference of Governmental Industrial Hygienists
CAS: Chemical Abstract Service
IARC: Internal Agency for Research on Cancer
IDLH: Immediately Dangerous to Life or Health level
LC50 : Median Lethal Concentration
LD50 : Median Lethal Dose
MSHA: Mine Safety and Health Administration
N/A: Not available
NIOSH: National Institute for Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
TWA: Time Weighted Average
MSDS - Colistin Sulfate Page 5 of 4
|