MATERIAL SAFETY DATA SHEET
DEXAMETHASONE SODIUM PHOSPHATE
PADDOCK LABORATORIES, INC. EMERGENCY ASSISTANCE:
3940 QUEBEC AVENUE NORTH CHEMTREC: 800-424-9300
MINNEAPOLIS, MINNESOTA 55427 202-483-7616
PHONE: (763)-546-4676 PADDOCK TECH. ASST. 800-424-8802
DATE PREPARED: 5-12-89 BY: Patrick L. Johnson
SECTION 1 - PRODUCT IDENTIFICATION AND HAZARDOUS COMPONENTS
PRODUCT: Dexamethasone Sodium Phosphate USP
SYNONYMS: Dexamethasone Phosphate Sodium, Dexamethasone 21-(Disodium Phosphate)
MOLECULAR FORMULA: C22 H28 FNa2 O8 P MOLECULAR WEIGHT: 516.41
CHEMICAL FAMILY: Corticosteroid
INGREDIENT (CAS #) % OSHA PEL ACGIH TLV
Dexamethasone sodium phosphate (2392-39-4) 100 N/A N/A
SECTION 2 - PHYSICAL AND CHEMICAL CHARACTERISTICS
BOILING POINT: N/A VAPOR PRESSURE: N/A
233-235o C
MELTING POINT: VAPOR DENSITY: N/A
SPECIFIC GRAVITY: N/A EVAPORATION RATE: N/A
(WATER = 1) (BUTYL ACETATE = 1)
WATER SOLUBILITY: Soluble. WATER REACTIVE: No.
APPEARANCE AND ODOR: White to slightly yellow, hygroscopic, crystalline powder; odorless or a slight odor of
alcohol.
SECTION 3 - FIRE AND EXPLOSION DATA
FLASH POINT (METHOD): N/A AUTOIGNITION TEMPERATURE: N/A
FLAMMABLE LIMITS: LOWER: N/A UPPER: N/A
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EXTINGUISHING MEDIA: Water, carbon dioxide, dry chemical
SPECIAL FIRE FIGHTING PROCEDURES: Fire fighters should wear self-contained breathing apparatus.
UNUSUAL FIRE AND EXPLOSION HAZARDS: As with any organic compound, this material may emit toxic
fumes when heated to decomposition and airborne dust may present a fire or explosion hazard.
SECTION 4 - REACTIVITY HAZARD DATA
STABILITY: Stable ( X ) Unstable ( )
INCOMPATIBILITY (MATERIALS TO AVOID): Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS: May emit toxic fumes if heated to decomposition.
HAZARDOUS POLYMERIZATION: May Occur ( ) Will Not Occur ( X )
SECTION 5 - HEALTH HAZARD DATA
TOXICITY: LD50 : Oral (mouse) 1800 mg/kg
Intravenous (mouse) 112 mg/kg
NOTE: Prolonged application to the eye could cause increased intra-ocular pressure and reduced visual
function. Intra-articular injection into a load-bearing joint could cause joint damage. Rapid intravenous injection
of large doses could cause cardiovascular collapse.
CARCINOGEN LISTED BY: NTP Yes ( ) No ( X )
IARC Yes ( ) No ( X )
OSHA Yes ( ) No ( X )
Other Yes ( ) No ( X )
ROUTES OF ENTRY: Inhalation, ingestion, absorption.
SIGNS AND SYMPTOMS OF OVEREXPOSURE: Hypersensitivity (anaphylactic) reactions may occur following
inhalation, ingestion, or eye or skin contact.
INHALATION: May cause respiratory tract irritation.
EYE CONTACT: May cause eye irritation, increased intra-ocular pressure, reduced visual function.
SKIN CONTACT: May cause irritation.
INGESTION: May cause gastrointestinal tract irritation.
CHRONIC EFFECTS OF OVEREXPOSURE: Suppression of adrenal gland secretion, Cushing's syndrome, water
retention, electrolyte imbalance.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Hypersensitivity to this material.
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EMERGENCY FIRST AID PROCEDURES: Any person developing serious hypersensitivity reactions after exposure
to this material must receive immediate medical attention.
INHALATION: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Seek immediate medical assistance.
EYE CONTACT: Flush eye with water for 15 minutes. If irritation persists or develops, seek medical attention.
SKIN CONTACT: Flush with water for 15 minutes. If irritation persists or develops, seek medical attention.
INGESTION: Rinse out mouth with water and seek medical attention or contact a poison control center
immediately.
SECTION 6 - CONTROL AND PROTECTIVE MEASURES
RESPIRATORY PROTECTION: Use of a NIOSH approved dust respirator is recommended.
PROTECTIVE GLOVES: Rubber.
EYE PROTECTION: Safety glasses or goggles recommended. Avoid wearing contact lenses when working with this
or any chemical due to the possibility of increased severity of eye injury.
VENTILATION: Local or mechanical recommended.
OTHER PROTECTIVE EQUIPMENT: Appropriate laboratory apparel.
HYGIENIC WORK PRACTICES: Wash thoroughly after handling and wash contaminated clothing before reuse. Do
not eat, smoke or drink near this material.
SECTION 7 - HANDLING AND STORAGE PRECAUTIONS
HANDLING PRECAUTIONS: Avoid contact with eyes, skin or clothing and avoid breathing dust. Wash thoroughly
after handling and wash any contaminated clothing before reuse.
STORAGE PRECAUTIONS: Store in tight, light resistant containers in a cool, dry location away from incompatible
materials.
OTHER PRECAUTIONS: Do not eat, smoke or drink near this material.
SECTION 8 - SPILL AND DISPOSAL PROCEDURES
STEPS TO BE TAKEN IN CASE OF SPILL OR DISCHARGE: Wear all protective gear including gloves, goggles,
respirator. Vacuum or sweep up spillage and place in a tight container. Ventilate spill area and wash down with soap
and water. Wash thoroughly after handling and wash all clothing and protective gear before reuse.
MSDS - Dexamethasone Sodium Phosphate Page 4 of 4
WASTE DISPOSAL METHOD: Dispose of in accordance with all applicable local, state, federal and environmental
regulations.
SECTION 9 - DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources and is believed to
be correct as of the date issued. It is the responsibility of the user to determine the appropriateness and applicability to
their situation. Paddock Laboratories, Inc. disclaims any expressed or implied warranty as to the accuracy of the above
information and shall not be held liable for any direct, incidental, or consequential damages from use or reliance on the
above information.
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DEFINITIONS OF ABBREVIATIONS USED:
ACGIH: American Conference of Governmental Industrial Hygienists
CAS: Chemical Abstract Service
IARC: Internal Agency for Research on Cancer
LD50 : Median Lethal Dose
N/A: Not available
NIOSH: National Institute of Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
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