MATERIAL SAFETY DATA SHEET
COLOCORT
PADDOCK LABORATORIES, INC. EMERGENCY ASSISTANCE:
3940 QUEBEC AVENUE NORTH CHEMTREC 800-424-9300
MINNEAPOLIS, MINNESOTA 55427 202-483-7616
PHONE: (763)-546-4676 PADDOCK TECH. ASST. 800-328-5113
DATE PREPARED: 8-01-01 BY: Eric Randall
SECTION 1 - PRODUCT IDENTIFICATION AND HAZARDOUS COMPONENTS
PRODUCT NAME: Colocort SYNONYMS: Hydrocortisone Enema
INGREDIENT: Hydrocortisone SYNONYMS: Cortisol
MOLECULAR FORMULA: C21H30O5 MOLECULAR WEIGHT: 362.47
CHEMICAL NAME: 11-Beta, 17-Alpha, 21-Trihydroxy-4-Pregnene-3, 20-Dione
CHEMICAL FAMILY: Steroid, glucocorticoid
CAS NUMBER: 50-23-7 RTECS NUMBER: GM8925000
INGREDIENT __% OSHA PEL ACGIH TLV
Hydrocortisone <0.5 N/A N/A
SECTION 2 - PHYSICAL AND CHEMICAL CHARACTERISTICS
BOILING POINT: N/A VAPOR PRESSURE: N/A
MELTING POINT: N/A VAPOR DENSITY: N/A
SPECIFIC GRAVITY: N/A EVAPORATION RATE: Nil
(WATER = 1) (BUTYL ACETATE = 1)
WATER SOLUBILITY: N/A WATER REACTIVE: No
APPEARANCE AND ODOR: White Liquid With Little to No Odor
page 2 of 4
SECTION 3 - FIRE AND EXPLOSION DATA
FLASH POINT (METHOD): None
EXTINGUISHING MEDIA: Water spray, carbon dioxide, dry chemical, or foam.
SPECIAL FIRE FIGHTING PROCEDURES: None
UNUSUAL FIRE AND EXPLOSION HAZARDS: As with any organic compound, this material may
produce toxic carbon monoxide and carbon dioxide fumes if heated to decomposition (as under fire
conditions).
SECTION 4 - REACTIVITY HAZARD DATA
STABILITY: Stable ( X ) Unstable ( )
INCOMPATIBILITY (MATERIALS TO AVOID): None reported.
HAZARDOUS DECOMPOSITION PRODUCTS: As with any organic compound, this material may
produce toxic carbon monoxide and carbon dioxide fumes if heated to decomposition.
HAZARDOUS POLYMERIZATION: May Occur ( ) Will Not Occur ( X )
SECTION 5 - HEALTH HAZARD DATA
No toxicity data is available for this product. The following toxicity information is for the active
ingredient only.
TOXICITY: LD50: Intraperitoneal (rat) = 150 mg/kg
Subcutaneous (rat) = 449 mg/kg
CARCINOGEN LISTED BY: NTP Yes ( ) No ( X )
IARC Yes ( ) No ( X )
OSHA Yes ( ) No ( X )
Other Yes ( ) No ( X )
ROUTES OF ENTRY: Ingestion, absorption.
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
INHALATION: None
EYE CONTACT: May cause irritation.
page 3 of 4
SKIN CONTACT: May cause irritation.
INGESTION: May cause irritation of the gastrointestinal tract.
HEALTH HAZARDS ACUTE AND CHRONIC: May cause burning, irritation, dryness, itching,
suppression of adrenal gland secretion, Cushing's syndrome, water retention, electrolyte imbalance,
and/or hyperglycemia. Possible hypersensitization to this material.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Hypersensitivity to this
material. Systemic fungal infection.
OTHER PRECAUTIONS TO CONSIDER: Persons developing hypersensitivity (anaphylactic)
reactions must receive immediate medical attention. Although long term human testing has not been
performed, studies in animals have shown that adrenocorticoids applied topically in large amounts or
for prolonged periods of time are systemically absorbed and may cause fetal abnormalities (FDA
Pregnancy Category C).
EMERGENCY FIRST AID PROCEDURES:
INHALATION: N/A.
EYE CONTACT: Flush with water for at least 15 minutes. If irritation persists or develops
seek medical attention.
SKIN CONTACT: Wash thoroughly with soap and water. If irritation persists or develops
seek medical attention.
INGESTION: Flush mouth out with water and seek medical attention or contact a poison
control center immediately.
SECTION 6 - CONTROL AND PROTECTIVE MEASURES
PROTECTIVE GLOVES: Latex, Vinyl
EYE PROTECTION: Safety glasses or goggles.
VENTILATION: No extra ventilation required
HYGIENIC WORK PRACTICES: Do not eat, drink or smoke near this material. Wash thoroughly
after handling and wash any contaminated clothing before reuse.
page 4 of 4
SECTION 7 - HANDLING AND STORAGE PRECAUTIONS
HANDLING PRECAUTIONS: Avoid contact with eyes, skin or clothing. Wash thoroughly after
handling and wash any contaminated clothing before reuse.
STORAGE PRECAUTIONS: Store in a tight container in a cool, dry location.
SECTION 8 - SPILL AND DISPOSAL PROCEDURES
STEPS TO BE TAKEN IN CASE OF SPILL OR DISCHARGE: Wash with copious amounts of
potable water.
WASTE DISPOSAL METHOD: Dispose of in accordance with all applicable local, state, federal, and
environmental regulations.
SECTION 9 - DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources
and is believed to be correct as of the date issued. It is the responsibility of the user to determine the
appropriateness and applicability to their situation. Paddock Laboratories, Inc. disclaims any
expressed or implied warranty as to the accuracy of the above information and shall not be held liable
for any direct, incidental, or consequential damages from use or reliance on the above information.
__________________________________________________________________________________
DEFINITIONS OF ABBREVIATIONS USED:
ACGIH: American Conference of Governmental Industrial Hygienists
CAS: Chemical Abstract Service
IARC: Internal Agency for Research on Cancer
IDLH: Immediately Dangerous to Life or Health level
LC50: Median Lethal Concentration
LD50: Median Lethal Dose
MSHA: Mine Safety and Health Administration
N/A: Not available
NIOSH: National Institute for Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
TWA: Time Weighted Average
|