MATERIAL SAFETY DATA SHEET
PEG 3350, NF Powder for Oral Solution
Paddock Laboratories, Inc. Emergency Assistance:
CHEMTREC庐 (24-hour)
3940 Quebec Avenue North 1-800-424-9300
Minneapolis, MN 55427
Tel: (763) 546-4676 Paddock Technical Assistance: 1-800-328-5113
Creation Date: 3/24/06 Revision Date:
SECTION 1: PRODUCT IDENTIFICATION
PRODUCT NAME: PEG 3350
COMMON NAME: PEG 3350
CHEMICAL NAME: Polyethylene Glycol
SYNONYMS: Polyoxyethylene 3350, Polyglycol, CarbowaxTM, Pluracol, Poly-6
CHEMICAL FORMULA: HO-(CH2CH2O)n-H
CHEMICAL FAMILY: Oxyalkylene Polymer
SECTION 2: COMPOSITION AND INGREDIENTS
CHEMICAL NAME CAS# OSHA PEL ACGIH TLV
Polyethylene Glycol 25322-68-3 5 mg/ m3 (respirable dust) 10 mg/ m3
15 mg/ m3 (total dust) (total dust)
SECTION 3: HEALTH HAZARDS
EMERGENCY OVERVIEW:
Symptoms of Overexposure: Overexposure to vapor generated at high temperatures may result in eye and
respiratory tract irritation, dizziness, nausea and the inhalation of harmful amounts of the material.
SECTION 4: FIRST AID MEASURES
Skin Exposure: Thoroughly wash with mild soap and water for at least 15 minutes. If irritation develops or
persists, seek medical attention.
Eye Exposure: Flush eyes with thoroughly with water for at least 15 minutes. If irritation develops or
persists, seek medical attention.
Inhalation: Move person to fresh air. Not expected to require first aid measures.
Ingestion: If large amounts are swallowed, give water to drink and seek medical attention.
SECTION 5: FIRE / EXPLOSION HAZARDS AND FIRE-FIGHTING MEASURES
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Flash Point: 246 掳C Pensky-Martens Closed Cup ASTM D93
Autoignition Temperature: ND
Flammable Limits (in air by volume, %): Lower: ND Upper: ND
Fire Extinguishing Equipment:
Use extinguishing agent suitable for type of surrounding fire.
Water Spray: OK Carbon Dioxide: OK Dry Chemical: OK Foam: OK
Special Fire Fighting Procedures: Do not direct a solid stream of water or foam into hot, burning pools; this may
cause frothing and increase fire intensity. Use a positive-pressure, self-contained breathing apparatus and protective
clothing
Unusual Fire and Explosion Hazards: A sufficient concentration of fine dust in the presence of an ignition source is a
potential dust explosion hazard. Container may rupture from gas generation in a fire situation.
Explosion Sensitivity to Mechanical Impact: None known.
Explosion Sensitivity to Static Discharge: Static ignition hazard can result from handling and use. Dust dispersed in
air may be ignited and burn rapidly. All metal parts and equipment should be properly bonded and grounded.
SECTION 6: SPILL AND LEAK PROCEDURES
Spill and Leak Response: Remove all sources of ignition. Ventilate area of spill. Wear appropriate protective
clothing. Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment.
Reduce dust and prevent scattering by moistening with water. Pick up spill for recovery of disposal and place in a
closed container.
SECTION 7: HANDLING AND STORAGE
Work and Hygiene Practices: As part of good industrial and personal hygiene safety procedures, avoid all
unnecessary exposure to the chemical substance and ensure prompt removal form skin, eyes and clothes.
Storage and Handling Practices: Keep in a tightly closed container stored in a cool, dry, ventilated area. Protect
against physical damage. Empty container may be hazardous since it retains product residues (solid/dust). Observe
all warnings and precautions listed for the product.
Use promptly after opening. Store in the following material(s): Stainless steel, polypropylene, polyethylene-lined
container, Teflon, glass-lined container, Plasite 3066-lined container, Plasite 3070-lined container, 316 stainless steel
SECTION 8: EXPOSURE CONTROLS AND PERSONAL PROTECTION
Ventilation and Engineering Controls: Use adequate ventilation (local exhaust) when working with this material.
Respiratory Protection: No special requirements under normal conditions. When airborne exposure limits may be
exceeded, use an approved air-purifying respirator.
Eye Protection: Safety glasses.
Hand Protection: Protective gloves.
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Body Protection: No special requirements under normal conditions of use. If dust is generated use appropriate
protective face and body covering.
Product Preparation Instructions for Medical Personnel:
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Boiling Point: NE Vapor Pressure: @ 20 掳C <0.01 mmHg
Melting Point: 54 鈥? 58 掳C pH: 5% aqueous solution @ 25 掳C 4.5 鈥? 7.5
Water Solubility: 67 % at 20 掳C Water Reactive: No
Specific Gravity (Water =1): 1.111 25 掳C/ 25 掳C Evaporation Rate (Butyl acetate = 1): <0.01
Appearance / Odor: White, free-flowing powder or creamy white flakes. Mild odor.
SECTION 10: STABILITY AND REACTIVITY
Stability: Stable under labeled storage conditions.
Incompatible Materials: Polymerization catalysts (peroxides, persulfates) and accelerants, strong oxidizers,
strong bases and strong acids.
Hazardous Polymerization: None known at this time.
Hazardous Decomposition: May produce toxic carbon monoxide and carbon dioxide fumes if heated to
decomposition.
Conditions to Avoid: Incompatibles.
SECTION 11: TOXICOLOGICAL INFORMATION
Toxicity Data: Oral Rat LD50 = 50 g/kg (ND for PEG 3350. Listed result is for PEG 4000)
Suspected Cancer Agent: This product has NOT been identified as a carcinogen by NTP, IARC, or OSHA
Sensitization to the Product/Adverse Reactions: Did not cause allergic skin reactions when tested in humans.
Mutagenicity: For similar materials, animal mutegenicity studies were negative.
SECTION 12: ECOLOGICAL INFORMATION
All work practices must be aimed at eliminating environmental contamination.
Environmental Stability: Material is readily biodegradable. Passes OECD test(s) for ready biodegradability.
Effect of Materials on Plants/Animals/Aquatic Life: Material is practically non-toxic to aquatic organisms on an acute
basis (LC 50/EC50 >100 mg/L in most sensitive species tested)
No bioconcentration is expected due to the materials high molecular weight (MW > 1000) and its relatively high water
solubility.
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SECTION 13: WASTE DISPOSAL
Preparing Wastes for Disposal: Dispose of container and unused contents in accordance with federal, state and
local requirements.
SECTION 14: TRANSPORTATION INFORMATION
This Material is not Hazardous as Defined by 49 CFR 172.101 by the U. S. Department of Transportation
Proper Shipping Name: Not regulated
Hazard Class Number and Description: NA
UN Identification Number: NA
Packing Group: NA
DOT Label(s) Required: NA
North American Emergency Response Guidebook Number (1996): NA
SECTION 15: REGULATORY INFORMATION
U.S. REGULATIONS:
U.S. SARA Reporting Requirements: 311/312 Hazard Categories: None, 313 Reportable Ingredients: None
U.S. SARA Threshold Planning Quantity: None
U.S. CERCLA Reportable Quantities: NA
U.S. TSCA Inventory Status: The ingredients of this product are on the TSCA inventory or are exempt from the
requirement.
California Safe Drinking Water and Toxic Enforcement Act (Proposition 65):
Component CAS # Amount
Acetaldehyde 75-07-0 = 0.0060 %
1,4-Dioxane 123-91-1 = 0.0001 %
Ethylene oxide 75-21-8 = 0.0001 %
Formaldehyde 50-00-0 = 0.0001 %
SECTION 16: OTHER INFORMATION
DEFINITIONS OF ABBREVATIONS USED:
ACGIH: American Conference of Governmental Industry Hygienists
CAS: Chemical Abstract Service
IARC: International Agency for Research on Cancer
IDLH: Immediately Dangerous to Life or Health Level
LC50: Medial Lethal Concentration
LD50: Medial Lethal Dose
MSHA: Mine Safety and Health Administration
NA: Not Available
ND: No Data
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NE: Not Established
NIOSH: National Institute for Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
TWA: Time Weighted Average
SECTION 17: DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources and is believed
to be correct as of the date issued. It is the responsibility of the user to determine the appropriateness and
applicability to their situation. Paddock Laboratories, Inc. disclaims any expressed or implied warranty as to the
accuracy of the above information and shall not be held liable for any direct, incidental, or consequential damages
from use or reliance on the above information.
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