MATERIAL SAFETY DATA SHEET
HYDROCORTISONE ACETATE
PADDOCK LABORATORIES, INC. EMERGENCY ASSISTANCE:
3940 QUEBEC AVENUE NORTH CHEMTREC 800-424-9300
MINNEAPOLIS, MINNESOTA 55427 202-483-7616
PHONE: (763)-546-4676 PADDOCK TECH. ASST. 800-328-5113
DATE PREPARED: 8-28-89 BY: Patrick L. Johnson
SECTION 1 - PRODUCT IDENTIFICATION AND HAZARDOUS COMPONENTS
PRODUCT: Hydrocortisone Acetate USP
SYNONYMS: Cortisol Acetate
MOLECULAR FORMULA: C23 H32 O6 MOLECULAR WEIGHT: 404.51
CHEMICAL FAMILY: Steroid
INGREDIENT (CAS #) % OSHA PEL ACGIH TLV
Hydrocortisone Acetate (50-03-3) 100 N/A N/A
SECTION 2 - PHYSICAL AND CHEMICAL CHARACTERISTICS
BOILING POINT: N/A VAPOR PRESSURE: N/A
MELTING POINT: N/A VAPOR DENSITY: N/A
SPECIFIC GRAVITY: N/A EVAPORATION RATE: N/A
(WATER = 1) (BUTYL ACETATE = 1)
WATER SOLUBILITY: 1 mg/100 ml WATER REACTIVE: No
APPEARANCE AND ODOR: White to practicall white powder. Odorless.
SECTION 3 - FIRE AND EXPLOSION DATA
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FLASH POINT (METHOD): N/A AUTOIGNITION TEMPERATURE: N/A
FLAMMABLE LIMITS: LOWER: N/A UPPER: N/A
EXTINGUISHING MEDIA: Water spray, carbon dioxide, dry chemical, foam.
SPECIAL FIRE FIGHTING PROCEDURES: Fire fighters should wear full protective gear including self-contained
breathing apparatus.
UNUSUAL FIRE AND EXPLOSION HAZARDS: May produce toxic fumes if heated to decomposition.
SECTION 4 - REACTIVITY HAZARD DATA
STABILITY: Stable ( X ) Unstable ( )
INCOMPATIBILITY (MATERIALS TO AVOID): None.
HAZARDOUS DECOMPOSITION PRODUCTS: May produce toxic fumes if heated to decomposition.
HAZARDOUS POLYMERIZATION: May Occur ( ) Will Not Occur ( X )
SECTION 5 - HEALTH HAZARD DATA
TOXICITY: LD50: (intraperitoneal - rat) 2300 mg/kg
(subcutaneous - mouse) 45.05 mg/kg
CARCINOGEN LISTED BY: NTP Yes ( ) No ( X )
IARC Yes ( ) No ( X )
OSHA Yes ( ) No ( X )
Other Yes ( ) No ( X )
ROUTES OF ENTRY: Inhalation, ingestion, absorption, contact.
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
INHALATION: May cause irritation of respiratory tract or allergic reaction.
EYE CONTACT: May cause irritation or allergic reaction.
SKIN CONTACT: May cause irritation or allergic reaction.
INGESTION: May cause irritation of gastrointestinal tract or allergic reaction.
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CHRONIC EFFECTS OF OVEREXPOSURE: Possible hypersensitization.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Hypersensitivity to this material. Systemic
fungal infection.
OTHER PRECAUTIONS TO CONSIDER: Persons developing serious hypersensitivity (anaphylactic) reactions must
receive medical attention immediately. Exposure may cause suppression of adrenal gland secretion, Cushing's
syndrome, water retention, electrolyte imbalance, hyperglycemia.
EMERGENCY FIRST AID PROCEDURES:
INHALATION: Remove to fresh air. If not breathing, give artificial respiration. Seek medical attention.
EYE CONTACT: Flush with water for at least 15 minutes. If irritation persists or develops, seek medical
attention.
SKIN CONTACT: Wash with soap and water. If irritation persists or develops, seek medical attention.
INGESTION: Flush mouth with water and seek medical attention.
SECTION 6 - CONTROL AND PROTECTIVE MEASURES
RESPIRATORY PROTECTION: NIOSH-approved respirator.
PROTECTIVE GLOVES: Rubber.
EYE PROTECTION: Safety glasses or goggles. Avoid wearing contact lenses when working with this material due to
the possibility of increased severity of eye damage.
VENTILATION: Use local ventilation if airborne levels are high.
OTHER PROTECTIVE EQUIPMENT: Appropriate laboratory apparel.
HYGIENIC WORK PRACTICES: Do not eat, drink or smoke near this material. Wash any contaminated clothing
before reuse.
SECTION 7 - HANDLING AND STORAGE PRECAUTIONS
HANDLING PRECAUTIONS: Avoid contact with skin, eyes or clothing. Avoid breathing dust.
STORAGE PRECAUTIONS: Store in tight containers in a cool, dry place.
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OTHER PRECAUTIONS: Wash any exposed skin areas after handling. Wash any contaminated clothing before
reuse.
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SECTION 8 - SPILL AND DISPOSAL PROCEDURES
STEPS TO BE TAKEN IN CASE OF SPILL OR DISCHARGE: Wear all protective clothing including respirator,
gloves and safety glasses/goggles. Vacuum or sweep up spillage and place in a tight container. Wash spill area with
soap and water. Wash any exposed skin area and wash contaminated clothing before reuse.
WASTE DISPOSAL METHOD: Dispose of in accordance with all applicable local, state, federal, and environmental
regulations.
SECTION 9 - DISCLAIMER
The information contained in this Material Safety Data Sheet has been compiled from reliable sources and is believed to
be correct as of the date issued. It is the responsibility of the user to determine the appropriateness and applicability to
their situation. Paddock Laboratories, Inc. disclaims any expressed or implied warranty as to the accuracy of the above
information and shall not be held liable for any direct, incidental, or consequential damages from use or reliance on the
above information.
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DEFINITIONS OF ABBREVIATIONS USED:
ACGIH: American Conference of Governmental Industrial Hygienists
CAS: Chemical Abstract Service
IARC: Internal Agency for Research on Cancer
IDLH: Immediately Dangerous to Life or Health level
LC50: Median Lethal Concentration
LD50: Median Lethal Dose
N/A: Not available
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
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