Material Safety Data Sheet
LA7510
NORKOOL (TM) SLH 50% PREMIX
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Id: LA7510
Product Name: NORKOOL (TM) SLH 50% PREMIX
Synonyms: None
Chemical Family: Glycols
Application: Intended as a heat transfer fuild for closed-loop systems.
Distributed By:
Univar Canada Ltd.
9800 Van Horne Way
Richmond, BC
V6X 1W5
Prepared By: The Safety, Health and Environment Department of Univar Canada Ltd.
Preparation date of MSDS: 05 January 2006
Telephone number of preparer: 1-866-686-4827
24-Hour Emergency Telephone Number (CANUTEC): (613) 996-6666
LA7510
NORKOOL (TM) SLH 50% PREMIX
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2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredients Percentage LD50s and LC50s Route & Species:
(W/W)
Ethylene Glycol 45-55 Oral LD50 (Rat) 4000 mg/kg
107-21-1 Dermal LD50 (Rabbit) 9530 碌L/kg
Water 45-55 Not available.
7732-18-5
Inhalation LC50 (Rat) 5500 碌g/m3
Sodium Nitrite 0.1-1
7632-00-0 Oral LD50 (Rat) 88 mg/kg
Dipotassium phosphate 1-3 Not available.
7758-11-4
1,4-dioxane 0.01 Oral LD50 (Rat) 7120 mg/kg
123-91-1 Dermal LD50 (Rabbit) 7600 碌L/kg
Ethylene Oxide 0.01 Oral LD50 (Rat) 0.05 mg/kg
75-21-8 Inhalation LC50 (Rat) 1.44 mg/L
Inhalation LC50 (Rat) 800 ppm
Inhalation LC50 (Rat) 9 mg/L
Propylene Oxide 0.01 Dermal LD50 (Rabbit) 1244 mg/kg
75-56-9 Oral LD50 (Rat) 380 mg/kg
Inhalation LC50 (Rat) 4000 ppm
Inhalation LC50 (Rat) 9.486 mg/L
Note: Remainder of the ingredients are non-hazardous.
3. HAZARDS IDENTIFICATION
Potential Acute Health Effects:
Eye Contact: Liquid, vapor, or mist causes irritation, experienced as stinging, excess blinking and tear production, with
excess redness of the conjunctiva.
Skin Contact: No evidence of harmful effects from available information.
Inhalation: Mist may irritate nose and throat. High vapor concentrations caused, for example, by heating the material in an
enclosed and poorly ventilated workplace, may produce nausea, vomiting, headache, dizziness, and irregular eye
movements.
Ingestion: Swallowing May cause abdominal discomfort or pain, nausea, vomiting, dizziness, drowsiness, malaise,
blurring of vision, irritability, lumbar pain, oliguria, uremia, and central nervous system effects, including irregular eye
movements, convulsions and coma. Cardiac failure, pulmonary edema, and severe kidney damage may develop. May be
fatal. A few reports have been published describing the development of weakness of the facial muscles, diminished
hearing, and difficulty with swallowing, during the late stages of severe poisoning.
LA7510
NORKOOL (TM) SLH 50% PREMIX
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4. FIRST AID MEASURES
Eye Contact: In case of contact, or suspected contact, immediately flush eyes with plenty of water for at least 15 minutes
and get medical attention immediately after flushing.
Skin Contact: Wash with soap and water. Remove contaminated clothing and launder before reuse. Get medical attention
if irritation persists.
Inhalation: Remove person to fresh air. If not breathing, give artificial respiration. If breathing is difficult, get immediate
medical attention.
Ingestion: Do NOT induce vomiting. Never give anything by mouth to an unconscious or convulsing person. Seek
immediate medical attention. If vomiting occurs spontaneously, keep head below hips to prevent aspiration of liquid into
the lungs.
Notes to Physician: It is estimated that the oral dose to adults is of the order of 1.0 ml/kg. Ethylene glycol is metabolized
by alcohol dehydrogenate to various metabolites including glyceraldehydes, glycolic acid and oxalic acid which cause an
elevated anion-gap metabolic acidosis and renal tubular injury. The signs and symptoms in ethylene glycol poisoning are
those of metabolic acidosis, CNS depression and kidney injury. Urinalysis may show albuminuria, hematuria and oxaluria.
Clinical chemistry may reveal anion-gap metabolic acidosis and uremia. The currently recommended medical
management of ethylene glycol poisoning includes elimination of ethylene glycol and metabolites, correction of metabolic
acidosis and prevention of kidney injury. It is essential to have immediate and follow up urinalysis and clinical chemistry.
There should be particular emphasis on acid-base balance and renal function tests. A continuous infusion of 5% sodium
bicarbonate with frequent monitoring of electrolytes and fluid balance is used to achieve correction of metabolic acidosis
and forced diuresis. As a competitive substrate for alcohol dehydogenase, ethanol is antidotal. Given in the early stages of
intoxication, it blocks the formulation of nephrotoxic metabolites. A therapeutically effective blood concentration of ethanol
is in the range 100 - 150 mg/dl and should be achieved by a rapid loading dose and maintained by intravenous infusion.
For severe and /or deteriorating cases, hemodialysis may be required. Dialysis should be considered for patients who are
symptomatic, have severe metabolic acidosis, a blood ethylene glycol concentration greater than 25 mg/dl, or compromise
of renal functions.
A more effective intravenous antidote for physician use in 4-methylpyrazole, a potent inhibitor of alcohol dehydrogenases
which effectively blocks the formation of toxic metabolites of ethylene glycol. It has been used to decrease the metabolic
consequences of ethylene glycol poisoning before metabolic acidosis coma, seizures and renal failure have occurred. A
generally recommended protocol is a loading dose of 15 mg/kg followed by 10 mg/kg every 12 hours for 4 doses and the
15 mg/kg every 12 hours until the ethylene glycol concentrations are below 20 mg/100ml.Slow intravenous infusion is
required. Since 4-methylpyrazole is dialyzable, increased dosage may be necessary during hemodialysis. Additional
therapeutic measures may include the administration of cofactors involved in the metabolism of ethylene glycol. Thiamine
(100 mg) and pyridoxine (50 mg) should be given every six hours.
Pulmonary edema with hypoxemia has been described in a number of patients following poisoning with ethylene glycol.
The mechanism of production has not been elucidated, but it appears to be non-cardiogenic in origin in several cases.
Respiratory support with mechanical ventilation and positive end expiratory pressure may be required. There may be
cranial nerve involvement in the late stages of toxicity from swallowed ethylene glycol. In particular, effects have been
reported involving the seventh, eighth and ninth cranial nerves, presenting with bilateral facial paralysis, diminished
hearing, and dysphagia.
5. FIRE FIGHTING MEASURES
Flash Point: 93 掳C / 199.4 掳F
Flash Point Method: Pensky-Martens Closed Cup
Autoignition Temperature: Not Available.
Flammable Limits in Air (%): Not Available.
Extinguishing Media: Apply alcohol-type or all-purpose-type foams by manufacturers' recommended techniques for large
fires. Use carbon dioxide or dry chemical media for small fires.
Special Exposure Hazards: During a fire, ammonia and nitrogen-containing compounds may be produced.
Hazardous Decomposition/Combustion Materials (under fire conditions): Not available.
Special Protective Equipment: Fire fighters should wear full protective clothing, including self-contained breathing
equipment.
NFPA RATINGS FOR THIS PRODUCT ARE: HEALTH 1, FLAMMABILITY 1, INSTABILITY 0
HMIS RATINGS FOR THIS PRODUCT ARE: HEALTH 1, FLAMMABILITY 1, REACTIVITY 0
LA7510
NORKOOL (TM) SLH 50% PREMIX
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6. ACCIDENTAL RELEASE MEASURES
Personal Precautionary Measures: Wear appropriate protective equipment.
Environmental Precautionary Measures: Prevent entry into sewers or streams, dike if needed. Consult local authorities.
Procedure for Clean Up: Isolate hazard area and restrict access. Absorb with an inert dry material and place in an
appropriate waste disposal container. Avoid direct contact with material.
7. HANDLING AND STORAGE
Handling: Do not swallow. Avoid contact with eyes, skin and clothing. Avoid breathing aerosols. Avoid breathing vapor.
Keep the containers closed when not in use. Use with adequate ventilation. Wash thoroughly after handling. For industrial
use only.
Storage: Store in a cool, dry, well ventilated area, away from heat and ignition sources. Place away from incompatible
materials. Store in accordance with good industrial practices.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Engineering Controls:
General (mechanical) room ventilation may be adequate, if handled at ambient temperatures or in covered equipment. If
ambient temperatures are exceeded or operations exist which may produce mist, aerosol or vapor, local exhaust
ventilation or other engineering controls may be required.
Respiratory Protection: If exposure exceeds occupational exposure limits, use an appropriate NIOSH-approved
respirator. NIOSH-approved atmosphere-supplying respirator or a NIOSH-approved air-purifying respirator with organic
vapor cartridge and dust/mist pre-filter is recommended.
Gloves: Natural rubber gloves. Neoprene gloves. Nitrile gloves. Polyvinylchloride gloves.
Skin Protection: Skin contact should be prevented through the use of suitable protective clothing, gloves and footwear,
selected for conditions of use and exposure potential. Consideration must be given both to durability as well as permeation
resistance.
Eyes: Chemical goggles; also wear a face shield if splashing hazard exists.
Other Personal Protection Data: Ensure that eyewash stations and safety showers are proximal to the work-station
location.
Ingredients Exposure Limit - ACGIH Exposure Limit - OSHA Immediately Dangerous
to Life or Health - IDLH
Ethylene Glycol 100mg/m鲁Ceiling 125 mg/m鲁 Ceiling Not Available.
50 ppm Ceiling
Water Not available. Not available. Not Available.
Sodium Nitrite Not available. Not available. Not Available.
Dipotassium phosphate Not available. Not available. Not Available.
1,4-dioxane 20 ppm TLV-TWA 25 ppm TWA 500 ppm
90 mg/m鲁 TWA
Ethylene Oxide 1 ppm TLV-TWA Not available. 800 ppm
Propylene Oxide 2 ppm TLV-TWA 20 ppm TWA 400 ppm
50 mg/m鲁 TWA
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Colour: Green
Odour: Mild
pH Not Available.
Specific Gravity: 1.079
Boiling Point: 107 掳C / 224.6 掳F
Freezing/Melting Point: -38 掳C / -36 掳F
Vapour Pressure: 13 mmHg
Vapour Density: 1
% Volatile by Volume: 98 Wt%
Evaporation Rate: 0.79
Solubility: 100%
VOCs: Not Available.
Viscosity: Not Available.
LA7510
NORKOOL (TM) SLH 50% PREMIX
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Molecular Weight: Not Available.
10. STABILITY AND REACTIVITY
Chemical Stability: Stable.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: WARNING: Do not mix this product with nitrites or other nitrosating agents because a nitrosamine
may be formed. Nitrosamines may cause cancer.
Materials to Avoid: Strong acids and bases. Explosive decomposition may occur if combined with strong acids or strong
bases and subjected to elevated temperatures. Materials reactive with hydroxyl compounds.
Hazardous Decomposition Products: Carbon monoxide. Carbon dioxide. Ammonia and nitrogen-containing
compounds.
Additional Information:
11. TOXICOLOGICAL INFORMATION
Principle Routes of Exposure
Ingestion: Swallowing May cause abdominal discomfort or pain, nausea, vomiting, dizziness, drowsiness, malaise,
blurring of vision, irritability, lumbar pain, oliguria, uremia, and central nervous system effects, including irregular eye
movements, convulsions and coma. Cardiac failure, pulmonary edema, and severe kidney damage may develop. May be
fatal. A few reports have been published describing the development of weakness of the facial muscles, diminished
hearing, and difficulty with swallowing, during the late stages of severe poisoning.
Skin Contact: No evidence of harmful effects from available information.
Inhalation: Mist may irritate nose and throat. High vapor concentrations caused, for example, by heating the material in an
enclosed and poorly ventilated workplace, may produce nausea, vomiting, headache, dizziness, and irregular eye
movements.
Eye Contact: Liquid, vapor, or mist causes irritation, experienced as stinging, excess blinking and tear production, with
excess redness of the conjunctiva.
Additional Information: Repeated skin contact with ethylene glycol may, in a very small proportion of cases, cause
sensitization with the development of allergic contact dermatitis. The incidence is significantly less than 1% with the
undiluted material.Repeated inhalation of ethylene glycol mist may produce signs of central nervous system involvement,
particularly dizziness and nystagmus (involuntary eye movement). Exposure may place individuals with existing heart
problems at added risk of potential cardiac irregularities and heart failure. In animals , effects have been reported on the
following organs: Kidney, liver.
May aggravate an existing kidney disease.
Acute Test of Product:
Acute Oral LD50: Not Available.
Acute Dermal LD50: Not Available.
Acute Inhalation LC50: Not Available.
Carcinogenicity:
Ingredients IARC - Carcinogens ACGIH - Carcinogens
Ethylene Glycol Not listed. A4 - Not Classifiable as a Human Carcinogen
(aerosol)
Water Not listed. Not listed.
Sodium Nitrite Not listed. Not listed.
Dipotassium phosphate Not listed. Not listed.
1,4-dioxane Group 2B A3 - Confirmed animal carcinogen with
unknown relevance to humans
Ethylene Oxide Group 1 A2 - Suspected Human Carcinogen
Propylene Oxide Group 2B A3 - Confirmed animal carcinogen with
unknown relevance to humans
Carcinogenicity Comment: Contains nitrites which may react with amines to form nitrosamines. Some nitrosamines have
been shown to be carcinogenic in laboratory animals.
LA7510
NORKOOL (TM) SLH 50% PREMIX
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Reproductive Toxicity/ Teratogenicity/ Embryotoxicity/ Mutagenicity: Ethylene glycol has been shown to produce
dose-related teratogenic effects in rats and mice when given by gavage or in drinking water at high concentrations or
doses. The no-effect doses for developmental toxicity for ethylene glycol given by gavage over the period of
organogenesis has been shown to be 150 mg/kg/day for the mouse and 500 mg/kg/day for the rat. Also, in a preliminary
study to assess the effects of exposure of pregnant rats and mice to aerosols at concentrations of 150, 1000 and 2500
mg/m3 for 6 hours a day throughout the period of organogenesis, teratogenic effects were produced at the highest
concentration, but only in mice. The conditions of these latter experiments did not allow a conclusion as to whether the
developmental toxicity was mediated by inhalation of aerosol, percutaneous absorption of ethylene glycol from
contaminated skin, or swallowing of ethylene glycol as a result of grooming the wetted coat. In a further study, comparing
effects from high aerosol concentration by whole-body or nose-only exposure, it was shown that nose-only exposure
resulted in maternal toxicity (1000 and 2500 mg/m3) and developmental toxicity with minimal evidence of teratogenicity
(2500 mg/m3). The no-effects concentration (based on maternal toxicity) was 500 mg/m3. In a further study in mice, no
teratogenic effects could be produced when ethylene glycol was applied to the skin of pregnant mice over the period of
organogenesis. The above observations suggest that ethylene glycol is to be regarded as an animal teratogen. There is
currently no available information to suggest that ethylene glycol has caused birth defects in humans. Cutaneous
application of ethylene glycol is ineffective in producing developmental toxicity. Exposure to high aerosol concentrations is
only minimally effective in producing developmental toxicity.
12. ECOLOGICAL INFORMATION
Ecotoxicological Information:
Ingredients Ecotoxicity - Fish Species Acute Crustaceans Toxicity: Ecotoxicity - Freshwater
Data Algae Data
Ethylene Glycol LC50 (bluegill) 27500 mg/L Not Available. Not Available.
LC50 (goldfish) 27500 mg/L
LC50 (rainbow trout) 41000
mg/L
Water Not Available. Not Available. Not Available.
Sodium Nitrite LC50 (rainbow trout (juvenile)) Not Available. Not Available.
0.19 mg/L
Dipotassium phosphate Not Available. Not Available. Not Available.
1,4-dioxane LC50 (fathead minnow) 9850 Not Available. Not Available.
mg/L
LC50 (bluegill sunfish) 10,000
mg/L
Ethylene Oxide LC50 (goldfish) 90 mg/L Not Available. Not Available.
Propylene Oxide LC50 (goldfish) 170 mg/L Not Available. Not Available.
Other Information:
13. DISPOSAL CONSIDERATIONS
Disposal of Waste Method: Disposal of all wastes must be done in accordance with municipal, provincial and federal
regulations.
Contaminated Packaging: Empty containers should be recycled or disposed of through an approved waste management
facility.
14. TRANSPORT INFORMATION
DOT (U.S.):
DOT Shipping Name: Not Regulated.
DOT Hazardous Class Not Applicable.
DOT UN Number: Not Applicable.
DOT Packing Group: Not Applicable.
DOT Reportable Quantity (lbs): Not Applicable.
Note: No additional remark.
Marine Pollutant: No.
ICAO/IATA:
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NORKOOL (TM) SLH 50% PREMIX
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IATA Proper Shipping Name: Not Regulated.
IATA Hazard Class: Not Applicable.
UN Number: Not Applicable.
Packing Group: Not Applicable.
IATA Label: Not Applicable.
IATA Remarks: No additional remark.
IMDG:
IMDG Proper Shipping Name: Not Regulated.
Hazard Class: Not Applicable.
UN Number: Not Applicable.
Packing Group: Not Applicable.
Marine Pollutant: No.
IMDG Label: Not Applicable.
Remarks: No additional remark.
TDG (Canada):
TDG Proper Shipping Name: Not Regulated.
Hazard Class: Not Applicable.
UN Number: Not Applicable.
Packing Group: Not Applicable.
Note: No additional remark.
Marine Pollutant: No.
LA7510
NORKOOL (TM) SLH 50% PREMIX
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15. REGULATORY INFORMATION
U.S. TSCA Inventory Status: All components of this product are either on theToxic Substances Control Act (TSCA)
Inventory List or exempt.
Canadian DSL Inventory Status: All components of this product are either on the Domestic Substances List (DSL), the
Non-Domestic Substances List (NDSL) or exempt.
Note: Not available.
U.S. Regulatory Rules
Ingredients CERCLA/SARA - Section SARA (311, 312) Hazard CERCLA/SARA - Section
302: Class: 313:
Ethylene Glycol Not Listed. LISTED LISTED
Water Not Listed. Not Listed. Not Listed.
Sodium Nitrite Not Listed. LISTED LISTED
Dipotassium phosphate Not Listed. Not Listed. Not Listed.
1,4-dioxane Not Listed. LISTED LISTED
Ethylene Oxide LISTED LISTED LISTED
Propylene Oxide LISTED LISTED LISTED
California Proposition 65: Listed.
MA Right to Know List: Listed.
New Jersey Right-to-Know List: Listed.
Pennsylvania Right to Know List: Listed.
WHMIS Hazardous Class:
D2A VERY TOXIC MATERIALS
D2B TOXIC MATERIALS
LA7510
NORKOOL (TM) SLH 50% PREMIX
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16. OTHER INFORMATION
Additional Information: This product has been classified in accordance with the hazard criteria of the
Canadian Controlled Products Regulations (CPR) and the MSDS contains all the
information required by the CPR.
Disclaimer: NOTICE TO READER:
Univar, expressly disclaims all express or implied warranties of merchantability and
fitness for a particular purpose, with respect to the product or information provided
herein, and shall under no circumstances be liable for incidental or consequential
damages.
Do not use ingredient information and/or ingredient percentages in this MSDS as a
product specification. For product specification information refer to a Product
Specification Sheet and/or a Certificate of Analysis. These can be obtained from your
local Univar Sales Office.
All information appearing herein is based upon data obtained from the manufacturer
and/or recognized technical sources. While the information is believed to be accurate,
Univar makes no representations as to its accuracy or sufficiency. Conditions of use
are beyond Univar's control and therefore users are responsible to verify this data
under their own operating conditions to determine whether the product is suitable for
their particular purposes and they assume all risks of their use, handling, and disposal
of the product, or from the publication or use of, or reliance upon, information
contained herein. This information relates only to the product designated herein, and
does not relate to its use in combination with any other material or in any other
process.
***END OF MSDS***
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NORKOOL (TM) SLH 50% PREMIX
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