Material Safety Data Sheet
Authorization date: 08/11/2000
Revision date: 08/22/2006
Print Date: 08/24/2006
Version: 0
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING
Product name: MITOMYCIN C
Product number: 107409
Global material number: 10107409001
Business area: Roche Applied Sciences
Product line: Not applicable
Instrument type: Not applicable
Supplier: Emergency telephone number:
Roche Diagnostics Corporation CHEMTREC:
9115 Hague Road 1-800-424-9300 (U.S. or Canada)
Indianapolis, IN 46250 1-703-527-3887 (International)
Site Phone Number: 1-800-428-5074
2. COMPOSITION/INFORMATION ON INGREDIENTS
Description 1: Bottle 1
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
MITOMYCIN C 50-07-7 99-100 NA NA NA NA
3. HAZARDS IDENTIFICATION
Emergency Overview
NFPA Ratings: Health= 3 Flammability= 0 Reactivity= 0 Special= T
Special Definitions: A=Allergen CA=Carcinogen CO=Corrosive F=Flammable H=Harmful I=Irritant Ox=Oxidizer PB=Potential Biohazard
R=Reproductive S=Sensitizer T=Toxic T+=Highly Toxic W=Water Reactive
Principle routes of exposure: Ingestion, inhalation, skin and/or eye contact.
Inhalation: Harmful by inhalation.
Ingestion: Toxic if swallowed.
Skin contact: None.
Eye contact: May cause irritation.
Sensitization or Odor threshold: None.
Medical conditions aggravated by None known
exposure:
Additional information: None
4. FIRST AID MEASURES
Inhalation: Consult a physician. Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen.
Skin contact: Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists, call a physician.
Ingestion: Call a physician immediately. Do not induce vomiting without medical advice.
Eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Notes to physician: None determined
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam.
Unusual hazards: None known.
Special protective equipment for In the event of fire, wear self-contained breathing apparatus.
firefighters:
6. ACCIDENTAL RELEASE MEASURES
Personal precautions: Use personal protective equipment. Evacuate personnel to safe areas. Remove all sources of ignition.
Avoid dust formation. Ensure adequate ventilation.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush into
surface water or sanitary sewer system. Do not let product enter drains.
Methods for cleaning up: Never return spills in original containers for re-use. Soak up with oil absorbent material. Sweep up or
vacuum (if powder) or soak up with inert absorbent material (if liquid), then place into a suitable clean, dry,
closed container, and label for disposal.
7. HANDLING AND STORAGE
Handling: Protect from contamination. Wear personal protective equipment. Can form a combustible mixture with air at pressures
above atmospheric when air concentration exceeds .? % by volume.
Storage: Keep containers dry and tightly closed to avoid moisture absorption and contamination.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Provide appropriate exhaust ventilation at places where dust is formed.
Personal Protective Equipment
Respiratory protection: Respiratory protection is required if dust formation with no local exhaust. If respiratory protection is
needed, follow the OSHA regulation, 29CFR1910.134. Always use a NIOSH approved respirator when
necessary.
Hand protection: Wear appropriate protective gloves to prevent skin contact. Replace torn or punctured gloves promptly.
Skin and body protection: Wear appropriate body protection to prevent skin contact.
Eye protection: Wear appropriate eye protection to prevent eye contact.
Hygiene measures: When using, do not eat, drink or smoke. Keep away from food and drink. Keep away from tobacco
products. Wash hands before breaks and immediately after handling the product. Handle in accordance
with good industrial hygiene and safety practice for diagnostics.
9. PHYSICAL AND CHEMICAL PROPERTIES
Boiling point/range: No information available
Color: Violet. Blue.
Melting point/range: >360C
pH: Not determined
Physical state: Solid.
Flash point: No information available.
LEL (%): Not determined
UEL (%): Not determined
10. STABILITY AND REACTIVITY
Stability: Stable under recommended storage conditions.
Polymerization: None under normal processing.
Hazardous decomposition products: Thermal decomposition can lead to release of irritating gases and vapours. Nitrogen oxides (nox).
Materials to avoid: Incompatible with strong acids and bases. Oxidising agents (strong).
11. TOXICOLOGICAL INFORMATION
Description 1: Bottle 1
Components NIOSH - NIOSH Pocket Guide -
Selected LD50s and LC50s: Target Organs:
MITOMYCIN C = 23 mg/kg Oral LD50 Mouse
= 30 mg/kg Oral LD50 Rat
Product number: 107409 Page 2 of 4
Product name: MITOMYCIN C
Inhalation: No additional data available
Skin: No additional data available
Oral: No additional data available
Mutagenic effects: No data is available on the product itself
Reproductive toxicity: Personnel who are pregnant, breast feeding, or who are concerned with other reproductive issues should
be encouraged to consult with the occupational health physician monitoring workers' health.
Carcinogenic effects:
Components IARC IARC IARC NTP OSHA EPA IRIS
Group 1 Group 2A or 2B Group 3 or 4 Select Carcinogen
Carcinogens Assessment
Supplement 7,
MITOMYCIN C
1987; Monograph
10, 1976
12. ECOLOGICAL INFORMATION
Bioaccumulation: No data available
Aquatic toxicity: Not applicable
Ecotoxicity effects: No data is available on the product itself
13. DISPOSAL CONSIDERATIONS
Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product,
if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local
hazardous waste regulatory authority. Residue from fires extinguished with this material may be
hazardous.
14. TRANSPORT INFORMATION
Is product hazardous to ship? Yes
DOT
Proper shipping name: Toxic solid, organic, n.o.s. (Mitomycin C)
UN Number: UN 2811 Hazard class: 6.1 Subsidiary risk: Not applicable Packing group: II
ICAO/IATA
Proper shipping name: Toxic solid, organic, n.o.s. (Mitomycin C)
UN Number: UN 2811 Hazard class: 6.1 Subsidiary risk: Not applicable Packing group: II
15. REGULATORY INFORMATION
U.S. Regulations:
U.S. CERCLA/SARA/TSCA Regulatory Information: The following chemicals are listed under the following TSCA/SARA/CERCLA lists. Refer to
TSCA regulation if you need a definition for acronyms that may be shown in the TSCA Inventory field in the table below
Components CERCLA/SARA 302 CERCLA/SARA 304 SARA 313 TSCA Inventory
RQ and TPQ RQ Emission reporting
(40 CFR 355, App.A) (40 CFR Table 302.4)
= 10,000 lb TPQ upper
MITOMYCIN C = 10 lb final RQ S
threshold = 4.54 kg final RQ
= 500 lb TPQ lower
threshold
U.S. Clean Water Act (CWA)/ California The following chemicals are listed under the CWA and/or California Proposition 65:
Proposition 65:
Components Clean Water Act Clean Water Act California Proposition 65
Hazardous Substances Priority Pollutants
MITOMYCIN C carcinogen; initial date 4/1/88
Product number: 107409 Page 3 of 4
Product name: MITOMYCIN C
Canadian Regulations:
Canada DSL Inventory List - This product does not comply with DSL
Canada NDSL Inventory List - This product complies with NDSL
Components Canada - WHMIS: Classifications of Substances:
MITOMYCIN C D1A; D2A
16. OTHER INFORMATION
Reason for revision: Not applicable
References: None.
Additional advice: None
Prepared by: Roche Diagnostics, Health & Safety Department, MSDS Contact: 317-521-7425 or 317-521-7505
The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation, after reasonable investigation and
research, to be accurate; however, Roche Diagnostics Corporation does not warrant the accuracy of this information. All materials and mixtures may present unknown
hazards and should be used with caution. When necessary or appropriate, independent opinions regarding the risk of handling or exposure should be obtained from trained
professionals. Roche Diagnostics Corporation disclaims any warranty against patent infringement and the implied warranties of merchantability and fitness for a particular
purpose. Customer's sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at Roche Diagnostics
Corporation's option. In no case shall Roche Diagnostics Corporation be liable for incidental or consequential damages, including lost profits.
End of Safety Data Sheet
Product number: 107409 Page 4 of 4
Product name: MITOMYCIN C
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