MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
SECTION 1: PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME: OSMIUM TETROXIDE 4% SOLUTION
SYNONYMS: OSMIC ACID SOLUTION, OSMIUM OXIDE
PRODUCT CODES: 19150,19160,19170,19190
MANUFACTURER: ELECTRON MICROSCOPY SCIENCES
DIVISION: 1560 INDUSTRY ROAD/P.O. BOX 550
ADDRESS: HATFIELD, PA 19440
EMERGENCY PHONE: 215-412-8400
CHEMTREC PHONE: 800-424-9300
FAX PHONE: 215-412-8450
CHEMICAL NAME: OSMIUM TETROXIDE, OSMIC SOLUTION
CHEMICAL FAMILY: PLATINUM GROUP METAL SALTS
CHEMICAL FORMULA: OsO4 IN H20
SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS
INGREDIENT:
OSMIUM TETROXIDE/OSMIUM OXIDE
CAS NO. % WT % VOL SARA 313 REPORTABLE
20816-12-0 4
mg/m3
ppm
OSHA PEL-TWA: -8H TWA- 0.002 MG/M3
OSHA PEL STEL :
OSHA PEL CEILING:
ACGIH TLV-TWA: 0.0002 MG/M3
ACGIH TLV STEL: 0.0006
ACGIH TLV CEILING:
SECTION 2 NOTES:
SECTION 3: HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW: THIS PRODUCT IS HIGHLY TOXIC. CONTACT WITH COMBUSTIBLE MATERIAL MAY
CAUSE FIRES. VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN, AND IF SWALLOWED. MAY CAUSE
SENSITIZATION BY INHALATION AND SKIN CONTACT.
ROUTES OF ENTRY: EYES-LIKELY INHALATION-HIGHLY
SKIN=LIKELY INGESTION-LIKELY
POTENTIAL HEALTH EFFECTS
EYES: IRRITATION, LACRIMATION, VISUAL DISTURBANCE, CONJUCTIVITIS, HEADACHE
POTENTIAL DAMAGE TO CORNEA.
SKIN: DERMATITUS, POSSIBLE SKIN DISCOLORATION (GREEN OR BLACK)
INGESTION: IRRITATION, COUGH, DYSPNEA, DEATH
INHALATION: COUGHING, SHORTNESS OF BREATH, UNCONSCIOUSNESS, COULD CAUSE
TRACHEITIS, BRONCHITUS, BRONCHIAL SPASM WHICH MAY LEAD TO INFLAMMATORY LESIONS
OF THE LUNG.
CONDITIONS AGGRAVATED BY OVEREXPOSURE: POTENTIAL KIDNEY DAMAGE
CHRONIC HEALTH HAZARDS: LABORATORY TESTS HAVE SHOWN MUTAGENIC EFFECTS.
SUBCHRONIC (TARGET ORGAN EFFECTS)-EYES AND CENTRAL NERVOUS SYSTEM ARE
TARGET ORGANS.
MEDICAL CONDITIONS GENERALLY AGGRAVATED BY EXPOSURE: ANY RESPIRATORY
PAGE 1 OF 6
MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
CONDITION SUCH AS ASTHMA WILL BE AGGRAVATED.
CARCINOGENICITY
OSHA: ACGIH: NTP: IARC:
OTHER:
NOT AVAILABLE
SECTION 4: FIRST AID MEASURES
EYES: FLUSH FOR 15 MINUTES WITH PLENTY OF WATER. IF DISCOMFORT OCCURS OR PERSISTS,
CONTACT A PHYSICIAN.
SKIN: FLUSH AREA FOR 15 MINUTES WITH WATER AND WASH WITH SOAP AND WATER. IF DISCOMFORT
OCCURS OR PERSISTS, CONTACT A PHYSICIAN. REMOVE CONTAMINATED CLOTHING AND SHOES AND
WASH BEFORE REUSE.
INGESTION: IF SWALLOWED GIVE LARGE QUANTITIES OF WATER AND INDUCE VOMITING UNLESS
PERSON IS UNCONSCIOUS. GET MEDICAL ATTENTION IMMEDIATELY.
INHALATION: REMOVE TO FRESH AIR IMMEDIATELY. IF DISCOMFORT OCCURS OR PERSISTS,
CONTACT A PHYSICIAN. IF BREATHING HAS STOPPED, PERFORM ARTIFICIAL RESPIRATION.
NOTES TO PHYSICIANS OR FIRST AID PROVIDERS: NONE LISTED
SECTION 5: FIRE-FIGHTING MEASURES
FLAMMABLE LIMITS IN AIR, UPPER: NA
(% BY VOLUME) LOWER:
FLASH POINT: NA
F:
C:
METHOD USED: NA
AUTOIGNITION TEMPERATURE: NA
F:
C:
NFPA HAZARD CLASSIFICATION
HEALTH: 4 FLAMMABILITY: 0 REACTIVITY: 1
OTHER: TOX
HMIS HAZARD CLASSIFICATION
HEALTH: 4 FLAMMABILITY: 0 REACTIVITY: 1
PROTECTION: J
EXTINGUISHING MEDIA: WATER SPRAY, CARBON DIOXIDE, AND DRY CHEMICAL.
SPECIAL FIRE FIGHTING PROCEDURES: USE NIOSH/MSHA APRROVED SELF-CONTAINED BREATHING
APARATUS AND FULL PROTECTIVE CLOTHING.
UNUSUAL FIRE AND EXPLOSION HAZARDS: OSO4 IS A STRONG OXIDIZER AND MAY REACT EXPLOSIVELY
WITH MANY ORGANIC COMPOUNDS.
HAZARDOUS DECOMPOSITION PRODUCTS: NONE
SECTION 6: ACCIDENTAL RELEASE MEASURES
PAGE 2 OF 6
MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
ACCIDENTAL RELEASE MEASURES: CLEAN UP IMMEDIATELY USING RECOMMENDED PERSONAL
PROTECTION. REMOVE MATERIAL TO A FUME HOOD OR OTHER WELL VENTILATED AREA. PERSON
PROTECTED WITH SELF-CONTAINED BREATHING APPARATUS WITH FULL FACE PIECE.
SECTION 7: HANDLING AND STORAGE
HANDLING AND STORAGE: IF EYES ARE EXPOSED TO VAPOR OVER A SHORT PERIOD OF TIME, NIGHT
VISION WILL BE AFFECTED FOR ABOUT ONE EVENING. ONE WILL NOTICE COLORED HALOS AROUND
LIGHTS. STORE SEALED VIALS IN A DRY COOL AREA (REFRIGERATOR) WITH SUFFICIENT PACKAGING
TO AVOID ACCIDENTAL BREAKAGE. USE COMPATIBLE CHEMICAL-RESISTANT GLOVES. WASH HANDS
THOROUGHLY AFTER HANDLING.
OTHER PRECAUTIONS: DO NOT STORE DIRECTLY ON GROUND. DO NOT STORE NEAR COMBUSTIBLE
MATERIALS. KEEP CONTAINER UPRIGHT. STORE IN DRY PLACE.
EMERGENCY OR PLANNED ENTRY IN UNKNOWN CONCENTRATION OR IMMEDIATELY DANGEROUS TO LIFE
OR HEALTH CONDITIONS. ANY SELF CONTAINED BREATHING APPARATUS WITH FULL FACEPIECE AND
OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE. ANY SELF-CONTAINED
BREATHING APPARATUS.
SECTION 7 NOTES:
ESCAPE- ANY AIR PURIFYING FULL FACE PIECE RESPIRATOR (GAS MASK) WITH CHIN-STYLE OR FRONT OR
BACK MOUNTED CANISTER PROVIDING PROTECTION AGAINEST OSMIUM TETROXIDE AND HAVING A HIGH
EFFICIENCY PARTICULATE FILTER. ANY APPROPRIATE ESCAPE TYPE SELF-CONTAINED BREATHING APPARATUS.
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
ENGINEERING CONTROLS: VENTILATION:
VENTILATION : LOCAL EXHAUST: YES, MECHANICAL: YES, OTHER: FUME HOOD.
RESPIRATORY PROTECTION: 0.1mg/m3 SUPPLIED AIR RESPIRATOR WITH A FULL FACEPIECE.
EYE PROTECTION: ANSI APPROVED SAFETY GLASSES/GOGGLES OR FULL FACE PIECE WIT HRESPIRATOR
SKIN PROTECTION: RUBBER/NEOPRENCE (USE COMPATIBLE CHEMCIAL-RESISTANT GLOVES)
OTHER PROTECTIVE CLOTHING OR EQUIPMENT: LAB COAT/APRON, FLAME AND CHEMICAL RESISTANT
PROTECTIVE CLOTHING, EYE WASH, SAFETY SHOWER, AND HYGIENE FACILITIES FOR WASHING.
WORK HYGIENIC PRACTICES: WASH THOROUGHLY AFTER HANDLING. WASH THOROUGHLY WITH SOAP
ANS WATER AFTER EVERY HANDLING.
EXPOSURE GUIDELINES: USE CHEMICAL GOGGLES AND FACE SHIELD
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE: COLORLESS TO PALE YELLOW SOLUTION
ODOR: SHARP CHLORINE LIKE ODOR.
PHYSICAL STATE: LIQUID
pH AS SUPPLIED: 6-7
pH (Other):
BOILING POINT: 1300 C
MELTING POINT: 350C
FREEZING POINT: NA
PAGE 3 OF 6
MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
VAPOR PRESSURE (mmHg): 11 TORR @ 270C
VAPOR DENSITY (AIR = 1): NE
@
SPECIFIC GRAVITY (H2O = 1): 1.016
@
EVAPORATION RATE: NE
BASIS (=1):
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (con鈥檛)
SOLUBILITY IN WATER: 5G/100ML
PERCENT SOLIDS BY WEIGHT: 5G 0s04/100ml
PERCENT VOLATILE: NA
BY WT/ BY VOL @
VOLATILE ORGANIC COMPOUNDS (VOC): NA
WITH WATER: LBS/GAL
WITHOUT WATER: LBS/GAL
MOLECULAR WEIGHT: 254.2
VISCOSITY:
@
SECTION 10: STABILITY AND REACTIVITY
STABLE UNSTABLE
STABILITY: STABLE
CONDITIONS TO AVOID (STABILITY): ELEVATED TEMPERATURE. CONTACT WITH HYDROCHLORIC ACID WILL
CAUSE FORMATION OF POISONOUS CHLORINE GAS.
INCOMPATIBILITY (MATERIAL TO AVOID): ORGANIC MATERIALS, HYDROCHLORIC ACID, BASES, AND
CHLORINE GAS.
HAZARDOUS DECOMPOSITION OR BY-PRODUCTS: NA
HAZARDOUS POLYMERIZATION: WILL NOT OCCUR
CONDITIONS TO AVOID (POLYMERIZATION): NA
SECTION 11: TOXICOLOGICAL INFORMATION
TOXICOLOGICAL INFORMATION: ACUTE DATA: LACRIMATION, VISUAL DISTURBANCE, CONJUNCTIVITIS,
HEADACHE, POTENTIAL DAMAGE TO CORNEAL DAMAGE, COUGHING, SHORTNESS OF BREATH, POTENTIAL
KIDNEY DAMAGE.
SECTION 12: ECOLOGICAL INFORMATION
ECOLOGICAL INFORMATION: NO DATA AVAILABLE
PAGE 4 OF 6
MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
SECTION 13: DISPOSAL CONSIDERATIONS
WASTE DISPOSAL METHOD: CRYSTALS AND SOLUTIONS MAY BE DISSOLVED AND OR NEUTRALIZED IN
AN AQUEOS SOLUTION OF SODIUM OR POTASSIUM HYDROXIDE (APPROX. 25%). CONSULT FEDERAL EPA,
STATE AND LOCAL REGULATIONS FOR PROPER DISPOSAL/RECYCLE/RECLAMATION MAY MAKE THE WASTE
MANAGEMENT INFO PRESENTED ABOVE INCOMPLETE, INACCURATE, OR OTHERWISE INAPPROPRIATE.
RCRA HAZARD CLASS: Os04 IS A LISTED EPA HAZARDOUS WASTE-P087
SECTION 13: DISPOSAL CONSIDERATIONS (con鈥檛)
SECTION 14: TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION
PROPER SHIPPING NAME: Toxic liquid inorganic, n.o.s.
HAZARD CLASS: 6.1
ID NUMBER: 3287
PACKING GROUP: PG-1
LABEL STATEMENT: P0SION
WATER TRANSPORTATION
PROPER SHIPPING NAME:
HAZARD CLASS: SAME
ID NUMBER:
PACKING GROUP:
LABEL STATEMENTS:
AIR TRANSPORTATION
PROPER SHIPPING NAME:
HAZARD CLASS:
ID NUMBER: SAME
PACKING GROUP:
LABEL STATEMENTS:
OTHER AGENCIES: NOT AVAILABLE
SECTION 15: REGULATORY INFORMATION
U.S. FEDERAL REGULATIONS
TSCA (TOXIC SUBSTANCE CONTROL ACT): THIS CHEMICAL IS TSCA LISTED, AND IS ALSO
CLASSIFIED WITH FDA AS AN IVD.
CERCLA (COMPREHENSIVE RESPONSE COMPENSATION, AND LIABILITY ACT):
SARA TITLE III (SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT):
311/312 HAZARD CATEGORIES:
313 REPORTABLE INGREDIENTS: OSMIUM TETROXIDE/OSMIUM OXIDE
RCRA HAZARDOUS WASTE
STATE REGULATIONS: NOT AVAILABLE
INTERNATIONAL REGULATIONS: THIS PRODUCT HAS BEEN CLASSIFIED IN ACCORDANCE WITH THE HAZARD
CRITERIA OF THE CPR, AND THE MSDS CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.
SECTION 16: OTHER INFORMATION
PAGE 5 OF 6
MATERIAL SAFETY DATA SHEET
MSDS DATE: 07/08/2007
PREPARATION INFORMATION:
DISCLAIMER: IN COMPLIANCE WITH THE OSHA HAZARD COMMUNICATION STANDARD, 2.9 C.F.R
1910. 1200, WE ARE PROVIDING YOU WITH A MSDS FOR THE HAZARDOUS MATERIAL YOU ARE
PURCHASING.
IT IS YOUR RESPONSIBILITY TO EDUCATE YOUR EMPLOYEES ON THE SAFE USE OF THE HAZARDOUS
MATERIAL.
ELECTRON MICROSCOPY SCIENCES MAKES NO PRESENTATION AS TO THE ACCURACY OF THE
INFORMATION IN THE MSDS. THE INFORMATION IS BELIEVED TO BE CORRECT; HOWEVER, YOU
(THE CUSTOMER), SHOULD PERFORM YOUR OWN INVESTIGATION AND INDEPENDENT
VERIFICATION. IF YOU RESELL THE PRODUCT, YOU ARE RESPONSIBLE TO FORWARD THE
INFORMATION IN THE MSDS TO YOUR CUSTOMER.
PAGE 6 OF 6
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