216 River Street
Suite 200
Troy, New York 12180
phone: (518) 273-6266
fax: (518) 273-6267
http://www.evidenttech.com
CdSe/ZnS EviFluors
MSDS
Section 1 - Chemical Product
Bioconjugated lipid coated EviDot (Cadmium Selenide/Zinc Sulfide nanocrystal compound)
Substance: packed in phosphate buffered saline
Trade Names/Synonyms: EviDots, EviFluors
Matrix: Water
Chemical Family: Nanocrystal: IV-VI semiconductor compound
Section 2 - Composition, Information on Ingredients
Component CAS# EC# % By Weight
Water 7732-18-5 N/A 85 - 90
Cadmium Selenide/Zinc Sulfide
1306-24-7 215-148-3 < 0.2
(as nanocrystal compound)
Lipid proprietary proprietary ~ 5 - 10
Phosphate Buffered Saline n/a n/a ~2-7
Highly Purified Antibody/Biotin/
n/a n/a < 0.2
Protein
Section 3 - Hazards Identification
Hazard Description: Moderately Toxic
NFPA Rating: Health = 1 Fire = 0 Reactivity = 0
Emergency Overview
Color: Yellow-Brown
Physical Form: Liquid
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page: 1
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Emergency Overview
Odor: None
Major Health Hazards: None known
Physical Hazards: None
Potential Health Effects
Inhalation: No data available
Skin Contact: No data available
Eye Contact: No data available
Ingestion: No data available
Cadmium Containing Selenium Containing Zinc Containing
Carcinogen Status: Compounds Compounds Compounds
OSHA: Yes No No
NTP: Yes No No
IARC: Yes No No
Section 4 - First Aid Measures
If inhaled, remove to fresh air. If not breathing give artificial
Inhalation: respiration and seek medical attention.
Wash skin with soap and water for at least 15 minutes while
Skin Contact: removing contaminated personal protective equipment, clothing and shoes. Seek medical
attention if needed.
Eye Contact: Irrigate eyes for at least 15 minutes. Seek medical attention.
Ingestion: If ingested, do not induce vomiting, seek medical attention immediately.
Section 5 - Fire Fighting Measures
Extinguishing Media: Material does not burn
Fire Fighting: Avoid inhalation of the material or combustion by-products.
Flash Point: Material does not burn
Flammable Limits: N/A
Autoignition Point: N/A
Flammability Class: Non-combustable
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page: 2
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Section 6 - Accidental Release Measures
Utilize personal protective equipment as described in section 8 and absorb with spill pillow.
Small Spills: Collect spilled material in appropriate container for disposal.
Section 7 - Handling and Storage
Utilize good hygienic work practices. Wash hands after use. Store in a tightly closed container. Store
refrigerated (4 C). Do not freeze.
Section 8 - Engineering Controls & Personal Protective Equipment
Exposure Limits
5 ug/m3 OSHA TWA (metal and compounds)
2.5 ug/m3 OSHA action level (metal and compounds)
0.2 mg/m3 OSHA TWA (dust) (where cadmium standard 1910.1027 is not in effect)
0.6 mg/m3 OSHA ceiling (dust) (where cadmium standard 1910.1027 is not in effect)
Cadmium compounds (as Cd) 0.01 mg/m3 ACGIH TWA (compounds and metal)
0.002 mg/m3 ACGIH TWA (respirable particulate, compounds and metal)
0.015 mg/m3 AGS TRK (inhalable dust fraction) (others)
0.025 mg/m3 UK MEL TWA (metal and compounds)
0.2 mg/m3 OSHA TWA
0.2 mg/m3 ACGIH TWA
0.2 mg/m3 NIOSH recommended TWA 10 hour(s)
Selenium compounds (as Se): 0.05 mg/m3 DFG MAK (peak limitation category - II, with excursion factor of 4) (inhalable
dust fraction) (metal and inorganic compounds)
0.1 mg(Se)/m3 UK OES TWA
Zinc Sulfide 15mg/m3 OSHA TWA (particulates not otherwise regulated)
Polymer Not regulated
Lipid Not regulated
No special ventilation requirements needed, unless heated to boiling point then provide
Ventiliation: local exhaust ventilation system or work in a chemical fume hood. Ensure compliance with
applicable exposure limits.
Wear safety glasses with side shields as a minimum level of protection. If splash or splat-
ter is possible, wear chemical/splash resistant safety goggles and or face shield. Emer-
Eye Protection: gency eye wash station and quick drench shower should be provided in the immediate
work area as per the ANSI Z358.1 guidelines.
Clothing: Wear appropriate chemical resistant clothing.
Wear appropriate chemical resistant gloves for type of exposure. Latex, nitrile or butyl
Gloves: gloves provide adequate protection.
Respirator: Material in liquid form, no respiratory protection required.
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page:
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Section 9 - Physical & Chemical Properties
Cadmium Selenide / Zinc Sulfide EviDots
Physical State: Liquid
Color: Yellow-brown
Odor: None
Boiling Point: ~212 F (100 C)
Freezing Point: ~32 F (0 C)
Vapor Pressure: N/A
Vapor Density ( air = 1 ): N/A
Specific Gravity ( water = 1 ): ~1.0
pH: Neutral
Section 10 - Reactivity
Stability: Stable at standard temperatures and pressure.
Conditions to avoid: Avoid freezing
Incompatible: Alkali metals.
Hazards Decomposition: N/A
Polymerization: Material will not polymerize
Section 11 - Toxicological Information
Zinc Sulfide
Oral Rat > 2,000 mg/kg LD50; Inhalation Rat > 5,040 mg/m3 LC50; Skin Rat> 2,000
Toxicity Data: mg/kg LD50
Acute inhalation, skin and eye
Zinc Sulfide is an irritant to the eyes, respiratory system and skin.
toxicity:
Cadmium Compounds
Exposure to sufficiently high concentrations of cadmium dusts may result in upper respira-
tory tract irritation with delayed symptoms of cough, sore throat, wheezing, headache,
Acute Inhalation: chest pain, dizziness, abdominal pain, nausea, diarrhea and vomiting. Exposure may also
cause sweating, chills, and difficulty in breathing. Severe exposures may result in lung,
kidney or liver damage or death from massive pulmonary edema.
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page:
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Cadmium Compounds
Cadmium is highly cumulative and respiratory effects from repeated or prolonged exposure
to dusts or fumes may include rhinitis, bronchitis, emphysema, cough, dyspnea, abnormal
lung function, obstructive disease, and possibly fibrosis. Ulceration of the nasal septum and
yellow discoloration of the teeth may occur. Cadmium induced kidney damage is irrevers-
ible and may progress after exposure ceases; some cases of progression to kidney failure
have been described. Osteomalacia, osteoporosis, and spontaneous and pseudofractures
Chronic Inhalation: may occur and may be manifested as back pain, pain in the extremities, difficulty in walk-
ing, and pain on bone pressure. Other effects may include irritability, weight loss, fatigue,
mild to moderate anemia, eosinophilia, damage to the olfactory nerve with anosmia, and
liver damage. An epidemiological study suggests a relationship between cadmium levels in
air and cardiovascular disease, but a causal association has not been proved. Occupation-
al exposure to cadmium is implicated in a significant increase in the incidence of prostatic
and respiratory cancers.
The persistent vomiting induced by cadmium compounds may limit the amount retained,
but if sufficient amounts are absorbed, symptoms of systemic toxicity may begin within 15
minutes to 2 hours. Salivation, choking, severe nausea, abdominal pain, diarrhea, tenes-
mus, blurred vision, dizziness, headache, muscular cramps, exhaustion, collapse, shock,
Acute Ingestion of Cadmium
unconsciousness and rarely, convulsions may occur. Recovery may begin within 5-10
Compounds: hours; sequelae may include delayed liver and kidney damage. Single doses of 10-20 mg
of soluble cadmium salts have induced severe toxic effects and doses above 300 mg may
be fatal. Death due to shock and dehydration may occur within 24 hours or may be delayed
7-14 days and be due to renal failure or cardiopulmonary depression.
Cadmium accumulates in the body and prolonged low level exposure may cause irre-
Chronic Ingestion of Cadmium
versible renal tubular dysfunction and bone effects as described in the chronic inhalation
Compounds: section.
Moderately Toxic: Ingestion
Target Organs: Nervous system
Selenium Compounds
May cause irritation and inflammation of the upper respiratory tract, redness of mucous
membranes, sneezing, coughing, sore throat, metallic taste in the mouth, and gastrointes-
Acute Inhalation: tinal distress. Exposure to high concentrations of fumes may cause dyspnea and possibly
slight tracheobronchitis. Central nervous effects may include frontal headaches, nervous-
ness, convulsions, and death from respiratory depression.
Repeated or prolonged exposure may result in a metallic taste in the mouth followed by a
garlic odor of the breath and sweat. Other symptoms may include pallor, coated tongue,
gastrointestinal disturbances including nausea, vomiting, abdominal pain, diarrhea, weight
Chronic Inhalation: loss, lumbar pain, depression, lassitude, fatigue, giddiness, and emotional instability.
Liver and spleen effects and albuminuria, porphyrinuria, and urobilinuria have also been
reported.
Contact with selenium compounds may cause irritation, rashes and skin eruptions. Some
Acute Skin Exposure: compounds are strong vesicants and can cause destruction of skin and possibly burns.
Repeated or prolonged exposure to light dust concentrations of selenium compounds
Chronic Skin Exposure: may cause dermatitis, paronychia, and skin eruptions. Some selenium compounds are
absorbed through the skin and may result in effects as detailed in the inhalation section.
Ingestion may cause severe irritation and disturbances of the gastrointestinal tract, metallic
Acute Ingestion: taste in the mouth, tachycardia, chills, and central nervous system effects as detailed in
acute inhalation.
Repeated or prolonged ingestion may result in a metallic taste in the mouth, garlic odor of
breath and sweat, and other symptoms as described in chronic inhalation. Additional ef-
fects reported from ingestion of food and water containing excessive amounts of selenium
include skin hyperpigmentation, nail changes, gingivitis, excess dental caries, maloc-
Chronic Ingestion: clusion, weight loss, vestibulotoxicity, amyotrophic lateral sclerosis, arthritis, problems
walking, diminished reflexes, substernal pain, disturbances of respiratory and endocrine
function, jaundice, hepatic disease, and socio-psychologic effects. In extreme cases, loss
of nails and hair, numbness and incoordination of arms and legs, paralysis, lack of mental
alertness and death from respiratory paralysis may occur.
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page:
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Selenium Compounds
To the best of our knowledge the acute and chronic toxicity of this substance is not fully
known. Cadmium Selenide, in the form of a nanocrystal may or may not present the same
Additional toxicological informa-
health hazards as a larger cadmium or selenium containing molecules. It is therefore en-
tion: couraged to use caution when handling this product as its toxicity and modes of exposure
are not well characterized or understood.
Lipid
No data available
Phosphate Buffered Saline
No data available
Antibodies / Biotin / Proteins
No data available
Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this Evitag material is not fully known.
Cadmium compounds, in the form of a nanocrystal may or may not present the same health hazards as
a larger cadmium containing molecules. It is therefore encouraged to use caution when handling this
product even though the concentration of cadmium is very low, its toxicity and modes of exposure are
not well characterized or understood.
Section 12 - Ecological Information
Do not allow material to be released to the environment (ground, air or water bodies) without proper
permits.
Section 13 - Transportation Information
U.S. DOT: Not regulated
Canadian Transportation of
Not regulated
Dangerous Goods:
Land Transport ADR/RID Not regulated
Air Transport IATA/ICAO Not regulated
Section 14 - Disposal
Dispose in accordance with all applicable local, state and federal regulations. Considered dangerous to the
environment. U.S. EPA 40 CFR 262: Hazardous Waste Number: D006 (cadmium), D010 (selenium)
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page: 6
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
MSDS Section 15 - Regulatory Information
US Regulations
CERCLA: No
SARA Title III, sec. 302, 304: No
SARA Title III, Section 311/312
Acute: No
Chronic: Yes
Fire: No
Reactive: No
Sudden Release: No
US Inventory (TSCA) listed: Yes
Canadian Regulations
WHMIS Classification: Not available
European Regulations
Xn, N
EC Risk Phrases
R22, R45,R51, S2, S60, S61
Section 16 - Other Information
The above information is believed to be correct but does not purport to be all inclusive and shall
be used only as a guide. Evident Technologies shall not be held liable for any damage resulting
from handling or from contact with the above product. See packing slip for additional terms and
conditions of sale.
Revision Date: 1/22/2006
Creation Date: 1/22/2006
216 River Street
Suite 200
Troy, New York 12180
phone: (518) 273-6266
fax: (518) 273-6267
http://www.evidenttech.com
January 2006 - CdSe/ZnS EviFluor MSDS v1.0 Page:
漏 2006 Evident Technologies, Inc. All specifications subject to change without notice
|