ISO9001:2000 Certified
Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Section 1 - Chemical Product and Company Identification
MSDS Name:
Diphenylcarbazone-Bromophenol Blue
Catalog Numbers:
Q08631
Synonyms:
Company Identification:
Qorpak
1195 Washington Pike
Bridgeville, PA 15017
Company Phone Number:
(412) 257-3100
Emergency Phone Number:
(800) 424-9300
CHEMTREC Phone Number:
(800) 424-9300
Section 2 - Composition, Information on Ingredients
Percent
Chemical Name
CAS#
538-62-5 Diphenylcarbazone 0.5
115-39-9 Bromophenol blue 0.05
64-17-5 Ethanol 90
67.56-1 Methanol 5
67-63-0 Isopropanol 5
Section 3 - Hazards Identification
Emergency Overview
Appearance: Green liquid.
Warning! Poison. Causes severe eye irritation. Causes respiratory tract irritation. Flammable
liquid and vapor. May be fatal or cause blindness if swallowed. Vapor harmful. This substance has
caused adverse reproductive and fetal effects in humans. May be absorbed through intact skin. May
cause digestive tract irritation. May cause central nervous system depression. May form explosive
peroxides. May cause liver, kidney and heart damage. Cannot be made non-poisonous. Causes
moderate skin irritation.
Target Organs: Kidneys, central nervous system, liver, eyes.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause painful sensitization to light. May cause chemical
conjunctivitis and corneal damage.
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Skin:
Causes moderate skin irritation. May be absorbed through the skin. May cause cyanosis of the
extremities.
Ingestion:
May be fatal or cause blindness if swallowed. May cause gastrointestinal irritation with nausea,
vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous
system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and
nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to
respiratory failure.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea,
headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause
narcotic effects in high concentration. Vapors may cause dizziness or suffocation.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. May cause reproductive and
fetal effects. Laboratory experiments have resulted in mutagenic effects. Animal studies have
reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart
damage.
Section 4 - First Aid Measures
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids
until no evidence of chemical remains. Get medical aid at once.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while
removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Ingestion:
Give conscious victim 2-4 cupfuls of milk or water. Get medical aid at once. Give oxygen if
respiration is depressed. Induce vomiting (touch finger to back of throat) keeping head lower than
hips (prevent aspiration into lungs).
Inhalation:
Give artificial respiration if necessary. Get medical aid. Keep victim warm, at rest. Move victim to
fresh air.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information:
Ethanol may inhibit methanol metabolism. As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may
form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will
burn if involved in a fire. Flammable liquid. Can release vapors that form explosive mixtures at
temperatures above the flash point. Use water spray to keep fire-exposed containers cool. Containers
may explode in the heat of a fire. May form explosive peroxides. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas. Will be easily ignited by
heat, sparks or flame.
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large
fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective. Do NOT use straight streams of water. Cool containers with
flooding quantities of water until well after fire is out.
Autoignition Temperature:
685掳F (362.8掳C)
Flash Point:
55掳F (12.8掳C)
NFPA Rating:
CAS # 538-62-5: H-2; F-2; I-1
CAS # 115-39-9: H-1; F-0; I-0
CAS # 64-17-5: H-0; F-3; I-0
CAS # 67-56-1: H-1; F-3; I-0
CAS # 67-63-0: H-1; F-3; I-0
Explosion Limits:
Lower: 3.3% Upper: 19%
Section 6 - Accidental Release Measures
General Information:
Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.
Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing
foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in
closed spaces.
Section 7 - Handling and Storage
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in
a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof
tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers
retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed.
Keep away from heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze,
solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from heat and flame. Keep away from sources
of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in
a cool, dry, well-ventilated area away from incompatible substances. Flammables area. Do not store
near perchlorates, peroxides, chromic acid or nitric acid.
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits:
Chemical Name ACGIH NIOSH OSHA
Diphenylcarbazone none listed none listed none listed
Bromophenol blue none listed none listed none listed
Ethyl alcohol 1000 ppm TWA 1000 ppm TWA; 1000 ppm TWA;
1900 mg/m3 TWA 1900 mg/m3 TWA
Methyl alcohol 200 ppm TWA; 200 ppm TWA; 200 ppm TWA;
250 ppm STEL; Skin - 260 mg/m3 TWA 260 mg/m3 TWA
potential significant 6000 ppm IDLH
contribution to overall
exposure by the
cutaneous route
Isopropyl alcohol 200 ppm TWA; 400 ppm TWA; 400 ppm TWA;
400 ppm STEL 980 mg/m3 TWA 980 mg/m3 TWA
2000 ppm IDLH
OSHA Vacated PELs:
Ethyl alcohol: 1000 ppm TWA; 1900 mg/m3 TWA
Methyl alcohol: 200 ppm TWA; 260 mg/m3 TWA
Isopropyl alcohol: 400 ppm TWA; 980 mg/m3 TWA
Personal Protective Equipment
Eyes:
Do not wear contact lenses when working with chemicals. An eye wash fountain should be available
in the immediate work area. Wear splash-proof safety goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2
requirements or European Standard EN 149 must be followed whenever workplace conditions
warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Color: Green
Odor: Alcohol-like
pH: No information found.
Vapor Pressure: 44 mm Hg
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Vapor Density: 1.24 kg/m3
Evaporation Rate: No information found.
Viscosity: 1.2 cP
Boiling Point: 173.3 掳 F (78.5 掳 C)
Freezing/Melting Point: -173.4 掳 F (-114 掳 C)
Decomposition Temperature: No information found.
Solubility in water: Soluble.
Specific Gravity/Density: 0.8
Molecular Formula: Not applicable.
Molecular Weight: Not applicable.
Section 10 - Stability and Reactivity
Chemical Stability:
This material may be sensitive to peroxide formation.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, acid chlorides, active metals, alkali metals, aluminum,
ammonia, halogens, hydrazine, nitric acid, peroxides, isocyanates, aliphatic amines, sodium,
caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium
hydroxide), acid anhydrides, calcium hypochlorite, cyanuric chloride, chromyl chloride, nitrosyl
perchlorate, diethyl zinc, bromine pentafluoride, perchloric acid, silver nitrate, chromic anhydride,
mercuric nitrate, phosphorus trioxide, potassium tert-butoxide, magnesium perchlorate, platinum,
uranium hexafluoride, silver oxide, iodine heptafluoride.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization:
Has not been reported
Section 11 - Toxicological Information
RTECS:
CAS# 538-62-5: LQ9420000.
CAS# 115-39-9: SJ7453000.
CAS# 67-56-1: PC1400000.
CAS# 67-63-0: NT8050000.
CAS# 64-17-5: KQ6300000.
LD50/LC50:
CAS# 538-62-5:
Oral, rat: LD50 >500mg/kg
CAS# 115-39-9:
Not available.
CAS# 64-17-5:
Inhalation, mouse: LC50 =39 gm/m3/4H
Inhalation, rat: LC50 =20000 ppm/10H
Oral, mouse: LD50 = 3450 mg/kg
Oral, rabbit: LD50 = 6300 mg/kg
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Oral, rat: LD50 = 7060 mg/kg.
CAS# 67-56-1:
Draize test, rabbit, eye: 40 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H Moderate;
Inhalation, rabbit: LC50 = 81000 mg/m3/14H;
Inhalation, rat: LC50 = 64000 ppm/4H;
Oral, mouse: LD50 = 7300 mg/kg;
Oral, rabbit: LD50 = 14200 mg/kg;
Oral, rat: LD50 = 5600 mg/kg;
Skin, rabbit: LD50 = 15800 mg/kg
CAS# 67-63-0:
Draize test, rabbit, eye: 100 mg Severe;
Draize test, rabbit, eye: 10 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 500 mg Mild;
Inhalation, mouse: LC50 = 53000 mg/m3;
Inhalation, rat: LC50 = 16000 ppm/8H;
Inhalation, rat: LC50 = 72600 mg/m3;
Oral, mouse: LD50 = 3600 mg/kg;
Oral, mouse: LD50 = 3600 mg/kg;
Oral, rabbit: LD50 = 6410 mg/kg;
Oral, rat: LD50 = 5045 mg/kg;
Oral, rat: LD50 = 5000 mg/kg;
Skin, rabbit: LD50 = 12800
Carcinogenicity:
CAS# 538-62-5: Not listed by ACGIH, IARC, NTP, or California Prop 65.
CAS# 115-39-9: Not listed by ACGIH, IARC, NTP, or California Prop 65.
CAS# 64-17-5: Not listed by ACGIH, IARC, NTP, or California Prop 65.
CAS# 67-56-1: Not listed by ACGIH, IARC, NTP, or California Prop 65.
CAS# 67-63-0: Not listed by ACGIH, IARC, NTP, or California Prop 65.
Epidemiology:
Methanol and phenol have been shown to produce fetotoxicity in the embryo or fetus in laboratory
animals. Specific developmental abnormalities for methanol include the musculoskeletal, urogenital.
and cardiovascular systems. Methanol has been shown to produce fetotoxicity in the embryo or
fetus of laboratory animals. Specific developmental abnormalities include cardiovascular,
musculoskeletal, and urogenital systems. Ethanol has been shown to produce fetotoxicity in the
embryo or fetus of laboratory animals. Experimental teratogenic and reproductive effects have been
reported for isopropanol. Prenatal exposure to ethanol is associated with a distinct pattern of
congenital malformations that have collectively been termed the "fetal alcohol syndrome".
Teratogenicity:
CAS# 64-17-5: Oral, Human - woman: TDLo = 41 gm/kg (female 41 week(s) after conception)
Effects on Newborn - Apgar score (human only) and Effects on Newborn - other neonatal measures
or effects and Effects on Newborn - drug dependence.
Reproductive:
CAS# 64-17-5: Intrauterine, Human - woman: TDLo = 200 mg/kg (female 5 day(s) pre-mating)
Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females
pregnant per # females mated).
Mutagenicity:
CAS# 64-17-5: DNA Inhibition: Human, Lymphocyte = 220 mmol/L.; Cytogenetic Analysis:
Human, Lymphocyte = 1160 gm/L.; Cytogenetic Analysis: Human, Fibroblast = 12000 ppm.;
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
Cytogenetic Analysis: Human, Leukocyte = 1 pph/72H (Continuous).; Sister Chromatid Exchange:
Human, Lymphocyte = 500 ppm/72H (Continuous).
Neurotoxicity:
No information found.
Section 12 - Ecological Information
Ecotoxicity:
Fish: Rainbow trout: LC50 = 12900-15300 mg/L; 96 Hr; Flow-through @ 24-24.3掳CFish: Rainbow
trout: LC50 = 11200 mg/L; 24 Hr; Fingerling (Unspecified) Bacteria: Phytobacterium phosphoreum:
EC50 = 34900 mg/L; 5-30 min; Microtox test. CAS# 64-17-5: When spilled on land, it is apt to
volatilize, biodegrade, and leach into the ground water, but no data on the rates of these processes could
be found. Its fate in ground water is unknown. When released into water it will volatilize and probably
biodegrade. It would not be expected to adsorb to sediment or bioconcentrate in fish.
Environmental:
CAS# 64-17-5: When released to the atmosphere it will photodegrade in hours (polluted urban
atmosphere) to an estimated range of 4 to 6 days in less polluted areas. Rainout should be significant.
Section 13 - Disposal Considerations
Dispose of in accordance with Federal, State, and local regulations.
Section 14 - Transport Information
US DOT
Shipping Name: Ethanol solution
Hazard Class: 3
UN Number: UN1170
Packing Group: PG III
Section 15 - Regulatory Information
US Federal
TSCA:
CAS# 538-62-5 is listed on the TSCA inventory.
CAS# 115-39-9 is listed on the TSCA inventory.
CAS# 64-17-5 is listed on the TSCA inventory.
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# 67-63-0 is listed on the TSCA inventory.
SARA Reportable Quantities (RQ):
CAS# 67-56-1: 5000 lb. final RQ; 2270 kg final RQ
CERCLA/SARA Section 313:
This material contains Methyl alcohol (CAS# 67-56-1, 4.5-5.5%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
This material contains Isopropyl alcohol (CAS# 67-63-0, 4.5-5.5%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
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Material Safety Data Sheet
Diphenylcarbazone-Bromophenol Blue
OSHA - Highly Hazardous:
None of the components are on this list.
US State
State Right to Know:
CAS# 538-62-5 is not present on state lists from California, Pennsylvania, Minnesota,
Massachusetts, Florida, or New Jersey.
CAS# 115-39-9 is not present on state lists from California, Pennsylvania, Minnesota,
Massachusetts, Florida, or New Jersey.
CAS# 64-17-5 can be found on the following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-56-1 can be found on the following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-63-0 can be found on the following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Regulations:
WARNING: This product contains Ethyl alcohol, a chemical known to the state of California to
cause birth defects or other reproductive harm.
European/International Regulations
Canadian DSL/NDSL:
CAS# 538-62-5 is listed on Canada's DSL List.
CAS# 115-39-9 is listed on Canada's DSL List.
CAS# 64-17-5 is listed on Canada's DSL List.
CAS# 67-56-1 is listed on Canada's DSL List.
CAS# 67-63-0 is listed on Canada's DSL List.
Canada Ingredient Disclosure List:
CAS# 538-62-5 is not listed on the Canadian Ingredient Disclosure List.
CAS# 115-39-9 is not listed on the Canadian Ingredient Disclosure List.
CAS# 64-17-5 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-63-0 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Other Information
MSDS Creation Date: November 1, 2006
Revision Date: None
Information in this MSDS is from available published sources and is believed to be accurate. No warranty,
express or implied, is made and Qorpak assumes no liability resulting from the use of this MSDS. The user
must determine suitability of this information for his application.
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