MATERIAL SAFETY DATA SHEET
MANUFACTURER Varian Instruments 鈥? Middelburg
ADDRESS Herculesweg 8
4338 PL Middelburg, Netherlands
PHONE 31.118.67100 MSDS Number: 1002-007 Rev. 0
EMERGENCY PHONE 1.800.424.9300 鈥? CHEMTREC USA Date: April 9, 2002
FAX 31.118.633118 Prepared by: Corporate EH&S
SECTION 1: MATERIAL IDENTIFICATION
Product Name: Testmix CP0007
Synonyms: Amino acids in Dichloromethane. Dichloromethane is also known as Methylene Chloride.
SECTION 2: COMPOSITION
An ampoule/vial containing the following:
Approximate NTP IARC
Component CAS Number Concentration Carcinogen Status Carcinogen Status
d-Alanine 338-69-2 1% not listed not listed
l-Alanine 56-41-7 1% not listed not listed
d-Leucine 328-38-1 1% not listed not listed
l-Leucine 61-90-5 1% not listed not listed
d-Aspartic acid 1783-96-6 1% not listed not listed
l-Aspartic acid 56-84-8 1% not listed not listed
d-Methionine 348-67-4 1% not listed not listed
l-Methionine 63-68-3 1% not listed not listed
Dichloromethane 75-09-2 balance listed* listed**
*Anticipated to be a human carcinogen
**Group 2B - Possibly carcinogenic to humans
WARNING: This product contains Dichloromethane [CAS# 75-09-2] a chemical known to the State of California to cause cancer.
NOTE: Unless otherwise noted, the information below pertains only to the Dichloromethane solvent in the ampoule/vial.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview: Colorless liquid. May cause central nervous system depression. This substance has caused adverse
reproductive and fetal effects in animals. Potential cancer hazard. Warning! Causes eye and skin irritation and possible burns.
Causes digestive and respiratory tract irritation with possible burns. May be harmful if swallowed. May cause blood abnormalities.
Target Organs: Blood, heart, central nervous system, liver, and pancreas.
Potential Health Effects
Inhalation: Causes irritation to respiratory tract. Has a strong narcotic effect with symptoms of mental confusion, light-headedness,
fatigue, nausea, vomiting and headache. Causes formation of carbon monoxide in blood that affects cardiovascular system and
central nervous system. Continued exposure may cause increased light-headedness, staggering, unconsciousness, and death.
Ingestion: May cause irritation of the gastrointestinal tract with vomiting. If vomiting results in aspiration, chemical pneumonia
could follow. Absorption through gastrointestinal tract may produce symptoms similar to those for inhalation exposure.
Skin Contact: May be absorbed through the skin. Causes irritation with burning pain, itching, and redness. Prolonged exposure
may result in skin burns.
Eye Contact: Both liquid and vapors may cause irritation, redness, and pain.
Carcinogen Status: NTP: Anticipated to be a human carcinogen IARC: Group 2B - Possibly carcinogenic to humans
SECTION 4: FIRST AID INFORMATION
Inhalation: Get medical attention immediately. Remove to fresh air. If breathing is difficult, give oxygen. If breathing has ceased
apply artificial respiration. using oxygen and a suitable mechanical device such as a bag and a mask. Do NOT use mouth-to-
mouth resuscitation.
Ingestion: If swallowed, get medical attention immediately. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never
give anything by mouth to an unconscious person.
Skin Contact: In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse.
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical
attention immediately. Do NOT allow victim to rub or keep eyes closed.
MSDS# 1002-007 Revision 0 Effective Date 04/09/02 Page 1 of 4
SECTION 5: FIRE-FIGHTING INFORMATION
Fire: Flash point (closed cup): None
Autoignition temperature: 556C (1033F)
Flammable limits in air % by volume: Lower = 12 Upper = 23
Forms flammable vapor-air mixtures above 100C (212F)
NFPA Rating: health-2; flammability-1; reactivity-0
Explosion: Concentrated vapor can be ignited by a high intensity ignition source. Vapor may form flammable mixture in
atmosphere that contains a high percentage of oxygen. Sealed containers may rupture when heated.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide. Water spray may be used to keep fire exposed containers cool.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Use proper personal protective equipment as indicated in Section 8. Ventilate area of leak or spill. Remove all sources of ignition.
Absorb spill with inert material (e.g. vermiculite, sand or earth), scoop up with a nonsparking tool, then place into a suitable
container for disposal. Do not flush to sewer!
SECTION 7: HANDLING AND STORAGE
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated
area. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and
inhalation.
Storage: Keep away from heat, sparks, flame and sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-
ventilated area away from incompatible substances.
SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTIVE EQUIPMENT
Airborne Exposure Limits: United States - OSHA Permissible Exposure Limit (PEL): 25 ppm (TWA), 125 ppm (STEL)
United States - ACGIH Threshold Limit Value (TLV): 50 ppm (TWA)
Australia: Time-weighted average 100 ppm (350 mg/m3), Carcinogen, JAN1993
The Netherlands: MAC-TGG 100 ppm (350 mg/m3), JAN1999
Personal Protective Equipment
Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166. Maintain eye wash fountain and quick-drench facilities in
work area.
Skin Protection: Wear impervious gloves, apron, and/or clothing.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Use a NIOSH or
European Standard EN 149 approved respirator when necessary.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its
source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, "Industrial Ventilation, A
Manual of Recommended Practices", most recent edition, for details.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Clear, colorless liquid Boiling Point: 39.8C (104F)
Odor: Ether odor Melting Point: -97C (-143F)
Solubility: Partially soluble in water (1.32 gm/100 gm @ 20C) Vapor Density: 2.9 (Air=1)
Specific Gravity: 1.33 (Water = 1) Vapor Pressure (mm Hg): 350 @ 20C (68F)
pH: Not available. Evaporation Rate: 27.5 (Butyl Acetate = 1)
Molecular Formula: CH2Cl2 % Volatiles by Volume: 100
Molecular Weight: 84.9
MSDS# 1002-007 Revision 0 Effective Date 04/09/02 Page 2 of 4
SECTION 10: STABILITY AND REACTIVITY DATA
Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
Hazardous Decomposition Products: Emits highly toxic fumes of phosgene when heated to decomposition. Decomposes in a
flame or hot surface to form toxic gas phosgene and corrosive mists of hydrochloric acid. Carbon dioxide and carbon monoxide
may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, liquid oxygen, nitric acid, potassium, lithium, sodium, caustics, powdered
aluminum, and active metals.
Conditions to Avoid: Incompatible materials, excess heat, strong oxidants, and active metals.
SECTION 11: TOXICOLOGICAL INFORMATION
RTECS#: PA8050000 for CAS# 75-09-2:
LD50/LC50:
Oral, mouse: LD50 = 873 mg/kg Inhalation, mouse: LC50 = 14,400 ppm 7/H
Oral, rat: LD50 = 1,600 mg/kg Inhalation, rat: LC50 = 52 gm/m3
Carcinogenicity: Listed by IARC as Group 2B - Possibly carcinogenic to humans and NTP as anticipated to be a human
carcinogen.
Toxicity to Reproductive System: Tests on laboratory animals for reproductive effects are cited in Registry of Toxic Effects on
Chemical Substances (RTECS).
Mutagenicity: Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances
(RTECS).
Other Studies: See actual entry in RTECS for complete information.
SECTION 12: ECOLOGICAL INFORMATION
Environmental Fate: When released into the soil, this material may leach into groundwater. When released into the soil, this
material is expected to quickly evaporate. When released into water, this material may biodegrade to a moderate extent. When
released to water, this material is expected to quickly evaporate. When released into the air, this material may be moderately
degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to
have a half-life of greater than 30 days. When released into the air, this material may be removed from the atmosphere to a
moderate extent by wet deposition.
Environmental Toxicity: This material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100
mg/l.
SECTION 13: DISPOSAL GUIDELINES
Dispose in compliance with federal, state, and local regulations. Chemical waste generators must determine whether a discarded
chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate
classification.
USEPA RCRA waste number U080..
The information offered here is for the product as shipped. Use and/or alterations to the product such as mixing with other
materials may significantly change the characteristics of the material and alter the RCRA classification and the proper disposal
method.
SECTION 14: TRANSPORT INFORMATION
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
United States (Land, D.O.T.) International (Air, I.C.A.O.)
Proper Shipping Name: Dichloromethane Proper Shipping Name: Dichloromethane
Hazard Class: 6.1 Hazard Class: 6.1
UN/NA: UN1593 UN/NA: UN1593
Packing Group: III Packing Group: III
MSDS# 1002-007 Revision 0 Effective Date 04/09/02 Page 3 of 4
SECTION 15: REGULATORY INFORMATION
US Federal
TSCA: CAS# 75-09-2 is listed on the TSCA inventory.
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: No
US State
CAS# 75-09-2can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota,
Massachusetts.
California Proposition 65: This product contains Dichloromethane [CAS# 75-09-2] a chemical known to the State of California to
cause cancer.
Other Regulations
EC Hazard Symbol: Xn 鈥? Harmful
EC Risk and Safety Phrases:
Risk Phrases:
R 40 Possible risks of irreversible effects.
Safety Phrases:
S 23 Do not breathe vapor.
S 24/25 Avoid contact with skin and eyes.
S 36/37 Wear suitable protective clothing and gloves.
Australian Hazchem Code: 2Z
SECTION 16: OTHER INFORMATION
NOTE: Unless otherwise noted, the information above pertains only to the Dichloromethane solvent in the ampoule.
This MSDS was prepared in accordance with ANSI Z400.1-1993 and 91/155/EEC recommended formats.
The information contained herein is believed to be accurate, but does not purport to be all-inclusive and shall be used only as a
guide. Varian, Inc., does not guarantee said information is accurate or complete, nor shall any of this information constitute a
warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods
for a particular purpose. It is the user鈥檚 responsibility to determine the suitability of this information and to assure the adoption of
necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact with the above
product, nor for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
MSDS# 1002-007 Revision 0 Effective Date 04/09/02 Page 4 of 4
|