MATERIAL SAFETY DATA SHEET
MANUFACTURER Varian Instruments 鈥? Middelburg
ADDRESS Herculesweg 8
4338 PL Middelburg, Netherlands
PHONE 31.118.67100 MSDS Number: 1002-206 Rev. 0
EMERGENCY PHONE 1.800.424.9300 鈥? CHEMTREC USA Date: April 29, 2002
FAX 31.118.633118 Prepared by: Corporate EH&S
SECTION 1: MATERIAL IDENTIFICATION
Product Name: Testmix CP0206
Synonyms: Uracil, Toluene, Fluorene, and Fluoranthene in a mixture of Acetonitrile and Water. Acetonitrile is also
known as Ethane Nitrile and Methyl Cyanide.
SECTION 2: COMPOSITION
An ampoule/vial containing the following:
Approximate NTP IARC
Component CAS Number Concentration Carcinogen Status Carcinogen Status
Uracil 66-22-8 6 mg/l not listed not listed
Toluene 108-88-3 1 ml/l not listed not listed
Fluorene 86-73-7 25 mg/l not listed not listed
Fluoranthene 206-44-0 40 mg/l not listed not listed
Water 7732-18-5 70% not listed not listed
Acetonitrile 75-05-8 30% not listed not listed
WARNING: This product contains Toluene [CAS# 108-88-3] a chemical known to the State of California to cause birth defects or
other reproductive harm.
NOTE: Unless otherwise noted, the information below pertains only to the Acetonitrile solvent in the ampoule/vial.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview: Colorless liquid. Flash Point: 2 deg C. Flammable liquid and vapor. Harmful or fatal if swallowed, inhaled,
or absorbed through the skin. May cause eye and skin irritation. Target Organs: blood, kidneys, central nervous system, liver, and
cardiovascular system. Metabolized to cyanide in the body, which may cause headache, dizziness, weakness, unconsciousness,
convulsions, coma and possible death. May be harmful to the environment if released in large amounts.
Potential Health Effects
Inhalation: Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Causes upper respiratory tract
irritation. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. May
cause tissue anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis (bluish discoloration of skin due to
deficient oxygenation of the blood), weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for
inhalation exposure.
Skin Contact: Causes mild skin irritation. Harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts
by inhibiting cytochrome oxidase impairing cellular respiration. Prolonged or repeated skin contact may cause dermatitis.
Eye Contact: May cause irritation, redness, and pain.
Carcinogen Status: NTP: Not listed IARC: Not listed
SECTION 4: FIRST AID INFORMATION
Inhalation: Get medical attention immediately. Remove to fresh air. If breathing is difficult, give oxygen. If breathing has ceased
apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Do NOT use mouth-to-mouth
resuscitation.
Ingestion: If swallowed, get medical attention immediately. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never
give anything by mouth to an unconscious person.
Skin Contact: In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse.
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical
attention immediately. Do NOT allow victim to rub or keep eyes closed.
MSDS# 1002-206 Revision 0 Effective Date 04/29/02 Page 1 of 4
SECTION 5: FIRE-FIGHTING INFORMATION
Fire: Flash point (closed cup): 2C (36F)
Autoignition temperature: 524C (975F)
Flammable limits in air % by volume: Lower = 4.4 Upper = 16.0
NFPA Rating: health-2; flammability-3; reactivity-0
Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along
surfaces to distant ignition source and flash back. Sealed containers may rupture when heated. Contact with strong oxidizers may
cause fire. Sensitive to static discharge.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire
exposed containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Use proper personal protective equipment as indicated in Section 8. Ventilate area of leak or spill. Remove all sources of ignition.
Absorb spill with inert material (e.g. vermiculite, sand or earth), scoop up with a nonsparking tool, then place into a suitable
container for disposal. Do not flush to sewer!
SECTION 7: HANDLING AND STORAGE
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated
area. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and
inhalation.
Storage: Keep away from heat, sparks, flame and sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-
ventilated area away from incompatible substances.
SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTIVE EQUIPMENT
Airborne Exposure Limits: United States - OSHA Permissible Exposure Limit (PEL): 40 ppm (TWA)
United States - ACGIH Threshold Limit Value (TLV): 40 ppm (TWA) ; 60 ppm (STEL)
Europe 鈥?80/1107/EEC: 70 ppm (TWA); 40 mg/m3 (TWA)
Australia: Time-weighted average 40 ppm (70 mg/m3), short term exposure limit 60 ppm, Skin
JAN1993
The Netherlands: MAC-TGG 40 ppm (70 mg/m3), JAN1999
Personal Protective Equipment
Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166. Maintain eye wash fountain and quick-drench facilities in
work area.
Skin Protection: Wear impervious gloves, apron, and/or clothing.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Use a NIOSH or
European Standard EN 149 approved respirator when necessary.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its
source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, "Industrial Ventilation, A
Manual of Recommended Practices", most recent edition, for details.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Clear, colorless liquid Boiling Point: 82C (180F)
Odor: Ether odor Melting Point: -46 (-51F)
Solubility: Miscible in water Vapor Density: 1.42 (Air=1)
Specific Gravity: 0.79 (Water = 1) Vapor Pressure (mm Hg): 73 @ 20C (68F)
pH: Not available. Evaporation Rate: 5.79 (Butyl Acetate = 1)
Molecular Formula: C2H3N % Volatiles by Volume: 100
Molecular Weight: 41.05
MSDS# 1002-206 Revision 0 Effective Date 04/29/02 Page 2 of 4
SECTION 10: STABILITY AND REACTIVITY DATA
Stability: Stable at room temperature in sealed containers.
Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Incompatibilities: Highly reactive with oxidizing agents, reducing agents, acids, alkalis.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water, oxidizers.
SECTION 11: TOXICOLOGICAL INFORMATION
RTECS#: AL7700000 for CAS# 75-05-8:
LD50/LC50:
Oral, mouse: LD50 = 269 mg/kg Inhalation, mouse: LC50 = 2693 ppm 1/H
Oral, rabbit: LD50 = 50 mg/kg Inhalation, rabbit: LC50 = 2828 ppm 4/H
Skin, rabbit: LD50 = 1250uL/kg
Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Toxicity to Reproductive System: Tests on laboratory animals for reproductive effects are cited in Registry of Toxic Effects on
Chemical Substances (RTECS).
Teratogenic Effects: Not available.
Mutagenicity: Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances
(RTECS).
SECTION 12: ECOLOGICAL INFORMATION
Environmental Fate: When released into the soil, this material may biodegrade to a moderate extent. When released into the soil,
this material is expected to leach into groundwater. When released into the soil, this material is expected to evaporate to a
moderate extent. When released to water, this material may evaporate to a moderate extent. This material is not expected to
significantly bioaccumulate. When released into the air, this material is not expected to react with photochemically produced
hydroxyl radicals. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet
deposition. When released into the air, this material is expected to have a half-life of greater than 30 days.
Environmental Toxicity: This material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100
mg/l.
SECTION 13: DISPOSAL GUIDELINES
Dispose in compliance with federal, state, and local regulations. Chemical waste generators must determine whether a discarded
chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate
classification.
USEPA RCRA waste numbers U003 and D001.
The information offered here is for the product as shipped. Use and/or alterations to the product such as mixing with other
materials may significantly change the characteristics of the material and alter the RCRA classification and the proper disposal
method.
SECTION 14: TRANSPORT INFORMATION
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
United States (Land, D.O.T.) International (Air, I.C.A.O.)
Proper Shipping Name: Acetonitrile Proper Shipping Name: Acetonitrile
Hazard Class: 3 Hazard Class: 3
UN/NA: UN1648 UN/NA: UN1648
Packing Group: II Packing Group: II
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SECTION 15: REGULATORY INFORMATION
US Federal
TSCA: CAS# 75-05-8 is listed on the TSCA inventory.
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: No
US State
CAS# 75-05-8 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota,
Massachusetts.
California Proposition 65: Not regulated.
Other Regulations
EC Hazard Symbols: F 鈥? Highly Flammable and T - Toxic
EC Risk and Safety Phrases:
Risk Phrases:
R 11 Highly flammable
R23/24/25 Toxic by inhalation, in contact with skin, and if swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Australian Hazchem Code: 2WE
SECTION 16: OTHER INFORMATION
NOTE: Unless otherwise noted, the information above pertains only to the Acetonitrile solvent in the ampoule.
This MSDS was prepared in accordance with ANSI Z400.1-1993 and 91/155/EEC recommended formats.
The information contained herein is believed to be accurate, but does not purport to be all-inclusive and shall be used only as a
guide. Varian, Inc., does not guarantee said information is accurate or complete, nor shall any of this information constitute a
warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods
for a particular purpose. It is the user鈥檚 responsibility to determine the suitability of this information and to assure the adoption of
necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact with the above
product, nor for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
MSDS# 1002-206 Revision 0 Effective Date 04/29/02 Page 4 of 4
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