MATERIAL SAFETY DATA SHEET
MANUFACTURER Varian Instruments 鈥? Middelburg
ADDRESS Herculesweg 8
4338 PL Middelburg, Netherlands
PHONE 31.118.67100 MSDS Number: 1002-391 Rev. 0
EMERGENCY PHONE 1.800.424.9300 鈥? CHEMTREC USA Date: March 12, 2003
FAX 31.118.633118 Prepared by: Corporate EH&S
SECTION 1: MATERIAL IDENTIFICATION
Product Name: LC2- 3,4-DMP mix - Testmix CP391
Synonyms: 3,4-Dimethylphenol in a mixture of water and Methanol. Methanol is also known as Methyl Alcohol,
Methyl hydroxide, and Wood Alcohol.
SECTION 2: COMPOSITION
An ampoule/vial containing the following:
Approximate NTP IARC
Component CAS Number Concentration Carcinogen Status Carcinogen Status
3,4-Dimethylphenol 95-65-8 200 ppm not listed not listed
Water 7732-18-5 30% not listed not listed
Methanol 67-56-1 70% not listed not listed
NOTE: Unless otherwise noted, the information below pertains only to the Methanol solvent in the ampoule/vial.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview: Colorless liquid. Flash Point: 11 deg C. Poison! Cannot be made non-poisonous. Causes eye and skin
irritation. May be absorbed through intact skin. This substance has caused adverse reproductive and fetal effects in animals.
Flammable liquid and vapor. Harmful if inhaled. May be fatal or cause blindness if swallowed. May cause central nervous system
depression. May cause digestive tract irritation with nausea, vomiting, and diarrhea. Causes respiratory tract irritation. May cause
liver, kidney and heart damage. Target Organs: Kidneys, heart, central nervous system, liver, eyes.
Potential Health Effects
Inhalation: Harmful if inhaled. May cause adverse central nervous system effects including headache, convulsions, and possible
death. May cause visual impairment and possible permanent blindness. Causes irritation of the mucous membrane.
Ingestion: May be fatal or cause blindness if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by
headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death
due to respiratory failure. May cause cardiopulmonary system effects. Usual fatal dose: 100-125 milliliters.
Skin Contact: Causes moderate skin irritation. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated
contact may cause defatting of the skin and dermatitis.
Eye Contact: Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury.
Carcinogen Status: NTP: Not listed IARC: Not listed
SECTION 4: FIRST AID INFORMATION
Inhalation: Get medical attention immediately. Remove to fresh air. If breathing is difficult, give oxygen. If breathing has ceased
apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Do NOT use mouth-to-mouth
resuscitation.
Ingestion: If swallowed, get medical attention immediately. Induce vomiting immediately as directed by medical personnel. If victim
is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person.
Skin Contact: In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention if irritation develops or persists. Wash clothing before reuse.
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical
attention immediately. Do NOT allow victim to rub or keep eyes closed.
MSDS# 1002-391 Revision 0 Effective Date 03/12/03 Page 1 of 4
SECTION 5: FIRE-FIGHTING INFORMATION
Fire: Flash point (closed cup): 12C (54F)
Autoignition temperature: 464C (867F)
Flammable limits in air % by volume: Lower = 6.0 Upper = 36.5
NFPA Rating: health-1; flammability-3; reactivity-0
Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Moderate explosion hazard
and dangerous fire hazard when exposed to heat, sparks or flames. Sensitive to static discharge.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire
exposed containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Use proper personal protective equipment as indicated in Section 8. Ventilate area of leak or spill. Remove all sources of ignition.
Absorb spill with inert material (e.g. vermiculite, sand or earth), scoop up with a nonsparking tool, then place into a suitable
container for disposal. Do not flush to sewer!
SECTION 7: HANDLING AND STORAGE
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated
area. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and
inhalation.
Storage: Keep away from heat, sparks, flame and sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-
ventilated area away from incompatible substances.
SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTIVE EQUIPMENT
Airborne Exposure Limits: United States - OSHA Permissible Exposure Limit (PEL): 200 ppm (TWA)
United States - ACGIH Threshold Limit Value (TLV): 200 ppm (TWA) ; 250 ppm (STEL)
Australia: Time-weighted average 200 ppm (260 mg/m3), short term exposure limit 250 ppm, Skin
JAN1993
The Netherlands: MAC-TGG 200 ppm (260 mg/m3), Skin, JAN1999
Personal Protective Equipment
Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166. Maintain eye wash fountain and quick-drench facilities in
work area.
Skin Protection: Wear impervious gloves, apron, and/or clothing.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Use a NIOSH or
European Standard EN 149 approved respirator when necessary.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its
source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, "Industrial Ventilation, A
Manual of Recommended Practices", most recent edition, for details.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Clear, colorless liquid Boiling Point: 64.5 (148F)
Odor: Characteristic, Alcohol-like Melting Point: -98 (-44F)
Solubility: Miscible in water Vapor Density: 1.11 (Air=1)
Specific Gravity: 0.79 (Water = 1) Vapor Pressure (mm Hg): 97 @ 20C (68F)
pH: Not available. Evaporation Rate: 5.9 (Butyl Acetate = 1)
Molecular Formula: CH4OH % Volatiles by Volume: 100
Molecular Weight: 32.05
SECTION 10: STABILITY AND REACTIVITY DATA
Stability: Stable at room temperature in sealed containers.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, formaldehyde.
Hazardous Polymerization: Will not occur.
Incompatibilities: Highly reactive with oxidizing agents, reducing agents, acids, alkalis, peroxides, nitrides, active metals, and
water reactive substances.
Conditions to Avoid: Incompatible materials, ignition sources, and excess heat.
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SECTION 11: TOXICOLOGICAL INFORMATION
RTECS#: PC1400000 for CAS# 67-56-1:
LD50/LC50:
Oral, mouse: LD50 = 7300 mg/kg Inhalation, rat: LC50 = 64000 ppm 4/H
Oral, rabbit: LD50 = 14200 mg/kg
Skin, rabbit: LD50 = 15800 mg/kg
Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Toxicity to Reproductive System: Tests on laboratory animals for reproductive effects are cited in Registry of Toxic Effects on
Chemical Substances (RTECS).
Teratogenic Effects: Not available.
Mutagenicity: Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances
(RTECS).
SECTION 12: ECOLOGICAL INFORMATION
Environmental Fate: When released into the soil, this material is expected to readily biodegrade. When released into the soil, this
material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When
released into the water, this material is expected to have a half-life between 1 and 10 days. When released into water, this material
is expected to readily biodegrade. When released into the air, this material is expected to exist in the aerosol phase with a short
half-life. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced
hydroxyl radicals. When released into air, this material is expected to have a half-life between 10 and 30 days. When released into
the air, this material is expected to be readily removed from the atmosphere by wet deposition.
Environmental Toxicity: This material is expected to be slightly toxic to aquatic life.
SECTION 13: DISPOSAL GUIDELINES
Dispose in compliance with federal, state, and local regulations. Chemical waste generators must determine whether a discarded
chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate
classification.
USEPA RCRA waste numbers U154 and D001.
The information offered here is for the product as shipped. Use and/or alterations to the product such as mixing with other
materials may significantly change the characteristics of the material and alter the RCRA classification and the proper disposal
method.
SECTION 14: TRANSPORT INFORMATION
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
United States (Land, D.O.T.) International (Air, I.C.A.O.)
Proper Shipping Name: Methanol Proper Shipping Name: Methanol
Hazard Class: 3 Hazard Class: 3, 6.1
UN/NA: UN1230 UN/NA: UN1230
Packing Group: II Packing Group: II
MSDS# 1002-391 Revision 0 Effective Date 03/12/03 Page 3 of 4
SECTION 15: REGULATORY INFORMATION
US Federal
TSCA: CAS# 67-56-1is listed on the TSCA inventory.
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: No
US State
CAS# 75-05-8 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota,
Massachusetts.
California Proposition 65: Not regulated.
Other Regulations
EC Hazard Symbols: F 鈥? Highly Flammable and T - Toxic
EC Risk and Safety Phrases:
Risk Phrases:
R 11 Highly flammable
R23/24/25 Toxic by inhalation, in contact with skin, and if swallowed.
R 39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 36/37 Wear suitable protective clothing and gloves.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S 7 Keep container tightly closed.
Australian Hazchem Code: 2PE
SECTION 16: OTHER INFORMATION
NOTE: Unless otherwise noted, the information above pertains only to the Methanol solvent in the ampoule/vial.
This MSDS was prepared in accordance with ANSI Z400.1-1993 and 91/155/EEC recommended formats.
The information contained herein is believed to be accurate, but does not purport to be all-inclusive and shall be used only as a
guide. Varian, Inc., does not guarantee said information is accurate or complete, nor shall any of this information constitute a
warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods
for a particular purpose. It is the user鈥檚 responsibility to determine the suitability of this information and to assure the adoption of
necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact with the above
product, nor for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
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