B眉hlmann Laboratories AG Postadresse/Mailing address:
Baselstrasse 55 B眉hlmann Laboratories AG
CH 鈥? 4124 Sch枚nenbuch/Basel Postfach
(Switzerland) CH 鈥? 4123 Allschwil 1
Tel.: +41 (61) 487 12 12 www.buhlmannlabs.ch
Fax: +41 (61) 487 12 34 info@buhlmannlabs.ch
MATERIAL SAFETY DATA SHEET FOR
ACE direct REA, RK-ACD
1. Identification of the Product and of the Company
Product: Angiotensin converting enzyme (ACE) radio enzymatic assay
Purpose:In vitro diagnostic reagents for the quantitative determination of angiotensin converting enzyme (ACE) in human serum
B脺HLMANN Laboratories AG
Company:
Baselstrasse 55
CH-4124 Sch枚nenbuch, Switzerland
Email: info@buhlmannlabs.ch
Emergency phone No: +41 (0)61 487 1212 Fax No: +41 (0)61 487 1234
2. Composition and Hazardous Ingredients
Kit Components: B-ACD-TR, B-ACD-CA, B-ACD-0CA, B-ACD-CONSET, B-ACD-HA, B-ACD-SCP
Hazardous Ingredient Kit Component Concentration
3
< 188 kBq (< 5.1 碌Ci) per vial
H (tritium) B-ACD-TR
Human serum B-ACD-CA, B-ACD-0CA, B-ACD-CONSET n/a
Hydrochloric acid B-ACD-HA 1N
2,5-Diphenyloxazole (PPO) B-ACD-SCP 97 - 99%
3. Hazard Identification
Human Serum (or its components) used for the production of the components was tested and found negative for HBsAg, HCV and
HIV I/II. However no known test method can offer assurance that these products will not be infectious.
3
H (tritium) is a radioactive tracer element, emits gamma rays, half life: 12.4 years.
Hydrochloric acid might cause irritations after skin or eye contact.
PPO might cause irritation after eye contact.
4. Emergency and First Aid Measures
It is not expected to give rise to an acute hazard under normal conditions of use.
Eye contact: Flush eyes with large amounts of water for at least 15 minutes.
Ingestion: Flush mouth with large amounts of water, make sure not to swallow rinse.
Skin: Wash well with soap and large amounts of water. If skin is injured or material gets into open wound.
If warranted, seek medical attention. If possible, save a sample of material that caused reaction for use in determination of
appropriate treatment.
5. Fire and Explosion Hazard Data
The components are non-flammable. Use extinguishing media appropriate to surrounding fire.
6. Accidental Release Measures
Absorb spills of reagent and patient samples with absorbent paper, taking care not to spread the material. Clean spill area with a
potent disinfectant. Discard all materials used to absorb spill and disinfect area into radioactive/biohazard waste collection.
7. Handling and storage
Storage
Store all reagents as dedicated in the relevant instruction for use.
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MSDS: ACE direct REA B脺HLMANN LABORATORIES AG
Handling
Adherence to the basic rules of radiation safety should provide adequate protection:
Do not eat, drink, smoke or apply cosmetics in the laboratory.
Do not pipet solutions by mouth.
Avoid splashing or forming an aerosol.
Avoid direct contact by using protective articles such as lab coats and disposable gloves
All radiological work must be done in a designated and separated area.
8. Exposure control/personal protection
Wear appropriate personal protective equipment when working with reagents or patient samples, including lab coats, disposable
gloves and eye protection. Avoid hand/mouth contact. Wash hands as immediately after handling reagents or patient specimens.
9. Physical and Chemical Properties
Appearance Odor Boiling Point pH Rel. Density Solubility in Water
clear colourless solution ~100 掳C
B-ACD-TR n/a 7.9- 8.1 ~1 g/ml complete
lyophilisate n/a
B-ACD-CA n/a n/a ~1 g/ml* complete
lyophilisate n/a
B-ACD-0CA n/a n/a ~1 g/ml* complete
lyophilisate n/a
B-ACD-CONSET n/a n/a ~1 g/ml* complete
clear solution ~100 掳C
B-ACD-HA n/a <1 ~1 g/ml complete
greenish powder n/a
B-ACD-SCP n/a n/a ~ 0.16 g/ml insoluble
* reconstituted solution
10. Stability and Reactivity
The reagents in the kit are stable under the storage conditions described in the instructions for use. Hazardous decomposition will not
occur.
11. Toxicological Information
3
Tritium ( H) emits gamma rays.
12. Ecological Information
not applicable
13. Disposal
All potential hazardous materials must be disposed of in accordance with the prevailing regulations and guidelines of the agencies
holding jurisdiction over the laboratory. Excess calibrators, patient samples or empty containers should be disposed according to
institutional policy for radioactive/biohazardous material.
14. Transportation Information
Radioactive material, excepted package-limited quantity of material, UN2910
15. Regulatory Information
CAS No. R-Phrases S-Phrases EC-Number
2,5-Diphenyloxazole (PPO) 92-71-7 -- -- 202-181-3
Hydrochloric acid (1 N) 7647-01-0 34-37 -- 017-002-01
16. Other informations
Only trained personal should handle this product. All actions should be done in accordance with legal regulations and common
practised hygiene measures in the labs. Read the instruction for use (IFU) carefully.
The information provided in this Material Safety Data Sheet (MSDS) is believed to be accurate and represents the best information
currently available to us. However, we make no warranty or merchantability or any other warranty, expressed or implied, with respect
to such information, and we assume no liability for its use. Users should make their own investigations to determine the suitability of
the information for their particular purposes.
June 21, 2004
This MSDS replaces all former versions.
MSDS No.: RK-ACD-04
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