MATERIAL SAFETY DATA SHEET ERYTHROMYCIN
PRODUCT CODE NUMBER(S): 4110-5
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: Erythromycin Flammability: Not combustible. However, as with most or-
ganic compounds, fine dust dispersed in air in the presence
Chemical Family: Antibiotic
of an ignition source is a potential dust explosion hazard.
Chemical Formula: C37H67NO13
Extinguishing Media: Use extinguishing media appropri-
Product Use: Laboratory reagent ate to the surrounding fire. Water in flooding amounts can
Manufacturer鈥檚 Name and Address: be used to cool containers, prevent dust formation, flush
chemcial away from fire. Fight fire from upwind, from a safe
Caledon Laboratories Ltd.
distance. Firefighters should wear protective equipment and
40 Armstrong Avenue
clothing sufficient to prevent inhalation of dust or fumes and
Georgetown, Ontario L7G 4R9
contact with skin and eyes.
Telephone No: (905) 877-0101
Flash Point (Method Used): Not applicable
Fax No: (905) 877-6666
Autoignition Temperature: Not applicable
Emergency Telephone No: CANUTEC (613) 996-6666
Upper Flammable Limit (% by volume): Not applicable
Lower Flammable Limit (% by volume): Not applicable
HAZARDOUS INGREDIENTS OF MATERIALS
Hazardous Combustion Products: COx, NOx
Ingredients % TLV Units CAS No. Sensitivity to Impact: None identified
Sensitivity to Static discharge: As with most organic pow-
Erythromycin 99 Not established 114-07-8
ders, mixtures of dust with air may be sensitive under
PHYSICAL DATA certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.
Physical State: Solid
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Odour and Appearance: White to off-white crystalline
powder, odourless
To the best of our knowledge, the physical, chemical and
Odour Threshold (ppm): Not applicable toxicological properties of this substance have not yet been
Vapour Pressure (mm Hg): Not available thoroughly investigated.
Vapour Density (Air = 1): Not available
Toxicological Data:
Evaporation Rate: Not applicable
Boiling Point (degrees C): Not available LD50: (oral, rat) 4,500 mg/kg; (oral, mouse) 2,580 mg/kg
Melting Point (degrees C): 133-138掳C LC50: Not available
pH: 8 to 10.5 (saturated solution)
Effects of Acute Exposure to Product:
Specific Gravity: Not available
Coefficient of Water/Oil distribution: Not available Inhaled: May cause irritation of the nasal and respiratory
passages, causing sore throat, coughing. May cause aller-
SHIPPING DESCRIPTION gic respiratory reaction.
In contact with skin: May cause irritation, with redness,
UN: Not regulated
itching. May be harmful if absorbed. Risk of skin absorption
T.D.G. Class: Not regulated not known. May cause skin sensitization, with skin rash and
eruptions on repeat exposure.
Pkg. Group: Not regulated
In contact with eyes: May cause mild mechanical irritation,
REACTIVITY DATA with temporary redness, itching, tearing, pain.
Ingested: May cause gastrointestinal irritation with nausea,
Chemical Stability: Stable in dry air. Slightly hygroscopic;
vomiting and diarrhea. May cause kidney damage. Can
absorbs moisture from air.
cause allergic reaction with nausea, vomiting, glossitis,
Incompatibility with other substances: Can react vio- rashes, in some sensitive individuals, usually those who
lently with strong oxidizing agents. May cake on exposure have a history of allergic reaction, asthma, hay fever, urti-
to moisture. caria. Allergic individuals may also develop blood effects
Reactivity Avoid excessive heat, ignition sources, incom- and central nervous system toxicity (including hallucinations,
patible materials, moisture. Avoid generation of dust. confusion, unconsciousness, and seizures, even fatal
Hazardous Decomposition Products: COx, NOx alaphylactic reaction.
ERYTHROMYCIN
MSDS
CODE: 4110-5
Effectsof Chronic Exposure to Product: Inhalation: Remove to fresh air. Give oxygen and get
medical attention for any breathing difficulty.
Carcinogenicity: No human or animal information avail-
Ingestion: If victim is alert and NOT convulsing, rinse
able
mouth, give several glasses of water to drink to dilute. If
Teratogenicity: No human information available. Has discomfort occurs, or if a large amount has been ingested,
caused effects in animal testing. get medical attention.
Reproductive Effects: No human information available.
Has caused effects in animal testing. REFERENCES USED
Mutagenicity: No information available
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
Synergistic Products: None known
ed., 1987
PREVENTIVE MEASURES Suppliers鈥? Material Safety Data Sheets
Engineering Controls: Local exhaust ventilation required. ADDITIONAL INFORMATION
Respiratory Protection: Dust/mist mask. For conditions
Date Issued: March 1999
where dust or mist is present, to the maximum use specified
Revision: March 2008
by the respirator supplier, NIOSH approved half- face
high-efficiency dust/mist filter respirator, or NIOSH approved MSDS: 4110-5
full face-piece high-efficiency dust/mist filter respirator. Proposed WHMIS Designation: D2B (sensitizer)
Higher or unknown concentrations, or for fire or spill condi-
tions, self-contained breathing apparatus, or full face-piece,
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
positive-pressure supplied-air respirator.
Caledon Laboratories Ltd. believes the information contained
Eye Protection: Safety glasses.
herein is reliable and accurate. Caledon makes no warranty
Skin Protection: Rubber or plastic gloves. Other protec-
with respect thereto and expressly disclaims all liability for reli-
tive clothing (apron, sleeves) as required to limit contact.
ance thereon. Such information is solely for your consider-
Other Personal Protective Equipment: Safety shower
ation, investigation, and verification.
and eye-wash fountain in work area.
Leak and Spill Procedure: Ventilate area. Eliminate
sources of ignition. Cleanup personnel should be trained in
the handling of hazardous chemicals and should wear pro-
tective equipment and clothing sufficient to prevent
inhalation of dust, mist or fumes, and contact with skin and
eyes. Prevent from entering sewers or waterways. Collect
in a manner that does not raise dust, transfer carefully into
container, and arrange removal by disposal company. Wash
site of spillage thoroughly with water and detergent.
Waste Disposal: Comply with federal, provincial and local
regulations.
Handling Procedures and Equipment: COMBUSTIBLE
DUST. Workers using this chemical must be properly
trained in its hazards and its safe use, and must wear appro-
priate protective equipment and clothing. Avoid generating
dust. If there is dust, keep away from heat, sparks, and all
sources of ignition; avoid the accumulation of static charge,
use anti-sparking tools and ground and bond equipment and
containers. Use the smallest amount possible for the pur-
pose, in a designated area with adequate ventilation. Use
good housekeeping to prevent accumulations of dust. Avoid
contact with skin and eyes. Avoid inhalation. Wash thor-
oughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight
and away fromheat and ignition sources and incompatible
materials. Keep containers tightly closed when not in use
and when empty. Protect from moisture.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with gently running water,
holding eyelids open while flushing, for five to ten (5-10)
minutes, or until no trace of chemical remains. Get medical
advice if irritation develops.
Skin: Remove contaminated clothing. Brush or wipe off dry
material. Flush skin with plenty of running water until no evi-
dence of chemical remains. If irritation develops get medical
attention.
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