Material Safety Data Sheet
Revision: 09/20/2005
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Acetamide 10000 200-473-5
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Acetamide 60-35-5 鈥? R:40 Limited evidence of a
$99%
carcinogenic effect.
S:36/37 Wear suitable
protective clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Carcinogen, Category 3
HCS
Group 2B Carcinogen, Irritant
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Potential dust
explosion hazard. This material, like most materials in powder form, is capable of creating a dust explosion. Emits
toxic fumes under fire conditions.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. Collect in a manner that does not create dust and place in a suitable waste container. Avoid
contact of material with skin or eyes. Use adequate ventilation. Additional protective clothing such as rubber apron
and rubber gloves may be required when handling acetamide in solutions or at elevated temperatures.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Additional protective
clothing such as rubber apron and rubber gloves may be required when handling acetamide in solutions or at
elevated temperatures. Moisture sensitive. Avoid moisture. Store ambient in a cool, dry area. Keep containers
tightly closed and away from heat, sparks and ignition sources.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection. Use
respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of material
with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust, vapors or mists.
Access to a safety shower and eye-wash. Additional protective clothing such as rubber apron and rubber gloves
may be required when handling acetamide in solutions or at elevated temperatures.
PHYSICAL AND CHEMICAL Appearance: White/clear crystals Boiling Point: 221掳C @ 760 mmHg
PROPERTIES Vapor Pressure: 1 mmHg (65掳C) Vapor Density: ~2
Solubility (Water): Soluble Specific Gravity: 1.159 g/cm3
Percent Volatile: No data available Evaporation Rate: No data available
Chemical Formula: C2-H5-N-O Odorless when pure; typically a mousy odor.
MSDS information may be continued on back of page.
STABILITY AND REACTIVITY Product is stable. Moisture sensitive. Avoid moisture. Hazardous decomposition products include ammonia and
oxides of nitrogen and carbon. Incompatible with strong reducing agents, strong bases, strong acids, metals,
halogenated materials and strong oxidizing agents. Hazardous polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation.
INHALATION: May cause irritation to mucous membranes and upper respiratory tract.
INGESTION: Low acute oral toxicity. Ingestion of large quantities may cause gastrointestinal irritation.
TARGET ORGAN(S): Liver.
ADDITIONAL INFORMATION:
May be harmful by inhalation, ingestion or skin absorption. Potential cancer hazard. May cause cancer based on
tests with laboratory animals. Mutagenic, reproductive and tumorigenic effects have been observed on tests with
laboratory animals. May cause liver damage.
Reproductive effects, toxicity, mutation, and tumorigenic data listed in RTECS under AB4025000.
Only select RTECS information is provided here. Please see actual RTECS entry for complete information.
Oral Rat LD50 = 7 gm/kg (1962). Details of toxic effects not reported other than lethal dose value.
Reproductive: Effects on embryo or fetus include fetotoxicity (except death, e.g. stunted fetus)(1980).
Specific developmental abnormalities - musculoskeletal system (1980).
Fertility - post-implantation mortality (e.g. dead/or resorbed implants per total number of
implants)(1980).
Tumorigenic data: carcinogenic by RTECS criteria (1980).
neoplastic by RTECS criteria (1969).
Carcinogenicity data: IARC Cancer Review: Animal - Sufficient Evidence (1999).
Human - No Adequate Data (1999).
Group 2B - Possibly carcinogenic to humans (1999).
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay.
Positive: Cell transform.-mouse embryo.
Definition(s): RTECS = Registry of Toxic Effects of Chemical Substances.
IARC = International Agency for Research on Cancer.
EPA = Environmental Protection Agency.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
Clean Air Act: Hazardous air pollutant (HAP).
SARA 302 - Final RQ = 100 lb (45.4 kg). This material does not have a TPQ.
SARA 313 - This material contains Acetamide (CAS# 60-35-5, 99%), which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
SARA 311/312 - chronic.
EPA TSCA Section 8(b) - Chemical Inventory.
Section 8(d) - unpublished health/safety studies.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the state of California to cause
cancer.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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