Material Safety Data Sheet
Revision: 11/03/2003
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Streptozotocin 21870 242-646-8
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Outside USA & Canada 703 527 3887
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Streptozotocin 18883-66-4 鈥? R:45 May cause cancer.
-97%
S:22 Do not breathe dust.
S:36/37 Wear suitable
protective clothing and gloves.
S:53 Avoid exposure - Obtain
special instructions before
use.
HAZARDS IDENTIFICATION CHIP
Toxic. Carcinogen, Category 2.
HCS
Toxic. Group 2B Carcinogen.
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and
wash before reuse. Seek immediate medical attention.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give
oxygen. If not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate
medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. Emits toxic fumes under fire conditions. For small fires only: use carbon dioxide,
dry powder or foam.
Flash Point: No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation. To safely deactivate small
quantities use sulfamic acid at a ratio of 0.5 gm sulfamic acid / 3 ml water.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Keep container tightly closed. Light
sensitive. Store at +4掳C away from incompatible substances.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the information
contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet must be determined by the user
to be in accordance with appropriate applicable regulations.
For Further Asia Pacific Canada Former Soviet Union Japan Norway Spain USA
Information, +852 2811 8693 1 800 463 5800 +7 (095) 232 0250 81 3 5331 9337 63 89 23 10 935 944 950 USB Corporation
contact your (216) 765-5000
local USB Australia Central and East Europe France Latin America Portugal Sweden If purchased from
authorized +61 2 9894 5188 +43 1 982 3826 0169 18 28 00 +55 11 3667 5700 01 417 70 35 018 164000 Amersham Pharmacia
distributor, Biotech use
Amersham Austria Denmark Germany Middle East and Africa South East Asia Switzerland 1 800 526 3593
Pharmacia 01 576 0616 10 +45 4516 2400 07 61 49 03 0 +30 (1) 96 00 687 60 3 724 2080 01 802 81 50
Biotech
Belgium Finland Italy Netherlands South East Europe UK
0800 73888 358 (9) 512 3940 02 27322 1 0165 580 410 +43 (1) 982 3826 0800 515313
MSDS information may be continued on back of page.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: White to off-white crystalline powder Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical formula: C18-H15-N3-O7 Melting Point: 115掳C
STABILITY AND REACTIVITY Product is stable under normal conditions. Light sensitive. Hazardous decomposition products include carbon
and nitrogen oxides. Incompatible with strong oxidizing agents, strong acids and strong bases. Hazardous
polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation. May be harmful if absorbed through the skin.
INHALATION: May be harmful if inhaled. Material is irritating to the tissue of the mucous membranes and upper
respiratory tract.
INGESTION: May be harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause anemia, leukopenia, and thrombocytopenia. May cause systemic effects including renal
dysfunction and impaired liver function.
ADDITIONAL INFORMATION:
Cancer suspect agent. May cause cancer in humans. May cause adverse reproductive effects based upon
animal studies. May cause liver and kidney damage.
TARGET ORGAN(S): Kidneys, liver.
Reproductive, mutation, toxicity and tumorigenic data listed in RTECS under LZ5775000.
Tumorigenic: neoplastic by RTECS criteria (1978).
equivocal tumorigenic agent by RTECS criteria (1978).
carcinogenic by RTECS criteria (1985).
Reproductive: Specific Developmental Abnormalities - cardiovascular system (1988), craniofacial
(including nose and tongue) (1988), endocrine system (1970), Central Nervous System
(1977), musculoskeletal system (1984).
Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
and fetotoxicity (except death, e.g., stunted fetus) (1986).
Maternal Effects - ovaries, fallopian tubes (1983).
Effects on Newborn - growth statistics (e.g.%, reduced weight gain) (1970).
Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number
of implants) (1987).
Carcinogenicity data:
IARC Cancer Review: Animal - Sufficient Evidence (1978).
Human - No Adequate Data (1978).
Group 2B - Possibly Carcinogenic (1987).
NCI Carcinogenesis Studies (ipr); clear evidence: mouse, rat. (1975).
NTP 9th Report on Carcinogens, 2000 : Reasonably anticipated to be a human.
carcinogen.
Definition(s): RTECS = Registry of Toxic Effects of Chemical Substances.
IARC = International Agency for Research on Cancer.
NCI = National Cancer Institute.
NTP = National Toxicology Program Annual Report on Carcinogens.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations. To safely deactivate
small quantities use sulfamic acid at a ratio of 0.5 gm sulfamic acid / 3 ml water.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - Hazardous Waste Number U206.
SARA 302 - Final RQ = 1 lb. This material does not have a TPQ.
SARA 313 - This material is not reportable under 313.
EPA TSCA Section 8(b) - No applicable information.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the State of California to cause
cancer. This product is or contains chemical(s) known to the State of
California to cause birth defects or other reproductive harm.
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