Material Safety Data Sheet
Revision: 01/30/2008
Formamide Glycerol; Tris-HCl
Hazard information is provided for compliance with both the UK Chemicals
and Magnesium
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Chloride
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
miRtect-ITTM
SUBSTANCE/PREPARATION 76400 None
AND COMPANY miRNA Labeling and Detection Kit
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
For Component 76405: 75-12-7 95% See R:61 May cause harm to the
Formamide 鈥淩egulatory unborn child.
Information鈥? S:53 Avoid exposure - Obtain
Section special instructions before use.
S:45 In case of accident or if
you feel unwell seek medical
advice immediately (show the
label where possible).
For Components 76407 & 76408: R:36/37/38 Irritating to eyes,
Proprietary 鈥? 鈥? 鈥? respiratory system and skin.
S:23 Do not breathe vapour.
S:24/25 Avoid contact with
skin and eyes.
S:36/37 Wear suitable
protective clothing and gloves.
For Components 78334 & 76404: See R:36/37/38 Irritating to eyes,
Glycerol 56-81-5 ~50% 鈥淩egulatory respiratory system and skin.
Information鈥? S:26 In case of contact with
Section eyes, rinse immediately with
plenty of water and seek
medical advice.
S:36/37 Wear suitable
protective clothing and gloves.
For Component 78336: 鈥淪ee Component 78334
Tris-HCl 1185-53-1 ~7.9% 鈥? Above鈥?
Magnesium Chloride, Hexahydrate 7791-18-6 ~2.0% 鈥?
For Component 76403: R:36/37/38 Irritating to eyes,
Glycerol 56-81-5 ~21% 鈥淪ee Above鈥? respiratory system and skin.
Tris-HCl 1185-53-1 ~2.4% 鈥? S:23 Do not breathe vapour.
S:26 In case of contact with
eyes, rinse immediately with
plenty of water and seek
medical advice.
S:36/37 Wear suitable
protective clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Component 76405: Toxic to Reproduction, Category 2.
Components 76403, 76404, 76407, 76408, 78334 and 78336: Irritant.
HCS
Component 76405: Teratogen and Irritant.
Components 76403, 76404, 76407, 76408, 78334 and 78336: Irritant.
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
MSDS information may be continued on back of page.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Emits toxic fumes
under fire conditions. Explosion Limits for Glycerol = Lower - 1.1; Upper - Not available.
Flash point for Glycerol = 193掳C (379.4掳F); Autoignition temperature for Glycerol = 400掳C (752掳F).
Flash point for Formamide = 154掳C (309掳F). Formamide decomposes at temperatures > 180掳C.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. Contain the spill with an inert absorbent and place in a suitable waste container. Avoid contact
of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. Use adequate ventilation. Avoid contact of material with skin or eyes. Store kit at -20掳C.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection. Use
respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of material
with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust, vapors or mists.
Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: Kit containing vials of solutions Solubility (Water): All components are soluble
PROPERTIES Chemical Formula: Not applicable Specific Gravity: No data available
STABILITY AND REACTIVITY Product is stable under normal conditions. Avoid excessive heat. Incompatible with isocyanates, iodine, pyridine,
sulfur trioxide, strong bases, strong acids and strong oxidizing agents. Hazardous decomposition products include
ammonia, hydrochloric acid vapor, hydrogen cyanide gas and carbon oxides. Hazardous polymerization will not
occur. Copper, brass, lead and rubber are attacked by Formamide. For Glycerol: Contact with Sodium Hypochlorite
and Hypochlorous acid may cause an explosion.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE TO COMPONENT 76405:
EYES: Contact causes irritation.
SKIN: Contact causes irritation. May be absorbed through the skin. Symptoms may parallel ingestion.
INHALATION: Causes irritation to the respiratory tract. Symptoms may include coughing and shortness of
breath. Excessive inhalation of vapor may cause symptoms that parallel ingestion.
INGESTION: Chronic ingestion or excessive dosage may cause central nervous system disorders, headache,
dizziness, nausea, vomiting, abdominal pain, and unconsciousness. May affect the reproductive system. May
cause damage to liver & denatures proteins. Has caused embryo toxicity and birth defects in animal studies.
TARGET ORGAN(S): Central Nervous System, Liver, Kidneys, Eyes, Reproductive System and Skin.
EFFECTS OF OVEREXPOSURE TO COMPONENTS 76403, 76404, 76407, 76408, 78334 & 78336:
EYES: Contact may cause irritation and slight corneal injury.
SKIN: Prolonged contact may cause irritation and/or allergic reaction.
INHALATION: Material may be irritating to mucous membranes and upper respiratory tract.
INGESTION: May cause irritation to the gastrointestinal tract with nausea, vomiting and diarrhea.
ADDITIONAL INFORMATION:
Only select RTECS information is provided here. Please see actual RTECS entries for complete information.
For Formamide: Reproductive effects, irritation, mutation and toxicity data listed in RTECS under LQ0525000.
Irritation data: Eye Rabbit 100 mg = Severe (1946).
Toxicity data: Oral Rat LD50 = 5577 mg/kg (1967). Inhalation Rat LC50 = >3900 ppm/6H.
Skin Rabbit LD50 = 17 gm/kg. Toxic effects may include incontinence and ataxia.
Harmful if swallowed, inhaled or absorbed through skin. May cause congenital malformation in the fetus.
For Glycerol: Irritation, mutation, reproductive effects and toxicity data listed in RTECS under MA8050000.
Irritation data: Skin Rabbit 500 mg/24H = Mild (1986). Eye Rabbit 500 mg/24H = Mild (1986).
Toxicity data: Oral Rat LD50 = 12600 mg/kg (1945). Inhalation Rat LC50 = >570 mg/m3/1H (1970).
For Magnesium Chloride Hexahydrate: Toxicity and mutation data listed in RTECS under OM2975000.
Oral Rat LD50 = 8100 mg/kg (1969).
For Tris-HCl: RTECS: No data available.
Definition(s): RTECS = Registry of Toxic Effects of Chemical Substances.
ACGIH = American Conference of Governmental Industrial Hygienists.
NIOSH = National Institute for Occupational Safety and Health.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - This material does not have an RQ or TPQ.
SARA 313 - This material is not reportable under 313.
EPA TSCA Section 8(b) - For Formamide, Glycerol and Tris-HCl: Chemical Inventory.
Exposure Limits - For Formamide: ACGIH TLV-TWA: 18 mg/m3 (10 ppm) Skin.
NIOSH REL TO FORMAMIDE - air: 10H TWA 10 ppm (Sk).
For Glycerol: ACGIH TLV-TWA: 10 mg/m3 (total particulate).
OSHA PEL TWA: 15 mg/m3 (total dust).
California Proposition 65 - No applicable information.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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