Material Safety Data Sheet
Revision: 04/27/2006
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Chloramphenicol 23660 200-287-4
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Chloramphenicol 56-75-7 >97% --- R:45 May cause cancer.
R:42/43 May cause
sensitization by inhalation and
skin contact.
S:53 Avoid exposure - Obtain
special instructions before
use.
S:22 Do not breathe dust.
S:45 In case of accident or if
you feel unwell, seek medical
advice immediately (show the
label where possible).
S:36/37/39 Wear suitable
protective clothing, gloves and
eye/face protection.
HAZARDS IDENTIFICATION CHIP
Carcinogen, Category 2
HCS
Group 2A Carcinogen, Sensitizer
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and
wash before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give
oxygen. If not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate
medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Emits toxic fumes
under fire conditions.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Light sensitive. Use adequate
ventilation. Store ambient away from incompatible material.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash.
MSDS information may be continued on back of page.
PHYSICAL AND CHEMICAL Appearance: White to grey-white crystalline powder; odorless Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: 11.1
Solubility (Water): Slightly soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical Formula: C11-H12-Cl2-N2-O5 Melting Point: 149-153掳C
STABILITY AND REACTIVITY Product is stable. Light Sensitive. Avoid humidity, light and heat. Incompatible with acids, acid chlorides, acid
anhydrides and oxidizing agents. Hazardous decomposition products include nitrogen oxides, carbon oxides and
hydrogen chloride gas. Hazardous polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation, dermatitis and hypersensitive individuals may experience an allergic
reaction.
INHALATION: May cause irritation, and hypersensitive individuals may experience an allergic reaction.
INGESTION: Chronic ingestion or excessive dosage may cause allergic reaction, central nervous system
effects, fever, headache, nausea, vomiting, diarrhea, perineal irritation, blurring of vision, numbness,
blood disorders and bone marrow depression.
TARGET ORGAN(S): Blood, Bone Marrow, Nerves and Liver.
ADDITIONAL INFORMATION:
May be harmful by inhalation, ingestion or skin absorption. May cause sensitization by inhalation and skin
contact. May cause cancer in humans. Possible risk of congenital malformation in the fetus. Laboratory
experiments have shown mutagenic effects. May cause adverse reproductive effects based upon animal
studies.
Reproductive effects, tumorigenic, mutation and toxicity data listed in RTECS under AB6825000.
Only select RTECS information is provided here. Please see actual RTECS entry for complete information.
Oral Human (woman) LDLo = 400 mg/kg (1975). Oral Rat LD50 = 2500 mg/kg (1955). Toxic effects may
include cyanosis, shock and coma.
Reproductive: Effects on embryo or fetus - fetotoxicity (except death, e.g. stunted fetus) (1977) and
fetal death (1971).
Specific developmental abnormalities - central nervous system (1973), eye/ear (1965),
urogenital system (1965) and musculoskeletal system (1971).
Fertility - litter size (e.g. # of fetuses per litter; measured before birth) (1971) and
abortion (1970).
Carcinogenicity data:
IARC Cancer Review: Animal - Inadequate Evidence (1990).
Human - Limited Evidence (1990).
Group 2A - Agent is probably carcinogenic to humans (1990).
NTP 10th Report on Carcinogens, 2002: Reasonably anticipated to be a human carcinogen.
Tumorigenic data: Carcinogenic by RTECS criteria (1981).
Equivocal tumorigenic agent by RTECS criteria (1981).
Definition(s): IARC = International Agency for Research on Cancer.
RTECS = Registry of Toxic Effects of Chemical Substances.
NTP = National Toxicology Program Annual Report on Carcinogens.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - This material does not have a RQ or TPQ.
SARA 313 - This material is not reportable under Section 313.
EPA TSCA Section 8(b) - Chemical Inventory.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the State of California to cause
cancer.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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