MATERIAL SAFETY DATA SHEET
Product Name: COMPONENT E-S/E-C Cattle Implants
Supplier of Data: Ivy Animal Health, Inc.
8857 Bond Street
Overland Park, KS 66214
Emergency Telephone Number: 1-888-462-3493
Revision Date: 07/31/2003
Warning Statement:
Warning: Chronic overexposure may cause reproductive system disorders. Avoid
ingestion, inhalation, skin contact, and eye contact. Material intended for
veterinary use only.
Material Identification:
Common Name: Progesterone with estradiol benzoate cattle implants
Chemical Name: pregn-4-ene-3, 20-dione with estra-1, 3, 5 (10)-triene, 3, 17 beta-
diol, 3-benzoate
Synonyms: COMPONENT E-S, COMPONENT E-C Cattle Implants
ACTIVE INGREDIENTS FORMULA PERCENT
Progesterone C21H30O2 74.1
CAS # 57-83-0
Estradiol benzoate C25H28O3 7.4
CAS # 50-50-0
Health Hazard:
COMPONENT E-S/E-C is packaged within a plastic cartridge belt and poses no exposure risk
unless the belt is damaged.
Eye: Not expected to produce eye irritation. Absorption through the eyes may cause
systemic effects.
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Skin: Not expected to cause skin irritation. Absorption through the skin may cause
systemic effects.
Systemic: In men, overexposure may lead to gynecomastia (breast tenderness, breast
nodules or enlarged breasts), galactorrhea (secretion of milk), decreased libido
and damage to the testes resulting in atrophy and infertility.
In women, overexposure may cause menstrual irregularities (breakthrough
bleeding, change in menstrual flow, spotting, amenorrhea), temporary infertility,
breast changes (tenderness, enlargement, and secretion), and fluid retention.
The IARC has determined that there is sufficient evidence that progesterone and
estradiol benzoate are carcinogenic in experimental animals. However, data are
inadequate to evaluate the carcinogenicity in humans. When COMPONENT ES/
E-C is handled according to directions there is no exposure to the active
ingredients.
Permissible Exposure Limit:
Progesterone: None currently established.
Estradiol benzoate: None currently established.
First Aid:
Eye Contact: Flush eyes thoroughly with water for at least 15 minutes. Contact
physician.
Skin Contact: If skin appears irritated wash thoroughly with soap and water. Contact
physician.
Inhalation: Not Applicable
Ingestion: Give moderate amounts of water. Contact physician.
Special Protection:
Eye Protection: The choice of protection should be appropriate for the activity being
conducted.
Skin Protection: Where the potential exists for extended skin contact with tablets, latex
gloves are recommended.
Reactivity:
Stability: Stable; Store according to label.
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Incompatibility: Strong oxidizing agents (e.g. peroxides, permanganates, nitric acid,
etc.) may produce violent reaction.
Hazardous Decomposition Products: Like any organic chemical, under certain
conditions of combustion, COMPONENT E-S/E-C may produce nitrogen oxides,
carbon monoxide and carbon dioxide.
Hazardous Polymerization: Will not occur.
Environmental Protection:
Waste Disposal Methods: All COMPONENT E-S/E-C waste should be contained in a
plastic bag and disposed of according to prescribed federal, state, and local
guidelines.
Physical Properties:
Boiling Point: Not applicable
Melting Point: The melting point of the finished dose form is unknown. The melting
point for progesterone is 121-131 degrees C and for estradiol benzoate is 191-
196 degrees C.
Molecular Weight: Not applicable.
Solubility: Soluble in alcohol or acetone.
Vapor Pressure: Nil
Specific Gravity: Unknown
Percent Volatile: Nil
Vapor Density: Unknown
Evaporation: Nil
Appearance, Color, Odor: Yellow pellets.
The above information is based on data available to us and is believed to be correct.
However, NO WARRANTY is expressed or to be implied regarding the accuracy of this
information, the results to be obtained from the use thereof, or the hazards connected with the
use of material. Since the information contained herein may be applied under conditions
beyond our control and with which we may be unfamiliar, we do not assume any responsibility
for the results of its use. This information is furnished upon the condition that the persons
receiving it shall make their own determinations of the effects, properties and protections which
pertain to their particular conditions.
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Disclaimer of Expressed and Implied Warranties: Although reasonable care has been taken in
the preparation of this document, we extend no warranties and make no representation as to
the accuracy or completeness of the information contained therein, and assume no
responsibility regarding the suitability of this information for the user鈥檚 intended purposes or for
the consequences of its use. Each individual should make a determination as to the suitability
of the information for their particular purpose(s).
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