MATERIAL SAFETY DATA SHEET
MANUFACTURER Varian Instruments 鈥? Middelburg
ADDRESS Herculesweg 8
4338 PL Middelburg, Netherlands
PHONE 31.118.67100 MSDS Number: 1002-913975 Rev. 0
EMERGENCY PHONE 1.800.424.9300 鈥? CHEMTREC USA Date: June 5, 2007
FAX 31.118.633118 Prepared by: Corporate EH&S
SECTION 1: MATERIAL IDENTIFICATION
Product Name: Mix 414 - Testmix CP913975
Synonyms: Benzene, Toluene, Ethylbenzene, n-Propylbenzene, and n-Butylbenzene in hexane. Hexane is also
known as Hexyl hydride and Dipropyl.
SECTION 2: COMPOSITION
An ampoule/vial containing the following:
Approximate NTP IARC
Component CAS Number Concentration Carcinogen Status Carcinogen Status
Benzene 71-43-2 3% listed* listed*
Toluene 108-88-3 3% not listed not listed
Ethylbenzene 100-41-4 3% not listed listed**
n-Propylbenzene 103-65-1 3% not listed not listed
n-Butylbenzene 104-51-8 3% not listed not listed
n-Hexane 110-54-3 balance not listed not listed
*Listed as a known human carcinogen by NTP and IARC.
**Group 2B - Possibly carcinogenic to humans.
WARNING: This product contains Benzene [CAS# 71-43-2] and Toluene [CAS# 108-88-3] chemicals known to the State of
California to cause cancer and birth defects or other reproductive harm.
NOTE: Unless otherwise noted, the information below pertains only to the n-Hexane solvent in the ampoule/vial.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview: Colorless liquid. Flash Point: -22 deg C. Flammable liquid and vapor. Vapor may cause a flash fire.
Harmful or fatal if swallowed. Aspiration hazard if swallowed. Causes irritation to skin, eyes, and respiratory tract. May cause
respiratory and digestive tract irritation. May cause eye and skin irritation. May affect central nervous system. Target Organs:
Central nervous system, respiratory system, eyes, and skin
Potential Health Effects
Inhalation: Causes irritation to the respiratory tract. Symptoms may include coughing, shortness of breath. Inhalation of high
concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and
coma.
Ingestion: Aspiration hazard. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Symptoms expected to
parallel inhalation.
Skin Contact: May cause skin irritation with itching and redness. Prolonged or repeated skin contact may cause defatting and
dermatitis.
Eye Contact: May cause irritation, redness, and pain.
Carcinogen Status: NTP: Not listed IARC: Not listed
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SECTION 4: FIRST AID INFORMATION
Inhalation: Get medical attention immediately. Remove to fresh air. If breathing is difficult, give oxygen. Do NOT use mouth-to-
mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a
bag and a mask.
Ingestion: If swallowed, vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting occurs, keep head below hips to
help prevent aspiration. If person is unconscious, turn head to side. Get medical attention immediately. Never give anything by
mouth to an unconscious person.
Skin Contact: In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if irritation develops or persists.
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical
aid. Do NOT allow victim to rub or keep eyes closed.
SECTION 5: FIRE-FIGHTING INFORMATION
Fire: Flash point (closed cup): -22C (10F)
Autoignition temperature: 224C (435F)
Flammable limits in air % by volume: Lower = 1.1 Upper = 7.7
NFPA Rating: health-1; flammability-3; reactivity-0
Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along
surfaces to distant ignition source and flash back. Sealed containers may rupture when heated. Contact with strong oxidizers may
cause fire. Sensitive to static discharge.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire
exposed containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Use proper personal protective equipment as indicated in Section 8. Ventilate area of leak or spill. Remove all sources of ignition.
Absorb spill with inert material (e.g. vermiculite, sand or earth), scoop up with a nonsparking tool, then place into a suitable
container for disposal. Do not flush to sewer!
SECTION 7: HANDLING AND STORAGE
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated
area. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and
inhalation.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTIVE EQUIPMENT
Airborne Exposure Limits: United States - OSHA Permissible Exposure Limit (PEL): 500 ppm (TWA)
United States - ACGIH Threshold Limit Value (TLV): 50 ppm (TWA) (skin)
Australia: Time-weighted average 50 ppm (180 mg/m3), 1993
The Netherlands: MAC-TGG 25 ppm (90 mg/m3), JAN1999
Personal Protective Equipment
Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166. Maintain eye wash fountain and quick-drench facilities in
work area.
Skin Protection: Wear impervious gloves, apron, and/or clothing.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Use a NIOSH or
European Standard EN 149 approved respirator when necessary.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its
source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, "Industrial Ventilation, A
Manual of Recommended Practices", most recent edition, for details.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Clear, colorless liquid Boiling Point: 68C (154F)
Odor: Gasoline-like odor Melting Point: -195C (-139F)
Solubility: Insoluble Vapor Density: 3.8 (Air=1)
Specific Gravity: 0.66 (Water = 1) Vapor Pressure (mm Hg): 130 @ 20C (68F)
pH: Not available. Evaporation Rate: 9 (Butyl Acetate = 1)
Molecular Formula: C6H14 % Volatiles by Volume: 100
Molecular Weight: 86.2
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SECTION 10: STABILITY AND REACTIVITY DATA
Stability: Stable at room temperature in sealed containers.
Hazardous Decomposition Products: Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizers, heat, and sources of ignition.
Conditions to Avoid: Incompatibles.
SECTION 11: TOXICOLOGICAL INFORMATION
RTECS#: MN9275000 for CAS# 110-54-3 (Hexane)
LD50/LC50:
Oral, rat: LD50 = 25 gm/kg
Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Mutagenicity: Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances
(RTECS).
SECTION 12: ECOLOGICAL INFORMATION
Environmental Fate: When released into the soil, this material may biodegrade to a moderate extent. When released into the
soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly
evaporate. When released to water, this material is expected to quickly evaporate. This material may bioaccumulate to some
extent. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced
hydroxyl radicals. When released into the air, this material is expected to have a half-life between 1 and 10 days.
Environmental Toxicity: Not available
SECTION 13: DISPOSAL GUIDELINES
Dispose in compliance with federal, state, and local regulations. Chemical waste generators must determine whether a discarded
chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate
classification.
USEPA RCRA waste number D001.
The information offered here is for the product as shipped. Use and/or alterations to the product such as mixing with other
materials may significantly change the characteristics of the material and alter the RCRA classification and the proper disposal
method.
SECTION 14: TRANSPORT INFORMATION
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
United States (Land, D.O.T.) International (Air, I.C.A.O.)
Proper Shipping Name: Hexanes Proper Shipping Name: : Hexanes
Hazard Class: 3 Hazard Class: 3
UN/NA: : UN1208 UN/NA: UN1208
Packing Group: II Packing Group: II
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SECTION 15: REGULATORY INFORMATION
US Federal
TSCA: CAS# 110-54-3 is listed on the TSCA inventory.
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: No
US State
CAS# 110-54-3 can be found on the following state right to know lists: New Jersey, Florida, Pennsylvania, Minnesota,
Massachusetts.
California Proposition 65: Not regulated.
Other Regulations
EC Classification: F 鈥? Highly Flammable, Xi - Irritant
EC Risk and Safety Phrases:
Risk Phrases:
R 11 Highly flammable.
R 38 Irritating to skin.
R 48/20 Harmful:danger of serious damage to health by prolonged exposure through inhalation.
R 62 Possible risk of impaired fertility.
R 65 May cause lung damage is swallowed.
R 67 Vapors may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static discharges.
S 36/37 Wear suitable protective clothing and gloves.
S 9 Keep container in a well-ventilated place.
S 61 Avoid release to the environment. Refer to special instructions/Safety data sheets.
S 62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
WHMIS Classification: B2, D2B
Inventory Status: Listed on EINECS and Canadian DSL
SECTION 16: OTHER INFORMATION
NOTE: Unless otherwise noted, the information above pertains only to the Hexane solvent in the ampoule/vial.
This MSDS was prepared in accordance with ANSI Z400.1-1993 and 91/155/EEC recommended formats.
The information contained herein is believed to be accurate, but does not purport to be all-inclusive and shall be used only as a
guide. Varian, Inc., does not guarantee said information is accurate or complete, nor shall any of this information constitute a
warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods
for a particular purpose. It is the user鈥檚 responsibility to determine the suitability of this information and to assure the adoption of
necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact with the above
product, nor for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
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