Acetonitrile Page 1 of 5
Material Safety Data Sheet
Section 1. Product and Company Identification
AX0145
Product Name Product Code
Acetonitrile
EMD Chemicals Inc.
Manufacturer Effective Date 3/3/2003
P.O. Box 70
480 Democrat Road
Gibbstown, NJ 08027
Prior to January 1, 2003 EMD Chemicals Inc. was EM Industries,
Inc. or EM Science, Division of EM Industries, Inc.
For More Information Call In Case of Emergency Call
856-423-6300 Technical Service 800-424-9300 CHEMTREC (USA)
Monday-Friday: 8:00 AM - 5:00 PM 613-996-6666 CANUTEC (Canada)
24 Hours/Day: 7 Days/Week
ETHANENITRILE; METHYL CYANIDE
Synonym
Analytical reagent.
Material Uses
Solvent.
Chemical Family
Section 2. Composition and Information on Ingredients
Component CAS # % by Weight
ACETONITRILE 75-05-8 100
Section 3. Hazards Identification
Liquid. (Colorless.)
Physical State and
Appearance
DANGER!
Emergency Overview
POISON!
FLAMMABLE LIQUID AND VAPOR.
VAPOR MAY CAUSE FLASH FIRE.
HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED.
CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, LIVER, RESPIRATORY TRACT, SKIN,
CENTRAL NERVOUS SYSTEM, EYE, LENS OR CORNEA.
Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Routes of Entry
Potential Acute Health Effects
Eyes No known acute effects of this product resulting from eye contact.
Skin Hazardous in case of skin contact (permeator).
Inhalation Hazardous in case of inhalation.
Ingestion Hazardous in case of ingestion.
Potential Chronic Health Effects
Carcinogenic Effects This material is not known to cause cancer in animals or humans.
Additional information See Toxicological Information (section 11)
Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in
Medical Conditions
one or many human organs.
Aggravated by
Overexposure:
Section 4. First Aid Measures
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
Eye Contact
keeping eyelids open. Cold water may be used. Get medical attention.
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing
Skin Contact
contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes
before reuse. Get medical attention immediately.
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Inhalation
Get medical attention immediately.
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
Ingestion
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.
Section 5. Fire Fighting Measures
Product will burn.
Flammability of the Product
524.05掳C (975.3掳F)
Auto-ignition Temperature
Closed cup: 5.9掳C (42.6掳F).
Flash Points
LOWER: 3% UPPER: 16%
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Highly flammable in presence of open flames, sparks and static discharge, of shocks, of heat, of oxidizing
Fire Hazards in Presence of
materials.
Various Substances
Explosion Hazards in Risks of explosion of the product in presence of static discharge:
Highly flammable in presence of open flames, sparks and static discharge.
Presence of Various
Highly explosive in presence of open flames, sparks and static discharge.
Substances
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Risks of explosion of the product in presence of mechanical impact:
Highly flammable in presence of shocks.
Highly explosive in presence of shocks.
Flammable liquid, soluble or dispersed in water.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
and Instructions
LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent
pressure build-up, autoignition or explosion.
Be sure to use an approved/certified respirator or equivalent.
Protective Clothing (Fire)
Dangerous fire and explosion risk. Vapor may travel considerable distance to source of ignition and flash back.
Special Remarks on Fire
Hazards
Not available.
Special Remarks on
Explosion Hazards
Section 6. Accidental Release Measures
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal
Small Spill and Leak
container.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Cover with DRY earth,
Large Spill and Leak
DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with
rain. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent
entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the
product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
The following EMD Chemicals Inc. SpillSolv 庐 absorbent is recommended for this product: SX1330 Solvent
Spill Kit Information
Treatment Kit
Section 7. Handling and Storage
Keep away from heat, sparks and flame. Keep container closed. Do not get in eyes, on skin, or on clothing. Do
Handling
not ingest. Do not breathe gas/fumes/ vapor/spray.
Keep container in a cool, well-ventilated area.
Storage
Section 8. Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below
Engineering Controls
their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-
station location.
Personal Protection
Eyes Safety glasses.
Body Lab coat.
Respiratory Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when
ventilation is inadequate.
Hands Gloves.
Feet Not applicable.
Protective Clothing
(Pictograms)
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to
Personal Protection in Case
avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
of a Large Spill
BEFORE handling this product.
Product Name Exposure Limits
ACETONITRILE 80/1107/EEC (Europe, 1991).
TWA: 40 mg/m3
TWA: 70 ppm
National Authority for Occupational Safety/Health (Ireland, 1999).
STEL: 105 mg/m3
STEL: 60 ppm
OEL: 70 mg/m3
OEL: 40 ppm
N-Arbeidstylsinet (Norway, 1996).
AN: 50 mg/m3
AN: 30 ppm
EH40-OES (United Kingdom (UK), 1997).
STEL: 102 mg/m3
STEL: 60 ppm
MEL: 68 mg/m3
MEL: 40 ppm
ACGIH (United States, 1996).
STEL: 101 mg/m3
STEL: 101 mg/m3
STEL: 60 ppm
TWA: 67 mg/m3
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TWA: 67 mg/m3
TWA: 40 ppm
NIOSH REL (United States, 1994).
TWA: 34 mg/m3 Period: 10 hour(s).
TWA: 20 ppm Period: 10 hour(s).
OSHA (United States, 1989).
STEL: 105 mg/m3
TWA: 70 mg/m3
OSHA Final Rule (United States, 1989).
STEL: 105 mg/m3
STEL: 60 ppm
TWA: 70 mg/m3
TWA: 40 ppm
Section 9. Physical and Chemical Properties
Aromatic.
Odor
Colorless.
Color
Liquid. (Colorless.)
Physical State and
Appearance
41.05 g/mole
Molecular Weight
C2H3N
Molecular Formula
Not available.
pH
81.72掳C (179.1掳F)
Boiling/Condensation Point
-41.85掳C (-43.3掳F)
Melting/Freezing Point
274.8掳C (526.6掳F)
Critical Temperature
0.787 (Water = 1)
Specific Gravity
9.7 kPa (72.8 mmHg) (@ 20掳C)
Vapor Pressure
1.42 (Air = 1)
Vapor Density
100% (v/v).
Volatility
40 ppm
Odor Threshold
2.33 compared to (n-BUTYL ACETATE=1)
Evaporation Rate
100 (%)
VOC
Not available.
LogKow
See solubility in water.
Dispersion Properties
Soluble in water.
Solubility
Section 10. Stability and Reactivity
The product is stable.
Stability and Reactivity
Not available.
Conditions of Instability
Highly reactive with oxidizing agents, reducing agents, acids, alkalis.
Incompatibility with Various
Substances
Not available.
Rem/Incompatibility
carbon oxides (CO, CO2) nitrogen oxides (NO, NO2...) Hydrogen Cyanide (HCN)
Hazardous Decomposition
Products
Will not occur.
Hazardous Polymerization
Section 11. Toxicological Information
RTECS Number:
Acetonitrile AL7700000
Acute oral toxicity (LD50): 50 mg/kg [Rabbit].
Toxicity
Not available.
Chronic Effects on Humans
Hazardous in case of skin contact (permeator). Hazardous in case of inhalation. Hazardous in case of ingestion.
Acute Effects on Humans
Not available.
Synergetic Products
(Toxicologically)
Draize Test: Not available.
Irritancy
Not available.
Sensitization
This material is not known to cause cancer in animals or humans.
Carcinogenic Effects
Tests on laboratory animals for reproductive effects are cited in Registry of Toxic Effects on Chemical
Toxicity to Reproductive
Substances (RTECS).
System
Not available.
Teratogenic Effects
Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances
Mutagenic Effects
(RTECS).
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
The products of degradation are less toxic than the product itself.
Toxicity of the Products of
Biodegradation
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Section 13. Disposal Considerations
U003 D001
EPA Waste Number
Specified Technology - Incineration to a level below TCA (Total Constituent Analyses) levels. Contact your local
Treatment
permitted waste disposal site (TSD) for permissible treatment sites. Always contact a permitted waste disposal
(TSD) to assure compliance with all current local, state, and Federal Regulations.
Section 14. Transport Information
Proper Shipping Name: ACETONITRILE
DOT Classification
Hazard Class: 3
UN number: UN1648
Packing Group: II
RQ: 5000 lbs. (2268 kg)
Not available.
TDG Classification
Proper Shipping Name: ACETONITRILE
IMO/IMDG Classification
Hazard Class: 3
UN number: UN1648
Packing Group: II
RQ: 5000
Not available.
ICAO/IATA Classification
Section 15. Regulatory Information
TSCA 8(a) PAIR: ACETONITRILE
U.S. Federal Regulations
TSCA 8(b) inventory: ACETONITRILE
TSCA 8(d) H and S data reporting: ACETONITRILE: 1982
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: ACETONITRILE
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: ACETONITRILE: Fire Hazard,
Immediate (Acute) Health Hazard, Delayed (Chronic) Health Hazard
SARA 313 toxic chemical notification and release reporting: ACETONITRILE
Clean Water Act (CWA) 307: ACETONITRILE
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
CLASS B-2: Flammable liquid with a flash point lower than 37.8掳C (100掳F).
WHMIS (Canada)
Class D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
CEPA DSL: ACETONITRILE
This product has been classiifed in accordance with the hazard criteria of the Controlled Product Regulations and
the MSDS contains all required information.
International Regulations
ACETONITRILE 200-835-2
EINECS
R11- Highly flammable.
DSCL (EEC)
R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
Australia (NICNAS): ACETONITRILE
International Lists
Japan (MITI): ACETONITRILE
Korea (TCCL): ACETONITRILE
Philippines (RA6969): ACETONITRILE
China: No products were found.
Pennsylvania RTK: ACETONITRILE: (environmental hazard, generic environmental hazard)
State Regulations
Massachusetts RTK: ACETONITRILE
New Jersey: ACETONITRILE
California prop. 65: No products were found.
Section 16. Other Information
Fire Hazard
National Fire 3
Protection 20
Health Reactivity
Association Specific Hazard
(U.S.A.)
Changed Since Last Revision +
Notice to Reader
The statements contained herein are based upon technical data that EMD Chemicals Inc. believes to be reliable, are offered for
information purposes only and as a guide to the appropriate precautionary and emergency handling of the material by a properly
trained person having the necessary technical skills. Users should consider these data only as a supplement to other information gathered
by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use,
storage and disposal of these materials and the safety and health of employees and customers and the protection of the environment.
EMD CHEMICALS INC. MAKES NO REPRESENTATION OR WARRANTY OF ANY KIND, EXPRESS OR IMPLIED,
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INCLUDING MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE, WITH RESPECT TO THE INFORMATION
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
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