Pharmacia & Upjohn
DEPO-MEDROL庐 Sterile Aqueous Suspension
MATERIAL SAFETY DATA SHEET
Agent ID# 43526
1. CHEMICAL PRODUCT AND 3. HAZARDS IDENTIFICATION
COMPANY IDENTIFICATION
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact,
COMMON NAME: DEPO-MEDROL庐 Sterile Aqueous eye contact, ingestion, and inhalation.
EFFECTS OF OVEREXPOSURE: Methylprednisolone
Suspension (Animal Health Product)
acetate is a glucocorticosteroid. Glucocorticoids affect
SYNONYMS: 468227 鈥? EDP Number; 468228 鈥? EDP
carbohydrate, protein and fat metabolism; functions of the
Number; 468391 鈥? EDP Number
cardiovascular system, kidney, skeletal muscle, nervous
MOLECULAR FORMULA: Mixture
system and other organs and tissues; and may modify the
USE: Veterinary drug for the treatment of inflammatory and
body鈥檚 immune responses to diverse stimuli. Chronic
allergic conditions in dogs and cats and for the alleviation
overexposure to glucocorticoids may produce pituitary-
of pain and lameness associated with acute localized or
adrenal suppression, Cushing鈥檚 syndrome [redistribution
general arthritic conditions in horses. Not for human use.
of body fat to face (鈥渕oon face鈥?), back of neck and trunk],
MANUFACTURER/SUPPLIER:
increased susceptibility to infections (suppression of in-
PHARMACIA & UPJOHN CO., A SUBSIDIARY OF
flammatory response), osteoporosis, cataracts, glaucoma
PHARMACIA CORP.
with possible damage to optic nerve, mental symptoms,
7171 PORTAGE RD
hyperglycemia and glycosuria, muscular weakness and
KALAMAZOO, MI 49001-0199
fatigue, acne, menstrual disorders and peptic ulcers.
TELEPHONE NUMBERS:
Naturally occurring glucocorticoids (such as hydrocorti-
(616) 833-5122 - (24 Hours)
sone and cortisone), in average and large doses, may cause
(616) 833-7555 - (8:00 AM - 4:30 PM, EST)
elevation of blood pressure, salt and water retention, and
increased potassium excretion. These effects are less likely
2. COMPOSITION/INFORMATION
to occur with methylprednisolone acetate except in large
ON INGREDIENTS doses. All corticosteroids increase calcium excretion.
MEDICAL CONDITIONS AGGRAVATED BY
EXPOSURE: Overexposure to corticosteroids may
INGREDIENT 1
increase susceptibility to infection (including reacti-
COMMON NAME: Water.
vation of latent tuberculosis and enhancement of
% BY WEIGHT: 91% to 93%
secondary eye infections due to fungi or viruses) or mask
CAS NUMBER: 7732-18-5
some signs of infection. Recent immunization proce-
EXPOSURE LIMIT(S): Not established.
dures may result in a lack of antibody response and
neurological disorders. Hypersensitivity to this material
INGREDIENT 2
may result. Corticosteroids exhibit enhanced effects on
COMMON NAME: Carbowax鈩? Polyethylene Glycol
persons with hypothyroidism or cirrhosis.
3350.
% BY WEIGHT: 3 %
EXPOSURE LIMIT(S): Not established. 4. FIRST AID MEASURES
INGREDIENT 3
EYES: Rinse immediately with plenty of water, also under
COMMON NAME: Non-hazardous Ingredient(s).
the eyelids, for at least 15 minutes.
% BY WEIGHT: 2 %
SKIN: Wash off with soap and water. Take off all
EXPOSURE LIMIT(S): Not established.
contaminated clothing immediately.
INHALATION: Move to fresh air.
INGREDIENT 4
INGESTION: Contact a physician or poison control center.
COMMON NAME: Methylprednisolone Acetate.
CHEMICAL NAME: Pregna-1,4-diene-3,20-dione, 21-
(acetyl-oxy)-11,17-dihydroxy-6-methyl-, (6a,11脽)-
5. FIRE FIGHTING MEASURES
% BY WEIGHT: 2% to 4%
CAS NUMBER: 53-36-1
EXPOSURE LIMIT(S):
FLASH POINT: Nonflammable.
PHARMACIA & UPJOHN EXPOSURE LIMIT-TWA:
LOWER EXPLOSION LIMIT (LEL): Not applicable.
4 碌g/m3
UPPER EXPLOSION LIMIT (UEL): Not applicable.
SKIN NOTATION: Yes.
EXTINGUISHING MEDIA: Water, carbon dioxide or dry
chemical.
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not
FIRE FIGHTING PROCEDURES: Wear self-contained
established.
breathing apparatus and full-body protective equipment.
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Pharmacia & Upjohn
DEPO-MEDROL庐 Sterile Aqueous Suspension
MATERIAL SAFETY DATA SHEET
Agent ID# 43526
UNUSUAL FIRE OR EXPLOSION HAZARDS: None EYE IRRITATION (RABBIT): Non-irritating.
known. SKIN IRRITATION (RABBIT): Non-irritating to intact
HAZARDOUS COMBUSTION PRODUCTS: Carbon or abraded skin.
monoxide. Carbon dioxide. SENSITIZATION: No information found.
ORAL LD50 (RAT): >10 g/kg (not acutely toxic)
INTRAPERITONEAL LD50 (MOUSE): >1,409 mg/kg
6. ACCIDENTAL RELEASE MEASURES OTHER STUDIES:
GENOTOXICITY: Mutagenicity: Methylprednisolone
was negative in the DNA damage/alkaline elution assay.
STEPS TO BE TAKEN IN CASE MATERIAL IS
TERATOGENICITY: Corticosteroids are generally
RELEASED OR SPILLED: Control the generation of
teratogenic in laboratory animals when administered
vapors; provide adequate ventilation and respiratory, skin
systemically, but there are no well-controlled studies
and eye protection to prevent overexposure. Keep out of
in women. The safety of their use in pregnant women
drains; prevent entry to surface water, groundwater and
has not been absolutely established.
soil. Vacuum or scoop spilled material and place in
CARCINOGENICITY: Methylprednisolone was negative
container.
in the DNA-cell-binding assay. Not listed as a carcinogen
by IARC, NTP or OSHA.
7. HANDLING AND STORAGE
12. DISPOSAL CONSIDERATIONS
PRECAUTIONS FOR HANDLING AND STORING:
Avoid contact with skin, eyes and clothing. Wash
WASTE DISPOSAL METHOD: Dispose of by
thoroughly after handling. Launder contaminated clothing
incineration in accordance with applicable international,
before use. Store in a cool, dry place. Protect from light.
national, state, and/or local waste disposal regulations.
Keep out of reach of children.
13. SHIPPING REGULATIONS
8. EXPOSURE CONTROLS/
PERSONAL PROTECTION
Not regulated for transportation by the United States
Department of Transportation (DOT), International Maritime
RESPIRATORY PROTECTION: Not required.
Organization (IMO), or International Air Transport
VENTILATION: Local exhaust.
Association (IATA). May be subject to state and/or local
PROTECTIVE GLOVES: Not required.
transportation requirements.
EYE PROTECTION: Not required.
OTHER PROTECTIVE EQUIPMENT: Not required.
14. OTHER INFORMATION
9. PHYSICAL AND CHEMICAL
PROPERTIES REVIEWED BY: Environment & Safety
DISCLAIMER: The information contained in the MSDS is
believed to be correct as of its date of issuance. BY
APPEARANCE/PHYSICAL STATE: Aqueous solution. MAKING THE MSDS AVAILABLE, PHARMACIA &
MOLECULAR WEIGHT: Mixture. UPJOHN CO. DOES NOT MAKE ANY EXPRESS OR
IMPLIED WARRANTY (INCLUDING ANY
WARRANTY OF MERCHANTABILITY OR FITNESS
10. STABILITY AND REACTIVITY FOR A PARTICULAR PURPOSE) REGARDING THE
MSDS, ITS ACCURACY OR THE PRODUCT TO
WHICH IT RELATES. Anyone using this information
STABILITY: Stable at normal conditions.
agrees that Pharmacia & Upjohn shall not be held liable
PHYSICAL CONDITIONS TO AVOID: None.
(based on its negligence or otherwise) for any personal
INCOMPATIBILITY WITH OTHER MATERIALS:
injury or other damage relating to, or arising from such
None.
use, including direct, incidental, or consequential damage
HAZARDOUS DECOMPOSITION PRODUCTS: None.
and such user agrees to indemnify Pharmacia & Upjohn
HAZARDOUS POLYMERIZATION: Does not occur.
for any claims arising out of its use.
11. TOXICOLOGICAL INFORMATION
ACUTE STUDIES: The following data applies to the active
ingredient methylprednisolone acetate.
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Pharmacia & Upjohn
DEPO-MEDROL庐 Sterile Aqueous Suspension
MATERIAL SAFETY DATA SHEET
Agent ID# 43526
15. LABELING
This drug is subject to FDA labeling requirements; therefore,
it is exempt from the labeling requirements of the OSHA
Hazard Communication Standard.
NDC 0009-0613-01
NDC 0009-0613-04
NDC 0009-0614-01
July 31, 2001
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