MATERIAL SAFETY DATA SHEET
SECTION 1 - IDENTIFICATION OF PRODUCT AND COMPANY
1-866-531-8896
Pfizer Inc Emergency telephone
24 Hours
Pfizer Animal Health Hours of operation
1-800-366-5288
235 East 42nd Street Telephone
New York, NY 10017
Product name Equimax庐
Chemical family Pyrazinoisoquinoline derivative/ Avermectin macrocyclic lactone
Therapeutic use Anthelmintic/ Antiparasitic
Odorless, white, thick, smooth paste
Description
SECTION 2 - COMPOSITION
Ingredient CAS Number Amount
Praziquantel* 55268-74-1 14.03%
Ivermectin* 70288-86-7 1.87% **
Proprietary Ingredients Not assigned 84.1%
*Hazardous
Note: Ingredient(s) indicated as hazardous have been assessed under standards
for workplace safety. The ingredients in this formulation are being held as
trade secret. In the event of a medical emergency or for use of this MSDS
outside the United States, contact the emergency telephone number listed
in Section 1 for ingredient information.
** Ivermectin is a mixture of Ivermectin component B1伪 (70161-11-4) and
Ivermectin component B1螔 (70209-81-3)
SECTION 3 - HAZARDS IDENTIFICATION
Signal word WARNING!
Statements of hazard TOXIC IF SWALLOWED
POSSIBLE RISK OF HARM TO THE UNBORN CHILD
May cause irritation based on components.
Eye effects
May cause irritation based on components.
Skin effects
Not expected due to physical form.
Inhalation effects
Ingestion effects May be harmful if swallowed. See 'Statements of hazard', 'Known clinical
effects', and/or 'Other potential health effects' in this section.
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SECTION 3 - HAZARDS IDENTIFICATION ... continued
Adverse effects most frequently reported with the use of praziquantel
Known clinical effects
include headache, diarrhea, dizziness, drowsiness, weakness, abdominal
discomfort, nausea, and vomiting. Adverse effects associated with the
clinical use of ivermectin may include joint or muscle pain, dizziness,
fever, headache, skin rash, itching, fast heartbeat, and swelling of face or
extremities.
Animal studies with ivermectin have shown a potential to cause adverse
Other potential health
effects on the fetus.
effects
This document has been prepared in accordance with standards for
NOTE:
workplace safety, which require the inclusion of all known hazards of the
product or its ingredients regardless of the potential risk. The
precautionary statements and warnings included may not apply in all
cases. Your needs may vary depending upon the potential for exposure in
your workplace.
SECTION 4 - FIRST AID MEASURES
Skin Remove clothing and wash affected skin with soap and water. This
material may not be completely removed by conventional laundering.
Consult professional laundry service. Do not home launder. If irritation
occurs or persists, get medical attention.
Eyes Immediately flush eyes with water for at least 15 minutes. Get medical
attention. If irritation occurs or persists, get medical attention.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get
medical attention immediately.
Ingestion Get medical attention immediately. Do not induce vomiting unless directed
by medical personnel. Never give anything by mouth to an unconscious
person.
SECTION 5 - FIRE FIGHTING MEASURES
Wear approved positive pressure, self-contained breathing apparatus and
Fire fighting instructions
full protective turn out gear. Evacuate area and fight fire from a safe
distance.
Water spray, carbon dioxide, dry chemical or foam.
Extinguishing media
No data available
Flash point
Carbon monoxide and carbon dioxide
Hazardous combustion
products
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SECTION 6 - ACCIDENTAL RELEASE MEASURES
Review Sections 3, 8 and 12 before proceeding with clean up.
General
Use non-combustible material to absorb spill; then place in a suitable,
Small spill
labeled recovery container. Clean spill area thoroughly. Prevent discharge
to drains.
Large spill Collect spill with a non-combustible absorbent material. Transfer all waste
to a labeled container and move it to a secure holding area. Prevent
discharge to drains.
SECTION 7 - HANDLING AND STORAGE
General handling Use only in a well-ventilated area. Avoid contact with eyes. Avoid contact
with skin and clothing. Wash thoroughly after handling.
Storage conditions Store in a cool, dry, well-ventilated area. Protect from light. Keep
container tightly closed when not in use.
Temperature range <30掳C (<86掳F)
for storage
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION
Engineering controls should be used as the primary means to control
Ventilation
exposures. Good general ventilation should be sufficient to control
airborne levels. Local and general ventilation should be used as necessary,
when handling this material in bulk.
Respiratory protection is recommended as a precaution to minimize
Respiratory protection
exposure when handling this material in bulk.
Safety glasses or goggles
Eye protection
Use protective clothing (uniforms, lab coats, disposable coveralls, etc.) in
Skin protection
both production and laboratory areas.
Rubber gloves
Hand protection
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Paste
Physical form
White
Color
Odorless
Odor
Mixture
Molecular weight
Mixture
Molecular formula
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SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ... continued
Not applicable
pH
Not applicable
Boiling point
Not applicable
Melting point
No data available
Density
No data available
Vapor pressure
No data available
Water solubility
No data available
Solvent solubility
SECTION 10 - STABILITY AND REACTIVITY
Stable
Reactivity
None known
Conditions to avoid
None known
Incompatibilities
Thermal decomposition products may include carbon monoxide and
Hazardous
carbon dioxide
decomposition
products
Will not occur
Hazardous
polymerization
SECTION 11 - TOXICOLOGY INFORMATION
The information included in this section describes the potential hazards of
Toxicology summary
the active ingredients.
Acute toxicity
Compound Type Route Species Result
Praziquantel LD50 Oral Rat 2840 mg/kg
Ivermectin LD50 Oral Rat 10 mg/kg
May cause eye irritation based on components.
Eye
May cause skin irritation based on components.
Skin
No data available
Inhalation
See Acute toxicity table.
Ingestion
Praziquantel was not mutagenic in a number of mammalian cell assays.
Mutagenicity
Ivermection showed no evidence of mutagenic activity in bacterial or
mammalian cells in vitro.
No data available
Subchronic effects
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SECTION 11 - TOXICOLOGY INFORMATION ... continued
Chronic effects/ Long term carcinogenicity studies with praziquantel in rats and
carcinogenicity golden hamsters did not reveal any carcinogenic effect.
None of the components of this formulation are listed as a carcinogen by
Carcinogen status
IARC, NTP or OSHA.
Reproduction studies have been performed in rats and rabbits at doses up
Reproductive effects
to 40 times the human dose and have revealed no evidence of impaired
fertility or harm to the fetus due to praziquantel. An increase of the
abortion rate was found in rats at three times the single human therapeutic
dose. Ivermectin had no adverse effects on the fertility in rats in studies at
repeated doses of up to3 times the maximum recommended human dose of
200 碌g/kg.
Praziquantel did not cause teratogenicity in rats, mice, or rabbits.
Teratogenicity
Ivermectin has been shown to be teratogenic in rats, rabbits, and mice at or
near maternotoxic dose levels. Mice are the most sensitive species to the
effects of ivermectin with maternotoxicity at a dose of 200 碌g/kg/day and
teratogenicity at 400 碌g/kg/day. In rabbits 6000 碌g/kg/day was
maternotoxic and teratogenic, and teratogenicity was also evident at a dose
of 3000 碌g/kg/day. The threshold for both maternotoxicity and
teratogenicity in rats was 10,000 碌g/kg/day.
SECTION 12 - ECOLOGICAL INFORMATION
As with other members of the avermectin family, ivermectin is highly
Environmental overview
toxic to fish and certain aquatic organisms. However, once in contact with
soil, it is tightly bound and does not readily desorb. It is unlikely to reach
groundwater and is also biodegradable by soil microflora.
Avermectin compounds may bind tightly to soil upon contact and become
Mobility, persistence,
inactive over time.
and degradability:
See aquatic toxicity data, below.
Bioaccumulation and
toxicity:
Aquatic toxicity
Compound Type Species Result
Ivermectin LC50/48h Rainbow Trout 0.000025 mg/L
SECTION 13 - DISPOSAL INFORMATION
Incineration is the recommended method of disposal for this material.
Disposal procedure
Observe all local and national regulations when disposing of this mixture.
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SECTION 14 - TRANSPORTATION INFORMATION
This material is regulated for transportation as a hazardous
General shipping
instructions material/dangerous good. Non-regulated in non-bulk packagings
transported by motor vehicles, rail cars or aircraft (49CFR 171.4(c)).
IMDG proper shipping Environmentally hazardous substance, solid, n.o.s. (ivermectin), Marine
name Pollutant
UN 3077
IMDG Identification No.
9
IMDG hazard class
III
IMDG packing group
SECTION 15 - REGULATORY INFORMATION
EU Classification Toxic; Dangerous for the Environment
EU Labelling T
EU Label Pictogram(s)
R25 - Toxic if swallowed.
Risk phrases
R52/53 - Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S36/37 - Wear suitable protective clothing and gloves.
Safety phrases
S45 - In case of accident or if you feel unwell seek medical advice
immediately (show the label where possible).
S61 - Avoid release to the environment. Refer to special instructions/safety
data sheets.
Class D, Division 1, Subdivision A
Canadian WHMIS
Class D, Division 2, Subdivision A
SECTION 16 - OTHER
Disclaimer Pfizer Inc believes that the information contained in this Material
Safety Data Sheet is accurate, and while it is provided in good faith, it
is without a warranty of any kind, expressed or implied.
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