Pharmacia & Upjohn
LINCO-SPECTIN庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 40769
MEDICAL CONDITIONS AGGRAVATED BY
1. CHEMICAL PRODUCT AND EXPOSURE: Hypersensitivity to lincomycin,
COMPANY IDENTIFICATION clindamycin or spectinomycin.
COMMON NAME: LINCO-SPECTIN庐 Sterile Solution 4. FIRST AID MEASURES
USE: Veterinary product used for extending bovine semen.
Not for human use.
EYES: Flush with water for 15 minutes. Hold eyelids open
MANUFACTURER/SUPPLIER:
to assure complete contact with water.
PHARMACIA & UPJOHN
SKIN: Wash with soap and water. Remove contaminated
7171 PORTAGE RD
clothing.
KALAMAZOO, MI 49001-0199
INHALATION: Remove from exposure.
TELEPHONE NUMBERS:
INGESTION: Contact a physician or poison control center.
(616) 833-5122 - (24 Hours, Emergency)
(616) 833-7555 - (8:00 AM - 4:30 PM, EST Emergency)
(800) 253-8600 - (8:00 AM - 4:30 PM, EST) 5. FIRE FIGHTING MEASURES
2. COMPOSITION/INFORMATION
FLASH POINT: Nonflammable.
ON INGREDIENTS
LOWER EXPLOSION LIMIT (LEL): Not applicable
UPPER EXPLOSION LIMIT (UEL): Not applicable.
EXTINGUISHING MEDIA: Water, carbon dioxide or dry
INGREDIENT 1
chemical.
COMMON NAME: Water.
FIRE FIGHTING PROCEDURES: Wear self-contained
% BY WEIGHT: 85% (approximately).
breathing apparatus and full-body protective equipment.
CAS NUMBER: 7732-18-5
HAZARDOUS COMBUSTION PRODUCTS: Carbon
EXPOSURE LIMIT(S): Not established.
monoxide. Carbon dioxide. Nitrogen oxides. Sulfur oxides.
Hydrochloric acid.
INGREDIENT 2
COMMON NAME: Spectinomycin SulfateTetrahydrate.
CHEMICAL NAME: 4H-Pyrano[2,3-b][1,4]benzo- 6. ACCIDENTAL RELEASE MEASURES
dioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-
bis(methylamino)-, [2r-(2,4a,5a,6,7,8,9,9a,10a)]-, sulfate
% BY WEIGHT: 10% (approximately). STEPS TO BE TAKEN IN CASE MATERIAL IS
CAS NUMBER: 64058-48-6 RELEASED OR SPILLED: Provide ventilation and
EXPOSURE LIMIT(S): PHARMACIA & UPJOHN respiratory, skin and eye protection to prevent over-
EXPOSURE LIMIT-TWA: 2 mg/m3. exposure. Keep out of drains; prevent entry to surface
Value is for spectinomycin. water, groundwater and soil. Vacuum or scoop spilled
material and place in container.
INGREDIENT 3
COMMON NAME: Lincomycin Hydrochloride
7. HANDLING AND STORAGE
% BY WEIGHT: 5% (approximately).
CAS NUMBER: 859-18-7
EXPOSURE LIMIT(S): PHARMACIA & UPJOHN
PRECAUTIONS FOR HANDLING AND STORING:
EXPOSURE LIMIT-TWA: 0.1 mg/m3
Harmful if swallowed, inhaled or absorbed through the
skin. Keep out of reach of children. Wash thoroughly after
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not
handling. Pregnant females should avoid exposure. Not for
established. PHARMACIA & UPJOHN EXPOSURE
human use. Caution, federal (U.S.A.) law restricts this
GUIDELINE: 0.2 mg/m3 (LINCO-SPECTIN, 1983).
drug to use by or on the order of a licensed veterinarian.
3. HAZARDS IDENTIFICATION 8. EXPOSURE CONTROLS/
PERSONAL PROTECTION
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact, eye
contact, inhalation, and ingestion.
RESPIRATORY PROTECTION: Not required.
EFFECTS OF OVEREXPOSURE: Skin, eye and upper
VENTILATION: Local exhaust.
respiratory tract irritation or allergic reactions. Repeated
PROTECTIVE GLOVES: Not required.
overexposure to lincomycin hydrochloride may cause
EYE PROTECTION: Not required.
abdominal cramps, diarrhea and colitis. This may begin
OTHER PROTECTIVE EQUIPMENT: Not required.
several weeks after exposure has ceased.
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Pharmacia & Upjohn
LINCO-SPECTIN庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 40769
pressure; therefore, it is not expected to enter the air.
9. PHYSICAL AND CHEMICAL Lincomycin hydrochloride is very soluble in water (500
PROPERTIES to 1,000 mg/mL) and undergoes hydrolysis at both acid
and basic pHs at elevated temperatures. Lincomycin can
be sorbed to soil, but it is readily leached away from
APPEARANCE/PHYSICAL STATE: Liquid in 50-mL soils. Lincomycin is expected to be relatively mobile and
bottles. migrate toward the aquatic compartment.
MOLECULAR WEIGHT: Mixture. PERSISTENCE/DEGRADABILITY: Lincomycin hydro-
SOLUBILITY IN WATER: Soluble. chloride can undergo hydrolysis at both acid and basic
pHs at elevated temperatures; however, in the pH range
3 to 6 at room temperature, degradation is small. Linco-
10. STABILITY AND REACTIVITY
mycin bioactivity is readily degraded by mixtures of
urine, feces and soil. The half-life of degradation was
about 20 days.
STABILITY: Stable.
BIOACCUMULATIVE POTENTIAL: Lincomycin has
PHYSICAL CONDITIONS TO AVOID: None.
a low octanol-water partition coefficient at all pHs. The
INCOMPATIBILITY WITH OTHER MATERIALS:
octanol-water partition at pH 7 is 2.550. Calculated
None.
flowing and static bioaccumulation factors are 2.21 and
HAZARDOUS DECOMPOSITION PRODUCTS: None.
9.96, respectively. Lincomycin will be expected to
HAZARDOUS POLYMERIZATION: Does not occur.
migrate to the aqueous environment, but it should not
bioaccumulate in aquatic organisms.
11. TOXICOLOGICAL INFORMATION ABIOTIC POTENTIAL: Lincomycin will have some
initial inhibitory effects on the most sensitive micro-
organisms until it is degraded. Small amounts sent to
ACUTE STUDIES: sanitary sewage will not adversely affect the abiotic
EYE IRRITATION (RABBIT): Minimally irritating to flora of sewage treatment facilities.
the eyes. ECOTOXICITY: No adverse effect 96-hour rainbow trout
SENSITIZATION: Hypersensitivity reactions such as 980 mg/L; no adverse effect 96-hour bluegill 980 mg/L;
angioneurotic edema, serum sickness and anaphylaxis have no adverse effect 48-hour daphnia magna >900 mg/L.
been reported from exposure to lincomycin hydrochloride.
Some of these people were known to be sensitive to
13. DISPOSAL CONSIDERATIONS
penicillin. Rare instances of erythema multiforme, some
resembling Stevens-Johnson syndrome, have been
associated with lincomycin hydrochloride. WASTE DISPOSAL METHOD: Dispose of by
INTRAVENOUS LD50 (RAT): 342 mg/kg (for incineration in accordance with applicable international,
lincomycin hydrochloride) national, state, and/or local waste disposal regulations.
INTRAVENOUS LD50 (MOUSE): 1,022 mg/kg (for
spectinomycin sulfate tetrahydrate); 214 mg/kg (for
14. SHIPPING REGULATIONS
lincomycin hydrochloride)
ORAL LD50 (RAT): >5,000 mg/kg for spectinomycin
sulfate tetrahydrate); >4000 mg/kg (for lincomycin Not regulated for transportation by the United States
hydrochloride) Department of Transportation (DOT), International Maritime
INTRAPERITONEAL LD50 (MOUSE): 3,577 mg/kg Organization (IMO), or International Air Transport
(for spectinomycin sulfate tetrahydrate); 1,000 mg/kg (for Association (IATA). May be subject to state and/or local
lincomycin hydrochloride) transportation requirements.
SUBCUTANEOUS LD50 (RAT): 9,778 mg/kg (for
lincomycin hydrochloride)
15. OTHER INFORMATION
OTHER STUDIES:
GENOTOXICITY: Negative.
TERATOGENICITY: No teratogenic effects seen in rats PREPARED BY: Environment & Safety
or dogs. DISCLAIMER: The MSDS information is believed to be
CARCINOGENICITY: Ingredient(s) are not listed as correct but should only be used as a guide. Pharmacia &
carcinogenic by IARC, NTP or OSHA Upjohn disclaims any express or implied warranty as to
the accuracy of the MSDS information and shall not be
held liable for any direct, incidental or consequential
12. ECOLOGICAL INFORMATION
damages resulting from reliance on the information.
ENVIRONMENTAL FATE:
MOBILITY: Lincomycin hydrochloride melts with
decomposition at 148潞C. It has no measurable vapor
2
Pharmacia & Upjohn
LINCO-SPECTIN庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 40769
16. LABELING
This drug is subject to FDA labeling requirements; there-
fore, it is exempt from the labeling requirements of the
OSHA Hazard Communication Standard.
NDC 0009-0618-01
June 23, 1997
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