Pharmacia & Upjohn
NEO-PREDEF庐 Sterile Ointment
MATERIAL SAFETY DATA SHEET
Agent ID# 34054
severe allergic reaction in susceptible individuals. Allergic
1. CHEMICAL PRODUCT AND response may include skin rash, fever, bronchospasm,
COMPANY IDENTIFICATION angioderma (swelling of lips, tongue, and face accom-
panied by asthmatic breathing and hives) and anaphy-
laxis. Overexposure to isoflupredone acetate may cause
COMMON NAME: NEO-PREDEF庐 Sterile Ointment
suppression of adrenal gland secretion; Cushing鈥檚
SYNONYMS: 424990 鈥? EDP Number; 424995 鈥? EDP
syndrome; water retention; electrolyte imbalance;
Number
hyperglycemia.
MOLECULAR FORMULA: Mixture
MEDICAL CONDITIONS AGGRAVATED BY
USE: Veterinary product for the treatment or adjunctive
EXPOSURE: Hypersensitivity and systemic fungal
therapy of certain eye, ear and skin conditions in horses,
infections.
cattle, dogs and cats caused by or associated with
neomycin-susceptible organisms and/or allergy. In
addition, it is indicated as superficial dressing applied to 4. FIRST AID MEASURES
minor cuts, wounds, lacerations, and for post-surgical
application where reduction of pain and inflammatory
EYES: Rinse immediately with plenty of water, also under
response is deemed desirable. Not for human use.
the eyelids, for at least 15 minutes.
MANUFACTURER/SUPPLIER:
SKIN: Wash off with soap and water. Take off all
PHARMACIA & UPJOHN CO., A SUBSIDIARY OF
contaminated clothing immediately.
PHARMACIA CORP.
INHALATION: Move to fresh air.
7171 PORTAGE RD
INGESTION: Contact a physician or poison control center.
KALAMAZOO, MI 49001-0199
TELEPHONE NUMBERS:
(616) 833-5122 - (24 Hours)
5. FIRE FIGHTING MEASURES
(616) 833-7555 - (8:00 AM - 4:30 PM, EST)
FLASH POINT: Nonflammable.
2. COMPOSITION/INFORMATION
LOWER EXPLOSION LIMIT (LEL): Not applicable.
ON INGREDIENTS
UPPER EXPLOSION LIMIT (UEL): Not applicable.
AUTOIGNITION TEMPERATURE: Not applicable.
EXTINGUISHING MEDIA: Water, carbon dioxide or dry
INGREDIENT 1
chemical.
COMMON NAME: Non-hazardous ingredient(s)
FIRE FIGHTING PROCEDURES: Wear self-contained
% BY WEIGHT: >99% (Includes mineral oil USP,
breathing apparatus and full-body protective equipment.
lanolin USP, and white petrolatum USP)
UNUSUAL FIRE OR EXPLOSION HAZARDS: None
EXPOSURE LIMIT(S): Not established.
known.
HAZARDOUS COMBUSTION PRODUCTS: Carbon
INGREDIENT 2
monoxide. Carbon dioxide. Nitrogen oxides. Sulfur oxides.
COMMON NAME: Neomycin Sulfate
% BY WEIGHT: 0.5 % (5 mg; equivalent to 3.5 mg
neomycin). 6. ACCIDENTAL RELEASE MEASURES
CAS NUMBER: 1405-10-3
EXPOSURE LIMIT(S): PHARMACIA & UPJOHN
EXPOSURE LIMIT-TWA: 2 mg/m3 STEPS TO BE TAKEN IN CASE MATERIAL IS
RELEASED OR SPILLED: Provide ventilation and
INGREDIENT 3 respiratory, skin and eye protection to prevent
COMMON NAME: Isoflupredone Acetate overexposure. Keep out of drains; prevent entry to surface
% BY WEIGHT: 0.1 % water, groundwater and soil. Vacuum or scoop spilled
CAS NUMBER: 338-98-7 material and place in container.
EXPOSURE LIMIT(S): Not established.
7. HANDLING AND STORAGE
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not
established.
PRECAUTIONS FOR HANDLING AND STORING:
3. HAZARDS IDENTIFICATION Avoid contact with skin, eyes and clothing. Wash
thoroughly after handling. Launder contaminated clothing
before reuse. Store in a cool, dry place and protect from
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact, eye
light. Keep out of the reach of children.
contact, ingestion, and inhalation.
EFFECTS OF OVEREXPOSURE: Inhalation or skin
exposure to neomycin sulfate may cause very mild to
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Pharmacia & Upjohn
NEO-PREDEF庐 Sterile Ointment
MATERIAL SAFETY DATA SHEET
Agent ID# 34054
8. EXPOSURE CONTROLS/ 13. DISPOSAL CONSIDERATIONS
PERSONAL PROTECTION
WASTE DISPOSAL METHOD: Dispose of by
incineration in accordance with applicable international,
RESPIRATORY PROTECTION: Not required.
national, state and/or local waste disposal regulations.
VENTILATION: Local exhaust.
PROTECTIVE GLOVES: Not required.
EYE PROTECTION: Not required.
14. SHIPPING REGULATIONS
OTHER PROTECTIVE EQUIPMENT: Not required.
Not regulated for transportation by the United States
9. PHYSICAL AND CHEMICAL Department of Transportation (DOT), International Mari-
PROPERTIES time Organization (IMO), or International Air Transport
Association (IATA). May be subject to state and/or local
transportation requirements.
APPEARANCE/PHYSICAL STATE: Ointment.
MOLECULAR WEIGHT: Mixture.
15. OTHER INFORMATION
10. STABILITY AND REACTIVITY
REVIEWED BY: Environment & Safety
DISCLAIMER: The information contained in the MSDS is
STABILITY: Stable at normal conditions.
believed to be correct as of its date of issuance. BY
PHYSICAL CONDITIONS TO AVOID: None.
MAKING THE MSDS AVAILABLE, PHARMACIA &
INCOMPATIBILITY WITH OTHER MATERIALS:
UPJOHN CO. DOES NOT MAKE ANY EXPRESS OR
None.
IMPLIED WARRANTY (INCLUDING ANY
HAZARDOUS DECOMPOSITION PRODUCTS: None.
WARRANTY OF MERCHANTABILITY OR FITNESS
HAZARDOUS POLYMERIZATION: Does not occur.
FOR A PARTICULAR PURPOSE) REGARDING THE
MSDS, ITS ACCURACY OR THE PRODUCT TO
WHICH IT RELATES. Anyone using this information
11. TOXICOLOGICAL INFORMATION
agrees that Pharmacia & Upjohn shall not be held liable
(based on its negligence or otherwise) for any personal
ACUTE STUDIES: injury or other damage relating to, or arising from such
SENSITIZATION: Hypersensitivity reactions (primarily use, including direct, incidental, or consequential damage
skin rashes) have occurred in persons treated with and such user agrees to indemnify Pharmacia & Upjohn
neomycin sulfate. for any claims arising out of its use.
ORAL LD50 (RAT): >4,325 mg/kg (neomycin sulfate).
SUBCHRONIC/CHRONIC STUDIES:
16. LABELING
ORAL (NOEL) (RAT): 25 mg/kg/day (lifetime feeding
study) (for neomycin sulfate).
OTHER STUDIES:
This drug is subject to FDA labeling requirements; therefore,
CARCINOGENICITY: Ingredient(s) are not listed as
it is exempt from the labeling requirements of the OSHA
carcinogenic by IARC, NTP or OSHA.
Hazard Communication Standard.
12. ECOLOGICAL INFORMATION NDC 0009-0582-01
NDC 0009-0582-02
NDC 0009-0582-05
ECOTOXICITY: Muscular injection (fish Chinook
salmon): 11 mg/kg, 10% mortality 10 days (for neomycin
sulfate).
November 21, 1995
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