MATERIAL SAFETY DATA SHEET
SECTION 1 - CHEMICAL PRODUCT & COMPANY IDENTIFICATION
1-800-228-5635
Pfizer Inc Emergency telephone
Animal Health Group 24 Hours
Hours of operation
812 Springdale Drive
1-800-877-6250
Telephone
Exton, PA 19341
Product name Medetomidine hydrochloride sterile injectable solution
DOMITOR庐 sterile injectable solution; Medetomidine hydrochloride sterile
Synonyms
injectable solution
Imidazole
Chemical family
Sedative/analgesic; alpha-2-adrenergic agonist agent
Therapeutic use
Clear aqueous solution.
Description
SECTION 2 - COMPOSITION/INFORMATION ON INGREDIENTS
Hazardous Ingredient CAS Number Amount
Propylparaben 94-13-3 Trade Secret
Methylparaben 99-76-3 Trade Secret
Medetomidine hydrochloride 86347-15-1 Trade Secret
Sodium chloride 7647-14-5 Trade Secret
Water for injection, USP 7732-18-5 Trade Secret
SECTION 3 - HAZARDS IDENTIFICATION
CERCLA ratings (scale 0-3) Health=1 Fire=0 Reactivity=0
Health=1 Fire=0 Reactivity=0
NFPA ratings (scale 0-4)
Signal word CAUTION!
Statements of hazard MAY CAUSE EYE, SKIN AND RESPIRATORY TRACT
IRRITATION.
MAY CAUSE HYPERSENSITIVITY REACTIONS IN
SUSCEPTIBLE INDIVIDUALS.
MAY CAUSE CENTRAL NERVOUS SYSTEM EFFECTS.
Eye
May cause eye irritation. Signs and symptoms might include redness,
Short term effects
swelling, blurred vision or pain.
None known; see short-term effects above.
Long term effects
Skin
May cause skin irritation and allergic skin reactions following direct or
Short term effects
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SECTION 3 - HAZARDS IDENTIFICATION continued
repeated contact with this material.
None known; see short term-effects above.
Long term effects
Inhalation
May cause mucous membrane and respiratory tract irritation. May cause
Short term effects
central nervous system effects. May also cause hypersensitivity reactions
in susceptible individuals.
Not known; see short-term effects above.
Long term effects
Ingestion
Ingestion of this material may cause effects similar to those seen in animal
Short term effects
studies including effects on nervous system and respiratory system
Not known; see short-term effects above.
Long term effects
SECTION 4 - FIRST AID MEASURES
Immediately flush eyes with plenty of water for at least 15 minutes. Get
Eyes
medical attention.
Wash skin with soap and plenty of water. Remove contaminated clothing and
Skin
shoes. Wash clothing and thoroughly clean shoes before reuse. If irritation
occurs or persists, get medical attention.
Remove to fresh air. If not breathing, give artificial respiration. Get medical
Inhalation
attention.
If swallowed, get medical attention immediately. Do not induce vomiting
Ingestion
unless directed by medical personnel. Never give anything by mouth to an
unconscious person.
SECTION 5 - FIRE FIGHTING MEASURES
Toxic or corrosive emissions may be given off in a fire. See Hazardous
General hazard
combustion products, below, and Hazardous decomposition products in
Section 10 - STABILITY AND REACTIVITY.
Wear approved positive pressure, self contained breathing apparatus and full
Fire fighting instructions
protective turn out gear. Use caution in approaching fire.
Use carbon dioxide, dry chemical, or water spray.
Extinguisher to use
Emits toxic fumes of carbon monoxide, carbon dioxide, oxides of nitrogen,
Hazardous combustion
hydrogen chloride and other chlorine-containing compounds.
products
Not known
Flash point
Not known
Autoignition
Not known
Minimum explosive
concentration for
dust/vapor
Not known
Flammability limits
SECTION 6 - ACCIDENTAL RELEASE MEASURES
Contain the source of the spill or leak. Absorb spills with non-combustible
Occupational spill
absorbent material and transfer to labeled container for treatment and
disposal. Clean spill area thoroughly with detergent and water.
Review Sections 3 and 8 before proceeding with clean up. Contain the source
Clean up - large spill
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SECTION 6 - ACCIDENTAL RELEASE MEASURES continued
of the spill or leak. Dike or pump spilled material into a labeled recovery
container or absorb with non-combustible material. Put saturated absorbent
material into a labeled container. Close container and move it to a secure
holding area. Clean spill area thoroughly with detergent and water. Collect
wash water with a non-combustible absorbant material and transfer to labeled
container for treatment and disposal.
SECTION 7 - HANDLING AND STORAGE
Keep away from heat. Use with adequate ventilation. Do not get in eyes.
General handling
Avoid prolonged or repeated contact with skin and clothing. Avoid breathing
vapor or mist. When handling, use proper personal protective equipment
specified in Section 8. Wash throughly after handling.
Store out of direct sunlight in a well ventilated area at ambient temperature.
Storage
Temperature range 15 - 30 掳C
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION
Hazardous Ingredient OEL Type Value
Exposure limits
Medetomidine Pfizer TWA-8 Not established
hydrochloride
No Occupational Exposure Limit (OEL) established by Pfizer for this mixture
Exposure information
or the active ingredient it contains.
General room ventilation is adequate unless the process generates airborne
Ventilation
mist or vapor.
None required under normal and foreseeable conditions of use.
Eye protection
None required under normal and foreseeable conditions of use.
Skin protection
Rubber gloves are recommended if there is a potential for contact.
Hand protection
Under normal conditions of use, respiratory protection is not expected to be
Respiratory protection
necessary. Whenever air contamination (mist, vapor or odor) is generated,
respiratory protection is recommended as a precaution to minimize exposure.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Liquid
Physical form
Colorless.
Color
Clear
Clarity
Odorless.
Odor
Not applicable
Molecular weight
Not applicable
Molecular formula
Not known
pH
Not known
Melting point
Not known
Pour point
Not known
Vapor pressure
Soluble in water
Water solubility
No data available
Solvent solubility
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SECTION 10 - STABILITY AND REACTIVITY
Stable.
Reactivity
Avoid excessive exposure to light.
Conditions to avoid
None known.
Incompatibilities
No data available. See Section 5 - under Hazardous combustion products.
Hazardous decomposition
products
Will not occur.
Hazardous polymerization
No data available.
Oxidizing properties
None known or expected.
Explosive properties
SECTION 11 - TOXICOLOGY INFORMATION
Type Route Species Dosage
Acute toxicity
LD50 Oral Rat 31 mg/kg
No data available. See Section 3 - HAZARD IDENTIFICATION, above.
Eye
No data available. See Section 3 - HAZARD IDENTIFICATION, above.
Skin
No data available. See Section 3 - HAZARD IDENTIFICATION, above.
Inhalation
Acute oral LD50s for the active ingredient are listed above in the table. While
Ingestion
this formulation has not been tested as a whole, it would not be expected to be
toxic orally based on the amount of active ingredient in the mixture.
No data available.
Mutagenicity
No data available.
Subchronic effects
See Chronic effects/Carcinogenicity below.
Chronic toxicity
No long-term toxicity studies have been conducted to evaluate the chronic
Chronic effects/
toxicity or carcinogenic potential of this material.
Carcinogenicity
No
OSHA carcinogen
Not classified
NTP carcinogen
Not classified
IARC carcinogen
No data available.
Reproductive effects
No data available.
Teratogenicity
Individuals with cardiac conditions may be more susceptible to toxicity in
At increased risk from
cases of
exposure
overexposure.
SECTION 12 - ECOLOGICAL INFORMATION
The use and/or disposal of this material, its metabolites and degradation
Environmental overview
products is not expected to cause adverse effects upon animals, plants,
humans, other organisms, or the environment.
SECTION 13 - DISPOSAL INFORMATION
Incineration is the recommended means of disposal for this material. This
Disposal procedure
material may also be disposed in landfills. Federal, State, Local
environmental regulations and Site conditions may affect proper disposal
options.
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SECTION 14 - TRANSPORTATION INFORMATION
Medetomidine hydrochloride sterile injectable solution
Proper shipping name
Non-regulated
General shipping
instructions
SECTION 15 - REGULATORY INFORMATION
No
TSCA status
No
SARA section 302
No
SARA section 313
No
California proposition 65
SECTION 16 - OTHER
Not applicable
Summary
Disclaimer Pfizer Inc believes that the information contained in this Material Safety
Data Sheet is accurate, and while it is provided in good faith, it is
without a warranty of any kind, expressed or implied.
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