Pharmacia & Upjohn
LINCOCIN AQUADROPS 庐 Liquid
MATERIAL SAFETY DATA SHEET
Agent ID# 43529
EFFECTS OF OVEREXPOSURE: Not acutely toxic.
1. CHEMICAL PRODUCT AND Irritation to the eyes, skin and respiratory passages may
COMPANY IDENTIFICATION occur. Repeated overexposure may cause abdominal
cramps, diarrhea and colitis. This may begin several weeks
after exposure has ceased. Some hemopoietic effects have
COMMON NAME: LINCOCIN AQUADROPS庐 Liquid
been reported.
SYNONYMS: 408670 鈥? EDP Number
MEDICAL CONDITIONS AGGRAVATED BY
MOLECULAR FORMULA: Mixture
EXPOSURE: Hypersensitivity to lincomycin,
USE: Veterinary product for the treatment of gram-positive
clindamycin or related antibiotics.
bacterial infections in cats and dogs. Not for human use.
MANUFACTURER/SUPPLIER:
4. FIRST AID MEASURES
PHARMACIA & UPJOHN CO., A SUBSIDIARY OF
PHARMACIA CORP.
7171 PORTAGE RD
EYES: Rinse immediately with plenty of water, also under
KALAMAZOO, MI 49001-0199
the eyelids, for at least 15 minutes.
TELEPHONE NUMBERS:
SKIN: Wash with soap and water. Remove contaminated
(616) 833-5122 - (24 Hours)
clothing.
(616) 833-7555 - (8:00 AM - 4:30 PM, EST)
INHALATION: Move to fresh air.
INGESTION: Contact a physician or poison control center.
2. COMPOSITION/INFORMATION NOTES TO PHYSICIAN: Lincomycin has been shown to
ON INGREDIENTS have neuromuscular-blocking properties that may
enhance the action of other neuromuscular-blocking
agents. If an allergic reaction should occur, epinephrine,
INGREDIENT 1
corticosteroids or antihistamines should be used as
COMMON NAME: Sucrose.
indicated.
% BY WEIGHT: 65 %
CAS NUMBER: 57-50-1
5. FIRE FIGHTING MEASURES
EXPOSURE LIMIT(S):
OSHA PEL-TWA (Respirable fraction): 5 mg/m3
OSHA PEL-TWL (Total dust): 15 mg/m3
FLASH POINT: Nonflammable.
ACGIH TLV-TWA: 10 mg/m3
LOWER EXPLOSION LIMIT (LEL): Not applicable.
UPPER EXPLOSION LIMIT (UEL): Not applicable.
INGREDIENT 2
EXTINGUISHING MEDIA: Water, carbon dioxide or dry
COMMON NAME: Water.
chemical.
% BY WEIGHT: <30 %
FIRE FIGHTING PROCEDURES: Wear self-contained
CAS NUMBER: 7732-18-5
breathing apparatus and full-body protective equipment.
EXPOSURE LIMIT(S): Not established.
UNUSUAL FIRE OR EXPLOSION HAZARDS: None
known.
INGREDIENT 3
HAZARDOUS COMBUSTION PRODUCTS: Carbon
COMMON NAME: Lincomycin Hydrochloride.
monoxide. Carbon dioxide. Nitrogen oxides. Sulfur
% BY WEIGHT: 5 % (50 mg/mL)
oxides. Hydrochloric acid.
CAS NUMBER: 859-18-7
EXPOSURE LIMIT(S): PHARMACIA & UPJOHN
EXPOSURE LIMIT-TWA: 0.1 mg/m3 6. ACCIDENTAL RELEASE MEASURES
INGREDIENT 4
STEPS TO BE TAKEN IN CASE MATERIAL IS
COMMON NAME: Saccharin.
RELEASED OR SPILLED: Provide ventilation and
% BY WEIGHT: 0.385 %
respiratory, skin and eye protection to prevent overexposure.
CAS NUMBER: 81-07-2
Keep out of drains; prevent entry to surface water, ground-
EXPOSURE LIMIT(S): Not established.
water and soil. Vacuum or scoop spilled material and place
in container.
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not
established.
7. HANDLING AND STORAGE
3. HAZARDS IDENTIFICATION
PRECAUTIONS FOR HANDLING AND STORAGE:
Avoid contact with skin, eyes and clothing. Wash
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact, eye
thoroughly after handling. Launder contaminated clothing
contact, ingestion, and inhalation.
before reuse. Store at controlled room temperature,
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Pharmacia & Upjohn
LINCOCIN AQUADROPS 庐 Liquid
MATERIAL SAFETY DATA SHEET
Agent ID# 43529
15潞 to 30潞C (59潞 to 86潞F). Protect from light. Keep out of basic pHs at elevated temperatures. Lincomycin can be
reach of children. sorbed to soil, but it is readily leached away from soils.
Lincomycin is expected to be relatively mobile and
migrate toward the aquatic compartment.
8. EXPOSURE CONTROLS/
PERSISTENCE/DEGRADABILITY: Lincomycin
PERSONAL PROTECTION hydrochloride can undergo hydrolysis at both acid and
basic pHs at elevated temperatures; however, in the pH
range 3 to 6 at room temperature, degradation is small.
RESPIRATORY PROTECTION: Not required.
Lincomycin bioactivity is readily degraded by mixtures
VENTILATION: Local exhaust.
of urine, feces and soil. The half-life of degradation was
PROTECTIVE GLOVES: Not required.
about 20 days.
EYE PROTECTION: Not required.
BIOACCUMULATIVE POTENTIAL: Lincomycin has
OTHER PROTECTIVE EQUIPMENT: Not required.
a low octanol-water partition coefficient at all pHs. The
octanol-water partition at pH 7 is 2.550. Calculated flow-
9. PHYSICAL AND CHEMICAL ing and static bioaccumulation factors are 2.21 and 9.96,
PROPERTIES respectively. Lincomycin will be expected to migrate to
the aqueous environment, but it should not bioaccum-
ulate in aquatic organisms.
APPEARANCE/PHYSICAL STATE: Liquid. ABIOTIC POTENTIAL: Lincomycin will have some
MOLECULAR WEIGHT: Mixture.
initial inhibitory effects on the most sensitive micro-
SOLUBILITY IN WATER: Freely soluble.
organisms until it is degraded. Small amounts sent to
sanitary sewage will not adversely affect the abiotic
10. STABILITY AND REACTIVITY flora of sewage treatment facilities.
ECOTOXICITY: No adverse effect 96-hour rainbow trout
980 mg/L; no adverse effect 96-hour bluegill 980 mg/L; no
STABILITY: Stable. adverse effect 48-hour daphnia magna >900 mg/L.
PHYSICAL CONDITIONS TO AVOID: None.
INCOMPATIBILITY WITH OTHER MATERIALS:
13. DISPOSAL CONSIDERATIONS
None.
HAZARDOUS DECOMPOSITION PRODUCTS: None.
HAZARDOUS POLYMERIZATION: Does not occur. WASTE DISPOSAL METHOD: Dispose of by
incineration in accordance with applicable international,
national, state, and/or local waste disposal regulations.
11. TOXICOLOGICAL INFORMATION
14. SHIPPING REGULATIONS
ACUTE STUDIES:
ORAL LD50 (RAT): 15,645 mg/kg
INTRAPERITONEAL LD50 (MOUSE): 1,000 mg/kg
Not regulated for transportation by the United States
(lincomycin hydrochloride)
Department of Transportation (DOT), International Maritime
SUBCUTANEOUS LD50 (RAT): 783 mg/kg
Organization (IMO), or International Air Transport
CHRONIC STUDIES: Oral Dosages: 300 mg/kg/day to
Association (IATA). May be subject to state and/or local
rats and dogs is well tolerated for up to 2 years.
transportation requirements.
OTHER STUDIES:
TERATOGENICITY: No evidence was obtained that
15. OTHER INFORMATION
LINCOCIN, when given in sustained parenteral dosage of
50 mg/kg daily to pregnant bitches, produced a teratogenic
effect in the canine embryo.
REVIEWED BY: Environment & Safety.
CARCINOGENICITY: Saccharin is listed by IARC as a
DISCLAIMER: The information contained in the MSDS is
Group 2B carcinogen.
believed to be correct as of its date of issuance. BY
MAKING THE MSDS AVAILABLE, PHARMACIA &
12. ECOLOGICAL INFORMATION UPJOHN CO. DOES NOT MAKE ANY EXPRESS OR
IMPLIED WARRANTY (INCLUDING ANY
WARRANTY OF MERCHANTABILITY OR FITNESS
ENVIRONMENTAL FATE:
FOR A PARTICULAR PURPOSE) REGARDING THE
MOBILITY: Lincomycin hydrochloride melts with
MSDS, ITS ACCURACY OR THE PRODUCT TO
decomposition at 148潞C. It has no measurable vapor
WHICH IT RELATES. Anyone using this information
pressure; therefore, it is not expected to enter the air.
agrees that Pharmacia & Upjohn shall not be held liable
Lincomycin hydrochloride is very soluble in water (500 to
(based on its negligence or otherwise) for any personal
1,000 mg/mL) and undergoes hydrolysis at both acid and
injury or other damage relating to, or arising from such
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Pharmacia & Upjohn
LINCOCIN AQUADROPS 庐 Liquid
MATERIAL SAFETY DATA SHEET
Agent ID# 43529
use, including direct, incidental, or consequential damage
and such user agrees to indemnify Pharmacia & Upjohn
for any claims arising out of its use.This drug is subject to
16. LABELING
FDA labeling requirements; therefore, it is exempt from
the labeling requirements of the OSHA Hazard
Communication Standard.
NDC 0009-0570-01
November 21, 1995
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