Pharmacia & Upjohn
DOXIROBE鈩? Gel
MATERIAL SAFETY DATA SHEET
Agent ID# 56470
SKIN: Wash off with soap and water. Take off all
1. CHEMICAL PRODUCT AND contaminated clothing immediately.
COMPANY IDENTIFICATION INHALATION: Move to fresh air.
INGESTION: Contact a physician or poison control center.
COMMON NAME: DOXIROBE鈩?
5. FIRE FIGHTING MEASURES
SYNONYMS: DOXIROBE鈩? brand of doxycycline gel
MOLECULAR FORMULA: Mixture
USE: Veterinary product indicated for the treatment and FLASH POINT (PENSKY-MARTENS CLOSED CUP
control of periodontal disease in dogs. Not for human use. TESTER): 91潞C (196潞F) (for 1-methyl-2-pyrrolidone)
MANUFACTURER/SUPPLIER: LOWER EXPLOSION LIMIT (LEL): 1.3% (for 1-
PHARMACIA & UPJOHN CO., A SUBSIDIARY OF methyl-2-pyrrolidone)
PHARMACIA CORP. UPPER EXPLOSION LIMIT (UEL): 9.5% (for 1-methyl-
7171 PORTAGE RD 2-pyrrolidone)
KALAMAZOO, MI 49001-0199 AUTOIGNITION TEMPERATURE: 245潞C (473潞F) (for
TELEPHONE NUMBERS: 1-methyl-2-pyrrolidone)
(616) 833-5122 - (24 Hours) EXTINGUISHING MEDIA: Water, carbon dioxide or dry
(616) 833-7555 - (8:00 AM - 4:30 PM, EST) chemical.
FIRE FIGHTING PROCEDURES: Wear self-contained
2. COMPOSITION/INFORMATION breathing apparatus and full-body protective equipment.
UNUSUAL FIRE OR EXPLOSION HAZARDS: None
ON INGREDIENTS
known.
HAZARDOUS COMBUSTION PRODUCTS: Carbon
INGREDIENT 1 monoxide. Carbon dioxide. Nitrogen oxides.
COMMON NAME: 1-Methyl-2-Pyrrolidone
% BY WEIGHT: 57 %
6. ACCIDENTAL RELEASE MEASURES
CAS NUMBER: 872-50-4
EXPOSURE LIMIT(S): Not established.
STEPS TO BE TAKEN IN CASE MATERIAL IS
INGREDIENT 2
RELEASED OR SPILLED: Provide ventilation and
COMMON NAME: Poly(lactic acid-glycolic acid)
respiratory, skin and eye protection to prevent
% BY WEIGHT: 33 %
overexposure. Keep out of drains; prevent entry to surface
EXPOSURE LIMIT(S): Not established.
water, groundwater and soil. Vacuum or scoop spilled
material and place in container.
INGREDIENT 3
COMMON NAME: Doxycycline hyclate
7. HANDLING AND STORAGE
% BY WEIGHT: 10 %
EXPOSURE LIMIT(S): Not established.
PRECAUTIONS FOR HANDLING AND STORING:
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not
Avoid contact with skin, eyes and clothing. Wash
established.
thoroughly after handling. Launder contaminated clothes
before reuse. Store in a refrigerator at 2-8潞C (36-46潞F).
3. HAZARDS IDENTIFICATION Protect from light. Keep out of the reach of children.
EMERGENCY OVERVIEW: May cause eye and skin
8. EXPOSURE CONTROLS/
irritation and allergic reactions.
PERSONAL PROTECTION
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact, eye
contact, ingestion, and inhalation.
EFFECTS OF OVEREXPOSURE: May cause gastro-
RESPIRATORY PROTECTION: Not required.
intestinal irritation via oral exposure. May cause
VENTILATION: Local exhaust.
hypersensitivity to tetracyclines.
PROTECTIVE GLOVES: Rubber.
EYE PROTECTION: Not required.
4. FIRST AID MEASURES OTHER PROTECTIVE EQUIPMENT: Not required.
EYES: Rinse immediately with plenty of water, also under
the eyelids, for at least 15 minutes.
1
Pharmacia & Upjohn
DOXIROBE鈩? Gel
MATERIAL SAFETY DATA SHEET
Agent ID# 56470
IMPLIED WARRANTY (INCLUDING ANY
9. PHYSICAL AND CHEMICAL WARRANTY OF MERCHANTABILITY OR FITNESS
FOR A PARTICULAR PURPOSE) REGARDING THE
PROPERTIES
MSDS, ITS ACCURACY OR THE PRODUCT TO
WHICH IT RELATES. Anyone using this information
APPEARANCE/PHYSICAL STATE: Each unit of agrees that Pharmacia & Upjohn shall not be held liable
DOXIROBE Gel contains Syringe A (polymer delivery (based on its negligence or otherwise) for any personal
system) and Syringe B (doxycycline), which when mixed injury or other damages relating to, or arising from such
result in approximately 0.5 ml of doxycycline solution. use, including direct, incidental, or consequential damage
MOLECULAR WEIGHT: Mixture and such user agrees to indemnify Pharmacia & Upjohn
for any claims arising out of its use.
10. STABILITY AND REACTIVITY
16. LABELING
STABILITY: Stable at normal conditions.
PHYSICAL CONDITIONS TO AVOID: None. This drug is subject to FDA labeling requirements; there-
INCOMPATIBILITY WITH OTHER MATERIALS: fore, it is exempt from the labeling requirements of the
None. OSHA Hazard Communication Standard
HAZARDOUS DECOMPOSITION PRODUCTS: None.
HAZARDOUS POLYMERIZATION: Does not occur.
11. TOXICOLOGICAL INFORMATION
OTHER STUDIES: July 13, 2000
TERATOGENICITY: The use of drugs of the tetracycline
class during tooth development (last half of pregnancy,
infancy and childhood to the age of 8 years) may cause
permanent discoloration of the teeth.
CARCINOGENICITY: Ingredient(s) are not listed as
carcinogenic by IARC, NTP or OSHA.
12. DISPOSAL CONSIDERATIONS
WASTE DISPOSAL METHOD: Dispose of by
incineration in accordance with applicable international,
national, state, and/or local waste disposal regulations.
13. SHIPPING REGULATIONS
Not regulated for transportation by the United States
Department of Transportation (DOT), International
Maritime Organization (IMO), or International Air
Transport Association (IATA). May be subject to state
and/or local transportation requirements.
14. OTHER INFORMATION
REVIEWED BY: Environment & Safety
DISCLAIMER: The information contained in the MSDS is
believed to be correct as of its date of issuance. BY
MAKING THE MSDS AVAILABLE, PHARMACIA &
UPJOHN DOES NOT MAKE ANY EXPRESS OR
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