Pharmacia & Upjohn
LINCOCIN 庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 43527
1. CHEMICAL PRODUCT AND 4. FIRST AID MEASURES
COMPANY IDENTIFICATION
EYES: Flush with water for 15 minutes. Hold eyelids open
COMMON NAME: LINCOCIN庐 Sterile Solution to assure complete contact with water.
SYNONYMS: LINCOCIN庐 Sterile Solution 100 mL, SKIN: Wash with soap and water. Remove contaminated
LINCOCIN庐 Sterile Solution 20 mL clothing.
USE: Veterinary product for the treatment of staphylococcal INHALATION: Remove from exposure.
infections, infectious swine arthritis and mycoplasmal INGESTION: Contact a physician or poison control center.
pneumonia. Not for human use. NOTES TO PHYSICIAN: Lincomycin has been shown to
MANUFACTURER/SUPPLIER: have neuromuscular-blocking properties that may enhance
PHARMACIA & UPJOHN the action of other neuromuscular-blocking agents. If an
7171 PORTAGE RD allergic reaction should occur, the usual agents
KALAMAZOO, MI 49001-0199 (epinephrine, corticosteroids, antihistamines) should be
TELEPHONE NUMBERS: used as indicated.
(616) 833-5122 - (24 Hours, Emergency)
(616) 833-7555 - (8:00 AM - 4:30 PM, EST Emergency)
(800) 253-8600 - (8:00 AM - 4:30 PM, EST) 5. FIRE FIGHTING MEASURES
2. COMPOSITION/INFORMATION FLASH POINT: Nonflammable.
ON INGREDIENTS LOWER EXPLOSION LIMIT (LEL): Not applicable.
UPPER EXPLOSION LIMIT (UEL): Not applicable.
EXTINGUISHING MEDIA: Water, carbon dioxide or dry
INGREDIENT 1 chemical.
COMMON NAME: Water. FIRE FIGHTING PROCEDURES: Wear self-contained
% BY WEIGHT: 70% to 90% breathing apparatus and full-body protective equipment.
CAS NUMBER: 7732-18-5 UNUSUAL FIRE OR EXPLOSION HAZARDS: None
EXPOSURE LIMIT(S): Not established. known.
HAZARDOUS COMBUSTION PRODUCTS: Carbon
INGREDIENT 2 monoxide. Carbon dioxide. Nitrogen oxides. Sulfur oxides.
COMMON NAME: Lincomycin Hydrochloride. Hydrochloric acid.
% BY WEIGHT: 10% to 30%
CAS NUMBER: 859-18-7
EXPOSURE LIMIT(S): PHARMACIA & UPJOHN 6. ACCIDENTAL RELEASE MEASURES
EXPOSURE LIMIT-TWA: 0.1 mg/m3
EXPOSURE LIMIT(S) FOR THE MATERIAL: Not STEPS TO BE TAKEN IN CASE MATERIAL IS
established. RELEASED OR SPILLED: Provide ventilation and
respiratory, skin and eye protection to prevent over-
exposure. Keep out of drains; prevent entry to surface
3. HAZARDS IDENTIFICATION
water, groundwater and soil. Vacuum or scoop spilled
material and place in container.
PRIMARY ROUTE(S) OF EXPOSURE: Skin contact, eye
contact, inhalation, and ingestion. 7. HANDLING AND STORAGE
EFFECTS OF OVEREXPOSURE: Not acutely toxic.
Irritation to the eyes, skin and respiratory passages may
occur. Repeated overexposure may cause abdominal PRECAUTIONS FOR HANDLING AND STORAGE:
cramps, diarrhea and colitis. This may begin several weeks Avoid contact with skin, eyes and clothing. Wash
after exposure has ceased. Some hemopoietic effects have thoroughly after handling. Launder contaminated
been reported. clothing before reuse. Store in a cool dry place. Protect
MEDICAL CONDITIONS AGGRAVATED BY from light. Keep out of reach of children.
EXPOSURE: Hypersensitivity to lincomycin,
clindamycin or related antibiotics.
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Pharmacia & Upjohn
LINCOCIN 庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 43527
Lincomycin is expected to be relatively mobile and
8. EXPOSURE CONTROLS/ migrate toward the aquatic compartment.
PERSONAL PROTECTION PERSISTENCE/DEGRADABILITY: Lincomycin
hydrochloride can undergo hydrolysis at both acid and
basic pHs at elevated temperatures; however, in the pH
RESPIRATORY PROTECTION: Not required. range 3 to 6 at room temperature, degradation is small.
VENTILATION: Local exhaust. Lincomycin bioactivity is readily degraded by mixtures
PROTECTIVE GLOVES: Not required. of urine, feces and soil. The half-life of degradation was
EYE PROTECTION: Not required. about 20 days.
OTHER PROTECTIVE EQUIPMENT: Not required. BIOACCUMULATIVE POTENTIAL: Lincomycin has
a low octanol-water partition coefficient at all pHs. The
octanol-water partition at pH 7 is 2.550. Calculated
9. PHYSICAL AND CHEMICAL flowing and static bioaccumulation factors are 2.21 and
PROPERTIES 9.96, respectively. Lincomycin will be expected to migrate
to the aqueous environment, but it should not bioaccumu-
late in aquatic organisms.
APPEARANCE/PHYSICAL STATE: Liquid.
ABIOTIC POTENTIAL: Lincomycin will have some
MOLECULAR WEIGHT: Mixture.
initial inhibitory effects on the most sensitive micro-
SOLUBILITY IN WATER: Freely soluble.
organisms until it is degraded. Small amounts sent to
sanitary sewage will not adversely affect the abiotic flora
of sewage treatment facilities.
10. STABILITY AND REACTIVITY
ECOTOXICITY: No adverse effect 96-hour rainbow trout
980 mg/L; no adverse effect 96-hour bluegill 980 mg/L; no
adverse effect 48-hour daphnia magna >900 mg/L.
STABILITY: Stable.
PHYSICAL CONDITIONS TO AVOID: None.
INCOMPATIBILITY WITH OTHER MATERIALS:
13. DISPOSAL CONSIDERATIONS
None.
HAZARDOUS DECOMPOSITION PRODUCTS: None.
HAZARDOUS POLYMERIZATION: Does not occur. WASTE DISPOSAL METHOD: Dispose of by
incineration in accordance with applicable international,
national, state, and/or local waste disposal regulations.
11. TOXICOLOGICAL INFORMATION
14. SHIPPING REGULATIONS
ACUTE STUDIES:
ORAL LD50 (RAT): 15,645 mg/kg
INTRAPERITONEAL LD50 (MOUSE): 1,000 mg/kg Not regulated for transportation by the United States
(lincomycin hydrochloride) Department of Transportation (DOT), International Maritime
SUBCUTANEOUS LD50 (RAT): 783 mg/kg Organization (IMO), or International Air Transport
CHRONIC STUDIES: Oral dosages of 300 mg/kg/day to Association (IATA). May be subject to state and/or local
rats and dogs is well tolerated up to 2 years. transportation requirements.
OTHER STUDIES:
TERATOGENICITY: No evidence was obtained that 15. OTHER INFORMATION
lincomycin hydrochloride, when given in sustained
parenteral dosage of 50 mg/kg daily to pregnant bitches,
produced a teratogenic effect in the canine embryo. PREPARED BY: Environment & Safety.
CARCINOGENICITY: Ingredient(s) are not listed as DISCLAIMER: The information contained in the MSDS
carcinogenic by IARC, NTP or OSHA. is believed to be correct as of its date of issuance. BY
MAKING THE MSDS AVAILABLE, PHARMACIA &
UPJOHN DOES NOT MAKE ANY EXPRESS OR
12. ECOLOGICAL INFORMATION
IMPLIED WARRANTY (INCLUDING ANY
WARRANTY OF MERCHANTABILITY OR FITNESS
FOR A PARTICULAR PURPOSE) REGARDING THE
ENVIRONMENTAL FATE:
MSDS, ITS ACCURACY OR THE PRODUCT TO
MOBILITY: Lincomycin hydrochloride melts with
WHICH IT RELATES. Anyone using this information
decomposition at 148潞C. It has no measurable vapor
agrees that Pharmacia & Upjohn shall not be held liable
pressure; therefore, it is not expected to enter the air.
(based on its negligence or otherwise) for any personal
Lincomycin hydrochloride is very soluble in water (500 to
injury or other damages relating to, or arising from such
1,000 mg/mL) and undergoes hydrolysis at both acid and
use, including direct, incidental, or consequential damage
basic pHs at elevated temperatures. Lincomycin can be
sorbed to soil, but it is readily leached away from soils.
2
Pharmacia & Upjohn
LINCOCIN 庐 Sterile Solution
MATERIAL SAFETY DATA SHEET
Agent ID# 43527
and such user agrees to indemnify Pharmacia & Upjohn
for any claims arising out of its use.
16. LABELING
This drug is subject to FDA labeling requirements; there-
fore, it is exempt from the labeling requirements of the
OSHA Hazard Communication Standard.
NDC 0009-0617-01
NDC 0009-0617-09
August 14, 2000
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