**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 101-77-9 |4,4'-Methylenedianiline | > 97 | 202-974-4 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T N
Risk Phrases: 43 45 39/23/24/25 48/20/21/22 51/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
May cause sensitization by skin contact. May cause cancer. Toxic :
danger of very serious irreversible effects through inhalation, in
contact with skin and if swallowed. Harmful : danger of serious
damage to health by prolonged exposure through inhalation, in
contact with skin and if swallowed. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be fatal if absorbed through the skin.
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. May cause photosensitive
skin reactions in certain individuals. MDA produces an intense yellow
staining of skin and nails and sometimes hair.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
4,4'-Methylenedianiline can cause liver disease (toxic hepatitis).
Symptoms include loss of appetite, jaundice, dark urine, fever,
upper abdominal pain and fatigue.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May cause
effects similar to those described for ingestion.
Chronic:
Repeated exposure may cause sensitization dermatitis. Chronic
exposure may cause liver damage. Potential cancer hazard.
4,4'-Methylenedianiline can cause heart damage. One case of
transient cardiac ischemia (deficiency of blood) following exposure
to MDA dusts has been documented.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Combustible material; may
burn but does not ignite readily.
Extinguishing Media:
Water or foam may cause frothing. Use water spray, dry chemical,
carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid runoff into storm sewers and ditches which lead to
waterways. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Do not get in eyes, on skin, or on
clothing. Keep container tightly closed. Avoid breathing dust.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower. See 29CFR
1910.1050 for regulations applying to all occupational exposures to
4,4'-Methylenedianiline.
Exposure Limits
CAS# 101-77-9:
United Kingdom, WEL - TWA: 0.01 ppm TWA; 0.08 mg/m3 TWA
United Kingdom, WEL - STEL: 0.03 ppm STEL; 0.24 mg/m3 STEL
United States OSHA: ; 10 ppb TWA; 100 ppb STEL; 5 ppb Action Leve
(Cancer suspect agent, Liver toxin - see 29 CFR 1910.1050)
Belgium - TWA: 0.1 ppm VLE; 0.82 mg/m3 VLE
Germany: 0.1 mg/m3 TWA
Germany: Skin absorber
Japan: 0.4 mg/m3 OEL
Spain: 0.1 ppm VLA-ED; 0.82 mg/m3 VLA-ED
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Powder
Color: white to beige
Odor: faint odor - amine-like
pH: 9-10 (10% slurry)
Vapor Pressure: 0.1 mm Hg @ 152 deg C
Viscosity: Not available.
Boiling Point: 398-399 deg C @ 768mmHg
Freezing/Melting Point: 88-92 deg C
Autoignition Temperature: Not available.
Flash Point: 221 deg C ( 429.80 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 270 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.056 g/ml @ 100C
Molecular Formula: C13H14N2
Molecular Weight: 198.27
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, aniline.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 101-77-9: BY5425000
LD50/LC50:
CAS# 101-77-9: Draize test, rabbit, eye: 100 mg/24H Moderate; Oral,
mouse: LD50 = 264 mg/kg; Oral, rabbit: LD50 = 620 mg/kg; Oral, rat:
LD50 = 517 mg/kg; Skin, rabbit: LD50 = 200 mg/kg.
Carcinogenicity:
4,4'-Methylenedianiline -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 1/1/88
NTP: Suspect carcinogen
IARC: Group 2B carcinogen
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing Group: III
IMO
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing Group: III
RID/ADR
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing group: III
USA RQ: CAS# 101-77-9: 10 lb final RQ; 4.54 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 39/23/24/25 Toxic : danger of very serious
irreversible effects through inhalation, in contact
with skin and if swallowed.
R 43 May cause sensitization by skin contact.
R 48/20/21/22 Harmful : danger of serious damage to
health by prolonged exposure through inhalation, in
contact with skin and if swallowed.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 101-77-9: 3
Canada
CAS# 101-77-9 is listed on Canada's DSL List.
CAS# 101-77-9 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 101-77-9 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 9/02/1997 Revision #7 Date: 7/16/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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