**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 4712-38-3 |n-Butan(ol-d) | > 98 | 225-201-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN
Risk Phrases: 10 22 37/38 41 67
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Flammable. Harmful if swallowed. Irritating to respiratory system
and skin. Risk of serious damage to eyes. Vapours may cause
drowsiness and dizziness.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause corneal edema and
inflammation. May cause lacrimation (tearing), blurred vision, and
photophobia.
Skin:
Causes skin irritation. Skin absorption is slight. Repeated or
prolonged exposure may cause drying and cracking of the skin.
Ingestion:
May cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and
possible death due to respiratory failure. Aspiration of material
into the lungs may cause chemical pneumonitis, which may be fatal.
May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause cardiovascular
disturbances, hearing abnormalities, central nervous system
depression, muscle weakness, and possible death due to respiratory
failure. May be absorbed through the lungs.
Chronic:
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause damage to the auditory nerve (some hearing
loss) and vestibular injury. Animal evidence suggests that
fetotoxicity and teratogenicity may be observed at doses that also
cause harmful effects in the mothers. The systemic toxicity of
n-butanol is low, although it may potentiate the hepatic (liver)
toxicity of other inhaled compounds, such as carbon tetrachloride.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Alcoholic beverage consumption may enhance the toxic effects of this
substance. Persons with liver, kidney, or central nervous system
diseases may be at increased risk from exposure to this product.
Butanol is especially toxic if aspirated. Treat symptomatically and
supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Flammable liquid and vapor. Vapors are heavier than air and may
travel to a source of ignition and flash back. Vapors can spread
along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Provide ventilation. Use only non-sparking tools and equipment.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Avoid
contact with eyes, skin, and clothing. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Do not
ingest or inhale. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames. Use only with adequate ventilation. Keep away from heat,
sparks and flame.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a cool, dry, well-ventilated area away from
incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
CAS# 71-36-3:
United Kingdom, WEL - STEL: 50 ppm STEL; 154 mg/m3 STEL
United States OSHA: 100 ppm TWA; 300 mg/m3 TWA
Belgium - TWA: 50 ppm VLE; 154 mg/m3 VLE
France - VLE: 50 ppm VLE; 150 mg/m3 VLE
Germany: 100 ppm TWA; 310 mg/m3 TWA
Japan: 50 ppm Ceiling; 150 mg/m3 Ceiling
Malaysia: 50 ppm Ceiling; 152 mg/m3 Ceiling
Netherlands: 15 ppm STEL; 45 mg/m3 STEL
Russia: 10 mg/m3 TWA
Spain: 50 ppm VLA-EC; 154 mg/m3 VLA-EC
CAS# 4712-38-3:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless
Odor: vinous or wine-like
pH: Not available.
Vapor Pressure: 6.7 mm Hg @ 25 deg C
Viscosity: 2.94 cP at 20 deg C
Boiling Point: 118 deg C
Freezing/Melting Point: -89.5 deg C
Autoignition Temperature: 343 deg C ( 649.40 deg F)
Flash Point: 35 deg C ( 95.00 deg F)
Explosion Limits, lower: 1.4 vol %
Explosion Limits, upper: 11.2 vol %
Decomposition Temperature: Not available.
Solubility in water: Slightly soluble.
Specific Gravity/Density: 0.8200 (Water=1)
Molecular Formula: C4H9DO
Molecular Weight: 75.13
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, alkali metals, halogens.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 71-36-3: EO1400000
CAS# 4712-38-3 unlisted.
LD50/LC50:
CAS# 71-36-3: Draize test, rabbit, eye: 2 mg Severe; Draize test,
rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 405 mg/24H
Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation,
rat: LC50 = 8000 ppm/4H; Inhalation, rat: LC50 = 24000 mg/m3/4H;
Oral, mouse: LD50 = 100 mg/kg; Oral, rabbit: LD50 = 3484 mg/kg;
Oral, rabbit: LD50 = 3400 mg/kg; Oral, rat: LD50 = 790 mg/kg; Oral,
rat: LD50 = 800 mg/kg; Skin, rabbit: LD50 = 3400 mg/kg.
CAS# 4712-38-3.
Carcinogenicity:
n-Butyl alcohol -
Not listed by ACGIH, IARC, or NTP.
n-Butan(ol-d) -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 1510-1730 mg/L; 96 Hr; Static bioassay
at 24.7C (pH 7.64)Water flea Daphnia: EC50 = 1980-1983 mg/L; 48 Hr;
UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 2817-3710
mg/L; 5,30 min; Microtox testRelease of n-butanol to soil may result
in volatilization from the soil surface and biodegradation is
expected to be significant. n-Butanol should not bind strongly to
soil and so is expected to leach into groundwater. Release of
n-butanol to water is expected to result in biodegradation and in
volatilization from the water surface. Photooxidation by hydroxyl
radicals is expected to be slow.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: BUTANOLS
Hazard Class: 3
UN Number: 1120
Packing Group: III
IMO
Shipping Name: BUTANOLS
Hazard Class: 3.3
UN Number: 1120
Packing Group: III
RID/ADR
Shipping Name: BUTANOLS
Hazard Class: 3
UN Number: 1120
Packing group: III
USA RQ: CAS# 71-36-3: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 22 Harmful if swallowed.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 7/9 Keep container tightly closed and in a
well-ventilated place.
S 13 Keep away from food, drink and animal feeding
stuffs.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 71-36-3: 1
CAS# 4712-38-3: No information available.
Canada
CAS# 71-36-3 is listed on Canada's DSL List.
CAS# 71-36-3 is listed on Canada's Ingredient Disclosure List.
CAS# 4712-38-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 71-36-3 is listed on the TSCA inventory.
CAS# 4712-38-3 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 10/06/1997 Revision #5 Date: 12/03/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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