872 W. Baltimore Pike, PO Box 9, West Grove, PA 19390
800-367-5296, 610-869-4024, FAX: 610-869-0171
cuserv@jacksonimmuno.com
www.jacksonimmuno.com
www.jireurope.com
Material Safety Data Sheet
Products: All products containing thimerosal and/or sodium azide as preservatives. Products in this category include:
鈥? Alkaline phosphatase-conjugated products
鈥? Allophycocyanin ( APC ) fluorescent protein-conjugated products
鈥? Aminomethylcoumarin (AMCA) fluorescent dye-conjugated products
鈥? Antiserums
鈥? Biotin-SP-conjugated products
鈥? Colloidal Gold-antibody complexes
鈥? Cyanine (Cy鈩?2, Cy鈩?3, or Cy鈩?5) fluorescent dye-conjugated products
鈥? Dichlorotriazinylamino fluorescein (DTAF) fluorescent dye-conjugated products
鈥? Fluorescein isothiocyanate (FITC)-conjugated products
鈥? Horseradish peroxidase-conjugated products
鈥? Normal serums
鈥? Phycoerythrin (R-PE) fluorescent protein-conjugated products
鈥? Purified proteins coupled to agarose
鈥? Rhodamine isothiocyanate (TRITC) fluorescent dye-conjugated products
鈥? Rhodamine Red-X (RR-X) fluorescent dye-conjugated products
鈥? Texas Red 庐 (TR) fluorescent dye-conjugated products
Description of Contents: Components common to all of these products are buffer salts and human, animal, or plant
proteins. Some products also contain fluorescent dyes, biotin, or agarose beads. None of these components are considered
to be hazardous. The hazardous substances, thimerosal and/or sodium azide, are present in these products in very small
amounts as anti-microbial preservatives.
Concentration of Hazardous Components: 0.1 mg thimerosal/ml (0.01%) and 0.5 mg sodium azide/ml (0.05%) of
reconstituted product. According to the OSHA Hazard Communications Standard ( CFR 1910.1200), if a mixture contains
less than 1% of a hazardous chemical or 0.1% of a carcinogen, the mixture shall not be considered hazardous. However,
precautions for handling potentially dangerous reagents should be practiced when using these products. To aide in
determining handling procedures, we offer the following additional information.
Toxicity Data: LD 50 (thimerosal) = 75 mg/kg (rat-oral), LD 50 (sodium azide) = 27 mg/kg (rat-oral)
Potential Hazard: The only hazards identified with this product are those associated with thimerosal and sodium azide,
which are present at very low concentrations.
Fire Hazard: Sodium azide emits toxic fumes under fire conditions.
Explosion Hazard: Azide reacts with many heavy metals, including copper and lead, to form explosive compounds. Use
large volumes of water to flush this product through any plumbing containing these heavy metals.
Biological Hazard: The source material for products of human origin (ChromPure human serum proteins, human gamma
globulin, and normal human serum) was tested according to FDA guidelines for the detection of Hepatitis B surface antigen,
antibodies to HIV, antibodies to Hepatitis C, HIV-1 antigens, and Syphilis. Each donor blood unit was negative for each test.
However, no test method can provide total assurance that these or other infective agents are absent. Therefore all products
of human origin we supply should be handled by procedures recommended in the CDC/NIH manual: 鈥淏iosafety in
Microbiological and Biomedical Laboratories (BMBL)鈥?, U.S. Department of Health and Human Services, CDC, and NIH. The
manual is available from the U.S. Government Printing Office or online at
http://www.cdc.gov/od/ohs/biosfty/bmbl4/bmbl4toc.htm.
Protective Clothing: None
Method of Disposal : Thimerosal and sodium azide are hazardous chemicals. Disposal of even small amounts of these
chemicals may be subject to federal, state, or local laws.
Special Precautions : These products are for in vitro research use only, not for household, diagnostic, or therapeutic use.
They are not medical devices.
Health and First Aid:
Eye Contact: May cause irritation or permanent damage. Irrigate with a copious amount of water. Contact physician
immediately.
Skin Contact: May cause irritation. Wash affected areas with water or soap and water.
Inhalation: Remove to fresh air. Contact poison control center or physician immediately for first aid instructions if
necessary.
Ingestion: Contact poison control center or physician immediately for potential thimerosal (merthiolate) and sodium
azide poisoning.
Date: October 18, 2005
The above information is believed to be correct but does not purport to be all inclusive and is intended to be used only as a guide. Jackson
ImmunoResearch Laboratories, Inc. will not be held responsible for any damage from handling or from contact with the above product.
*Cy is a trademark of Amersham Biosciences Limited. Jackson ImmunoResearch is licensed by Amersham Biosciences Limited to manufacture and
sell conjugates of Cy2, Cy3, and Cy5 reactive dyes under US Patent Number 5,268,486 and other patents pending.
*Rhodamine Red-X is a trademark of Molecular Probes, Inc. Jackson ImmunoResearch is licensed by Molecular Probes, Inc. to manufacture and sell
conjugates of Rhodamine Red-X reactive dye.
*Texas Red is a trademark of Molecular Probes, Inc. and is registered with the U.S. Patent and Trademark Office.
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