EMS CATALOG NO: 19700 THROUGH 19775
EMS PRODUCT: Polyethylene Glycol
DATE: 11/17/2002
PAGE NUMBER: One of 12
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
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FOR PRODUCT AND SALES INFORMATION
_________________________________________________________________
CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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PRODUCT NAME: Carbowax Polyethylene Glycol
CHEMICAL NAME: Polyethylene Glycol
CHEMICAL FAMILY: Oxyalkylene Polymer
COMMON NAME: Carbowax Polyethylene Glycol
FORMULA: HO-(CH2CH2O)n-H
SYNONYMS: Polyoxyethylene 200
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COMPOSITION INFORMATION
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COMPONENT CAS # AMOUNT
Poly(ethylene oxide) 25322-68-3 >=95.%
Diethylene glycol 111-46-6 <= 5.%
Ethylene glycol 107-21-1 <= 1.%
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HAZARDS IDENTIFICATION
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EMERGENCY OVERVIEW
APPEARANCE:
Transparent colorless above freezing/melting point - opaque
white below freezing/melting point.
PHYSICAL STATE:
Liquid above freezing/melting point - solid below
freezing/melting point.
ODOR: Mild.
HAZARDS OF PRODUCT:
ATTENTION! USE PRODUCT PROMPTLY AFTER OPENING. AVOID
PROLONGED EXPOSURE TO HEAT AND AIR.
POTENTIAL HEALTH EFFECTS
Effects of Single Acute Overexposure
INHALATION:
Short-term harmful health effects are not expected from
vapor generated at ambient temperature.
EYE CONTACT:
No evidence of harmful effects from available information.
SKIN CONTACT:
No evidence of harmful effects from available information.
SKIN ABSORPTION:
No evidence of harmful effects from available information.
SWALLOWING:
No evidence of harmful effects from available information.
Chronic, Prolonged or Repeated Overexposure
EFFECTS OF REPEATED OVEREXPOSURE:
Although this material is not a skin irritant, submersion by
workers of unprotected skin in highly concentrated solutions
of this material for prolonged periods of time could result
in skin dehydration.
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OTHER EFFECTS OF OVEREXPOSURE:
Overexposure to vapor generated at high temperatures may
result in eye and respiratory tract irritation, dizziness,
nausea and the inhalation of harmful amounts of material.
Medial Conditions Aggravated By Exposure
A knowledge of available toxicology information and of the
physical and chemical properties of the material suggests that
overexposure is unlikely to aggravate existing medical
conditions.
POTENTIAL ENVIRONMENTAL EFFECTS
See Section labeled ECOLOGICAL INFORMATION for further
information.
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FIRST AID PROCEDURES
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INHALATION: No emergency care anticipated.
EYE CONTACT:
Flush eyes thoroughly with water for several minutes.
Remove contact lenses, if worn.
SKIN CONTACT: Wash skin with soap and water.
SWALLOWING: No emergency care anticipated.
NOTES TO PHYSICIAN:
Toxicology studies have shown this or similar material to be
of very low acute toxicity and nonirritating. There is no
specific antidote. Treatment of overexposure should be
directed at the control of symptoms and the clinical
condition of the patient.
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FIRE FIGHTING MEASURES
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FLAMMABLE PROPERTIES
FLASH POINT-CLOSED CUP:
Pensky-Martens Closed Cup ASTM D93 185oC (365oF)
FLASH POINT-OPEN CUP:
Cleveland Open Cup ASTM D 92 190oC (375oF)
AUTOIGNITION TEMPERATURE: Not currently available.
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FLAMMABLE LIMITS IN AIR:
Lower: Not determined
Upper: Not determined
EXTINGUISHING MEDIA:
Apply alcohol-type or all-purpose-type foam by
manufacturer's recommended techniques for large fires. Use
carbon dioxide or dry chemical media for small fires.
EXTINGUISHING MEDIA TO AVOID:
No information currently available.
SPECIAL FIRE FIGHTING PROCEDURES:
Do not direct a solid stream of water or foam into hot,
burning pools; this may cause frothing and increase fire
intensity.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS:
Use self-contained breathing apparatus and protective
clothing.
UNUSUAL FIRE AND EXPLOSION HAZARDS:
See section labelled EXPOSURE CONTROLS AND PERSONAL
PROTECTION for Engineering Controls.
HAZARDOUS COMBUSTION PRODUCTS:
Burning can produce the following products: Carbon monoxide
and/or carbon dioxide. Carbon monoxide is highly toxic if
inhaled; carbon dioxide in sufficient concentrations can
act as an asphyxiant.
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ACCIDENTAL RELEASE MEASURES
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STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED:
Small spills can be flushed with large amounts of water;
larger spills should be collected for disposal.
PERSONAL PRECAUTIONS:
Wear suitable protective equipment. See section labelled
EXPOSURE CONTROLS AND PERSONAL PROTECTION for more
information.
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HANDLING AND STORAGE
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GENERAL HANDLING:
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
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FOR INDUSTRY USE ONLY.
This product may contain trace amounts of ethylene oxide
(CAS No 75-21-8), a condition which creates the potential
for accumulation of ethylene oxide in the head space of
shipping and storage containers and in enclosed areas where
the product is being handled or used. Ethylene oxide is
listed by OSHA as probably carcinogenic to humans, IARC as
carcinogenic to humans, and NTP as reasonably anticipated to
be carcinogenic. OSHA considers that, at excessive levels,
ethylene oxide may present reproductive, mutagenic,
genotoxic, neurologic and sensitization hazards. If the
product is handled with adequate ventilation, the presence
of these trace amounts is not expected to result in any
short or long term hazard.
This product may not be exempt from OSHA'S ethylene oxide
standard, 29CFR1910.1047. Users should comply with all
applicable provisions. Personnel should be monitored to
determine levels of exposure to ethylene oxide. If
necessary, protective measures should be taken. The OSHA
permissible exposure limit for ethylene oxide is 1 ppm TWA8,
the action level is 0.5 ppm TWA8, the ACGIH TLV is 1 ppm
TWA8 and OSHA has established an excursion limit of 5 ppm
(15 minute average).
VENTILATION:
General (mechanical) room ventilation is expected to be
satisfactory.
STORAGE:
No information currently available.
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EXPOSURE CONTROLS AND PERSONAL PROTECTION
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EXPOSURE LIMITS
COMPONENT: EXPOSURE LIMITS: SKIN IH STATE:
Ethylene glycol 100 mg/m3 CEILING ACGIH Aerosol
125 mg/m3 CEILING OSHA
50 ppm CEILING OSHA
100 mg/m3 ceiling UCC Mist
Diethylene Glycol 50 ppm/TWA8 AIHA WEEL No Vapor and Aerosol
10 mg/m3 TWA8 AIHA No Aerosol
WEEL
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PERSONAL PROTECTION
RESPIRATORY PROTECTION: None expected to be needed.
VENTILATION:
General (mechanical) room ventilation is expected to be
satisfactory.
EYE PROTECTION: Safety glasses or monogoggles
PROTECTIVE GLOVES: PVC-Coated
OTHER PROTECTIVE EQUIPMENT: Eye bath, Safety shower.
ENGINEERING CONTROLS
PROCESS HAZARD:
Sudden release of hot organic chemical vapors or mists from
process equipment operating at elevated temperature and pressure,
or sudden ingress of air into hot equipment under a vacuum, may
result in ignitions without the presence of obvious ignition
sources. Published "autoignition" or "ignition" temperature
values cannot be treated as safe operating temperatures in
chemical processes without analysis of the actual process
conditions. Any use of this product in elevated-temperature
processes should be thoroughly evaluated to establish and
maintain safe operating conditions.
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PHYSICAL AND CHEMICAL PROPERTIES
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PHYSICAL STATE:
Liquid above freezing/melting point - solid below
freezing/melting point.
APPEARANCE:
Transparent colorless above freezing/melting point-opaque white
below freezing/melting point.
pH: Not currently available.
SOLUBILITY IN WATER (BY WEIGHT): 20oC 100%
ODOR: Mild
FLASH POINT-CLOSED CUP:
Pensky-Martens Closed Cup ASTM D 93 185oC 365oF
FLASH POINT-OPEN CUP:
Cleveland Open Cup ASTM D 92 190oC 375oF
PERCENT VOLATILES: 3.5 Wt%
MOLECULAR WEIGHT: 190-210 g/mol
BOILING POINT (760 mmHg): >200oC >392oF Decomposes
FREEZING POINT: Sets to glass -65oC -85oF
SPECIFIC GRAVITY (H20=1): 1.127 20oC/
VAPOR PRESSURE AT 20oC: <0.001 kPa <0.01 mmHg
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VAPOR DENSITY (air=1): 7
EVAPORATION RATE (BUTYL ACETATE=1): <0.01
MELTING POINT: Not applicable.
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STABILITY AND REACTIVITY
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STABILITY/INSTABILITY: Stable
INCOMPATIBLE MATERIALS:
Normally unreactive; however, avoid stron bases at high
temperatures, strong acids, strong oxidizing agents and materials
reactive with hydroxyl compounds.
THERMAL DECOMPOSITION:
Thermal decomposition may produce aldehydes. Acute overexposure
to aldehydes may result in irritation of the eyes, skin and
respiratory tract. In addition, some aldehydes are skin
sensitizers and/or probable carcinogens.
HAZARDOUS POLYMERIZATION: Will not occur.
INHIBITORS/STABILIZERS: Not applicable.
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TOXICOLOGICAL INFORMATION
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ACUTE TOXICITY
Peroral: rat LD50 33.99 (30.70-37.65) ml/kg
MAJOR SIGNS: Narcosis, tremors
GROSS PATHOLOGY: lungs, liver, kidneys, intestines discolored
Percutaneous: rabbit 24 hr occluded 20 ml/kg
KILL RATE: 1/6
MAJOR SIGNS: No information available.
INHALATION: Static generation of vapors at room temperature Exposure
Time 8 h rat
KILL RATE: 0/6
INHALATION: Mist from vapor generated at 170oC Exposure Time 4 h rat
KILL RATE: 0/6
INHALATION: Mist from vapor generated at 170oC Exposure Time 5 h rat
KILL RATE: 6/6
IRRITATION
SKIN: Rabbit 24 hr uncovered no irritation
EYE: Rabbit 0.5ml no corneal injury
SENSITIZATION (ANIMAL AND HUMAN STUDIES)
Human patch test erythema on 22% of subjects upon initial contact and
retest
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SIGNIFICANT DATA WITH POSSIBLE RELEVANCE TO HUMANS
A chronic dietary feeding study of diethylene glycol with rats
showed mild kidney injury at 1% while concentrations of 2% and 4%
caused more marked kidney injury. In addition, at 2% and 4% of
diethylene glycol in the diet, some rats developed benign
papillary tumors in the urinary bladder. These have been
attributed to the presence of urinary bladder calcium oxalate
stones. No evidence of carcinogenicity was found with a chronic
skin-painting study with diethylene glycol in mice. The absence
of a direct chemical carcinogenic effect accords with the results
in-vitro genotoxicity studies which show that it does not
produce mutagenic or clastogenic effects. A feeding study
employing up to 5.0% diethylene glycol in the diet failed to
produce any teratogentic effects. In a mouse continuous breeding
study with large doses of diethylene glycol in drinking water,
there was evidence for reproductive toxicity at 3.5% (equivalent
to 6.1 g/kg/day) as reduced numbers of litters, live pups per
litter, and live pup weight. No such effects were seen at 1.75%
(approximately 3.05 g/kg/day). The relevance of these very high
dosages to human health is uncertain. Pregnant rats receiving
undiluted diethylene glycol by gavage over the period of
organogenesis had toxic effects at 4.0 and 8.0 ml/kg/day as
mortality, decreased body weight, decreased food consumption,
increased water consumption, and increased liver and kidney
weights. Fetotoxicity was seen only at these maternally toxic
dosages. Decreased fetal body weight occurred at 8.0 ml/kg/day,
and increased skelatal variants at 4.0 and 8.0 ml/kg/day. No
embryotoxic or teratogenic effects were seen. Neither maternal
toxicity nor fetotoxicity occurred at 1.0 ml/kg/day. In a study
with mice also receiving undiluted diethylene glycol over the
period of organogenesis, maternal toxicity occurred at 2.5 and
10.0 ml/kg/day, but not at 0.5 ml/kg/day. Definitive
developmental toxicity was not seen in this species.
ADDITIONAL STUDIES:
Although this material is not a skin irritant, submersion by
workers of unprotected skin in highly concentrated solutions of
this material for prolonged periods of time could result in skin
dehydration.
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ECOLOGICAL INFORMATION
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ENVIRONMENTAL FATE
BOD (% OXYGEN CONSUMPTION)
DAY 5: 4%
DAY 10: 14%
DAY 20: 47%
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ECOTOXICITY:
ECOTOXICITY TO MICRO-ORGANISMS: IC50 >5000 mg/l
ECOTOXICITY TO AQUATIC INVERTEBRATES: Daphnia LC50 48 h> 10000 mg/l
ECOTOXICITY TO FISH: Fathead Minnow LC50 96 h>10000 mg/l
FURTHER INFORMATION
THOD (MEASURED): 1.70 mg/mg
THOD (CALCULATED): 1.67 mg/mg
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DISPOSAL CONSIDERATIONS
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WASTE DISPOSAL METHOD
Incinerate in a furnace where permitted under Federal, State, and
local regulations. Dispose in accordance with all applicable
Federal, State, Provincial, and local environmental
regulations. Empty containers should be recycled or disposed
of through an approved waste management facility.
DISPOSAL CONSIDERATIONS
At very low concentrations in water, this product is
biodegradable in a biological wastewater treatment plant.
Disposal methods identified are for the product as sold. For
proper disposal of used material, an assessment must be completed
to determine the proper and permissible waste management options
permissible under applicable rules, regulations and/or laws
governing your location.
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TRANSPORT INFORMATION
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U.S.D.O.T.
NON-BULK
PROPER SHIPPING NAME: Not regulated.
BULK
PROPER SHIPPING NAME: Not regulated.
This information is not intended to convey all specific regulatory or
operational requirements/information relating to this product. It is
the responsibility of the transporting organization to follow all
applicable laws, regulations and rules relating to the transportation
of the material.
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REGULATORY INFORMATION
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FEDERAL/NATIONAL
CERCLA (Comprehensive Environmental Response, Compensation, and
Liability Act of 1980 Section 103)
The following components of this product are specifically listed as
hazardous substances in 40 CFR 302.4 (unlisted hazardous substances
are not identified) and are present at levels which could require
reporting.
COMPONENT CAS# AMOUNT
Ethylene glycol 107-21-1 <=1.0000%
Acetaldehyde 75-07-0 <=0.0006%
Ethylene Oxide 75-21-8 <=0.0005%
1,4-Dioxane 123-91-1 <=0.0005%
Formaldehyde 50-00-0 <=0.0004%
SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT OF 1986 (SARA) TITLE III
SECTIONS 302 AND 304
The following components of this product are listed as extremely
hazardous substances in 40 CFR Part 355 and are present at levels
which could require reporting and emergency planning: None
SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT OF 1986 (SARA) TITLE III
SECTION 313
The following components of this product are listed as toxic chemicals
in 40 CFR 372.65 and are present at levels which could require
reporting and customer notification under Section 313 and 40 CFR Part
372:
COMPONENT CAS# AMOUNT
Ethylene glycol 107-21-1 <=1.0000%
SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT OF 1986 (SARA) TITLE III
SECTIONS 311 AND 312
DELAYED HAZARD: No
FIRE HAZARD: No
IMMEDIATE HEALTH HAZARD: No
REACTIVE HAZARD: No
SUDDEN RELEASE OF PRESSURE HAZARD: No
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TOXIC SUBSTANCES CONTROL ACT (TSCA)
All components of this product are on the TSCA Inventory or are exempt
from TSCA Inventory requirements.
STATE/LOCAL
PENNSYLVANIA (WORKER AND COMMUNITY RIGHT-TO-KNOW ACT)
This product is subject to the Worker and Community Right-to-Know Act.
The following components of this product are at levels which could
require identification in the MSDS:
COMPONENT CAS# AMOUNT
Diethylene Glycol 111-46-6 <=5.0000%
Ethylene Glycol 107-21-1 <=1.0000%
MASSACHUSETTS (HAZARDOUS SUBSTANCES DISCLOSURE BY EMPLOYERS)
The following components of this product appear on the Massachusetts
Substance List and are present at levels which could require
identification in the MSDS:
COMPONENT CAS# AMOUNT
Ethylene glycol 107-21-1 <=1.0000%
Acetaldehyde 75-07-0 <=0.0006%
1,4-Dioxane 123-91-1 <=0.0005%
Ethylene oxide 75-21-8 <=0.0005%
Formaldehyde 50-00-0 <=0.0004%
CALIFORNIA PROPOSITION 65 (SAFE DRINKING WATER AND TOXIC ENFORCEMENT
ACT OF 1986)
This product contains the following chemical(s) known to the State of
California to cause cancer and/or birth defects or other reproductive
harm.
COMPONENT CAS# AMOUNT
Acetaldehyde 75-07-0 <=0.0006%
1,4-Dioxane 123-91-1 <=0.0005%
Ethylene oxide 75-21-8 <=0.0005%
Formaldehyde 50-00-0 <=0.0004%
CALIFORNIA SCAQMD RULE 443.1 (SOUTH COAST AIR QUALITY MANAGEMENT
DISTRICT RULE 443.1, LABELING OF MATERIALS CONTAINING ORGANIC
SOLVENTS)
VOC: Vapor pressure <0.01 mmHg at 20oC
91 g/l
93 g/l less water and less exempted solvents
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This section provides selected regulatory information on this product
including its components. This is not intended to include all
regulations. It is the responsibility of the user to known and comply
with all applicable rules, regulations and laws relating to the
product being used.
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