Material Safety Data Sheet
Date Prepared: 09/12/2006 X-GEN Pharmaceuticals
Prepared By: M. MacDougall PO Box 445
Technical Assistance: 607-562-2700 Big Flats, NY 14814
LIOTHYRONINE SODIUM NDC# 39822-0151-1
IDENTIFICATION
Common Name: Liothyronine Sodium
Chemical Name: L-Tyrosine,O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-,monosodium salt
Synonym: T3 Liothyronine Sodium; L-triiodothyronine
Formula: C5H11I3NNaO4 CAS Number: 55-06-1
Chemical Family: Thyroxine derivative Therapeutic Category: Thyroid Hormone
INGREDIENT INFORMATION
Principle Components Percent Exposure Limits
Liothyronine Sodium 0.001 n/f
HEALTH HAZARD INFORMATION
Adverse Effects: Adverse effects may include clumsiness, coldness, constipation, dry and puffy
skin, sleepiness, weight gain, weakness, muscle aches, and listlessness. Possible allergic reaction
to material if inhaled, ingested, or in contact with skin.
Overdose Effects: Excessive doses of Liothyronine may cause hyperthyroidism. Symptoms may
include changes in appetite, changes in menstrual periods, sensitivity to heat, fast or irregular
heartbeat, headache, dizziness, hand tremors, nervousness, irritability, leg cramps, shortness of
breath, chest pain, sweating, fever, vomiting, diarrhea, increased bowel motility, trouble sleeping,
and weight loss. Effects may be delayed 4 to 12 hours. A massive overdose may cause "thyroid
storm" effects including confusion, fever, jaundice, mood swings, muscle wasting, psychosis,
extreme restlessness, marked weakness, convulsions, cardiac arrhythmias, heart failure, coma,
and death.
Acute: Possible eye, skin, gastrointestinal, and/or respiratory tract irritation.
Chronic: Possible hyper-sensitization and hyperthyroidism.
Inhalation: May cause irritation allergic reactions. Avoid inhalation. Remove to fresh air.
Eye: May cause irritation. Flush with copious quantities of water.
Skin: May cause irritation, allergic reactions. Flush with copious quantities of water.
Target Organs: heart, central nervous system
n/f = not found
LIOTHYRONINE SODIUM NDC# 39822-0151-1
HEALTH HAZARD INFORMATION CONTINUED
Ingestion: May cause gastrointestinal irritation, sensitivity to heat, fever, vomiting, diarrhea,
dizziness, weight loss, chest pain, irregular heartbeat, headache, sleep disturbances, tremors,
menstrual disorders, heart disorders.
Medical Conditions Aggravated by Exposure: Hypersensitivity to material, adrenocortical
insufficiency, cardiovascular disease, thyroid problems, and pituitary insufficiency.
Cross Sensitivity: n/f
Pregnancy Comments: Clinical experience in humans has shown that appropriate therapeutic
use of thyroid hormones does not cause adverse effects on the fetus.
FIRST AID MEASURES
Inhalation: May cause irritation. Avoid inhalation. Remove to fresh air.
Eye: May cause irritation. Flush with copious quantities of water.
Skin: May cause irritation. Avoid contact. Flush with copious quantities of water.
Ingestion: May cause irritation. Avoid ingestion. Flush out mouth with water. This material is
absorbed from the gastrointestinal tract.
General: Remove from exposure. Remove contaminated clothing. Persons developing serious
hypersensitivity (anaphylactic) reactions must receive immediate medical attention. If person is
not breathing give artificial respiration. If breathing is difficult give oxygen. Obtain medical
attention.
Note to Physicians
Overdose Treatment: Overdose treatment should be symptomatic and supportive and may
include the following;
1. Empty the stomach to reduce gastrointestinal absorption. Activated charcoal may be
useful for up to four hours following ingestion.
2. Administer cardiac glycosides if congestive heart failure develops.
3. Use appropriate measures to control fever, hypoglycemia, or fluid loss. Administer
oxygen if necessary.
4. Give beta-adrenergic blocking agents such as propranolol for treatment of increased
sympathetic activity.
5. Administer hydrocortisone intravenously to partially inhibit conversion of T4 to T3.
TOXICOLOGICAL INFORMATION
Oral Rat: LD50: n/f
Oral Mouse: LD50: n/f
Irritancy Data: n/f
Target Organs: heart, central nervous system
Listed as a Carcinogen? NTP: No IARC: No OSHA: No
2
n/f = not found
LIOTHYRONINE SODIUM NDC# 39822-0151-1
FIREFIGHTING MEASURES
Flash Point: n/f Upper Flammable Limit: n/f
Auto-Ignition Temperature: n/f Lower Flammable Limit: n/f
Extinguisher Media: Water spray, dry chemical, carbon dioxide or foam as appropriate for
surrounding fire and materials.
Fire and Explosion Hazards: Product has slight fire hazard
Firefighting Procedures: As with all fires, evacuate personnel to a safe area. Firefighters should
use self-contained breathing equipment and protective clothing.
PHYSICAL HAZARDS
Conditions to Avoid: Avoid exposure to light. Avoid Exposure to heat, flames, sparks, and other
sources of ignition. Avoid Contact with incompatible materials.
Incompatibilities: Oxidizing agents.
Decomposition Products: When heated to decomposition, material emits oxides of nitrogen,
oxides of carbon, iodine, chlorine.
Stable? Yes Hazardous Polymerization? No
HANDLING / SPILL / DISPOSAL MEASURES
Handling: As a general rule, when handling Liothyronine Sodium, avoid all contact and
inhalation of mists, and/or vapors associated with the material. Wash thoroughly after handling.
Storage: Store in tight, light-resistant container as defined in the USP. This material should be
handled and stored per label instructions to ensure product integrity. Store between 2掳 and 8掳 C
(36掳 and 46掳 F).
Spill Response: Wear approved respiratory protection, chemically compatible gloves and
protective clothing. Absorb small spills with sand or other non-combustible material. Collect
spilled material in appropriate container for disposal.
Disposal: Dispose of waste in accordance with all applicable Federal, State and local laws.
EXPOSURE CONTROLS / PERSONAL PROTECTION
Respiratory Protection: When working with small quantities in a well-ventilated area,
respiratory protection may not be required. The use of an approved dust mask is recommended.
Respirator: Under conditions characterized as frequent or heavy exposure, use of a NIOSH-
approved chemical cartridge respirator with organic vapor cartridges may be necessary. For
situations involving unknown concentrations or dangerous to life or health, any air-supplied
respirator with full face-piece should be utilized.
3
n/f = not found
LIOTHYRONINE SODIUM NDC# 39822-0151-1
EXPOSURE CONTROLS / PERSONAL PROTECTION CONTINUED
Ventilation: Provide local exhaust ventilation system. Ensure compliance with any applicable
exposure limits.
Gloves: Chemically compatible gloves.
Eye Protection: Safety gasses or safety goggles.
Protective Clothing: Protect exposed skin.
Exposure Limits: n/f
PHYSICAL AND CHEMICAL PROPERTIES
Physical State: liquid Appearance: clear
Color: colorless Odor: n/f
Melting Point: n/f Solubility in Water: soluble
Vapor Density: n/f Evaporation Rate: n/f
Boiling Point: n/f Specific Gravity: n/f
Reactivity in Water: n/f Vapor Pressure: n/f
% Volatile by Volume: n/fb
4
n/f = not found
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