MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION AND USE
PRODUCT IDENTIFICATION NUMBER (PIN):
PRODUCT IDENTIFIER
Methimazole ME183X
PRODUCT USE
MANUFACTURERS NAME: SUPPLIERS NAME:
Xenex Labs XENEX LABORATORIES INC.
STREET ADDRESS: STREET ADDRESS:
2402 CANOE AVENUE
CITY: PROVINCE: CITY: PROVINCE:
COQUITLAM B.C.
POSTAL CODE: EMERGENCY TELEPHONE NO: POSTAL CODE: EMERGENCY TELEPHONE NO:
SPE100 V3K 6C2 (CHEMTREC) 1-800-424-9300
SECTION 2 - HAZARDOUS INGREDIENTS
HAZARDOUS INGREDIENTS
% CAS NUMBER LD50 / LC50 OF INGREDIENT
/ CHEMICAL FORMULA
(SPECIFY SPECIES) (SPECIFY ROUTE AND DOSE)
Methimazole 100 60-56-0 RAT ORAL 2250 mg/kg
C4H6N2S MOUSE ORAL 860 mg/kg
SECTION 3 - PHYSICAL DATA
PHYSICAL STATE AND APPEARANCE ODOR TASTE ODOR THRESHOLD (ppm)
Solid (White to Buff Crystalline powder) Characteristic (Slight) Not Available Not Available
MELTING POINT (C) BOILING POINT (C) VAPOR PRESSURE VAPOR DENSITY VOLATILITY
147掳C (296.6掳F) Decomposition 280掳C (536掳F) Not Applicable Not Available Not Available
pH SPECIFIC GRAVITY COEFF. WATER/OIL DIST.
Not Available Not Available The product is more soluble in water; log(oil/water) = -0.3
DISPERSION PROPERTIES / SOLUBILITY
Soluble in cold water, hot water. Solubility in water: 1 g/5 ml Solubility in ether: 1 g/125 ml
Soluble in alcohol, chloroform, pyridine. Solubility in alcohol: 1 g/5 ml. Solubility in chloroform: 1 g/4.5 ml
Partially soluble in diethyl ether.
Sparingly soluble in petroleum ether.
Slightly soluble in benzene.
SECTION 4 - FIRE AND EXPLOSION DATA
NO YES
FLAMMABILITY IF YES, UNDER WHAT CONDITIONS?
May be combustible at high temperature
MEANS OF EXTINCTION
SMALL: Use DRY chemical powder.
LARGE: Use water spray, fog or foam. Do NOT use water jet.
FLASHPOINT (C) AND METHOD FLAMMABLE LIMITS (% BY VOLUME) CRITICAL TEMPERATURE
Not Available UPPER: Not Available LOWER: Not Available Not Available
AUTOIGNITION TEMPERATURE (C) HAZARDOUS COMBUSTION PRODUCTS
Not Available (CO,CO2,NO,NO2) Oxides of carbon and nitrogen. Acrid smoke and fume
SECTION 5 - REACTIVITY DATA
YES NO IF NO, UNDER WHICH CONDITIONS?
CHEMICAL STABILITY
The product is stable
INCOMPATIBILITY WITH OTHER SUBSTANCES IF SO, WHICH ONES?
NO YES
Not Available
REACTIVITY, AND UNDER WHAT CONDITIONS
Sensitive to light
HAZARDOUS DECOMPOSITION PRODUCTS
The product itself and the products of degradation are not toxic
MATERIAL SAFETY DATA SHEET
ME183X
PRODUCT IDENTIFIER
Methimazole
SECTION 6 - TOXICOLOGICAL PROPERTIES
ROUTE OF ENTRY
INGESTION
INHALATION
SKIN CONTACT SKIN ABSORPTION EYE CONTACT
EFFECTS OF ACUTE EXPOSURE TO PRODUCT
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Skin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: It may cause gastrointestinal tract irritation with nausea, vomiting, epi-gastric distress, behavior/central nervous system/peripheral nervous system
(somnolence, headache, malaise, excitement, tremor, spastic paralysis, joint pain ).
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT
CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
TERATOGENIC EFFECTS: Classified POSSIBLE for human.
The substance is toxic to thyroid.
The substance may be toxic to blood, liver.
Repeated or prolonged exposure to the substance can produce target organs damage.
Causes damage to the following organs: thyroid.
May cause damage to the following organs: blood, liver.
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
May cause cancer based on animal test data. Evidence for carcinogenicity in humans is inadequate.
Excreted in maternal milk in human. Passes through the placental barrier in human.
May cause adverse reproductive effects and birth defects (teratogenic). May induce goiter and even cretinism in the developing fetus.
May affect genetic material (mutagenic)
Ingestion: Prolonged or repeated ingestion can affect the skin (skin eruptions), blood (agranulocytosis, granulocytopenia, thrombocytopenia, aplastic anemia,
hypoprothrombinemia), endocrine system (thyroid gland, thyroid hypo function), metabolism (weight loss or decreased weight gain), liver (abnormal liver
function, hepatitis, jaundice). Agranulocytosis is potentially the most serious effects. Symptoms of agranulocytosis may include fever, sore throat. Other
symptoms of chronic exposure may include nephritis (rarely occurs), periarteritis, abnormal loss of hair, loss of taste, sialadenopathy, and lymphadenopathy.
SYNERGISTIC PRODUCTS
EXPOSURE LIMITS IRRITANCY OF PRODUCT SENSITIZATION OF PRODUCT
Not Available Yes Not Available Not Available
REPRODUCTIVE TOXICITY MUTAGENICITY
TERATOGENICITY CARCINOGENICITY
As Specified Not Available Not Available As Specified
SECTION 7 - PREVENTATIVE MEASURE
PERSONAL PROTECTIVE EQUIPMENT
GLOVES (SPECIFY) RESPIRATOR (SPECIFY) EYE (SPECIFY)
Yes ( impervious ) Approved / Certified respirator Safety goggles, face shield
FOOTWEAR (SPECIFY) CLOTHING (SPECIFY) OTHER (SPECIFY)
No Coveralls / Lab coat Eyewash equipment nearby
ENGINEERING CONTROLS (SPECIFY eg. VENTILATION, ENCLOSED PROCESS)
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user
operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
LEAK AND SPILL PROCEDURE
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface.
WASTE DISPOSAL
According to local, provincial, and federal regulations.
HANDLING PROCEDURES AND EQUIPMENT
Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient
ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and
eyes.
STORAGE REQUIREMENTS
Do not store above 40掳C (104掳F). Sensitive to light. Store in light-resistant containers. Keep container tightly closed. Keep container in a cool, dry, well-
ventilated area. Container may be hazardous when empty since they retain product residues (Dust, Solids) observe all warnings and precautions listed for the
product
SPECIAL SHIPPING INFORMATION
Not a DOT controlled material
MATERIAL SAFETY DATA SHEET
ME183X
PRODUCT IDENTIFIER
Methimazole
SECTION 8 - FIRST AID MEASURES
SPECIFIC MEASURES
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an
SKIN
emollient. Remove contaminated clothing and shoes. Cold water may be used. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of
EYES
water for at least 15 minutes. Get medical attention
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
INHALATION
oxygen. Get medical attention.
INGESTION Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as collar, tie, belt or waistband. Get
medical attention if symptoms appear.
IF IRRITATION PERSISTS AND IN ALL OTHER CASES, GET IMMEDIATE MEDICAL ATTENTION.
SECTION 9 - PREPARATION DATE OF M.S.D.S.
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packa
If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the us
responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical
data judged to be reliable, Xenex Laboratories Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
PREPARED BY (GROUP, DEPARTMENT, ETC.) PHONE NUMBER DATE:
CONTROL DEPARTMENT (604) 552 3031 June 07 2007
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