The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "MANZATE" "PRO-STICK" FUNGICIDE
M0000607 Revised 1-MAY-2008
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"MANZATE" is a registered trademark of DuPont.
"PRO-STICK", "DuPont" are trademarks of DuPont.
# Tradenames and Synonyms
Manzate 75DF Fungicide
Manzate 200DF Fungicide
Manzate Evolution
Manzate 75WG
Manzate DF
Manzate 200WG
Innova Mancozeb 750
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
MANCOZEB 8018-01-7 75
A coordination product of zinc ion and
manganese ethylenebisdithiocarbamate
INERT INGREDIENTS 25
Components (Remarks)
DISPERSIBLE GRANULES
Contains 0.75 Pounds of Mancozeb Per Pound of Product
M0000607 DuPont Page 2
Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Emergency Overview
HAZARDS TO HUMANS (AND DOMESTIC ANIMALS)
CAUTION. MAY IRRITATE EYES, NOSE, THROAT AND SKIN. MAY BE
HARMFUL IF ABSORBED THROUGH SKIN, INHALED OR SWALLOWED.
Avoid breathing dust or spray mist. Avoid contact with
skin, eyes and clothing. Keep away from fire or sparks.
Potential Health Effects
Skin contact may cause skin irritation with discomfort and rash.
Repeated exposure may cause skin sensitization with allergic
rashes. Significant skin permeation and systemic toxicity after
contact appears unlikely.
Eye contact may cause eye irritation with discomfort, tearing, or
blurring of vision.
Based on animal studies, long term exposure to high levels may
cause abnormal thyroid function.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
IF SWALLOWED: Call a poison control center or doctor
immediately for treatment advice. Have person sip a glass
of water if able to swallow. Do not induce vomiting unless
told to do so by a poison control center or doctor. Do not
give anything by mouth to an unconscious person.
IF INHALED: Move person to fresh air. If person is not
breathing, call 911 or an ambulance, then give artificial
respiration, preferably mouth-to-mouth, if possible. Call a
poison control center or doctor for further treatment
advice.
IF IN EYES: Hold eye open and rinse slowly and gently
with water for 15-20 minutes. Remove contact lenses, if
present, after the first 5 minutes, then continue rinsing
eye. Call a poison control center or doctor for treatment
advice.
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
M0000607 DuPont Page 3
Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
Rinse skin immediately with plenty of water for 15 to 20
minutes. Call a poison control center or doctor for
treatment advice.
Have the product container or label with you when calling
a poison control center or doctor, or going for treatment.
For medical emergencies involving this product, call toll
free 1-800-441-3637. See Label for Additional Precautions
and Directions for Use.
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point & Method : Not determined
Flammable Limits : 0.29 g/L (% by volume in air)
Autoignition Temperature : 205掳C (401掳F)
Hazardous Combustion Products:
Hazardous gases/vapors produced in a fire are H2S, CS2, and
oxides of sulfur, nitrogen, and carbon.
Extinguishing Media
Dry Chemical, CO2, Water Spray, Foam.
Fire Fighting Instructions
Evacuate personnel to a safe area. Keep personnel removed and
upwind of fire. Wear self-contained breathing apparatus. Wear
full protective equipment. Use water spray. Runoff from fire
control may be a pollution hazard.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Evacuate personnel, thoroughly ventilate area, use self-contained
breathing apparatus.
Spill Clean Up
Remove source of heat, sparks, flame, impact, friction, or
electricity. Dike spill. Prevent material from entering
sewers, waterways, or low areas. Shovel or sweep up. Never
return to container for reuse. Scoop into bags or boxes
with plastic or aluminum shovel.
M0000607 DuPont Page 4
Material Safety Data Sheet
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HANDLING AND STORAGE
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Handling (Personnel)
USERS SHOULD: Wash hands before eating, drinking, chewing
gum, using tobacco or using the toilet. Remove Personal
Protective Equipment (PPE) immediately after handling this
product. Wash the outside of gloves before removing. As
soon as possible, wash thoroughly and change into clean
clothing.
Handling (Physical Aspects)
Keep away from heat, sparks and flames.
Storage
Do not contaminate water, food or feed by storage or disposal.
Never allow product to become wet during storage. This may lead
to chemical changes which will reduce its effectiveness as a
fungicide and create flammable vapors.
Keep container tightly closed. Store product in original
container only. Store in a well ventilated place. Store in a
cool, dry area away from feed, seed or fertilizer.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Engineering Control Statements:
When handlers use enclosed cabs or aircraft in a manner that
meets the requirements listed in the Worker Protection
Standard (WPS) for agricultural pesticides [40 CFR 170.240
(d)(4-6)], the handler PPE requirements may be reduced or
modified as specified in the WPS.
During aerial application, Human flaggers must be in
enclosed cabs.
Personal Protective Equipment
Some materials that are chemical resistant to this
product are listed below. If you want more options,
follow the instructions for Category A on an EPA chemical-
resistance category selection chart.
Applicators and other handlers (other than mixers and
loaders) must wear:
- Coveralls over long-sleeved shirt and long pants.
- Chemical-resistant gloves such as nitrile rubber,
natural rubber, or butyl rubber.
- Shoes plus socks.
M0000607 DuPont Page 5
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Mixers and Loaders must wear:
- Coveralls over long-sleeved shirt and long pants.
- Chemical-resistant gloves such as nitrile rubber,
natural rubber, or butyl rubber.
- Shoes plus socks.
- Protective eyewear.
- Chemical-resistant apron when mixing or loading.
Discard clothing and other absorbent materials that have
been drenched or heavily contaminated with this product鈥檚
concentrate. Do not reuse them. Follow the manufacturer鈥檚
instructions for cleaning/maintaining PPE. If no such
instructions for washables, use detergent and hot water.
Keep and wash PPE separately from other laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been treated, such
as plants, soil, or water, is:
- Coveralls over long-sleeved shirt and long pants.
- Chemical-resistant gloves such as nitrile rubber,
natural rubber, or butyl rubber.
- Shoes plus socks.
Exposure Guidelines
Applicable Exposure Limits
MANCOZEB
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
WEEL (AIHA) : 1 mg/m3, 8 Hr. TWA, SEN
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Vapor Pressure : Not determined
Bulk Density (loose) : 40-45 lb/cu ft
Solubility in Water : Dispersible
Odor : Sulfurous
Color : Yellow
Physical State : Solid
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal conditions.
Conditions to Avoid
Acids and moisture (in storage).
M0000607 DuPont Page 6
Material Safety Data Sheet
(STABILITY AND REACTIVITY - Continued)
Incompatibility with Other Materials
Incompatible or can react with acids.
Decomposition
Decomposes with heat. Hazardous gases/vapors produced are
hydrogen sulfide, carbon disulfide, and oxides of carbon,
nitrogen, and sulfur. Elevated temperature or free water
promotes decomposition, which may cause spontaneous
combustion.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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Animal Data
Manzate Pro-Stick Fungicide
Oral LD50: > 5000 mg/kg in rats
Dermal LD50: > 2000 mg/kg in rabbits
4-hour Inhalation LC50: > 5.4 mg/L in rats
Manzate Pro-Stick Fungicide was a mild to moderate eye irritant.
It was classified as a non-irritant per EEC Guidance and given a
Toxicity Category III rating by EPA Guidance. Manzate Pro-Stick
Fungicide is a mild to slight skin irritant and a sensitizer in
animals.
MANCOZEB
The effects in animals from repeated high inhalation doses of
mancozeb (dust) equivalent to 150-250 times the AEL include
reduced body weight, inflammation of the lungs, and abnormal
thyroid function.
Toxic effects in animals from repeated ingestion of high doses of
Mancozeb include reduced body weight and thyroid effects. In a
different study, repeated dosing caused toxic and
neuropathological effects in male and female rats which included
compound-related mortality, decreased body weight, impaired hind
limb motor activity and histopathological evidence of nerve
damage. The no-observable-effect level was 125 ppm.
Increased incidences of thyroid tumors and ocular lesions
(retinopathy) were observed in rats administered 750 ppm
(equivalent to approximately 35 mg/kg/day) of mancozeb in their
diet for two years. Mancozeb is considered to show weak
carcinogenic activity. Tests in some animals indicate that
Mancozeb may produce embryo and fetal toxicity, but only at
maternally toxic doses. Multi-generation studies in animals
demonstrate no reproductive toxicity.
M0000607 DuPont Page 7
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
Mancozeb is in the ethylene-bis-dithiocarbamate (EBDC) class of
fungicides. EBDCs including mancozeb, which are metabolized to
ethylene thiourea (ETU), have produced thyroid tumors in animal
studies.
Mancozeb does not produce genetic damage in bacterial or most
mammalian cell culture systems. It has been reported to produce
genetic damage in some, but not all, animal tests. It has not
been tested adequately for heritable genetic damage.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
MANCOZEB
AQUATIC TOXICITY:
96 hour LC50 - Rainbow trout: 0.073 mg/L.
96 hour LC50 - Fathead minnows: 0.57 mg/L.
96 hour LC50 - Bluegill sunfish: 0.84 mg/L.
72 hour EC50 (growth inhibition) - freshwater
algae: 0.43 mg/L.
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Do not contaminate water, food or feed by disposal. Wastes
resulting from the use of this product may be disposed of on
site or at an approved waste disposal facility.
ENVIRONMENTAL HAZARDS:
This product is toxic to fish. Drift and runoff from
treated areas may be hazardous to aquatic organisms in
neighboring areas. Do not apply directly to water, to areas
where surface water is present or to intertidal areas below
the mean high water mark. Cover or incorporate spilled
treated seed. Do not contaminate water by disposing of
equipment washwaters.
Container Disposal
Completely empty bag into application equipment. Then
dispose of empty bag in a sanitary landfill, or by
incineration, or, if allowed by State and local authorities,
by burning. If burned, stay out of smoke.
M0000607 DuPont Page 8
Material Safety Data Sheet
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TRANSPORTATION INFORMATION
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Shipping Information
DOT :
Proper Shipping Name : Not Regulated by DOT unless
shipped in bulk package or by
water. See IMO/IMDG description
IMO/IMDG:
Proper Shipping Name : Environmentally Hazardous
Substances, Solid, n.o.s.,
(mancozeb 75%)
Hazard Class : 9
UN/NA Number : UN 3077
Packaging Group : III
Marine Pollutant : Yes
Reportable Quantity : Yes - add RQ if 5,000 or more
pounds mancozeb in a single
package.
IATA/ICAO : Not Regulated if less than 5,000
pounds mancozeb per package.
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REGULATORY INFORMATION
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# U.S. Federal Regulations
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : Yes
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-704
State Regulations (U.S.)
CALIFORNIA PROPOSITION 65
This product contains mancozeb and ethylene thiourea (ETU),
chemicals known to the State of California to cause cancer
in laboratory animals. ETU is also known to the State of
California to cause birth defects or other reproductive
harm in laboratory animals.
M0000607 DuPont Page 9
Material Safety Data Sheet
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OTHER INFORMATION
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NFPA, NPCA-HMIS
HAZARDS CLASSIFICATION:
(0-minimal, 1-slight, 2-moderate, 3-serious, 4-severe)
NFPA: HEALTH-1 FIRE-1 REACTIVITY-1
HMIS: HEALTH-2 FIRE-1 REACTIVITY-1
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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