The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "VELPAR" "ALFAMAX" HERBICIDE
M0000645 Revised 21-DEC-2007
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"VELPAR" is a registered trademark of DuPont.
"DuPont", "ALFAMAX" are trademarks of DuPont.
Tradenames and Synonyms
DuPont Hexazinone/Diuron
Hexazinone/Diuron
KARMEX XP
VELPAR DF
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
*DIURON 330-54-1 42.4
3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA
*HEXAZINONE 51235-04-2 35.3
[3-CYCLOHEXYL-6-(DIMETHYLAMINO)-1-METHYL-1,3,5-
TRIAZINE-2,4(1H,3H)-DIONE]
INERT INGREDIENTS 22.3
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
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Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Emergency Overview
DANGER! CAUSES EYE DAMAGE.
Corrosive, causes irreversible eye damage. May irritate
nose, throat, and skin. Avoid breathing dust or spray mist.
Harmful if swallowed. Do not get in eyes or on clothing.
Avoid contact with skin. Wash thoroughly with soap and
water after handling.
Potential Health Effects
[Based on results from laboratory tests in animals with
individual components of Velpar AlfaMax]:
Skin contact may cause skin irritation with discomfort
or rash.
Eye contact may cause eye irritation with discomfort,
tearing, or blurring of vision.
Ingestion of large amounts may cause alterations in red
blood cell counts and/or anemia, and spleen and liver
effects.
Carcinogenicity Information
The following components are listed by IARC, NTP, OSHA or ACGIH as
carcinogens.
Material IARC NTP OSHA ACGIH
DIURON A4
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FIRST AID MEASURES
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First Aid
IF IN EYES: Hold eye open and rinse slowly and gently with
water for 15-20 minutes. Remove contact lenses, if present,
after the first 5 minutes, then continue rinsing eye. Call
a poison control center or doctor for treatment advice.
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
Rinse skin immediately with plenty of water for 15-20
minutes. Call a poison control center or doctor for
treatment advice.
IF SWALLOWED: Call a poison control center or doctor
immediately for treatment advice. Have person sip a glass
of water if able to swallow. Do not induce vomiting unless
told to do so by a poison control center or doctor Do not
give anything by mouth to an unconscious person.
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Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
IF INHALED: No specific intervention is indicated as the
product is not likely to be hazardous by inhalation.
Consult a physician if necessary.
Have the product container or label with you when calling a
poison control center or doctor, or going for treatment.
You may also contact 1-800-441-3637 for medical emergencies
involving this product.
Notes to Physicians
Probable mucosal damage may contraindicate the use of
gastric lavage.
Have the product container or label with you when calling a
poison control center or doctor, or going for treatment.
You may also contact 1-800-441-3637 for medical emergencies
involving this product.
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FIRE FIGHTING MEASURES
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Flammable Properties
Hexazinone
Autoignition : >350掳C (>662掳F)
Diuron
Flammable limits in Air, % by volume
LEL : 0.096 g/L
Autoignition : 440掳C (824掳F)
Like most organic powders or crystals, under severe dusting
conditions, this material may form explosive mixtures in
air. May be ignited by heat or open flame. Hazardous
gases/vapors produced in fire are highly toxic.
Extinguishing Media
Water, Water spray, Foam, Dry Chemical, CO2.
Fire Fighting Instructions
Evacuate personnel to a safe area. Keep personnel removed and
upwind of fire. Wear self-contained breathing apparatus. Use
water spray. Cool tank/container with water spray. Runoff from
fire control may be a pollution hazard.
M0000645 DuPont Page 4
Material Safety Data Sheet
(FIRE FIGHTING MEASURES - Continued)
Wear self-contained breathing apparatus. Wear full
protective equipment Runoff from fire control may be a
pollution hazard. Use water spray. Cool tank/container
with water spray.
If area is exposed to fire and conditions permit, let fire
burn itself out. Burning chemicals may produce by-products
more toxic than the original material. If product is on
fire, wear self-contained breathing apparatus and full
protective equipment. Use water spray. Control runoff.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Emergency Response - Chemical resistant coveralls,
waterproof gloves, waterproof boots and face / eye
protection. If dusting occurs use NIOSH approved respirator
protection.
Initial Containment
Dike spill. Prevent material from entering sewers, waterways, or
low areas.
Spill Clean Up
Shovel or sweep up.
Never return to container for reuse. Scoop into bags or
boxes with plastic or aluminum shovel.
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HANDLING AND STORAGE
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Handling (Personnel)
USER SHOULD: Wash hands before eating, drinking, chewing
gum, using tobacco or using the toilet.
Handling (Physical Aspects)
Avoid dust generation.
Storage
Do not contaminate water, food or feed by storage. Store
product in original container only. Store in a cool, dry
place.
M0000645 DuPont Page 5
Material Safety Data Sheet
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation. Keep container tightly
closed.
When handlers use closed systems, enclosed cabs or aircraft
in a manner that meets the requirements listed in the Worker
Protection Standard (WPS) for agricultural pesticides
[40 CFR 170.240 (d)(4-6)], the handler PPE requirements may
be reduced or modified as specified in the WPS.
Personal Protective Equipment
Some of the materials that are chemical-resistant to this
product are listed below. If you want more options, follow
the instructions for Category A on the EPA chemical-
resistance category selection chart.
Applicators and other handlers must wear:
- Long-sleeved shirt and long pants.
- Shoes plus socks.
- Protective eyewear.
- Dust mist respirator.
- Chemical-resistant gloves made of any waterproof
material such as polyethylene or polyvinyl chloride.
Mixers and loaders must also wear:
- Apron.
Discard clothing and other absorbent materials that have
been drenched or heavily contaminated with this product鈥檚
concentrate. Do not reuse them. Follow manufacturer鈥檚
instructions for cleaning/maintaining PPE. If no such
instructions for washables, use detergent and hot water.
Keep and wash PPE separately from other laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been treated, such
as plants, soil, or water, is:
Coveralls.
Chemical-resistant gloves made of any waterproof
material.
Shoes plus socks.
Protective eyewear.
Exposure Guidelines
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Material Safety Data Sheet
Applicable Exposure Limits
DIURON
PEL (OSHA) : None Established
TLV (ACGIH) : 10 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : 1 mg/m3, 8 & 12 Hr. TWA, total dust
HEXAZINONE
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 10 mg/m3, 8 Hr. TWA
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Color : (light), Beige.
Form : Granular Solid.
Odor : (slight).
pH : 7.4
Density : 0.672 g/mL
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal temperatures and storage conditions.
Incompatibility with Other Materials
Hexazinone : Incompatible with strong acids or bases.
Diuron : None reasonably foreseeable.
Decomposition
Decomposition temperature: 180-190掳C (356-374掳F)
Hexazinone:
Decomposition will not occur.
Diuron:
Decomposition temperature: 180-190掳C (356-374掳F)
Polymerization
Polymerization will not occur.
M0000645 DuPont Page 7
Material Safety Data Sheet
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TOXICOLOGICAL INFORMATION
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Animal Data
KARMEX XP
Oral LD50: > 5,000 mg/kg in rats
Dermal LD50: > 5,000 mg/kg in rabbits
Inhalation LC50, 4 hr: > 2.02 mg/L in rats
KARMEX XP is a moderate eye irritant, and a mild skin
irritant. It is not a skin sensitizer in animals.
DIURON
Repeated ingestion of Diuron led to increased hemolysis
(destruction) of red blood cells and hemolytic anemia after
continued exposure to high doses. Secondary effects as a
result of excessive red blood cell hemolysis included
enlarged spleens, pigment deposits in the spleen, changes in
the bone marrow and kidney. Decreased body weights were
also related to repeated ingestion of high doses of Diuron.
In addition to the effects described above, long-term
effects observed in rodents after repeated ingestion of high
doses also included thickening of the urinary bladder and
kidney epithelium and liver toxicity. In chronic feeding
studies, an increase in urinary bladder and renal pelvic
tumors was observed in high-dose rats. A borderline increase
in mammary tumors was observed in high-dose female mice,
which is considered equivocal.
The weight of the evidence indicates that Diuron does not
produce genetic damage in bacterial or mammalian cell
cultures or in animals. Diuron is not considered a
developmental toxicant. There was no evidence of
developmental toxicity in rabbits. In rats, developmental
effects occurred at doses higher than those which produced
maternal toxicity. Testing in rats demonstrate no
reproductive toxicity.
VELPAR DF
Oral LD50: 1310 mg/kg in rats
Dermal LD50: > 5000 mg/kg in rabbits
Inhalation 4 hour LC50: 5.2 mg/L in rats
VELPAR DF is a moderate skin irritant, is corrosive to the
eye, but is not a skin sensitizer in animals.
HEXAZINONE
Repeated skin applications indicated no irritation or
systemic activity.
Repeated dosing by ingestion of excessive dietary levels of
Hexazinone resulted in weight loss, alterations in liver
weights, alteration in blood chemical measurements, and
alterations in enzyme activities. No evidence of
M0000645 DuPont Page 8
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
pathological organ damage was observed. Long-term dosing
produced decreased weight gain, alterations in hematology,
clinical chemistry, and blood enzyme levels, increased liver
weights in some species, and pathological liver changes.
Animal data showed that chronic, excessive dietary exposure
to Hexazinone produced a slight, equivocal increase in liver
tumors in female mice.
Animal data show developmental effects occurred only at
exposure levels producing other toxic effects in the adult
animal. Animal testing indicates Hexazinone does not have
reproductive effects. The weight of evidence from a battery
of cell culture and laboratory animal tests indicates
Hexazinone does not cause genetic toxicity.
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ECOLOGICAL INFORMATION
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# Ecotoxicological Information
AQUATIC TOXICITY:
DIURON
96-Hour LC50 - Bluegill sunfish: 25 mg/L
96-Hour LC50 - Rainbow trout: 14.7 mg/L
48-Hour EC50 - Daphnia magna: 1.4 mg/L
EC50 - Algae - 0.018 mg/L
AVIAN TOXICITY:
DIURON
LD50 - Bobwhite Quail: 1104 mg/kg
HEXAZINONE
AQUATIC TOXICITY:
96-Hour LC50 - Fathead minnows: 274 mg/L
96-Hour LC50 - Bluegill sunfish: > 370 mg/L
96-Hour LC50 - Rainbow trout: > 320 mg/L
AVIAN TOXICITY:
LD50 - Bobwhite quail: 2258 mg/kg
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Do not contaminate water, food, or feed by disposal.
Waste resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility.
ENVIRONMENTAL HAZARDS
Do not apply directly to water, or to areas where surface
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Material Safety Data Sheet
(DISPOSAL CONSIDERATIONS - Continued)
water is present or to intertidal areas below the mean high
water mark. Do not contaminate water when disposing of
equipment washwaters.
The active ingredient, hexazinone, in this product is known
to leach through soil into groundwater under certain
conditions as a result of agricultural use. Use of this
chemical in areas where soils are permeable, particularly
where the water table is shallow, may result in groundwater
contamination.
Container Disposal
For Plastic Containers: Triple rinse (or equivalent). Then
offer for recycling or reconditioning, or puncture and
dispose of in a sanitary landfill, or incineration, or, if
allowed by State and local authorities, by burning. If
burned, stay out of smoke.
For Fiber Sacks: Completely empty fiber sack by shaking and
tapping sides and bottom to loosen clinging particles.
Empty residue into manufacturing or application equipment.
Then dispose of sack in a sanitary landfill or by
incineration if allowed by State and local authorities.
For Fiber Drums with Liners: Completely empty liner by
shaking and tapping sides and bottom to loosen clinging
particles. Empty residue into application equipment. Then
dispose of liner in a sanitary landfill or by incineration
if allowed by State and local authorities. If drum is
contaminated and cannot be reused, dispose of in the same
manner.
For Paper and Plastic Bags: Completely empty bag into
application equipment. Then dispose of empty bag in a
sanitary landfill or by incineration, or, if allowed by
State and local authorities, by burning. If burned, stay
out of smoke.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT
Proper Shipping Name : Not Regulated if < 100 lbs/pkg. (See
*NOTE)
DOT/IMO
Proper Shipping Name : Not Regulated by IMO
M0000645 DuPont Page 10
Material Safety Data Sheet
(TRANSPORTATION INFORMATION - Continued)
*NOTE: If 100 lbs. Diuron or more per package:
Proper Shipping Name : Environmentally Hazardous
Substance, Solid, N.O.S. (Diuron)
Hazard Class : 9
UN/NA No. : UN 3077
Packaging Group : III
Reportable Quantity : 100 Pounds (Diuron)
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REGULATORY INFORMATION
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U.S. Federal Regulations
Superfund reportable discharge = 100 lb.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : No
Pressure : No
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-665
ADDITIONAL REGULATORY INFORMATION
SARA/CERCLA Reportable Quantity: Diuron (100 lbs.)
State Regulations (U.S.)
*** CALIFORNIA PROPOSITION 65 ***
THIS PRODUCT CONTAINS DIURON, A CHEMICAL KNOWN TO THE STATE
OF CALIFORNIA TO CAUSE CANCER IN LABORATORY ANIMALS.
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health : 2
Flammability : 1
Reactivity : 0
NPCA-HMIS Rating
Health : 2
Flammability : 1
M0000645 DuPont Page 11
Material Safety Data Sheet
(Continued)
Reactivity : 0
Personal Protection rating to be supplied by user depending
on use conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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