The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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DuPont(TM) ISCEON(R) 39TC(R)
6210FR Revised 18-JUL-2006
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
Molecular Weight : 126
Tradenames and Synonyms
R-423A
ISCEON(R)
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont Fluoroproducts
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
1,1,1,2-Tetrafluoroethane 811-97-2 52.5
1,1,1,2,3,3,3-Heptafluoropropane 431-89-0 47.5
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HAZARDS IDENTIFICATION
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Potential Health Effects
Gross overexposure by inhalation may cause central nervous
system depression with dizziness, confusion, incoordination,
drowsiness or unconsciousness; irregular heart beat with a
strange sensation in the chest, "heart thumping",
apprehension, lightheadedness, feeling of fainting,
dizziness, weakness, sometimes progressing to loss of
consciousness and death; and suffocation, if air is
displaced by vapors.
Skin contact with liquid or escaping vapor may cause
frostbite. Significant skin permeation, and systemic
6210FR DuPont Page 2
Material Safety Data Sheet
(HAZARDS IDENTIFICATION - Continued)
toxicity, after contact appears unlikely. There are no
reports of human sensitization.
"Frostbite-like" effects may occur if liquid or escaping
vapors contact the eyes.
Increased susceptibility to the effects of overexposure to
this product may be observed in persons with pre-existing
disease of the central nervous system or cardiovascular
system.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
If inhaled, immediately remove to fresh air. Keep person calm.
If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Call a physician.
SKIN CONTACT
Flush area with lukewarm water. Do not use hot water. If
frostbite has occurred, call a physician.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Call a physician.
INGESTION
Ingestion is not considered a potential route of exposure.
Notes to Physicians
Because of possible disturbances of cardiac rhythm, catecholamine
drugs, such as epinephrine, should only be used with special
caution in situations of emergency life support.
6210FR DuPont Page 3
Material Safety Data Sheet
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point赂: 赂No Flash point
Flammable Limits in Air, % by Volume:
LEL 赂:赂None per ASTM E681-98
UEL赂 :赂None per ASTM E681-98
Autoignition赂:赂Not determined
Fire and Explosion Hazards:
Cylinders may rupture under fire conditions. Decomposition
may occur.
Contact of welding or soldering torch flame with high
concentrations of refrigerant can result in visible changes
in the size and color of torch flames. This flame effect
will only occur in concentrations of product well above the
recommended exposure limit, therefore stop all work and
ventilate to disperse refrigerant vapors from the work area
before using any open flames.
This product is not flammable in air at temperatures up to
100 deg. C (212 deg. F) at atmospheric pressure. However,
mixtures of this product with high concentrations of air at
elevated pressure and/or temperature can become combustible
in the presence of an ignition source. This product can
also become combustible in an oxygen enriched environment
(oxygen concentrations greater than that in air). Whether a
mixture containing this product and air, or this product in
an oxygen enriched atmosphere becomes combustible depends on
the inter-relationship of 1) the temperature 2) the
pressure, and 3) the proportion of oxygen in the mixture. In
general, this product should not be allowed to exist with
air above atmospheric pressure or at high temperatures, or
in an oxygen-enriched environment. For example: This
product should NOT be mixed with air under pressure for leak
testing or other purposes.
Experimental data have also been reported which indicate
combustibility of HFC-134a, a component in this blend, in
the presence of chlorine.
Extinguishing Media
Use media appropriate for surrounding material.
Fire Fighting Instructions
Cool cylinders with water spray or fog. Self-contained
breathing apparatus (SCBA) is required if cylinders rupture
and contents are released under fire conditions. Water
runoff should be contained and neutralized prior to release.
6210FR DuPont Page 4
Material Safety Data Sheet
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Initial Containment
Prevent material from entering sewers, waterways, or low areas.
Spill Clean Up
Recover free liquid for reuse or reclamation.
Accidental Release Measures
Ventilate area using forced ventilation, especially in low
or enclosed places where heavy vapors might collect. Remove
open flames. Use self-contained breathing apparatus (SCBA)
for large spills or releases.
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HANDLING AND STORAGE
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Handling (Personnel)
Avoid breathing vapor. Avoid liquid contact with eyes and
skin. Use with sufficient ventilation to keep employee
exposure below recommended limits. Contact with chlorine or
other strong oxidizing agents should also be avoided. See
Fire and Explosion Data section.
Handling (Physical Aspects)
Keep container tightly closed.
Storage
Store in a cool, dry place.
Store below 52 C (125 F).
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Avoid breathing vapors. Avoid contact with skin or eyes.
Use with sufficient ventilation to keep employee exposure
below the recommended exposure limit. Local exhaust should
be used if large amounts are released. Mechanical
ventilation should be used in low or enclosed places.
6210FR DuPont Page 5
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Refrigerant concentration monitors may be necessary to
determine vapor concentrations in work areas prior to use of
torches or other open flames, or if employees are entering
enclosed areas.
Personal Protective Equipment
Impervious gloves should be used to avoid prolonged or
repeated exposure. Chemical splash goggles should be
available for use as needed to prevent eye contact. Under
normal manufacturing conditions, no respiratory protection
is required when using this product. Self-contained
breathing apparatus (SCBA) is required if a large release
occurs.
Exposure Guidelines
Applicable Exposure Limits
1,1,1,2-Tetrafluoroethane
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 1000 ppm, 8 & 12 Hr. TWA
WEEL (AIHA) : 1000 ppm, 8 Hr. TWA
1,1,1,2,3,3,3-Heptafluoropropane
AEL * (DuPont) : 1000 ppm, 8 & 12 Hr. TWA
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Boiling Point: -11 F (-24 C) @ atmospheric pressure
Vapor Pressure: 88 psia @ 77 F (25 C)
Vapor Density: 4.5 (Air = 1) @ 77 F (25 C)
% Volatile: 100%
Solubility in Water: <0.5 wt% @ 77 F (25 C)
pH: Neutral
Odor: Slight Ether-like
Form: Liquified Gas
Color: Colorless
Specific Gravity: 1.28 @ 77 F (25 C)
Density: Liquid = 79.7 lb/cu ft @ 77 F (25 C)
6210FR DuPont Page 6
Material Safety Data Sheet
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STABILITY AND REACTIVITY
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Chemical Stability
Stable.
Incompatibility with Other Materials
Incompatible with alkali or alkaline earth metals - powdered
Al, Zn, Be, etc.
Decomposition
Decomposition products are hazardous. This material can be
decomposed by high temperatures (open flames, glowing metal
surfaces, etc.) forming hydrofluoric acid and possibly
carbonyl fluoride.
These materials are toxic and irritating. Contact should be
avoided.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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Animal Data
1,1,1,2-Tetrafluoroethane (HFC-134a):
Inhalation 4 hour ALC: 567,000 ppm in rats
A short duration spray of HFC-134a vapor produced very
slight eye irritation. Animal testing indicates HFC-134a is
a slight skin irritant, but not a skin sensitizer.
Single inhalation exposures caused lethargy, narcosis,
increased respiratory difficulties, incoordination, tremors,
lack of response to sound and salivation; following the
cessation of treatment most animals returned to normal.
Death occurred at very high concentrations (> 500,000 ppm)
in some animals. Single exposure to near lethal doses
caused pulmonary edema. Repeated exposure caused increased
weight of the adrenals, liver and spleen, and decreased
uterine and prostate weight. Repeated dosing of higher
concentrations caused temporary tremors and incoordination.
In other repeated exposure studies with rats exposed to
concentrations of 49,500 ppm, and mice exposed up to 300,000
ppm, no significant differences were seen between exposed
and control animals; in a different study mice exposed to
concentrations up to 350,000 ppm there were mortalities,
tremors and incoordination in the 350,000 ppm group. Head
shaking and salivation occurred in dogs exposed to 150,000
6210FR DuPont Page 7
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
ppm for 7 days; other parameters such as hematology,
clinical chemical, body weight, and food consumption were
unaffected. Testicular hormonal levels were affected in
male rats and pituitary hormone changes occurred in female
rats in a 2-week inhalation study but there were no other
treatment-related changes. In a long-term inhalation study
in rats and mice no treatment-related effects were seen. No
signs of neurological disturbances were seen in an
inhalation study to access neurotoxicity in rats.
Cardiac sensitization, a potentially fatal disturbance of
heart rhythm associated with a heightened sensitivity to the
action of epinephrine, occurred in dogs at concentrations of
75,000 ppm and higher.
In a two-year inhalation study, HFC-134a, at a concentration
of 50,000 ppm, produced an increase in late-occurring benign
testicular tumors, testicular hyperplasia and testicular
weight. The no-effect-level for this study was 10,000 ppm.
Animal data show slight fetotoxicity but only at exposure
levels producing other toxic effects in the adult animal.
Reproductive data on male mice and male or female rats show
no change in reproductive performance. Tests have shown
that HFC-134a does not cause genetic damage in bacterial or
mammalian cell cultures, or in animals. In animal testing
testing, HFC-134a has not caused permanent genetic damage in
reproductive cells of mammals (has not produced heritable
genetic damage).
1,1,1,2,3,3,3-Heptafluoropropane (HFC-227ea):
Inhalation 4 hour LC50: > 788,698 ppm in rats
Repeated exposure of rats by inhalation for 4 weeks at
concentrations up to 50,000 ppm revealed no toxicologically
significants effects. The NOEL for this study was 50,000
ppm. A 90-day inhalation study in rats did not find any
exposure related effects at 105,000 ppm. The NOEL for this
study was 105,000 ppm.
Cardiac sensitization, a potentially fatal disturbance of
heart rhythm associated with a heightened sensitivity to the
action of epinephrine, occurred in dogs at 105,000 ppm. The
NOAEL for cardiac sensitization was 90,000 ppm. In a
different study to evaluate cardiac sensitization in dogs,
concentrations of 90,000, 105,000, and 14,000 ppm caused a
dose-related increase in incidence and severity; at 90,000
ppm efffects were minimal or mild in nature.
Inhalation studies of HFC-227ea in rabbits and rats do not
suggest developmental toxicity at concentrations up to
105,000 ppm. Tests have shown that HFC-227ea does not cause
genetic damage in bacterial or mammalian cell cultures.
Tests in animals for carcinogenicity or reproductive
6210FR DuPont Page 8
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
toxicity have not been conducted.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity:
1,1,1,2-Tetrafluoroethane:
48 hour LC50 - daphnia magna: 980 mg/L
96 hour LC50 - rainbow trout: 450 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be in
accordance with applicable Federal, State/Provincial, and Local
regulations.
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TRANSPORTATION INFORMATION
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# Shipping Information
DOT/IMO
Proper Shipping Name : Refrigerant Gas, N.O.S.
(Tetrafluoroethane, Heptafluoropropane)
Hazard Class : 2.2
UN No. : 1078
Reportable quantity : No
Marine Pollutant : No
DOT/IMO Label : Nonflammable Gas
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REGULATORY INFORMATION
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U.S. Federal Regulations
TSCA Inventory Status : Listed.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : No
Pressure : Yes
6210FR DuPont Page 9
Material Safety Data Sheet
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NPCA-HMIS Rating
Health :1
Flammability :0
Reactivity :1
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : MSDS Coordinator
> : DuPont Fluoroproducts
Address : Wilmington, DE 19898
Telephone : (800) 441-7515
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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