The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "Envive" Herbicide
M0000691 Revised 21-DEC-2007
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"DuPont", "Envive" are trademarks of DuPont.
Tradenames and Synonyms
DPX-QER54
B12500618
Envive
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
FLUMIOXAZIN 103361-09-7 29.2
2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-
2H-1,4-benzoxazin-6-yl]-4,5,6,7- tetrahydro-1H-
isoindole-1,3(2H)-dione
*CHLORIMURON ETHYL 90982-32-4 9.2
Ethyl 2-[[[[(4-Chloro-6-methoxypyrimidin-2-YL)
amino]carbonyl]amino]sulfonyl]-benzoate
THIFENSULFURON METHYL 79277-27-3 2.9
Methyl 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-
2-yl)amino]carbonyl]amino] sulfonyl]-2-
thiophenecarboxylate
INERT INGREDIENTS (including percentages of the 58.7
following)
KAOLIN CLAY 1332-58-7
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
M0000691 DuPont Page 2
Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Emergency Overview
CAUTION! Harmful if swallowed, absorbed through skin,
or inhaled. Causes moderate eye irritation. Avoid contact
with skin, eyes or clothing. Avoid breathing dust or spray
mist. Wash thoroughly with soap and water after handling
and before eating, drinking, chewing gum, or using tobacco.
Remove and wash contaminated clothing before reuse.
# Potential Health Effects
Based on data from components, eye contact may cause minor
irritation including redness and possible swelling.
Based on data from components, skin contact may cause minor
iritation including redness and possibly some minor swelling.
Slightly toxic when absorbed through the skin, but is not expected
to cause allergic skin reactions.
Based on data from components, inhalation may cause irritation of
the upper respiratory passages, with coughing and discomfort.
Exposure to higher concentrations of Flumioxazin dust may result
in in respiratory irritation. Signs and symptoms may include, but
not limited to, nasal discharge, sore throat, coughing and
difficulty in breathing.
Based on data from components, may be minimally toxic when
ingested. Repeated or excessive overexposure to Chlorimuron Ethyl
or Flumioxazin by ingestion may cause abnormal liver function with
altered enzyne levels in blood, or alterations in blood cell
counts and/or anemia.
Exposure to very high concentrations of Flumioxazin Technical in
the air resulted in breathing difficulties, decreased activity and
some changes in the tissue of the respiratory system.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
Rinse skin immediately with plenty of water for 15-20
minutes. Call a poison control center or doctor for
treatment advice.
M0000691 DuPont Page 3
Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
IF IN EYES: Hold open eye and rinse slowly and gently
with water for 15-20 minutes. Remove contact lenses,
if present, after the first 5 minutes, then continue
rinsing eye. Call a poison control center doctor for
treatment advice.
IF INHALED: Move person to fresh air. If person is not
breathing, call 911 or an ambulance, then give artificial
respiration, preferably by mouth-to-mouth, if possible.
Call a poison control center or doctor for further treatment
advice.
IF SWALLOWED: Call a poison control center or doctor
immediately for treatment advice. Have person sip a glass
of water if able to swallow. Do not induce vomiting unless
told to do so by a poison control center or doctor. Do not
give anything by mouth to an unconscious person.
Have the product container or label with you when calling
a poison control center or doctor, or going for treatment.
For medical emergencies involving this product, call toll-
free 1-800-441-3637.
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FIRE FIGHTING MEASURES
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Flammable Properties
Not a fire or explosion hazard.
Extinguishing Media
Water Fog, CO2, Foam, Dry Chemical.
Fire Fighting Instructions
Wear self-contained breathing apparatus. Wear full protective
equipment. Runoff from fire control may be a pollution hazard.
If area is heavily exposed to fire and if conditions permit,
let fire burn itself out since water may increase the area
contaminated. Decontaminate personal protective equipment
and fire fighting equipment before reuse.
HAZARDOUS COMBUSTION PRODUCTS:
Normal combustion forms carbon dioxide, water vapor and may
produce: Oxides of nitrogen. Combustion may produce toxic:
Nitrogen compounds, fluorine compounds. Incomplete
combustion can produce carbon monoxide.
M0000691 DuPont Page 4
Material Safety Data Sheet
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Avoid dust generation.
Initial Containment
Dike spill. Prevent material from entering sewers, waterways, or
low areas. Follow applicable Federal, State/Provincial and Local
laws/ regulations. Prevent groundwater contamination.
Spill Clean Up
Shovel or sweep up. Dispose of in an approved container.
LAND: Clean up spill immediately. Vacuum or sweep up
material and place in a chemical waste container. Wash area
with soap and water. Pick up wash liquid with additional
absorbent and place in a chemical waste container.
WATER: Clean up spill immediately. Absorb spill with inert
material. Remove contaminated water for treatment or
disposal.
For minor spills, leaks, etc., follow all precautions
indicated on the product label and clean up immediately.
Take special care to avoid contamination of equipment and
facilities during cleanup procedures and disposal of
wastes. In the event of a major spill, fire or other
emergency, call 1-800-441-3637 day or night.
Accidental Release Measures
If spill area is on ground near valuable plants or trees
remove top 2 inches of soil after initial cleanup
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HANDLING AND STORAGE
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Handling (Personnel)
Do not store or consume food, drink or tobacco in areas where they
may become contaminated with this material.
M0000691 DuPont Page 5
Material Safety Data Sheet
(HANDLING AND STORAGE - Continued)
USERS SHOULD: Wash thoroughly with soap and water after
handling and before eating, drinking, chewing gum, using
tobacco or using the toilet. Remove clothing immediately
if pesticide gets inside. Then wash thoroughly and put on
clean clothing. Remove PPE immediately after handling this
product. Wash the outside of gloves before removing. As
soon as possible, wash thoroughly and change into clean
clothing.
Handling (Physical Aspects)
Avoid dust generation.
Storage
Do not contaminate water, other pesticides, fertilizer,
food or feed in storage. Store in a cool, dry place.
Keep out of reach of children.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation. Keep container tightly closed.
When handlers use closed systems, enclosed cabs, or
aircraft in a manner that meets the requirements listed in
the Worker Protection Standard (WPS) for agricultural
pesticides [40 CFR part 170.240 (d)(4-6)], the handler PPE
requirements may be reduced or modified as specified in
the WPS.
Important: When reduced PPE is worn because a closed
system is being used, handlers must be provided all PPE
specified above for "Applicators and Other Handlers" and
have such PPE immediately available for use in an
emergency, such as a spill or equipment breakdown.
Personal Protective Equipment
Always follow the label instructions when handling this product.
Some of the materials that are chemically-resistant to this
product are listed below. If you want more options, follow
the instructions for category A on an EPA chemical-resistant
category selection chart.
Applicators and other handlers must wear:
- Long-sleeved shirt and long pants.
- Chemical-resistant gloves made of any water proof
material such as polyethylene or polyvinylchloride.
- Shoes plus socks.
M0000691 DuPont Page 6
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Discard clothing and other absorbent material that have
been drenched or heavily contaminated with the product.
Follow manufacturer鈥檚 instructions for cleaning/maintain-
ing PPE. If no such instructions for washables, use
detergent and hot water. Keep and wash PPE separately from
other laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been treated, such
as plants, soil, or water, is:
- Coveralls.
- Chemical-resistant gloves made of any water proof
material such as polyethylene or polyvinylchloride.
- Shoes plus socks.
Exposure Guidelines
Applicable Exposure Limits
CHLORIMURON ETHYL
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 10 mg/m3, 8 & 12 Hr. TWA, total dust
5 mg/m3, 8 & 12 Hr. TWA, respirable dust
THIFENSULFURON METHYL
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 5 mg/m3, 8 & 12 Hr. TWA
KAOLIN CLAY
PEL (OSHA) : 15 mg/m3, total dust, 8 Hr. TWA
5 mg/m3, respirable dust, 8 Hr. TWA
TLV (ACGIH) : 2 mg/m3, respirable dust, 8 Hr. TWA, A4
AEL * (DuPont) : None Established
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Odor : Slight, non-descript
Form : Solid, dispersible granules
Color : Light brown granules with ivory colored
granules
pH : 6.3-7.1
Bulk Density : 0.60 - 0.67 g/mL
M0000691 DuPont Page 7
Material Safety Data Sheet
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal temperatures and storage conditions.
Incompatibility with Other Materials
None reasonably foreseeable.
May react with strong oxidizing agents, such as chlorates,
nitrates, peroxides.
Decomposition
Decomposition will not occur.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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# Animal Data
Oral LD50: > 5,000 mg/kg in rats
Dermal LD50: > 2000 mg/kg in rabbits
Inhalation 4-hr LC50: > 0.96 mg/L in rats
Based on data from components, this product is a moderate eye
irritant, a slight skin irritant, but is not a skin sensitizer in
animals.
Compound related effects of Flumioxazin Technical noted in rats
following subchronic exposures at high dose levels were
hamatoxicity including anemia, and increases in liver, spleen,
heart, kidney, and thyroid weights in dogs, the effects produced
at high dose levels included a slight prolongation in activated
partial thromboplastin time, increased cholesterol and
phospholipid, elevated alkaline phophatase, increased liver
weights and histopathological changes in the liver. The lowest
no-observable-effect- level (NOEL) in subschonic studies was 10
ppm in the three- month toxicity study in dogs.
Flumioxazin Technical produces developmental toxicity in rats in
the absence of maternal toxicity. Developmental effects noted
consisted primarily of decreased number of live fetuses and fetal
weights, cardiovascular abnormalities, wavy ribs and decreased
number of ossified sacrococcygeal vertebral bodies. Developmental
NOEL in the rat oral and dermal developmental toxicity studies
were 10 30 mg/kg/day, respectively. The response in rabbits was
very different from that in rats. No developmental toxicity was
noted in rabbits at doses up to 3000 mg/kg/day, a dose well above
the maternal NOEL of 1000 mg/kg/day.
M0000691 DuPont Page 8
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
1000 mg/kg/day.
In a one-year dog feeding study, Flumioxazin Technical produced
treatment-related changes in blood chemistry and increased liver
weights. Based on these data the NOEL 10 mg/kg/day. Dietary
administration of Flumioxazin Technical for 18 months produced
liver changes in mice. There was no evidence of any
treatment-related oncogenic effect. The NOEL for this study is 754
mg/kg/day. Dietary administration of Flumioxazin Technical for 24
months produced anemia and chronic nephropathy in rats. The
anemia lasted throughout the treatment period; however, it was not
progressive nor aplastic in nature. No evidence of an oncogenic
effect was observed. The lowest NOEL for this study was 1.8
mg/kg/day. Reproductive toxicity was observed in F1 males, P1
females and F1 females at 18.9 mg/kg/day. Flumioxazin Technical,
the highest dose tested and a dose that also produced signs
systemic toxicity. Toxicity was also observed in the F1 and F2
offspring at doses of 12.7 mg/kg/day and greater.
The lowest NOELs for parents and offspring were 12.7 and 6.3
mg/kg/day, respectively.
Flumioxazin Technical was not mutagenic in most in vitro assays,
gene mutation and a chromosome aberration assay in the absence of
metabolic activation. In three in vivo assays, chromosome
aberration, unscheduled DNA synthesis and micronucleus assay,
Flumioxazin Technical was not mutagenic. The only positive
response was observed in the in vitro chromosome aberration assay
in the presence of metabolic activation. Overall, Flumioxazin
Technical does not present a genetic hazard.
CHLORIMURON ETHYL
Repeated applications of Chlorimuron Ethyl to the skin of rabbits
for 21 days at doses up to and including the limit dose resulted
in no significant toxicological effects. Repeated and long-term
ingestion of Chlorimuron Ethyl by rats, mice, and dogs caused
liver effects, anemia, altered clinical chemistry, and/or
decreased body weight at higher exposure levels. In rats and
mice, Chlorimuron Ethyl has not caused carcinogenicity.
Exposure of pregnant rabbits caused developmental delays in the
fetus at maternally toxic doses. However, studies in rats
produced no evidence of developmental toxicity. Reproductive data
in rats show nutritional and organ effects in offspring only at
levels which produce other toxic effects in the adult animal.
There were no effects on fertility or lactation indices in rats.
Tests have shown that Chlorimuron Ethyl does not cause genetic
damage in bacterial or mammalian cell cultures, or in animals.
THIFENSULFURON METHYL
The effects in animals from short inhalation exposure to
Thifensulfuron Methyl include nonspecific effects such as weight
loss, and irritation when compared to the control group.
M0000691 DuPont Page 9
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
Repeated ingestion exposures to Thifensulfuron Methyl caused
decreased body and organ weights, and some blood chemistry
changes, including increased blood urea nitrogen and decreased
protein and globulins. Long-term exposures caused an increase in
liver weights, decreased body weight gain, and a decreased level
of sodium in the blood when compared to the control group.
No carcinogenic effects were observed in animal tests with
Thifensulfuron Methyl. Animal data show developmental effects
only at exposure levels producing toxic effects in the adult
animal. Tests in animals demonstrate no reproductive toxicity.
Thifensulfuron Methyl does not produce genetic damage in bacterial
or mammalian cell cultures or animals.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
AQUATIC TOXICITY:
CHLORIMURON ETHYL
Low toxicity.
96 hour LC50 - Rainbow trout: > 1,000 mg/L.
AVIAN TOXICITY:
CHLORIMURON ETHYL
LD50 - Mallard Duck: > 2,510 mg/kg.
LC50 - Bobwhite Quail: > 5,600 ppm.
AQUATIC TOXICITY:
THIFENSULFURON METHYL
96 hour LC50 - Rainbow trout: > 100 mg/L.
96 hour LC50 - Bluegill sunfish: > 100 mg/L.
96 hour EC50 - Freshwater algae: 0.840 - 1.03 mg/L.
AVIAN TOXICITY:
Acute Oral LD50 - Mallard Duck: > 2510 mg/kg.
Acute Dietary LC50 - Mallard Duck: > 5620 mg/kg.
Acute Dietary LC50 - Bobwhite Quail: > 5620 mg/kg
AQUATIC TOXICITY:
FLUMIOXAZIN
96-hour LC50 rainbow trout: 2.3 mg/L
96-hour LC50 bluegill sunfish: > 21 mg/L
48-hour LC50 Daphnia magna: 5.5 mg/L
96-hour LC50 sheepshead minnow: > 4.7 mg/L
96-hour (shell deposition) EC50 eastern oyster: 2.8 mg/L
96-hour LC50 mysid shrimp: 0.23 mg/L
AVIAN TOXICITY:
FLUMIOXAZIN:
Oral LD50 Bobwhite quail: > 2250 mg/kg
Dietary LC50 Bobwhite quail: > 5620 ppm
Dietary LC50 Mallard duck: > 5620 ppm
OTHER NON-TARGET ORGANISM TOXICITY: Flumioxazin Technical is
M0000691 DuPont Page 10
Material Safety Data Sheet
(ECOLOGICAL INFORMATION - Continued)
practically non-toxic to bees. The acute contact LC50 in
bees was >105 ug/bee.
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be in
accordance with applicable Federal, State/Provincial, and Local
regulations.
Do not contaminate water, food, or feed by disposal. Waste
resulting from the use of this product may be disposed of
on site or at an approved waste disposal facility.
ENVIRONMENTAL HAZARDS
Do not apply directly to water, or to areas where surface
water is present, or to intertidal areas below the mean high
water mark. Do not contaminate water when cleaning equipment
or disposing of equipment washwaters. Do not apply where/-
when conditions favor runoff.
This product is toxic to non-target plants and aquatic
invertebrates. Drift or runoff may be hazardous to
non-target plants and aquatic organisms in neighboring
areas.
This pesticide is toxic to plants and should be used
strictly in accordance with the drift and run off
precautions listed on the product label to minimize
off site exposures.
Container Disposal
For Plastic Containers: Triple rinse (or equivalent).
Then offer for recycling or reconditioning, or puncture and
dispose of in a sanitary landfill, or incineration, or, if
allowed by State and local authorities, by burning. If
burned, stay out of smoke.
For Fiber Sacks: Completely empty fiber sack by shaking and
tapping sides and bottom to loosen clinging particles.
Empty residue into manufacturing or application equipment.
Then dispose of sack in a sanitary landfill or by
incineration if allowed by State and local authorities.
For Fiber Drums With Liners: Completely empty liner by
shaking and tapping sides and bottom to loosen clinging
particles. Empty residue into application equipment. Then
dispose of liner in a sanitary landfill or by incineration
if allowed by State and local authorities. If drum is
contaminated and cannot be reused, dispose of in the
same manner.
M0000691 DuPont Page 11
Material Safety Data Sheet
(DISPOSAL CONSIDERATIONS - Continued)
For Bags Containing Water Soluble Packets: Do not reuse the
outer box or the resealable plastic bag. When all water-
soluble packets are used, the outer packaging should be
clean and may be disposed of in a sanitary landfill or by
incineration, or if allowed by State and local authorities,
by open burning. If burned, stay out of smoke. If the
resealable plastic bag contacts the formulated product in
any way, the bag must be triple-rinsed with clean water.
Add the rinsate to the spray tank and dispose of the outer
wrap as described above.
For Metal Containers (non aerosol): Triple rinse (or
equivalent) the container. Then offer for recycling or
reconditioning, or puncture and dispose of in a sanitary
landfill, or by other procedures approved by State and local
authorities.
For Paper and Plastic Bags: Completely empty bag into
application equipment. Then dispose of empty bag in a
sanitary landfill or by incineration, or, if allowed by
State and local authorities, by burning. If burned, stay
out of smoke.
Container Refilling and Disposal (For Containers up to
250 gal): Refer to the product label for instructions.
If the container is to be refilled, do not rinse with any
material or introduce any pesticide other than this
product.
Container Disposal for Bulk Containers: Refer to the
product label for instructions.
The container must only be refilled with this pesticide
product. DO NO REUSE THE CONTAINER FOR ANY OTHER PURPOSE.
Do not transport if the container is damaged or leaking.
Disposal of the container must be in compliance with state
and local regulations.
For minor spills, leaks, etc., follow all precautions
indicated on the product label and clean up immediately.
Take special care to avoid contamination of equipment and
facilities during cleanup procedures and disposal of
wastes. In the event of a major spill, fire or other
emergency, call 1-800-441-3637 day or night.
M0000691 DuPont Page 12
Material Safety Data Sheet
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO
Proper Shipping Name : NOT REGULATED
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REGULATORY INFORMATION
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U.S. Federal Regulations
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : No
Pressure : No
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-756
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health :1
Flammability :1
Reactivity :0
NPCA-HMIS Rating
Health :1
Flammability :1
Reactivity :0
Personal Protection rating to be supplied by user depending on use
conditions.
Additional Information
Product uses a kaolin clay without silica quartz or titanium
dioxide.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
M0000691 DuPont Page 13
Material Safety Data Sheet
(Continued)
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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