The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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DuPont(TM) R-403B
6211FR Revised 14-OCT-2006
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
Molecular Weight : 103
Tradenames and Synonyms
R-403B
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont Fluoroproducts
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
*Chlorodifluoromethane (HCFC-22) 75-45-6 56
Octafluoropropane 76-19-7 39
Propane 74-98-6 5
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
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HAZARDS IDENTIFICATION
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Potential Health Effects
Immediate effects of overexposure may include central
nervous system depression with dizziness, confusion,
incoordination, drowsiness or unconsciousness. Gross
overexposure may cause irregular heart beat with a strange
sensation in the chest, "heart thumping", apprehension,
lightheadedness, feeling of fainting, dizziness, weakness,
sometimes progressing to loss of consciousness and death.
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Material Safety Data Sheet
(HAZARDS IDENTIFICATION - Continued)
Other effects include fatality from gross overexposure.
Short-term overexposure by skin contact may cause frostbite,
if liquid or escaping vapor contacts the skin. Repeated
and/or prolonged exposure may cause defatting of the skin
with itching, redness or rash. Data to evaluate the skin
permeation hazard of this compound are insufficient. There
are no reports of human sensitization.
Eye contact with the vapor or aerosol may cause eye
irritation with tearing, pain or blurred vision.
Increased susceptibility to the effects of this material may
be observed in persons with pre-existing disease central
nervous and cardiovascular systems.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
If inhaled, immediately remove to fresh air. Keep person calm.
If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Call a physician.
SKIN CONTACT
Flush area with lukewarm water. Do not use hot water. If
frostbite has occurred, call a physician.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Call a physician.
INGESTION
Ingestion is not considered a potential route of exposure.
Notes to Physicians
Because of possible disturbances of cardiac rhythm, catecholamine
drugs, such as epinephrine, should only be used with special
caution in situations of emergency life support.
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Material Safety Data Sheet
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point赂: 赂No Flash point
Flammable Limits in Air, % by Volume:
LEL 赂:赂None per ASTM E681-98
UEL赂 :赂None per ASTM E681-98
Autoignition赂:赂Not determined
Fire and Explosion Hazards:
Cylinders may rupture under fire conditions. Decomposition
may occur.
Contact of welding or soldering torch flame with high
concentrations of refrigerant can result in visible changes
in the size and color of torch flames. This flame effect
will only occur in concentrations of product well above the
recommended exposure limit, therefore stop all work and
ventilate to disperse refrigerant vapors from the work area
before using any open flames.
This product is not flammable in air at temperatures up to
100 deg. C (212 deg. F) at atmospheric pressure. However,
mixtures of this product with high concentrations of air at
elevated pressure and/or temperature can become combustible
in the presence of an ignition source. This product can
also become combustible in an oxygen enriched environment
(oxygen concentrations greater than that in air). Whether a
mixture containing this product and air, or this product in
an oxygen enriched atmosphere becomes combustible depends on
the inter-relationship of 1) the temperature 2) the
pressure, and 3) the proportion of oxygen in the mixture. In
general, this product should not be allowed to exist with
air above atmospheric pressure or at high temperatures, or
in an oxygen-enriched environment. For example: This
product should NOT be mixed with air under pressure for leak
testing or other purposes.
Experimental data have also been reported which indicate
combustibility of HCFC-22, a component in this blend, in
the presence of chlorine.
Extinguishing Media
Use media appropriate for surrounding material.
Fire Fighting Instructions
Cool cylinders with water spray or fog. Self-contained
breathing apparatus (SCBA) is required if cylinders rupture
and contents are released under fire conditions. Water
runoff should be contained and neutralized prior to release.
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Material Safety Data Sheet
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Initial Containment
Prevent material from entering sewers, waterways, or low areas.
Spill Clean Up
Recover free liquid for reuse or reclamation.
Accidental Release Measures
Ventilate area using forced ventilation, especially in low
or enclosed places where heavy vapors might collect. Remove
open flames. Use self-contained breathing apparatus (SCBA)
for large spills or releases.
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HANDLING AND STORAGE
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Handling (Personnel)
Avoid breathing vapor. Avoid liquid contact with eyes and
skin. Use with sufficient ventilation to keep employee
exposure below recommended limits. Contact with chlorine or
other strong oxidizing agents should also be avoided. See
Fire and Explosion Data section.
Handling (Physical Aspects)
Keep container tightly closed.
Storage
Store in a cool, dry place.
Store below 52 C (125 F).
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Avoid breathing vapors. Avoid contact with skin or eyes.
Use with sufficient ventilation to keep employee exposure
below the recommended exposure limit. Local exhaust should
be used if large amounts are released. Mechanical
ventilation should be used in low or enclosed places.
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Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Refrigerant concentration monitors may be necessary to
determine vapor concentrations in work areas prior to use of
torches or other open flames, or if employees are entering
enclosed areas.
Personal Protective Equipment
Impervious gloves should be used to avoid prolonged or
repeated exposure. Chemical splash goggles should be
available for use as needed to prevent eye contact. Under
normal manufacturing conditions, no respiratory protection
is required when using this product. Self-contained
breathing apparatus (SCBA) is required if a large release
occurs.
# Exposure Guidelines
Applicable Exposure Limits
Chlorodifluoromethane (HCFC-22)
PEL (OSHA) : None Established
TLV (ACGIH) : 1,000 ppm, 3,540 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : None Established
Propane
PEL (OSHA) : 1,000 ppm, 1,800 mg/m3, 8 Hr. TWA
AEL * (DuPont) : None Established
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
Exposure Guideline Comments
Octafluoropropane
1000 ppm (8 hour TWA)**
**Interim guidance value - DuPont AEL pending
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Boiling Point: -57 F (-49 C) @ atmospheric pressure
Vapor Pressure: 189 psia @ 77 F (25 C)
Vapor Density: 3.6 (Air = 1) @ 77 F (25 C)
% Volatile: 100%
Solubility in Water: <0.5 wt% @ 77 F (25 C)
pH: Neutral
Odor: Slight Ether-like
Form: Liquified Gas
Color: Colorless
Specific Gravity: 1.11 @ 77 F (25 C)
Density: Liquid = 69.3 lb/cu ft @ 77 F (25 C)
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Material Safety Data Sheet
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STABILITY AND REACTIVITY
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Chemical Stability
Stable.
Incompatibility with Other Materials
Incompatible with alkali or alkaline earth metals - powdered
Al, Zn, Be, etc.
Decomposition
Decomposition products are hazardous. This material can be
decomposed by high temperatures (open flames, glowing metal
surfaces, etc.) forming hydrofluoric acid and possibly
carbonyl fluoride.
These materials are toxic and irritating. Contact should be
avoided.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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Animal Data
Chlorodifluoromethane:
Inhalation 4 hour, LC50, rat: 220,000 ppm
Animal testing indicates this material is a slight eye
irritant.
Animal testing indicates this material is a skin irritant,
but not a skin sensitizer.
Long-term exposure caused no significant toxicological
effects.
A single exposure to high doses by inhalation caused central
nervous system depression, inactivity or anaesthesia, lung
noise, altered respiratory rate, histopathological changes
of the liver, cardiac sensitization, a potentially fatal
disturbance of heart rhythm associated with a heightened
sensitivity to the action of epinephrine. Repeated exposure
caused no significant toxicological effects. Long-term
exposure caused reduced weight gain, increased adrenals,
kidney, liver, and pituitary weight.
In chronic inhalation studies, HCFC-22, at a concentration
of 50,000 ppm (v/v), produced a small, but statistically
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Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
significant increase of late-occurring tumors involving
salivary glands in male rats, but not female rats or male or
female mice. In the same studies, no increased incidence of
tumors was seen in either species at concentrations of
10,000 ppm or 1000 ppm (v/v). Animal data show
developmental effects only at exposure levels producing
other toxic effects in the adult animal. This material is
not considered a unique developmental hazard to the
conceptus. Reproductive data on male animals show: No change
in reproductive performance. Specific studies to evaluate
the effect on female reproductive performance have not been
conducted; however, limited information obtained from
studies on developmental toxicity do not indicate adverse
effects on female reproductive performance. This material
produces genetic damage in bacterial cell cultures. In
mammalian cell cultures and animals, this material has not
produced genetic toxicity. In animal testing, this material
has not caused permanent genetic damage in reproductive
cells of mammals (has not produced heritable genetic
damage).
Octafluoropropane:
Inhalation 1 hour LC50 (rat): >80% v/v
Very low acute toxicity; weak anaesthetic at very high
concentrations. Not mutagenic in Ames test or CHO cell
assay.
Propane:
The compound is untested for skin and eye irritancy, and is
untested for animal sensitization.
Toxicity in animals occurring only with inhalation exposures
at high concentrations (10% or greater) are cardiac
sensitization, analgesia, and hypotension. Concentrations
up to 43% caused no anaesthesia. Sniffing, chewing, and
irregular breathing was observed in guinea pigs exposed to
concentrations of 2.4-5.5% for 5 to 90 minutes, but no
adverse signs or pathologic changes were noted during a 10
day post recovery period.
No animal test reports are available to define carcinogenic,
developmental, or reproductive hazards. Tests in bacterial
cell cultures demonstrate no mutagenic activity.
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Material Safety Data Sheet
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity:
Chlorodifluoromethane:
48 hour EC50 - daphnia magna: 433 mg/L
96 hour LC50 - zebra fish: 777 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be in
accordance with applicable Federal, State/Provincial, and Local
regulations.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO
Proper Shipping Name : Refrigerant Gas, N.O.S.
(Chlorodifluoromethane,
Octafluoropropane)
Hazard Class : 2.2
UN No. : 1078
Reportable quantity : No
Marine Pollutant : No
DOT/IMO Label : Nonflammable Gas
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REGULATORY INFORMATION
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U.S. Federal Regulations
TSCA Inventory Status : Listed.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : No
Pressure : Yes
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Material Safety Data Sheet
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NPCA-HMIS Rating
Health :1
Flammability :0
Reactivity :1
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : MSDS Coordinator
> : DuPont Fluoroproducts
Address : Wilmington, DE 19898
Telephone : (800) 441-7515
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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