AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 1 of 16
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
AMYL ACETATES, MIXED HFP
SYNONYMS
C7-H14-O2, CH3COO(CH2)4CH3, "primary amyl acetate", "1-pentyl acetate", "acetic acid,
amyl ester", "amyl acetic ether", birnenoel, "pear oil", pent-acetate, "1-pentanol
acetate", "amylacetic ester"
PROPER SHIPPING NAME
AMYL ACETATES
PRODUCT USE
The use of a quantity of material in an unventilated or confined space may result in
increased exposure and an irritating atmosphere developing. Before starting consider
control of exposure by mechanical ventilation. Component of coatings, solvent for lacquers
and paints, photographic film, leather polishes, nail polishes, and nail polish removers.
As an additive in flavouring; and as a warning odour. Used as solvent in extraction of
penicillin
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 2 of 16
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
Sched. B
RISK SAFETY
Flammable. Keep away from sources of ignition. No smoking.
HARMFUL- May cause lung damage if swallowed. Do not breathe gas/fumes/vapour/spray.
Repeated exposure may cause skin dryness and Avoid contact with eyes.
cracking.
Inhalation and/or ingestion may produce health Wear suitable protective clothing.
damage*.
May produce discomfort of the eyes, respiratory Use only in well ventilated areas.
tract and skin*.
Vapours potentially cause drowsiness and Keep container in a well ventilated place.
dizziness*.
* (limited evidence). Do not empty into drains.
To clean the floor and all objects contaminated
by this material, use water and detergent.
Keep container tightly closed.
Keep away from food, drink and animal feeding
stuffs.
Take off immediately all contaminated clothing.
In case of contact with eyes, rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
If swallowed, IMMEDIATELY contact Doctor or
Poisons Information Centre. (show this container
or label).
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
n- amyl acetate 628-63-7 60 approx
sec- amyl acetate 53496-15-4 35 approx
iso- amyl acetate 123-92-2 5 approx
Section 4 - FIRST AID MEASURES
SWALLOWED
If spontaneous vomiting appears imminent or occurs, hold patient's head down, lower than
their hips to help avoid possible aspiration of vomitus.
路 If swallowed do NOT induce vomiting.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 3 of 16
Section 4 - FIRST AID MEASURES
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Treat symptomatically.
Any material aspirated during vomiting may produce lung injury. Therefore emesis should
not be induced mechanically or pharmacologically. Mechanical means should be used if it
is considered necessary to evacuate the stomach contents; these include gastric lavage
after endotracheal intubation. If spontaneous vomiting has occurred after ingestion, the
patient should be monitored for difficult breathing, as adverse effects of aspiration
into the lungs may be delayed up to 48 hours.
for simple esters:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
路 Establish a patent airway with suction where necessary.
路 Watch for signs of respiratory insufficiency and assist ventilation as necessary.
路 Administer oxygen by non-rebreather mask at 10 to 15 l/min.
路 Monitor and treat, where necessary, for pulmonary oedema .
路 Monitor and treat, where necessary, for shock.
路 DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml
water (5 ml/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
路 Give activated charcoal.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
路 Consider orotracheal or nasotracheal intubation for airway control in unconscious
patient or where respiratory arrest has occurred.
路 Positive-pressure ventilation using a bag-valve mask might be of use.
路 Monitor and treat, where necessary, for arrhythmias.
路 Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 4 of 16
Section 4 - FIRST AID MEASURES
solution. Fluid overload might create complications.
路 Drug therapy should be considered for pulmonary oedema.
路 Hypotension with signs of hypovolaemia requires the cautious administration of fluids.
Fluid overload might create complications.
路 Treat seizures with diazepam.
路 Proparacaine hydrochloride should be used to assist eye irrigation.
--------------------------------------------------------------
EMERGENCY DEPARTMENT
--------------------------------------------------------------
路 Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine,
glucose, urinalysis, baseline for serum aminotransferases (ALT and AST), calcium,
phosphorus and magnesium, may assist in establishing a treatment regime. Other useful
analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs
and electrocardiograph.
路 Positive end-expiratory pressure (PEEP)-assisted ventilation may be required for acute
parenchymal injury or adult respiratory distress syndrome.
路 Consult a toxicologist as necessary.
BRONSTEIN, A.C. and CURRANCE, P.L. EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2n
Ed. 1994.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Alcohol stable foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 If safe, switch off electrical equipment until vapour fire hazard removed.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Liquid and vapour are flammable.
路 Moderate fire hazard when exposed to heat or flame.
路 Vapour forms an explosive mixture with air.
路 Moderate explosion hazard when exposed to heat or flame.
路 Vapour may travel a considerable distance to source of ignition.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), nitrogen
oxides (NOx), other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure
buildup under fire conditions.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 5 of 16
Section 5 - FIRE FIGHTING MEASURES
HAZCHEM: 3[Y]
Personal Protective Equipment
Gloves, boots (chemical resistant).
Breathing apparatus.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb small quantities with vermiculite or other absorbent material.
路 Wipe up.
路 Collect residues in a flammable waste container.
MAJOR SPILLS
Chemical Class: ester and ethers
For release onto land: recommended sorbents listed in order of priority.
SORBENT TYPE RANK APPLICATION COLLECTION LIMITATIONS
LAND SPILL - SMALL
cross- linked 1 shovel shovel R, W, SS
polymer -
particulate
cross- linked 1 throw pitchfork R, DGC, RT
polymer - pillow
sorbent clay - 2 shovel shovel R, I, P
particulate
wood fiber - 3 shovel shovel R, W, P, DGC
particulate
wood fiber - 3 throw pitchfork R, P, DGC, RT
pillow
treated wood 3 throw pitchfork DGC, RT
fiber - pillow
LAND SPILL - MEDIUM
cross- linked 1 blower skiploader R, W, SS
polymer -
particulate
cross- linked 2 throw skiploader R, DGC, RT
polymer - pillow
sorbent clay - 3 blower skiploader R, I, P
particulate
polypropylene - 3 blower skiploader W, SS, DGC
particulate
expanded mineral 4 blower skiploader R, I, W, P, DGC
- particulate
wood fiber - 4 blower skiploader R, W, P, DGC
particulate
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 6 of 16
Section 6 - ACCIDENTAL RELEASE MEASURES
Legend
DGC: Not effective where ground cover is dense
R; Not reusable
I: Not incinerable
P: Effectiveness reduced when rainy
RT:Not effective where terrain is rugged
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation 1988.
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 May be violently or explosively reactive.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 No smoking, naked lights or ignition sources.
路 Increase ventilation.
路 Stop leak if safe to do so.
路 Water spray or fog may be used to disperse / absorb vapour.
路 Contain spill with sand, earth or vermiculite.
路 Use only spark-free shovels and explosion proof equipment.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance 50 metres
Downwind Protection Distance 300 metres
IERG Number 18
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
life-threatening concentrations of the material.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 7 of 16
Section 6 - ACCIDENTAL RELEASE MEASURES
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 129 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
n-amyl acetate 1000 ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
n-amyl acetate 100 ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
n-amyl acetate 100 ppm
The threshold concentration below which most people will experience no appreciable risk of health effects:
n-amyl acetate 100 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ X X X X +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Containers, even those that have been emptied, may contain explosive vapours.
路 Do NOT cut, drill, grind, weld or perform similar operations on or near containers.
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of overexposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 Avoid smoking, naked lights or ignition sources.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 8 of 16
Section 7 - HANDLING AND STORAGE
路 Avoid generation of static electricity.
路 DO NOT use plastic buckets.
路 Earth all lines and equipment.
路 Use spark-free tools when handling.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions.
DO NOT allow clothing wet with material to stay in contact with skin.
SUITABLE CONTAINER
Packing as supplied by manufacturer. Plastic containers may only be used if approved for
flammable liquid. Check that containers are clearly labelled and free from leaks.
路 For low viscosity materials (i) : Drums and jerry cans must be of the non-removable
head type. (ii) : Where a can is to be used as an inner package, the can must have a
screwed enclosure.
路 For materials with a viscosity of at least 2680 cSt. (23 deg. C)
路 For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
路 Manufactured product that requires stirring before use and having a viscosity of at
least 20 cSt (25 deg. C)
(i) : Removable head packaging;
(ii) : Cans with friction closures and
(iii) : low pressure tubes and cartridges may be used.
路 Where combination packages are used, and the inner packages are of glass, there must be
sufficient inert cushioning material in contact with inner and outer packages
路 In addition, where inner packagings are glass and contain liquids of packing group I
there must be sufficient inert absorbent to absorb any spillage, unless the outer
packaging is a close fitting moulded plastic box and the substances are not incompatible
with the plastic.
STORAGE INCOMPATIBILITY
路 Esters react with acids to liberate heat along with alcohols and acids.
路 Strong oxidising acids may cause a vigorous reaction with esters that is sufficiently
exothermic to ignite the reaction products.
路 Heat is also generated by the interaction of esters with caustic solutions.
路 Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
路 Esters may be incompatible with aliphatic amines and nitrates.
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
路 Store in original containers in approved flammable liquid storage area.
路 DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
路 No smoking, naked lights, heat or ignition sources.
路 Keep containers securely sealed.
路 Store away from incompatible materials in a cool, dry, well-ventilated area.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak TWA
ppm mg/m鲁 ppm mg/m鲁 ppm mg/m鲁 F/CC
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 9 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Source Material TWA TWA STEL STEL Peak Peak TWA
ppm mg/m鲁 ppm mg/m鲁 ppm mg/m鲁 F/CC
_________________ __________________ ______ ______ ______ ______ ______ ______ _____
_________________ __________________ ______ ______ ______ ______ ______ ______ _____
Australia Exposure n- amyl acetate 50 270 100 541
Standards (n- Amyl acetate)
Australia Exposure iso- amyl acetate 50 270 100 541
Standards (Isoamyl acetate)
The following materials had no OELs on our records
鈥? sec-amyl acetate: CAS:53496-15-4
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
n- amyl acetate 1, 000
sec- amyl acetate 1, 000
iso- amyl acetate 1, 000
ODOUR SAFETY FACTOR (OSF)
OSF=9.3E2 (n-AMYLACETATE)
Exposed individuals are reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class A or B.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed
individuals are aware by smell
that the Exposure Standard
(TLV- TWA for example) is
being reached, even when
distracted by working
activities
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
MATERIAL DATA
TLV TWA: 100 ppm, 532 mg/m3
ES TWA: 100 ppm, 530 mg/m3
Odour Threshold Value: 0.080 ppm
IDLH Level: 4000 ppm
INGREDIENT DATA
N-AMYL ACETATE:
Odour Threshold Value: 0.051-0.053 ppm (detection)
Saturation concentration at 20 deg. C.: 5200 ppm (approx).
The TLV-TWA is thought to be protective against significant irritation of
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 10 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
the eyes and respiratory system.
SEC-AMYL ACETATE:
ES TWA: 50 ppm; STEL 100 ppm
IDLH Level: 1000 ppm
Odour Threshold: <1ppm.
ISO-AMYL ACETATE:
Odour Threshold Value: 0.0034-209.0 ppm (detection)
The TLV-TWA is thought to be protective against respiratory irritation.
Human exposure at 1000 ppm isoamyl acetate for 0.5 hour, produced
irritation, dyspnea, increased pulse and fatigue. Exposure to high
concentrations is associated with oedema of the glottis. Severe throat
irritation follows exposure to 200 ppm amyl acetate and slight throat
discomfort occurs at 100 ppm.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
路 Overalls.
路 PVC Apron.
路 PVC protective suit may be required if exposure severe.
路 Eyewash unit.
路 Ensure there is ready access to a safety shower.
RESPIRATOR
Where the concentration of gas/particulates in the breathing zone, approaches or exceeds
the "Exposure Standard" (or ES), respiratory protection is required.
Degree of protection varies with both face-piece and Class of filter; the nature of
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 11 of 16
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
protection varies with Type of filter.
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air
Respirator
10 x ES A- AUS - A- PAPR- AUS
50 x ES Air- line* - -
100 x ES - A- 3 -
100+ x ES - Air- line** -
* - Continuous-flow; ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
CARE: Use of a quantity of this material in confined space or poorly ventilated area,
where rapid build up of concentrated atmosphere may occur, could require increased
ventilation and/or protective gear.
For flammable liquids and flammable gases, local exhaust ventilation or a process
enclosure ventilation system may be required. Ventilation equipment should be explosion
-resistant.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to effectively
remove the contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow 1- 2.5 m/s (200- 500 f/min.)
booths, drum filling, conveyer loading,
crusher dusts, gas discharge (active
generation into zone of rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 12 of 16
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Colourless to yellow flammable liquid with a banana or pear- like odour. Solubility in
water: Slight = 0.2% @ 20 deg. C. Odour Threshold: <1ppm. Note: " Amyl Acetate" of
Commerce may be ambiguous as it may be a mixture of isomers; n- amyl, isoamyl and sec-
amyl acetates. Exact specifications of product should be obtained from the manufacturer
PHYSICAL PROPERTIES
Liquid.
Molecular Weight: 130.19 Boiling Range (掳C): 142- 149
Melting Range (掳C): - 71 Specific Gravity (water=1): 0.88 @ 20 deg. C
Solubility in water (g/L): Partly Miscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): 0.53 @ 20 deg.
Volatile Component (%vol): 100 Evaporation Rate: 0.42 BuAc=1
Relative Vapour Density (air=1): 4.5 Flash Point (掳C): 25- 38
Lower Explosive Limit (%): 1.1 Upper Explosive Limit (%): 7.5
Autoignition Temp (掳C): 360 Decomposition Temp (掳C): Not Available
State: Liquid Viscosity: Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be damaging to the health of the individual.
Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical
pneumonitis; serious consequences may result. (ICSC13733).
Considered an unlikely route of entry in commercial/industrial environments. The liquid
may produce gastrointestinal discomfort and may be harmful if swallowed. Ingestion may
result in nausea, pain and vomiting. Vomit entering the lungs by aspiration may cause
potentially lethal chemical pneumonitis.
EYE
There is some evidence to suggest that this material can cause eye irritation and damage
in some persons.
SKIN
There is some evidence to suggest that the material may cause mild but significant
inflammation of the skin either following direct contact or after a delay of some time.
Repeated exposure can cause contact dermatitis which is characterised by redness,
swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
Repeated exposure may cause skin cracking, flaking or drying following normal handling
and use.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 13 of 16
Section 11 - TOXICOLOGICAL INFORMATION
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
INHALED
Inhalation of aerosols (mists, fumes), generated by the material during the course of
normal handling, may be damaging to the health of the individual.
There is some evidence to suggest that the material can cause respiratory irritation in
some persons. The body's response to such irritation can cause further lung damage.
Inhalation hazard is increased at higher temperatures.
Inhalation of high concentrations of gas/vapour causes lung irritation with coughing and
nausea, central nervous depression with headache and dizziness, slowing of reflexes,
fatigue and inco-ordination.
If exposure to highly concentrated solvent atmosphere is prolonged this may lead to
narcosis, unconsciousness, even coma and possible death.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by
sleepiness, reduced alertness, loss of reflexes, lack of co-ordination, and vertigo.
The use of a quantity of material in an unventilated or confined space may result in
increased exposure and an irritating atmosphere developing.
Before starting consider control of exposure by mechanical ventilation.
The main effects of simple esters are irritation, stupor and insensibility. Headache,
drowsiness, dizziness, coma and behavioural changes may occur. Respiratory symptoms may
include irritation, shortness of breath, rapid breathing, throat inflammation, bronchitis
, lung inflammation and pulmonary oedema, sometimes delayed. Nausea, vomiting, diarrhoea
and cramps are observed. Liver and kidney damage may result from massive exposures.
CHRONIC HEALTH EFFECTS
Long-term exposure to the product is not thought to produce chronic effects adverse to
the health (as classified by EC Directives using animal models); nevertheless exposure by
all routes should be minimised as a matter of course.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (rat) LD50: 6500 mg/kg Eye (human): 300 ppm
Inhalation (human) TCLo: 200 ppm [RTECS]
Inhalation (rat) LCLo: 5200 ppm
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
N-AMYL ACETATE:
TOXICITY IRRITATION
Oral (rat) LD50: 6500 mg/kg Eye (human): 300 ppm
Inhalation (human) TCLo: 200 ppm
Inhalation (rat) LCLo: 5200 ppm
Oral (Rabbit) LD50: 7400 mg/kg
Intraperitoneal (Guinea pig) LD: 1500 mg/kg
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
SEC-AMYL ACETATE:
TOXICITY IRRITATION
data for isomeric form: 1- methylbutyl acetate CAS
626- 38- 0
Inhalation (human) TCLo: 200 ppm Nil Reported
Inhalation (gpig) LCLo: 10000 ppm/5h.
ISO-AMYL ACETATE:
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 14 of 16
Section 11 - TOXICOLOGICAL INFORMATION
TOXICITY IRRITATION
Oral (rat) LD50: 16600 mg/kg Nil Reported
Section 12 - ECOLOGICAL INFORMATION
DO NOT discharge into sewer or waterways.
Refer to data for ingredients, which follows:
N-AMYL ACETATE:
Fish LC50 (96hr.) (mg/l): 180
Daphnia magna EC50 (48hr.) (mg/l): 440
DO NOT discharge into sewer or waterways.
Koc: 73
Half-life (hr) air: 68
Half-life (hr) H2O surface water: 5.9-240
Half-life (hr) soil: 324
Henry's atm m鲁 /mol: 3.91E-04
BOD 5 if unstated: 0.31-0.88
ThOD: 2.34
BCF: 31
Toxicity Fish: TLm(96)10mg/L,LC50(96)650ppm
Toxicity invertebrate: cell mult. inhib. 145-550mg/L
Bioacculmulation: not sig
Effects on algae and plankton: cell mult. inhib. 63-80mg/L
Degradation Biological: sig
processes Abiotic: hydrol unlikely,Rxn OH*
ISO-AMYL ACETATE:
BCF<100: 24
log Kow (Prager 1995): 2.128
log Pow (Verschueren 1983): 1.16
BOD5: 0.15
COD: 77%
ThOD: 2.74
nbsp;log#nbsp;Kow#nbsp;#nbsp;:#nbsp;2.13
Koc: 66
Half-life (hr) air: 65
Half-life (hr) H2O surface water: 5
Half-life (hr) soil: 336
Henry's atm m鲁 /mol: 5.87E-04
BCF: 24
Bioacculmulation: not sig
processes Abiotic: no hydrol&RxnOH*,photol in stratos
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material)
路 Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 15 of 16
Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE LIQUID
HAZCHEM: 3[Y]
UNDG:
Dangerous Goods 3 Subrisk: None
Class:
UN Number: 1104 Packing Group: III
Shipping Name:AMYL ACETATES
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1104 Packing Group: III
ERG Code: 3L
Shipping Name: Amyl acetates
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1104 Packing Group: III
EMS Number: F- E, S- D
Shipping Name: AMYL ACETATES
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: Sched. B
REGULATIONS
n-amyl acetate (CAS: 628-63-7) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
sec-amyl acetate (CAS: 53496-15-4) is found on the following regulatory lists;
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
iso-amyl acetate (CAS: 123-92-2) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
AMYL ACETATES, MIXED HFP
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 8-Jul-2006 CHEMWATCH 1104-2
NC317TCP CD 2006/4 Page 16 of 16
Section 16 - OTHER INFORMATION
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 8-Jul-2006
Print Date: 4-Jan-2007
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