BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 1 of 15
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
BISPHENOL A
SYNONYMS
C15-H16-O2, HOC6H4C(CH3)2C6H4OH, "phenol, 4, 4'-isopropylidenedi-", "phenol, 4, 4'
-isopropylidenedi-", "dimethyl bis(p-hydroxyphenyl)methane", bis(4
-hydroxyphenyl)dimethylmethane, diphenylolpropane, bis(4-hydroxyphenyl)propane, "2, 2
-di(4-phenylol)propane", "2, 2-di(4-phenylol)propane", "2, 2-bis(p-hydroxyphenyl)propane"
, "2, 2-bis(p-hydroxyphenyl)propane", "p, p'-isopropylidenebisphenol", "p, p'
-isopropylidenebisphenol", "2, 2-bis(4-hydroxyphenyl)propane", "2, 2-bis(4
-hydroxyphenyl)propane", "4, 4'-isopropylidenebisphenol", "4, 4'-isopropylidenebisphenol"
, "4, 4'-bisphenol A", "4, 4'-bisphenol A", "p, p'-bisphenol A", "p, p'-bisphenol A", "p,
p'-isopropylidenediphenol", "p, p'-isopropylidenediphenol", "p, p'
-dihydroxydiphenyldimethylmethane", "p, p'-dihydroxydiphenyldimethylmethane", "4, 4'
-isopropylidenediphenol", "4, 4'-isopropylidenediphenol", "4, 4'
-dihydroxydiphenyldimethylmethane", "4, 4'-dihydroxydiphenyldimethylmethane", "phenol, 4
, 4'-dimethylmethylenedi-", "phenol, 4, 4'-dimethylmethylenedi-", "p, p'
-dihydroxydiphenylpropane", "p, p'-dihydroxydiphenylpropane", "2, 2-(4, 4'
-dihydroxydiphenyl)propane", "2, 2-(4, 4'-dihydroxydiphenyl)propane", "4, 4'
-dihydroxydiphenylpropane", "4, 4'-dihydroxydiphenylpropane", "4, 4'-dihydroxydiphenyl-2,
2-propane", "4, 4'-dihydroxydiphenyl-2, 2-propane", "4, 4'-dihydroxy-2, 2'
-diphenylpropane", "4, 4'-dihydroxy-2, 2'-diphenylpropane", "dimethylmethylene-p, p'
-diphenol", "dimethylmethylene-p, p'-diphenol", beta-di-p-hydroxyphenylpropane, beta-di-p
-hydroxyphenylpropane, "2, 2-di(4-hydroxyphenyl)propane", "2, 2-di(4
-hydroxyphenyl)propane", "4, 4'-(1-methylethylidene)bisphenol", "4, 4'-(1
-methylethylidene)bisphenol"
PRODUCT USE
Intermediate in manufacture of epoxy, polycarbonate, phenoxy, polysulphone and certain
polyester resins, flame retardants, rubber chemicals, fungicide.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 2 of 15
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Risk of explosion by shock friction fire or Use only in well ventilated areas.
other sources of ignition.
Irritating to respiratory system. Keep container in a well ventilated place.
Risk of serious damage to eyes. Avoid exposure - obtain special instructions
before use.
May cause SENSITISATION by skin contact. To clean the floor and all objects contaminated
by this material use water and detergent.
Possible risk of impaired fertility. Keep away from food drink and animal feeding
stuffs.
Inhalation and/or ingestion may produce health Take off immediately all contaminated clothing.
damage*.
Cumulative effects may result following If swallowed IMMEDIATELY contact Doctor or
exposure*. Poisons Information Centre (show this container
or label).
May be harmful to the foetus/embryo*.
* (limited evidence).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
bisphenol A 80-05-7 > 97
2, 4' - (1- methylethylidene)phenol 837-08-1 2
phenol 108-95-2 0.2
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 3 of 15
Section 4 - FIRST AID MEASURES
SWALLOWED
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
EYE
If this product comes in contact with the eyes:
路 Immediately hold eyelids apart and flush the eye continuously with running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital or doctor without delay.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor, without delay.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 4 of 15
Section 5 - FIRE FIGHTING MEASURES
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Combustible solid which burns but propagates flame with difficulty.
路 Avoid generating dust, particularly clouds of dust in a confined or unventilated space
as dusts may form an explosive mixture with air, and any source of ignition, i.e.
flame or spark, will cause fire or explosion. Dust clouds generated by the fine
grinding of the solid are a particular hazard; accumulations of fine dust may burn
rapidly and fiercely if ignited.
路 Dry dust can be charged electrostatically by turbulence, pneumatic transport, pouring,
in exhaust ducts and during transport.
路 Build-up of electrostatic charge may be prevented by bonding and grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
路 All movable parts coming in contact with this material should have a speed of less than
1-meter/sec.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), other
pyrolysis products typical of burning organic material.
May emit poisonous fumes.
May emit corrosive fumes.
Dust Explosion Hazard Class 3
Dusts fall into one of three Kst* classes. Class 1 dusts; Kst 1-200 m3/sec; Class 2 dusts
; 201-299 m3/sec. Class 3 dusts; Kst 300 or more. Most agricultural dusts (grains,
flour etc.) are Class 1; pharmaceuticals and other speciality chemicals are typically
Class 1 or 2; most unoxidised metallic dusts are Class 3. The higher the Kst, the
more energetically the dust will burn and the greater is the explosion risk.
* Kst - a normalised expression of the burning dust pressure rise rate over time.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Gas tight chemical resistant suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Use dry clean up procedures and avoid generating dust.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
Moderate hazard.
路 CAUTION: Advise personnel in area.
路 Alert Emergency Services and tell them location and nature of hazard.
路 Control personal contact by wearing protective clothing.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Recover product wherever possible.
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 5 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
路 IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and
place in sealed plastic bags or other containers for disposal. IF WET: Vacuum/shovel up
and place in labelled containers for disposal.
路 ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise Emergency Services.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
bisphenol A 500 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
bisphenol A 50 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
bisphenol A 30 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
bisphenol A 10 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Glass container.
路 Polyethylene or polypropylene container.
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 6 of 15
Section 7 - HANDLING AND STORAGE
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X + X 0 +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA ppm TWA mg/m鲁
_________ _________ _____ _____
Australia Exposure 2, 4' - (1- 10
Standards methylethylidene)pheno
l (Inspirable dust
(Not specified))
Australia Exposure phenol (Phenol) 1 4
Standards
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
phenol 250 [Unch]
ODOUR SAFETY FACTOR (OSF)
OSF=25 (bisphenol A)
Exposed individuals are NOT reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class C, D or E.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed individuals
are aware by smell that the
Exposure Standard (TLV- TWA for
example) is being reached, even
when distracted by working
activities
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 7 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent)
for all substances for which there is evidence of health effects at airborne
concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce adverse
health effects (as evidenced in animal experiments or clinical experience). Airborne
concentrations must be maintained as low as is practically possible and occupational
exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified
(P.N.O.S) does NOT apply.
CEL TWA: 5 mg/m3 [Dow Chemical]
INGREDIENT DATA
2,4'-(1-METHYLETHYLIDENE)PHENOL:
These "dusts" have little adverse effect on the lungs and do not produce toxic effects
or organic disease. Although there is no dust which does not evoke some cellular response
at sufficiently high concentrations, the cellular response caused by P.N.O.C.s has the
following characteristics:
路 the architecture of the air spaces remain intact,
路 scar tissue (collagen) is not synthesised to any degree,
路 tissue reaction is potentially reversible.
Extensive concentrations of P.N.O.C.s may:
路 seriously reduce visibility,
路 cause unpleasant deposits in the eyes, ears and nasal passages,
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 8 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
路 contribute to skin or mucous membrane injury by chemical or mechanical action, per
se, or by the rigorous skin cleansing procedures necessary for their removal. [ACGIH]
This limit does not apply:
路 to brief exposures to higher concentrations
路 nor does it apply to those substances that may cause physiological impairment at
lower concentrations but for which a TLV has as yet to be determined.
This exposure standard applies to particles which
路 are insoluble or poorly soluble* in water or, preferably, in aqueous lung fluid (if
data is available) and
路 have a low toxicity (i.e.. are not cytotoxic, genotoxic, or otherwise chemically
reactive with lung tissue, and do not emit ionizing radiation, cause immune sensitization
, or cause toxic effects other than by inflammation or by a mechanism of lung overload).
PHENOL:
Odour Threshold Value: 0.060 ppm (detection)
NOTE: Detector tubes for phenol, measuring in excess of 1 ppm, are
commercially available.
Systemic absorption by all routes may induce convulsions with damage to
the lungs and central nervous system.
Exposure at or below the recommended TLV-TWA is thought to protect the
worker from respiratory, cardiovascular, hepatic, renal and neurological
toxicity. Workers or volunteers exposed at or below 5.2 ppm have
experienced no ill-effects. Because phenol as a vapour, liquid or solid
can penetrate the skin causing systemic effects, a skin notation is
considered necessary. Although ACGIH has not recommended a STEL it is felt
that ACGIH excursion limits (15 ppm limited to a total duration of 30
minutes with brief excursions limited to no more than 25 ppm) and NIOSH
Ceiling values are sufficiently similar so as to provide the same margin
of safety.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Experience indicates that the following polymers are suitable as glove materials for
protection against undissolved, dry solids.
路 polychloroprene
路 nitrile rubber
路 butyl rubber
路 fluorocaoutchouc
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 9 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
路 polyvinyl chloride
Gloves should be examined for wear and/ or degradation constantly.
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
NOTE: The material may produce skin sensitisation in predisposed individuals. Care must
be taken, when removing gloves and other protective equipment, to avoid all possible skin
contact.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
ppm (volume) Factor
1000 10 A- AUS P -
1000 50 - A- AUS P
5000 50 Airline * -
5000 100 - A- 2 P
10000 100 - A- 3 P
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 Exhaust ventilation should be designed to prevent accumulation and recirculation of
particulates in the workplace.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered. Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks
路 Build-up of electrostatic charge on the dust particle, may be prevented by bonding and
grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to efficiently
remove the contaminant.
BISPHENOL A
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Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White to light tan flakes or powder with mild phenolic odour. Insoluble in water. Soluble
in alcohol and dilute alkalis. Slightly soluble in carbon tetrachloride.
PHYSICAL PROPERTIES
Solid.
Does not mix with water.
Sinks in water.
Molecular Weight: 228.31 Boiling Range (掳C): 220 (@ 4 mm)
Melting Range (掳C): 153- 156 Specific Gravity (water=1): 1.20
Solubility in water (g/L): Immiscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): Negligible
Volatile Component (%vol): Negligible Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not available. Flash Point (掳C): 213 (OC)
Lower Explosive Limit (%): Not available. Upper Explosive Limit (%): Not available.
Autoignition Temp (掳C): 570 Decomposition Temp (掳C): Not available.
State: Divided solid Viscosity: Not Applicable
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
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Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be damaging to the health of the individual.
EYE
If applied to the eyes, this material causes severe eye damage.
SKIN
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
The material is not thought to produce adverse health effects or skin irritation
following contact (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
gloves be used in an occupational setting.
INHALED
The material can cause respiratory irritation in some persons. The body's response to
such irritation can cause further lung damage.
Persons with impaired respiratory function, airway diseases and conditions such as
emphysema or chronic bronchitis, may incur further disability if excessive concentrations
of particulate are inhaled.
The material is not thought to produce adverse health effects following inhalation (as
classified by EC Directives using animal models). Nevertheless, adverse systemic effects
have been produced following exposure of animals by at least one other route and good
hygiene practice requires that exposure be kept to a minimum and that suitable control
measures be used in an occupational setting.
If phenols are absorbed via the lungs, systemic effects may occur affecting the
cardiovascular and nervous systems. Inhalation can result in profuse perspiration,
intense thirst, nausea, vomiting, diarrhoea, cyanosis, restlessness, stupor, falling
blood pressure, hyperventilation, abdominal pain, anaemia, convulsions, coma, swelling
and inflammation of the lung. This is followed by respiratory failure and kidney damage.
Phenols also cause loss of sensation and general depression at high concentrations. The
toxicities of phenol derivatives vary.
CHRONIC HEALTH EFFECTS
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
Long term exposure to high dust concentrations may cause changes in lung function i.e.
pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the
lung. Prime symptom is breathlessness; lung shadows show on X-ray.
Long-term exposure to respiratory irritants may result in disease of the airways
involving difficult breathing and related systemic problems.
Skin contact with the material is more likely to cause a sensitisation reaction in some
persons compared to the general population.
BISPHENOL A
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Section 11 - TOXICOLOGICAL INFORMATION
There is some evidence from animal testing that exposure to this material may result in
toxic effects to the unborn baby.
Ample evidence from experiments exists that there is a suspicion
this material directly reduces fertility.
Bisphenol A may have effects similar to female sex hormones and when administered to
pregnant women, may damage the foetus. It may also damage male reproductive organs and
sperm.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 3250 mg/kg Skin (rabbit): 250 mg Open - Mild
Inhalation (rat) LC50: 200 ppm Skin (rabbit): 500 mg/24h - Mild
Dermal (rabbit) LD50: 3000 mg/kg Eye (rabbit): 0.25 mg/24h- SEVERE
Oral (Mouse) LD50: 2400 mg/kg
Intraperitoneal (Mouse) LD50: 150 mg/kg
Subcutaneous (Mouse) LD: 2500 mg/kg
Oral (Rabbit) LD50: 2230 mg/kg
Subcutaneous (Rat) TDLo: 5.9 mg/kg
Oral (Rat) LD50: 1200 mg/kg
Oral (Rat) TDLo: 1000 mg/kg
Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria
or Quincke's oedema. The pathogenesis of contact eczema involves a cell-mediated (T
lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g.
contact urticaria, involve antibody-mediated immune reactions. The significance of the
contact allergen is not simply determined by its sensitisation potential: the
distribution of the substance and the opportunities for contact with it are equally
important. A weakly sensitising substance which is widely distributed can be a more
important allergen than one with stronger sensitising potential with which few
individuals come into contact. From a clinical point of view, substances are noteworthy
if they produce an allergic test reaction in more than 1% of the persons tested.
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
Asthma-like symptoms may continue for months or even years after exposure to the material
ceases. This may be due to a non-allergenic condition known as reactive airways
dysfunction syndrome (RADS) which can occur following exposure to high levels of highly
irritating compound. Key criteria for the diagnosis of RADS include the absence of
preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the
irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to
severe bronchial hyperreactivity on methacholine challenge testing and the lack of
minimal lymphocytic inflammation, without eosinophilia, have also been included in the
criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an
infrequent disorder with rates related to the concentration of and duration of exposure
to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that
occurs as result of exposure due to high concentrations of irritating substance (often
particulate in nature) and is completely reversible after exposure ceases. The disorder
is characterised by dyspnea, cough and mucus production.
2,4'-(1-METHYLETHYLIDENE)PHENOL:
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
No significant acute toxicological data identified in literature search.
PHENOL:
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 317 mg/kg Skin(rabbit): 500 mg/24hr - SEVERE
Oral (human) LDLo: 140 mg/kg Skin(rabbit): 500 mg Open - SEVERE
Inhalation (rat) LC50: 316 mg/m鲁 Eye(rabbit): 5 mg - SEVERE
Dermal (rabbit) LD50: 850 mg/kg Eye(rabbit): 100 mg rinse - Mild
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 13 of 15
Section 11 - TOXICOLOGICAL INFORMATION
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
phenol IARC:3
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: phenol Category:
3
Section 12 - ECOLOGICAL INFORMATION
DO NOT discharge into sewer or waterways.
log Kow 3.32
Kow: 314-1524
Half-life (hr) air: 4
Half-life (hr) H2O surface water: 96
BCF: 42-96
Toxicity Fish: LC50(96)42mg/l
processes Abiotic: violent,fast decomp.in H2O
Biodegradation dominant (half-life <= 4 days; not expected to bioaccumulate
significantly in aquatic organisms
Refer to data for ingredients, which follows:
2,4'-(1-METHYLETHYLIDENE)PHENOL:
log Kow: 0.72
Toxicity Fish: LC50(96)0.14-0.23mg/L
Toxicity invertebrate: LC50(96)0.23mg/L
PHENOL:
Hazardous Air Pollutant: Yes
Fish LC50 (96hr.) (mg/l): 0.001- 56
Daphnia magna EC50 (48hr.) (mg/l): 56
Algae IC50 (72hr.) (mg/l): 4.6- 7.5
BCF<100: 7.6
log Kow (Prager 1995): 1.46
log Kow (Sangster 1997): 1.5
log Pow (Verschueren 1983): 1.46
BOD5: 1.68
COD: 2.33
ThOD: 2.26
Half- life Soil - High (hours): 240
Half- life Soil - Low (hours): 24
Half- life Air - High (hours): 22.8
Half- life Air - Low (hours): 2.28
Half- life Surface water - High (hours): 56.5
Half- life Surface water - Low (hours): 5.3
Half- life Ground water - High (hours): 168
Half- life Ground water - Low (hours): 12
Aqueous biodegradation - Aerobic - High (hours): 84
Aqueous biodegradation - Aerobic - Low (hours): 6
Aqueous biodegradation - Anaerobic - High (hours): 672
Aqueous biodegradation - Anaerobic - Low (hours): 192
Aqueous biodegradation - Removal secondary treatment - High (hours): 99.90%
Aqueous biodegradation - Removal secondary treatment - Low (hours): 90%
Aqueous photolysis half- life - High (hours): 173
Aqueous photolysis half- life - Low (hours): 46
Photolysis maximum light absorption - High (nano- m): 269
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 14 of 15
Section 12 - ECOLOGICAL INFORMATION
Aqueous photolysis half- life - High (hours): 173
Aqueous photolysis half- life - Low (hours): 46
Photooxidation half- life water - High (hours): 3840
Photooxidation half- life water - Low (hours): 77
Photooxidation half- life air - High (hours): 22.8
Photooxidation half- life air - Low (hours): 2.28
The material is classified as an ecotoxin* because the Fish LC50 (96 hours) is less than
or equal to 0.1 mg/l
* Classification of Substances as Ecotoxic (Dangerous to the Environment)
Appendix 8, Table 1
Compiler's Guide for the Preparation of International Chemical Safety Cards: 1993
Commission of the European Communities.
Koc: 39-148
Half-life (hr) air: 0.25-16
Half-life (hr) H2O surface water: 19-100
Henry's atm m鲁 /mol: 3.97E-07
BOD 5 if unstated: 1.68
COD: 2.28-2.37
ThOD: 2.26-2.40
BCF: 1.9-277
Nitrif. inhib.: 50% inhib at 9mg/L
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material)
路 Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
路 Containers may still present a chemical hazard/ danger when empty.
路 Return to supplier for reuse/ recycling if possible.
Otherwise:
路 If container can not be cleaned sufficiently well to ensure that residuals do not
remain or if the container cannot be used to store the same product, then puncture
containers, to prevent re-use, and bury at an authorised landfill.
路 Where possible retain label warnings and MSDS and observe all notices pertaining to the
product.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
BISPHENOL A
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 23320
Issue Date: 6-Mar-2007 Version No:4
NC317TLP CD 2007/3 Page 15 of 15
Section 15 - REGULATORY INFORMATION
REGULATIONS
bisphenol A (CAS: 80-05-7) is found on the following regulatory lists;
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 6
OECD Representative List of High Production Volume (HPV) Chemicals
OSPAR List of Substances of Possible Concern
No data available for bisphenol A as CAS: 27360-89-0, CAS: 28106-82-3, CAS: 37808-08-5, CAS: 137885-53-1.
Section 16 - OTHER INFORMATION
Denmark Advisory list for selfclassification of dangerous substances
Substance CAS Suggested codes
2, 4' - (1- methylethylidene)phenol 837- 08- 1 R43
INGREDIENTS WITH MULTIPLE CAS NUMBERS
Ingredient Name CAS
bisphenol A 80- 05- 7, 27360- 89- 0, 28106- 82- 3, 37808-
08- 5, 137885- 53- 1
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for reproductive no
-observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoi CR Adeq
nt TLV
bisphenol A 0.3 mg/m3 1000 D NA -
phenol 3.6 mg/m3 100 D NA -
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 6-Mar-2007
Print Date: 17-Dec-2007
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