CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 1 of 13
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
CHROMIC SULFATE, BASIC
SYNONYMS
Cr-O5-H-S, Cr(OH)SO4.nH2O, Cr8(OH)8(SO4)8.4Na2SO4.24H2O, "chromic (III) sulphate, basic"
, "chromic (III) sulphate, basic", "chromium hydroxide sulfate", "basic chrome sulfate",
"monobasic chromium sulfate", "chrome sulfate", "chrome sulphate"
PRODUCT USE
Leather tanning reagent.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 2 of 13
Section 2 - HAZARDS IDENTIFICATION
POISONS SCHEDULE
None
RISK SAFETY
Causes severe burns. Keep locked up.
Risk of serious damage to eyes. Do not breathe dust.
Harmful to aquatic organisms. Avoid contact with eyes.
Cumulative effects may result following Wear suitable protective clothing.
exposure*.
* (limited evidence). To clean the floor and all objects contaminated
by this material use water and detergent.
Take off immediately all contaminated clothing.
In case of accident or if you feel unwell
IMMEDIATELY contact Doctor or Poisons
Information Centre (show label if possible).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
chromic sulfate, basic 12336-95-7 100
Section 4 - FIRST AID MEASURES
SWALLOWED
路 For advice, contact a Poisons Information Centre or a doctor at once.
路 Urgent hospital treatment is likely to be needed.
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Transport to hospital or doctor without delay.
EYE
If this product comes in contact with the eyes:
路 Immediately hold eyelids apart and flush the eye continuously with running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital or doctor without delay.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 3 of 13
Section 4 - FIRST AID MEASURES
SKIN
If skin or hair contact occurs:
路 Immediately flush body and clothes with large amounts of water, using safety shower if
available.
路 Quickly remove all contaminated clothing, including footwear.
路 Wash skin and hair with running water. Continue flushing with water until advised to
stop by the Poisons Information Centre.
路 Transport to hospital, or doctor.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor, without delay.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Water spray or fog.
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear full body protective clothing with breathing apparatus.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Use fire fighting procedures suitable for surrounding area.
路 Do not approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Non combustible.
路 Not considered a significant fire risk, however containers may burn.
Decomposition may produce toxic fumes of: sulfur oxides (SOx), metal oxides.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
None known.
HAZCHEM: None
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 4 of 13
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Use dry clean up procedures and avoid generating dust.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear full body protective clothing with breathing apparatus.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Consider evacuation (or protect in place).
路 Stop leak if safe to do so.
路 Contain spill with sand, earth or vermiculite.
路 Collect recoverable product into labelled containers for recycling.
路 Neutralise/decontaminate residue.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 After clean up operations, decontaminate and launder all protective clothing and
equipment before storing and re-using.
路 If contamination of drains or waterways occurs, advise emergency services.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 WARNING: To avoid violent reaction, ALWAYS add material to water and NEVER water to
material.
路 Avoid smoking, naked lights or ignition sources.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to
ensure safe working conditions are maintained.
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 5 of 13
Section 7 - HANDLING AND STORAGE
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
路 Limit all unnecessary personal contact.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
路 Lined metal can, lined metal pail/ can.
路 Plastic pail.
路 Polyliner drum.
路 Packing as recommended by manufacturer.
路 Check all containers are clearly labelled and free from leaks.
Multi-ply paper bag with sealed plastic liner or heavy gauge plastic bag.
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse. Check that all containers are clearly
labelled and free from leaks. Packing as recommended by manufacturer.
STORAGE INCOMPATIBILITY
Dangerous goods of other classes.
Metals and their oxides or salts may react violently with chlorine trifluoride. Chlorine
trifluoride is a hypergolic oxidiser. It ignites on contact (without external source of
heat or ignition) with recognised fuels - contact with these materials, following an
ambient or slightly elevated temperature, is often violent and may produce ignition. The
state of subdivision may affect the results.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ + + + + +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 6 of 13
Section 7 - HANDLING AND STORAGE
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁
_________ _________ _____
Australia Exposure Standards chromic sulfate, basic 0.5
(Chromium (III) compounds (as
Cr))
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
chromic sulfate, basic 25
MATERIAL DATA
Because of the low toxicity of chromium metal and its divalent/ trivalent compounds the
recommended TLV is thought to minimise the potential of pulmonary disease and other toxic
effects. Some jurisdictions require that health surveillance be carried on workers
occupationally exposed to inorganic chromium.
Such surveillance should emphasise
路 demography, occupational and medical history and health advice
路 physical examination with emphasis on the respiratory system and skin
路 weekly skin inspection of hands and forearms by a "responsible person".
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
PERSONAL PROTECTION
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 7 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EYE
路 Chemical goggles.
路 Full face shield may be required for supplementary but never for primary protection of
eyes
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Elbow length PVC gloves.
Experience indicates that the following polymers are suitable as glove materials for
protection against undissolved, dry solids.
路 polychloroprene
路 nitrile rubber
路 butyl rubber
路 fluorocaoutchouc
路 polyvinyl chloride
Gloves should be examined for wear and/ or degradation constantly.
OTHER
路 Overalls.
路 PVC Apron.
路 PVC protective suit may be required if exposure severe.
路 Eyewash unit.
路 Ensure there is ready access to a safety shower.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 8 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation usually required. If risk of overexposure exists, wear approved
respirator. Correct fit is essential to obtain adequate protection. Supplied-air type
respirator may be required in special circumstances. Correct fit is essential to ensure
adequate protection.
An approved self contained breathing apparatus (SCBA) may be required in some situations.
Provide adequate ventilation in warehouse or closed storage area. Air contaminants
generated in the workplace possess varying "escape" velocities which, in turn, determine
the "capture velocities" of fresh circulating air required to effectively remove the
contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 9 of 13
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Family of products which vary in their physical properties as a result of variations in
production. Data presented here is for typical family member. Technical grades are
available in two degrees of basicity, one- third and one- half, as finely granular dark-
green flakes or powders containing about 25% Cr2O3. These are readily soluble in water.
PHYSICAL PROPERTIES
Solid.
Does not mix with water.
Molecular Weight: Not available Boiling Range (掳C): Not available
Melting Range (掳C): Not available Specific Gravity (water=1): Not available
Solubility in water (g/L): Partly miscible pH (as supplied): Not available
pH (1% solution): 2 Vapour Pressure (kPa): Not applicable
Volatile Component (%vol): Not applicable Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not applicable Flash Point (掳C): Not applicable
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
Autoignition Temp (掳C): Not available Decomposition Temp (掳C): Not available
State: Divided solid Viscosity: Not Applicable
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Sulfates are not well absorbed orally, but can cause diarrhoea.
The material can produce severe chemical burns within the oral cavity and
gastrointestinal tract following ingestion.
The material has NOT been classified by EC Directives or other classification systems as
"harmful by ingestion". This is because of the lack of corroborating animal or human
evidence. The material may still be damaging to the health of the individual, following
ingestion, especially where pre-existing organ (eg. liver, kidney) damage is evident.
Present definitions of harmful or toxic substances are generally based on doses producing
mortality rather than those producing morbidity (disease, ill-health). Gastrointestinal
tract discomfort may produce nausea and vomiting. In an occupational setting however,
ingestion of insignificant quantities is not thought to be cause for concern.
EYE
The material can produce severe chemical burns to the eye following direct contact.
Vapours or mists may be extremely irritating.
If applied to the eyes, this material causes severe eye damage.
Although the material is not thought to be an irritant (as classified by EC Directives),
direct contact with the eye may cause transient discomfort characterised by tearing or
conjunctival redness (as with windburn). Slight abrasive damage may also result. The
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 10 of 13
Section 11 - TOXICOLOGICAL INFORMATION
material may produce foreign body irritation in certain individuals.
SKIN
Solution of material in moisture on the skin, or perspiration, may increase irritant
effects.
The material can produce severe chemical burns following direct contact
with the skin.
The material is not thought to produce adverse health effects or skin irritation
following contact (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
gloves be used in an occupational setting.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
INHALED
The material can cause respiratory irritation in some persons. The body's response to
such irritation can cause further lung damage.
The material is not thought to produce adverse health effects or irritation of the
respiratory tract (as classified by EC Directives using animal models). Nevertheless,
good hygiene practice requires that exposure be kept to a minimum and that suitable
control measures be used in an occupational setting.
CHRONIC HEALTH EFFECTS
Chromium (III) is an essential trace mineral. Chronic exposure to chromium (III)
irritates the airways, malnourishes the liver and kidneys, causes fluid in the lungs, and
adverse effects on white blood cells, and also increases the risk of developing lung
cancer. Chromium (VI) can irritate the skin, eyes and airways. Allergic reactions can
involve both the skin and airways, and the compounds can diminish taste and smell,
discolour the skin and eyes, cause blood disorders and damage the liver, kidneys,
digestive tract and lungs. It predisposes humans to cancers of the respiratory tract and
digestive system. Ulceration to the skin can occur, and, chromium (VI) is one of the most
allergenic substances known.
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
Repeated or prolonged exposure to acids may result in the erosion of teeth, swelling
and/or ulceration of mouth lining. Irritation of airways to lung, with cough, and
inflammation of lung tissue often occurs. Chronic exposure may inflame the skin or
conjunctiva.
Long-term exposure to respiratory irritants may result in disease of the airways
involving difficult breathing and related systemic problems.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (woman) LDLo: 960 mg/kg Nil Reported
Oral (Human) LD: 960 mg/kg
Oral (Rat) LD50: 7760 mg/kg
Oral (Mouse) LD50: 2900 mg/kg
Asthma-like symptoms may continue for months or even years after exposure to the material
ceases. This may be due to a non-allergenic condition known as reactive airways
dysfunction syndrome (RADS) which can occur following exposure to high levels of highly
irritating compound. Key criteria for the diagnosis of RADS include the absence of
preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the
irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to
severe bronchial hyperreactivity on methacholine challenge testing and the lack of
minimal lymphocytic inflammation, without eosinophilia, have also been included in the
criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an
infrequent disorder with rates related to the concentration of and duration of exposure
to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 11 of 13
Section 11 - TOXICOLOGICAL INFORMATION
occurs as result of exposure due to high concentrations of irritating substance (often
particulate in nature) and is completely reversible after exposure ceases. The disorder
is characterised by dyspnea, cough and mucus production.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
chromic sulfate, IARC:3
basic
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: chromic sulfate,
basic Category: 3
Section 12 - ECOLOGICAL INFORMATION
Chromium in the oxidation state +3 (the trivalent form) is poorly absorbed by cells found
in microorganisms, plants and animals. Chromate anions (CrO4-, oxidation state +6, the
hexavalent form) are readily transported into cells and toxicity is closely linked to the
higher oxidation state.
Chromium Ecotoxicology:
Toxicity in Aquatic Organisms:
Chromium is harmful to aquatic organisms in very low concentrations. Fish food organisms
are very sensitive to low levels of chromium. Chromium is toxic to fish although less so
in warm water. Marked decreases in toxicity are found with increasing pH or water
hardness; changes in salinity have little if any effect. Chromium appears to make fish
more susceptible to infection. High concentrations can damage and/or accumulate in
various fish tissues and in invertebrates such as snails and worms.
Reproduction of Daphnia is affected by exposure to 0.01 mg/kg hexavalent chromium/litre
Toxicity of chromium in fresh-water organisms (50% mortality)*
Compound Category Exposure Toxicity Range Most sensitive
(mg/litre) species
hexavalent chrome invertebrate acute 0.067- 59.9 scud
long- term - -
vertebrate acute 17.6- 249 fathead minnow
long- term 0.265- 2.0 rainbow trout
trivalent chrome invertebrate acute 2.0- 64.0 cladoceran
long- term 0.066 cladoceran
vertebrate acute 33.0- 71.9 guppy
invertebrate long- term 1.0 fathead minnow
* from Environmental Health Criteria 61: WHO Publication.
Toxicity in Microorganisms:
In general, toxicity for most microorganisms occurs in the range of 0.05-5 mg chromium/kg
of medium. Trivalent chromium is less toxic than the hexavalent form. The main signs of
toxicity are inhibition of growth and the inhibition of various metabolic processes such
as photosynthesis or protein synthesis. Gram-negative soil bacteria are generally more
sensitive to hexavalent chromium (1-12 mg/kg) than the gram-positive types. Toxicity to
trivalent chromium is not observed at similar levels. The toxicity of low levels of
hexavalent chromium (1 mg/kg) indicates that soil microbial transformation, such as
nitrification, may be affected. Chromium should not be introduced to municipal sewage
treatment facilities.
Toxicity in Plants: Chromium in high concentrations can be toxic for plants. The main
feature of chromium intoxication is chlorosis, which is similar to iron deficiency.
Chromium affects carbohydrate metabolism and leaf chlorophyll concentration decreases
with hexavalent chromium concentration (0.01-1 mg/l). The hexavalent form appears to more
toxic than the trivalent species.
Biological half-life: The elimination curve for chromium, as measured by whole-body
counting, has an exponential form. In rats, three different components of the curve have
been identified, with half-lives of 0.5, 5.9 and 83.4 days, respectively.
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 12 of 13
Section 12 - ECOLOGICAL INFORMATION
Water Standards: Chromium is identified as a hazardous substance in the Federal (U.S.)
Water Pollution Control Act and further regulated by Clean Air Water Act Amendments (US).
These regulations apply to discharge. The US Primary drinking water Maximum Contaminant
Level (MCL), for chromium, is 0.05 mg/l (total chromium).
Prevent, by any means available, spillage from entering drains or water
courses.
Section 13 - DISPOSAL CONSIDERATIONS
Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Treat and neutralise at an approved treatment plant. Treatment should involve: Mixing
or slurrying in water; Neutralisation with soda-lime or soda-ash followed by: Burial in a
licenced land-fill or Incineration in a licenced apparatus (after admixture with suitable
combustible material)
路 Decontaminate empty containers with 5% aqueous sodium hydroxide or soda ash, followed
by water. Observe all label safeguards until containers are cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
chromic sulfate, basic (CAS: 12336-95-7) is found on the following regulatory lists;
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
International Agency for Research on Cancer (IARC) Carcinogens
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
chromic sulfate, basic (CAS: 129039-96-9) is found on the following regulatory lists;
Australia Exposure Standards
Australia National Pollutant Inventory
International Agency for Research on Cancer (IARC) Carcinogens
No data available for chromic sulfate, basic as CAS: 60938-72-9, CAS: 122483-54-9, CAS: 12190-92-0, CAS: 85251-54-3.
Section 16 - OTHER INFORMATION
INGREDIENTS WITH MULTIPLE CAS NUMBERS
Ingredient Name CAS
chromic sulfate, basic 12336- 95- 7, 129039- 96- 9, 60938- 72- 9,
122483- 54- 9, 12190- 92- 0, 85251- 54- 3
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
CHROMIC SULFATE, BASIC
Chemwatch Material Safety Data Sheet (REVIEW)
For Workplace - Small Volume Use Only. CHEMWATCH 36023
Issue Date: 9-Feb-2007 Version No:4
NC317TLP CD 2007/3 Page 13 of 13
Section 16 - OTHER INFORMATION
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 9-Feb-2007
Print Date: 17-Dec-2007
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