SECTION 1: CHEMICAL PRODUCT and COMPANY IDENTIFICATION
Product Name: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid, 99%
Synonyms: (+)-6-Methoxy- -methyl-2-naphthaleneacetic acid, Naproxen
Yangzhou Chemical Co.,ltd.
Manufacturer/Supplier Name:
Address: 18 west wenchang road
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SECTION 2 : COMPOSITION, INFORMATION ON INGREDIENTS
Chemical Name (S)鈥?(+)鈥?2鈥?(6鈥揗ethoxy鈥?2鈥搉aphthyl)propionic acid
CAS# 22204-53-1
% Weight (Typical) 99
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SECTION 3 : HAZARDS IDENTIFICATION
Emergency Overview: Reproductive effects. Mutation data. Irritant.
(S)鈥?(+)鈥?2鈥?(6鈥揗ethoxy鈥?2鈥搉aphthyl)propionic acid:
Route of Exposure: Eyes. Skin. Inhalation. Ingestion.
Potential Health Effects:
Eye Contact: May cause eye irritation.
Skin Contact: May cause skin irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: Toxic by ingestion.
Target Organs: Eyes. Skin. Respiratory system. G.I. Tract. Liver. Kidney. Cardiovascular.
Reproductive System.
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SECTION 4 : FIRST AID MEASURES
Eye Contact: Immediately flush eyes with plenty of water for at least 20 minutes.
Assure adequate flushing of the eyes by separating the eyelids with
fingers. Get immediate medical attention if irritation persists, or symptoms
of overexposure become apparent.
Skin Contact: Immediately wash skin with plenty of water for at least 20 minutes, while
removing contaminated clothing and shoes. Get medical attention
especially, if irritation develops, persists, or symptoms of overexposure
become apparent.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration or give
oxygen by trained personnel. Keep warm. Get immediate medical
attention.
Ingestion: If swallowed, call a physician or poison control center immediately. Never
give anything by mouth to an unconscious person. Do not induce vomiting
unless instructed by medical personnel. Get medical attention.
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SECTION 5 : FIRE FIGHTING MEASURES
Flash Point: No data
Extinguishing Media: Use dry powder or carbon dioxide when fighting a fire involving this
material.
Unsuitable Media: Water extinguishers are not recommended.
Protective Equipment: As in any fire, wear self-contained breathing apparatus pressure-demand,
NIOSH (approved or equivalent) and full protective gear.
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SECTION 6 : ACCIDENTAL RELEASE MEASURES
Personal Precautions: Use proper personal protective equipment as listed in section 8.
Spill Cleanup Measures: Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Refer to section 13 for disposal requirements.
Environmental Precautions: Do not allow material to enter drains or streams.
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SECTION 7 : HANDLING and STORAGE
Handling: This product should be handled only by, or under the close supervision of,
those properly qualified in the handling and use of potentially hazardous
chemicals, who should take into account the fire, health and chemical
hazard data. It should always be handled in an efficient fume hood or
equivalent system. The user should consider that the toxicological and
physiological properties of many compounds are not yet well determined
and that new hazardous products may arise from reactions between
chemicals. Care should be taken to prevent any chemical from coming into
contact with the skin or eyes and from contaminating personal clothing.
Storage: Store in a cool, dry, well ventilated area away from sources of heat and
incompatible substances. Keep container tightly closed when not in use.
Hygiene Practices: Wash thoroughly after handling. Avoid contact with eyes and skin. Avoid
inhaling dust.
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SECTION 8 : EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls: Use appropriate engineering control such as process enclosures, local
exhaust ventilation, or other engineering controls to control airborne
levels below recommended exposure limits. Where such systems are not
effective wear suitable personal protective equipment, which performs
satisfactorily and meets OSHA or other recognized standards. Consult with
local procedures for selection, training, inspection and maintenance of the
personal protective equipment.
Skin Protection Description: Wear suitable protective clothing to prevent contact with skin.
Hand Protection Description: Wear appropriate protective gloves. Consult glove manufacturers for glove
permeability data.
Eye/Face Protection: Wear appropriate protective glasses or splash goggles as described by 29
CFR 1910.133, OSHA eye and face protection regulation, or the European
standard EN 166.
Respiratory Protection: A NIOSH approved air-purifying respirator with an appropriate cartridge or
canister may be permissible under certain circumstances where airborne
concentrations are expected to exceed exposure limits. Protection
provided by air purifying respirators is limited to airborne concentrations
that are typically within 10 times the exposure limit. Use a positive
pressure air supplied respirator if there is any potential for an uncontrolled
release, exposure levels are not known, or any other circumstances where
air-purifying respirators may not provide adequate protection. A
respiratory protection program that meets OSHAs 29 CFR 1910.134 and
ANSI Z88.2 requirements must be followed whenever workplace
conditions warrant a respirators use.
Other Protective: Facilities storing or utilizing this material should be equipped with an
eyewash facility and a safety shower.
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SECTION 9 : PHYSICAL and CHEMICAL PROPERTIES
Physical State/Appearance: Solid
Color: White
Flash Point: No data
Boiling Point: No data
Melting Point: 154-155掳C (309.2-311掳F)
Solubility in Water: Almost insoluble
Density: No data
Molecular Formula: C 14H14O 3
Molecular Weight: 230.27
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SECTION 10 : STABILITY and REACTIVITY
Conditions to Avoid: High temperatures, flames and sparks.
Incompatibilities with Other Strong oxidizing agents. Strong reducing agents. Bases.
Materials:
Possible Decomposition Carbon monoxide.
Product:
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SECTION 11 : TOXICOLOGICAL INFORMATION
(S)鈥?(+)鈥?2鈥?(6鈥揗ethoxy鈥?2鈥搉aphthyl)propionic acid :
RTECS Number: UF5275000
Eye Effect: No data reported in the cited references as of the revision date.
Skin Effects: No data reported in the cited references as of the revision date.
Ingestion Effects: Oral - rat LD50: 248 mg/kg (RTECS);
Oral - mouse LD50: 360 mg/kg (RTECS);
Oral - guinea pig LD50: 665 mg/kg (RTECS);
Oral - woman LDLo: 200 mg/kg/10D-I [Behavioral - muscle contraction or
spasticity Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder
- changes in tubules (including acute renal failure, acute tubular necrosis)]
(RTECS);
Oral - woman TDLo: 315 mg/kg/3W-I [Behavioral - excitement
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or
vomiting] (RTECS);
Oral - man TDLo: 214 mg/kg/30D-I [Liver - jaundice, other or unclassified
Liver - other changes Kidney, Ureter, Bladder - other changes in urine
composition] (RTECS);
Oral - Human TDLo: 50 mg/kg/7D-I [Behavioral - somnolence (general
depressed activity) Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes] (RTECS);
Oral - Human TDLo: 50 mg/kg/7D-I (RTECS);
Oral - man TDLo: 54 mg/kg [Gastrointestinal - nausea or vomiting Kidney,
Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria]
(RTECS);
Oral - man TDLo: 3429 mg/kg/35W-I [Vascular - BP elevation not
characterized in autonomic section Lungs, Thorax, or Respiration -
cyanosis] (RTECS);
Oral - woman TDLo: 126 mg/kg/3W-I [Lungs, Thorax, or Respiration -
fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea
Blood - eosinophilia] (RTECS);
Oral - woman TDLo: 900 mg/kg/9W-I [Skin and Appendages -
photosensitivity (after systemic exposure)] (RTECS);
Oral - woman TDLo: 40 mg/kg/2D-I [Kidney, Ureter, Bladder - changes in
tubules (including acute renal failure, acute tubular necrosis)] (RTECS);
Oral - woman TDLo: 70 mg/kg/W-I [Liver - jaundice, cholestatic] (RTECS)
Inhalation Effects: No data reported in the cited references as of the revision date.
Chronic Ingestion Effects: Oral - rat TDLo: 20 mg/kg/4D-I Gastrointestinal - ulceration or bleeding
from stomach;
Oral -rat TDLo: 970 mg/kg/17D-I Gastrointestinal - ulceration or bleeding
from small intestine Blood - other changes (RTECS);
Oral -rabbit TDLo: 280 mg/kg/4W-I Liver - liver function tests impaired
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases (RTECS)
Mutagenicity: Human mutation data reported. (RTECS).
Teratogenicity: Teratogenic effects. (RTECS)
Reproductive Toxicity: Human reproductive effects by ingestion (effects on newborn): change in
condition of newborn at birth, biochemical and metabolic effects, and
other neonatal measures or effects (Sax)
Other Toxicological Intraperitoneal - rat LD50: 354 mg/kg;
Information: Intraperitoneal - mouse LD50: 500 mg/kg;
Intravenous - mouse LD50: 435 mg/kg Behavioral - convulsions or effect
on seizure threshold Behavioral - excitement;
Subcutaneous - rat LD50: 928 mg/kg Lungs, Thorax, or Respiration -
dyspnea Nutritional and Gross Metabolic - body temperature decrease;
Subcutaneous - mouse LD50: 475 mg/kg
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SECTION 12 : ECOLOGICAL INFORMATION
Ecotoxicity: No information provided.
Bioaccumulation: No information provided.
Biodegredation: No information provided.
Environmental Stability: No information provided.
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SECTION 13 : DISPOSAL CONSIDERATIONS
Waste Disposal: Consult with the US EPA Guidelines listed in 40 CFR Part 261.3 for the
classifications of hazardous waste prior to disposal. Furthermore, consult
with your state and local waste requirements or guidelines, if applicable,
to ensure compliance. Arrange disposal in accordance to the EPA and/or
state and local guidelines, by a licensed disposal company.
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SECTION 14 : TRANSPORT INFORMATION
DOT Hazard Class: No data.
DOT Identification Number: No data.
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SECTION 15 : REGULATORY INFORMATION
(S)鈥?(+)鈥?2鈥?(6鈥揗ethoxy鈥?2鈥搉aphthyl)propionic acid :
TSCA 8(b): Inventory Status: No data
Risk Phrases: R22 Harmful if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrase: S26 In case of contact with eyes, rinse immediately with plenty of water
and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face
protection.
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SECTION 16 : ADDITIONAL INFORMATION
MSDS Preparation Date: January 1, 2002, Version 1
MSDS Revision Date: April 14, 2003.
Disclaimer:
This Health and Safety Information is correct to the best of our knowledge and belief at the date of its
publication but we cannot accept liability for any loss, injury or damage which may result from its use. We
shall ensure, so far as is reasonably practicable, that any revision of this Data Sheet is sent to all
customers to whom we have directly supplied this substance, but must point out that it is the
responsibility of any intermediate supplier to ensure that such revision is passed to the ultimate user. The
information given in the Data Sheet is designed only as a guidance for safe handling, storage and the use
of the substance. It is not a specification nor does it guarantee any specific properties. All chemicals
should be handled only by competent personnel, within a controlled environment.
Should further information be required, this can be obtained through the sales office whose address is at
the top of this data sheet. We welcome any additional information about our products that customers have
obtained by personal experience.
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