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File Name: gen-probe_com---301001.asp
                                                          Date Prepared: June 23,1999




Gen-Probe Product
Nonhazardous Statement


Product name: Mycobacterium Tuberculosis Direct (MTD)

Product description: Negative Control

MSDS number: 301001.019

As directed by the Code of Federal Regulations, Title 29, section 1910.1200 and the
California Code of Regulations, Title 8, section 5194, Hazard Communication, Gen-
Probe Incorporated has determined that the product mentioned above is
nonhazardous. A Material Safety Data Sheet (MSDS) is not required to be provided
with this product as determined by applicable federal and state hazard
communication regulations.
The information provided herein represents the most reasonable current information
available when this determination was made and is believed to be accurate and
dependable. Nevertheless, Gen-Probe Incorporated makes no representation as to
the accuracy or sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in
humans or animals. Use only as directed on the enclosed package insert. Gen-
Probe Incorporated will assume no liability for the improper use of this product by
misfeasance or malfeasance, nor will Gen-Probe Incorporated assume liability from
any nonfeasance as a result of the use of this product. Good laboratory practices
should be observed at all times, including, but not limited to, "universal precautions"
and "work practice controls." Skin, mucous membranes, or eyes that come in
contact with this product should be washed with plenty of water. If irritation results or
persists, get medical attention.
Date Prepared: June 23,1999




Gen-Probe Product
Nonhazardous Statement


Product name: Mycobacterium Tuberculosis Direct (MTD)

Product description: Positive Control

MSDS number: 301001.030

As directed by the Code of Federal Regulations, Title 29, section 1910.1200 and the
California Code of Regulations, Title 8, section 5194, Hazard Communication, Gen-
Probe Incorporated has determined that the product mentioned above is
nonhazardous. A Material Safety Data Sheet (MSDS) is not required to be provided
with this product as determined by applicable federal and state hazard
communication regulations.
The information provided herein represents the most reasonable current information
available when this determination was made and is believed to be accurate and
dependable. Nevertheless, Gen-Probe Incorporated makes no representation as to
the accuracy or sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in
humans or animals. Use only as directed on the enclosed package insert. Gen-
Probe Incorporated will assume no liability for the improper use of this product by
misfeasance or malfeasance, nor will Gen-Probe Incorporated assume liability from
any nonfeasance as a result of the use of this product. Good laboratory practices
should be observed at all times, including, but not limited to, "universal precautions"
and "work practice controls." Skin, mucous membranes, or eyes that come in
contact with this product should be washed with plenty of water. If irritation results or
persists, get medical attention.
Date Prepared: June 23,1999




Gen-Probe Product
Nonhazardous Statement


Product name: Mycobacterium Tuberculosis Direct (MTD)

Product description: Mycobacterium Amplification Reconstitution Buffer

MSDS number: 301001.124

As directed by the Code of Federal Regulations, Title 29, section 1910.1200 and the
California Code of Regulations, Title 8, section 5194, Hazard Communication, Gen-
Probe Incorporated has determined that the product mentioned above is
nonhazardous. A Material Safety Data Sheet (MSDS) is not required to be provided
with this product as determined by applicable federal and state hazard
communication regulations.
The information provided herein represents the most reasonable current information
available when this determination was made and is believed to be accurate and
dependable. Nevertheless, Gen-Probe Incorporated makes no representation as to
the accuracy or sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in
humans or animals. Use only as directed on the enclosed package insert. Gen-
Probe Incorporated will assume no liability for the improper use of this product by
misfeasance or malfeasance, nor will Gen-Probe Incorporated assume liability from
any nonfeasance as a result of the use of this product. Good laboratory practices
should be observed at all times, including, but not limited to, "universal precautions"
and "work practice controls." Skin, mucous membranes, or eyes that come in
contact with this product should be washed with plenty of water. If irritation results or
persists, get medical attention.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Lysing Tubes
MSDS number: 301001.018

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Sorbitol D-glucitol 5% 50-70-4




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.018




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.018




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Not applicable



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Sorbitol, anhydrous: orl-wmn TDLO-15,900 mg/kg; orl-rat LD50-17,800 mg/kg; ipr-mus
LD50-15 gm/kg.



Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.018




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Tuberculosis Hybridization Reagent
MSDS number: 301001.118

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Polyvinylpyrrolidone PVP 42% 9003-39-8


Lithium lauryl sulfate Dodecyl lithium sulfate 42% 2044-56-6


Succinic acid Butanedioic acid 16% 110-15-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.118




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.118




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Not applicable



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: strong oxidizing agents.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Polyvinylpyrrolidone: orl-rat LD50-100 gm/kg; ipr-mus LD50-12 gm/kg.
RTECS#: TR8370000 (Poly (1-vinyl-2-pyrrolidone) homopolymer).
Lithium lauryl sulfate: No Data Available.
Succinic acid: orl-rat LD50-2260 mg/kg; ipr-mus LD50-2702 mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.118




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Tuberculosis Lyophilized Amplification Reagent
MSDS number: 301001.119

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Polyvinylpyrrolidone PVP 51% 9003-39-8


Tris (hydroxymethyl) Tris base 5% 77-86-1
aminomethane




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.119




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention, if irritation
persists.

Inhalation: No specific treatment is necessary since this material is not likely to be hazardous
by inhalation. If exposed to excessive levels of vapors, remove to fresh air and
get medical attention if symptoms develop.


Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.119




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Lyophilized powder. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely solubel
pH- 7.5


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: stong oxidizing agents.
Hazardous
decomposition products
Carbon monoxide and carbon dioxide.
and polymerization:
Hazardous polymerization will not occur.


11. Toxicological Information
Polyvinylpyrrolidone: orl-rat LD50-100 gm/kg; ipr-mus LD50-12 gm/kg.
RTECS#: TR8370000 (Poly (1-vinyl-2-pyrrolidone) homopolymer).
Tris (hydroxymethyl) aminomethane: orl-rat LD50-5900 mg/kg; ivn-rat LD50-1800 mg/kg; ivn-
mus LD50-1210 mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.119




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Enzyme Dilution Buffer
MSDS number: 301001.120

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Polyoxyethylene sorbitan Tween 40 15% 9005-66-7
monopalmitate

Tris (hydroxymethyl) Trizma base 2% 77-86-1
aminomethane




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.120




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.120




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble



Other characteristics: Not determined as a whole.




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.

Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Polyoxyethylene sorbitan monopalmitate: ivn-rat LD50-1580 mg/kg; ivn-mus LD50-50 gm/kg.
RTECS #: WG2933000.
Tris (hydroxymethyl) aminomethane: orl-rat LD50-5900 mg/kg; ivn-rat LD50-1800 mg/kg; ivn-
mus LD50-1210 mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.120




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Specimen Dilution Buffer
MSDS number: 301001.121

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Tris (hydroxymethyl) Trizma Base 10% 77-86-1
aminomethane

Lithium Lauryl Sulfate Dodecyl lithium sulfate 3% 2044-56-6


N-Acetyl-L-Cysteine Acetylcysteine 2% 616-91-1




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.121




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Not applicable




7. Handling and Storage

Not applicable
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.121




8. Exposure Controls/Personal Protection

Ventilation: Not applicable


Protective gloves: Not applicable


Eye protection: Not applicable


Other equipment: Not applicable



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Not applicable

Hazardous
decomposition products
Not applicable
and polymerization:



11. Toxicological Information
Tris (hydroxymethyl) aminomethane: orl-rat LD50-5900 mg/kg; ivn-rat LD50-1800; ivn-mus
LD50-1210 mg/kg.
Lithium lauryl sulfate: No Data Available.
N-Acetyl-L-Cysteine: orl-rat LD50- 5050 mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.121




12. Ecological Information
Ecotoxicity and environmental fate: Not applicable




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Lyophilized Enzyme Reagent
MSDS number: 301001.139

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Trehalose alpa-D-glucopyranosyl 75% 6138-23-4
alpha-D-glucopyranoside

N-Acetyl-L-Cysteine Acetylcysteine 20% 616-91-1


N-[2-Hydroxyethyl] piperazine- HEPES 5% 7365-45-9
N'-[2-ethanesulfonic acid]




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.139




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Reduce possibility of material becoming airborne
by wiping up spill immediately with a damp cloth or paper towel and placing in a disposal
container.


7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.139




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Lyophilized powder. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble.
pH-7.5


Other characteristics: Not determined as a whole.




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents.
Hazardous
decomposition products
Carbon monoxide and carbon dioxide.
and polymerization:
Hazardous polymerization will not occur.


11. Toxicological Information
Trehalose: Contact exposure may cause skin, eye, or respiratory tract irritation.
N-[2-Hydroxyethyl] piperazine-N'-[2-ethanesulfonic acid]: May be harmful by inhalation,
ingestion, or skin absorption. May cause irritation.


The chemical, physical, and toxicological properties of these materials have not been
thoroughly investigated.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.139




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available.




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Selection Reagent
MSDS number: 301001.140

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Boric acid Boracic acid 4% 10043-35-3




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.140




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.140




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble
Specific gravity- 1.02
pH: 8.5
Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: Strong oxidizing agents.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Boric acid: orl-hmn LDLO-429 mg/kg; orl-rat LD50-2660 mg/kg; ivn-rat LD50-1330 mg/kg.
RTECS #: ED4550000.



Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information. This report contains only
selected information from the RTECS.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.140




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Hybridization Buffer
MSDS number: 301001.141

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Lithium chloride Not available 5% 7447-41-8


Lithium lauryl sulfate Dodecyl lithium sulfate 2% 2044-56-6


Succinic acid Butanedioic acid 1% 110-15-6




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.141




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: Not applicable

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Not applicable

Extinguishing instructions/media: Not applicable




6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.141




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- freely soluble



Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.

Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Lithium chloride: orl-hmn LDLO-200 mg/kg; orl-rat LD50-526 mg/kg; ipr-rat LD50-514 mg/kg.
Lithium lauryl sulfate: No Data Available.
Succinic acid: orl-rat LD50-2260 mg/kg; ipr-mus LD50-2702 mg/kg; ivn-mus LD50-1400
mg/kg.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.141




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.
Date Prepared: June 23,1999
Page 1 of 4




1. Chemical Product and Company Identification

Product name: Mycobacterium Tuberculosis Direct (MTD)
Product description: Mycobacterium Oil Reagent
MSDS number: 301001.150

MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
Gen-Probe Incorporated (800) 424-9300 (CHEMTREC National)
10210 Genetic Center Drive (703) 527-3887 (CHEMTREC International)
San Diego, CA 92121-4362 (858) 410-8000 (Gen-Probe Corporate Office)
For technical issues regarding reagents or instrumentation which do not pertain to a
hazardous spill, contact Gen-Probe Technical Service at (800) 523-5001 Monday through
Friday, 6:00 a.m. to 5:00 p.m. Pacific Time.


2. Composition/Information on Hazardous Ingredients
Percent
(weight/weight)
Component Synonym CAS number


Polydimethylsiloxane Dimethyl silicone 100% 63148-62-9




3. Hazards Identification

Emergency Overview: This material may be irritating to the skin, mucous membranes or
eyes. Contact should be avoided. Do not inhale or take internally.
Date Prepared:June 23,1999
Page 2 of 4
MSDS No: 301001.150




4. First Aid Measures
Skin contact: Wash with soap and water. Get medical attention if irritation develops or persists.

Eye contact: Immediately flush eyes with plenty of water. Get medical attention if irritation
persists.

Inhalation: No specific treatment is necessary because this material is not likely to be
hazardous by inhalation. If exposed to excessive levels of vapors or if cough or
other symptoms develop, remove exposed individual to fresh air and get medical
attention.

Ingestion: This substance may be harmful if swallowed. If swallowed, rinse mouth out with
water. Seek medical attention if adverse health symptoms develop.



5. Fire Fighting Measures
Flashpoint: >260 C (>500 F)

Upper and Lower flammable limit: Not applicable

Flammability classification: Not applicable

General fire hazard information: Emits toxic fumes under fire conditions.

Extinguishing instructions/media: Extinguishing media- water spray, carbon dioxide, or dry
chemical.


6. Accidental Release Measures
Containment, treatment, and clean-up procedures:
Wear suitable laboratory protective clothing. Absorb spill with inert material then place in a
disposal container.



7. Handling and Storage

Observe good laboratory handling practices. Always wash hands thoroughly after removing
protective gloves.
Date Prepared:June 23,1999
Page 3 of 4
MSDS No: 301001.150




8. Exposure Controls/Personal Protection

Ventilation: General room ventilation is satisfactory.


Protective gloves: Impervious chemical-resistant gloves.


Eye protection: Safety glasses and faceshield or goggles.


Other equipment: Safety shower, eye wash, and other applicable equipment.



9. Physical and Chemical Properties

Physical state, appearance and Odor: Clear liquid. Odorless.


Vapor pressure and density, specific
density, solubility, pH, etc: Solubility in water- insoluble
Specific gravity- 0.92


Other characteristics: Not applicable




10. Stability and Reactivity
Conditions to avoid: Stable under normal temperature and pressures.
Incompatibilities: alkali and acids.
Hazardous
decomposition products
Hazardous polymerization will not occur.
and polymerization:



11. Toxicological Information
Polydimethylsiloxane: orl-rat LD50- >35g/kg; skn-rbt LD50-3g/kg; inh-rat LC50- 11mg/l.




Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for definition of
abbreviations used in the above text and for additional information.
Date Prepared:June 23,1999
Page 4 of 4
MSDS No: 301001.150




12. Ecological Information
Ecotoxicity and environmental fate: Data not yet available




13. Disposal Considerations
Dispose of by means as to comply with federal, state, and local regulations.




14. Transport Information
Proper shipping name and identification number: Not applicable


Hazard class: Not applicable



15. Regulatory Information

The information provided herein represents the most reasonable current information available
when this determination was made and is believed to be accurate and dependable.
Nevertheless, Gen-Probe Incorporated makes no representation as to the accuracy or
sufficiency of this information.

This product, or all the components thereof, is not for internal or external use in humans or
animals. Use only as directed on the enclosed package insert. Gen-Probe Incorporated will
assume no liability for the improper use of this product by misfeasance or malfeasance, nor
will Gen-Probe Incorporated assume liability from any nonfeasance as a result of the use of
this product. Good laboratory practices should be observed at all times, including, but not
limited to, "universal precautions" and "work practice controls." Skin, mucous membranes, or
eyes that come in contact with this product should be washed with plenty of water. If irritation
results or persists, get medical attention.




16. Other Information

None.

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