PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 1 of 12
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
PROPYLENE GLYCOL
SYNONYMS
C3-H8-O2, "1, 2-propandiol", "1, 2-propandiol", "methylethylene glycol", "monopropylene
glycol", "propane-1, 2-diol", "propane-1, 2-diol", "propan-1, 2-diol", "propan-1, 2-diol"
, "alpha-propylene glycol", "1, 2-propylene glycol", "1, 2-propylene glycol", Sirlene,
"Solar winter ban", "trimethyl glycol", "methyl glycol", Dowfrost, PG-12, "1, 2
-dihydroxypropane", "1, 2-dihydroxypropane", USP, "humectant 1520"
PRODUCT USE
A large volume industrial chemical. Manufacture of polypropylene glycols and polyester
resins, cellophane. Component of brake fluids, antifreeze solution, aircraft deicing
fluid. As Food additive 1520, used as a humectant to prevent foods drying out and as
solvent for fats, flavouring extracts, perfumes, colours, antioxidants. Used in cosmetics,
pharmaceuticals, cleansing creams, sun tan lotions. Mild retardation of mould, fungal
growth and is used a preservative, humectant in tobacco. Animal feed and pet food
component. Used in textiles as conditioner, softener, plasticiser. As a coolant in
refrigeration systems. Has been used as obscurant fog in smoke generators.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 2 of 12
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Inhalation and/or ingestion may produce health Do not breathe gas/ fumes/ vapour/ spray.
damage*.
May produce discomfort of the eyes and skin*. Wear eye/ face protection.
Possible skin sensitiser*. Use only in well ventilated areas.
Vapours potentially cause drowsiness and Keep container in a well ventilated place.
dizziness*.
* (limited evidence). Keep container tightly closed.
Take off immediately all contaminated clothing.
In case of contact with eyes rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
propylene glycol 57-55-6 >98
Section 4 - FIRST AID MEASURES
SWALLOWED
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 3 of 12
Section 4 - FIRST AID MEASURES
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Propylene glycol is primarily a CNS depressant in large doses and may cause hypoglycaemia
, lactic acidosis and seizures.
路 The usual measures are supportive care and decontamination (Ipecac/ lavage/ activated
charcoal/ cathartics), within 2 hours of exposure should suffice.
路 Check the anion gap, arterial pH, renal function and glucose levels.
Ellenhorn and Barceloux: Medical Toxicology.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Alcohol stable foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
路 Water spray or fog - Large fires only.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear full body protective clothing with breathing apparatus.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Use water delivered as a fine spray to control fire and cool adjacent area.
路 Avoid spraying water onto liquid pools.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Combustible.
路 Slight fire hazard when exposed to heat or flame.
路 Heating may cause expansion or decomposition leading to violent rupture of containers.
路 On combustion, may emit toxic fumes of carbon monoxide (CO).
路 May emit acrid smoke.
路 Mists containing combustible materials may be explosive.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), other
pyrolysis products typical of burning organic material.
May emit poisonous fumes.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Gas tight chemical resistant suit.
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 4 of 12
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid breathing vapours and contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Contain and absorb spill with sand, earth, inert material or vermiculite.
路 Wipe up.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
Chemical Class: alcohols and glycols
For release onto land: recommended sorbents listed in order of priority.
SORBENT TYPE RANK APPLICATION COLLECTION LIMITATIONS
LAND SPILL - SMALL
cross- linked 1 shovel shovel R, W, SS
polymer -
particulate
cross- linked 1 throw pitchfork R, DGC, RT
polymer - pillow
sorbent clay - 2 shovel shovel R, I, P
particulate
wood fiber - 3 throw pitchfork R, P, DGC, RT
pillow
treated wood fiber 3 throw pitchfork DGC, RT
- pillow
foamed glass - 4 throw pichfork R, P, DGC, RT
pillow
LAND SPILL - MEDIUM
cross- linked 1 blower skiploader R, W, SS
polymer -
particulate
polypropylene - 2 blower skiploader W, SS, DGC
particulate
sorbent clay - 2 blower skiploader R, I, W, P, DGC
particulate
polypropylene - 3 throw skiploader DGC, RT
mat
expanded mineral - 3 blower skiploader R, I, W, P, DGC
particulate
polyurethane - mat 4 throw skiploader DGC, RT
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 5 of 12
Section 6 - ACCIDENTAL RELEASE MEASURES
Legend
DGC: Not effective where ground cover is dense
R; Not reusable
I: Not incinerable
P: Effectiveness reduced when rainy
RT:Not effective where terrain is rugged
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation 1988.
Moderate hazard.
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 No smoking, naked lights or ignition sources.
路 Increase ventilation.
路 Stop leak if safe to do so.
路 Contain spill with sand, earth or vermiculite.
路 Collect recoverable product into labelled containers for recycling.
路 Absorb remaining product with sand, earth or vermiculite.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise emergency services.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
propylene glycol 750 ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
propylene glycol 75 ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
propylene glycol 50 ppm
The threshold concentration below which most people will experience no appreciable risk of health effects:
propylene glycol 50 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
DO NOT allow clothing wet with material to stay in contact with skin.
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 6 of 12
Section 7 - HANDLING AND STORAGE
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 Avoid smoking, naked lights or ignition sources.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to
ensure safe working conditions.
SUITABLE CONTAINER
路 Metal can or drum
路 Packaging as recommended by manufacturer.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Avoid storage with strong acids, acid chlorides, acid anhydrides, oxidising agents.
Incompatible with aluminium. DO NOT heat above 49 deg. C. in aluminium equipment.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 No smoking, naked lights or ignition sources.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ + + + + +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA ppm TWA mg/m鲁
_________ _________ _____ _____
Australia Exposure propylene glycol 10
Standards (Propane- 1, 2- diol:
particulates only)
Australia Exposure propylene glycol 150 474
Standards (Propane- 1, 2- diol
total: (vapour &
particulates))
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 7 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
MATERIAL DATA
Saturated vapour concentration @ 20 deg C.= 65.8 ppm, 204.6 mg/m3; i.e
higher concentrations can only occur as aerosols or at higher temperatures.
Odour Threshold: Practically odourless.
A small number of individuals show skin irritation or sensitisation from
repeated or prolonged exposure to propylene glycol. A workplace
environmental exposure limit (WEEL) has been established by AIHA and is
thought to be protective against systemic effects.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
#72glove#726#72glosen#76a-p()
#76a-p()
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
" Forsberg Clothing Performance Index" .
The effect(s) of the following substance(s) are taken into account in the
computer- generated selection: propylene glycol
Protective Material CPI *.
__________________________________________
PE/EVAL/PE A
__________________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 8 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent use.
A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing
zone contaminant and the chemical nature of the contaminant. Protection Factors (defined
as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level Maximum Protection Half- face Respirator Full- Face Respirator
ppm (volume) Factor
1000 10 A- AUS P -
1000 50 - A- AUS P
5000 50 Airline * -
5000 100 - A- 2 P
10000 100 - A- 3 P
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation usually required. If risk of overexposure exists, wear approved
respirator. Correct fit is essential to obtain adequate protection. Supplied-air type
respirator may be required in special circumstances. Correct fit is essential to ensure
adequate protection.
An approved self contained breathing apparatus (SCBA) may be required in some situations.
Provide adequate ventilation in warehouse or closed storage area. Air contaminants
generated in the workplace possess varying "escape" velocities which, in turn, determine
the "capture velocities" of fresh circulating air required to effectively remove the
contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 9 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Material is hygroscopic, absorbs moisture from surrounding air. Colourless, moderately
viscous, combustible liquid; mixes with water. Practically odourless with a slightly acrid
taste. Soluble in acetone, chloroform, ether and many organic solvents. Will dissolve
essential oils, but not hydrocarbon oils. Available as Technical, BP and Food grades.
PHYSICAL PROPERTIES
Liquid.
Mixes with water.
Molecular Weight: 76.11 Boiling Range (掳C): 187.4
Melting Range (掳C): - 59 Specific Gravity (water=1): 1.04 @ 20 C
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): 0.01 @ 20 C
Volatile Component (%vol): 100 Evaporation Rate: Not available
Relative Vapour Density (air=1): 2.6 Flash Point (掳C): 103
Lower Explosive Limit (%): 2.6 Upper Explosive Limit (%): 12.6
Autoignition Temp (掳C): 421 Decomposition Temp (掳C): Not available.
State: Liquid Viscosity: Not Available
log Kow (Prager 1995): - 0.92
log Kow (Sangster 1997): - 0.92
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 10 of 12
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be damaging to the health of the individual.
Overexposure to non-ring alcohols causes nervous system symptoms. These include headache,
muscle weakness and inco-ordination, giddiness, confusion, delirium and coma. Digestive
symptoms may include nausea, vomiting and diarrhoea. Aspiration is much more dangerous
than ingestion because lung damage can occur and the substance is absorbed into the body.
Alcohols with ring structures and secondary and tertiary alcohols cause more severe
symptoms, as do heavier alcohols.
Ingestion of propylene glycol produced reversible central nervous system depression in
humans following ingestion of 60 ml. Symptoms included increased heart-rate (tachycardia)
, excessive sweating (diaphoresis) and grand mal seizures in a 15 month child who
ingested large doses (7.5 ml/day for 8 days) as an ingredient of vitamin preparation.
Excessive repeated ingestions may cause hypoglycaemia (low levels of glucose in the blood
stream) among susceptible individuals; this may result in muscular weakness,
incoordination and mental confusion.
Very high doses given during feeding studies to rats and dogs produce central nervous
system depression (although one-third of that produced by ethanol), haemolysis and
insignificant kidney changes.
In humans propylene glycol is partly excreted unchanged in the urine and partly
metabolised as lactic and pyruvic acid. Lactic acidosis may result.
If swallowed, the toxic effects of glycols (dihydric alcohols) are similar to those of
alcohol, with depression of the central nervous system, nausea, vomiting, and
degenerative changes in the liver and kidney.
EYE
Irritation of the eyes may produce a heavy secretion of tears (lachrymation).
Limited evidence or practical experience suggests, that the material may cause eye
irritation in a substantial number of individuals. Prolonged eye contact may cause
inflammation characterised by a temporary redness of the conjunctiva (similar to
windburn).
SKIN
There is some evidence to suggest that the material may cause moderate inflammation of
the skin either following direct contact or after a delay of some time. Repeated exposure
can cause contact dermatitis which is characterised by redness, swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
Most liquid alcohols appear to act as primary skin irritants in humans. Significant
percutaneous absorption occurs in rabbits but not apparently in man.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
A single prolonged exposure is not likely to result in the material causing harm. However
, when applied in large quantities to damaged skin as a topical preparation or by contact
with clothing accidentally contaminated by the material, there may be the potential to
absorb the material in harmful amounts. This can lead to shock.
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the
course of normal handling, may be damaging to the health of the individual.
Inhalation hazard is increased at higher temperatures.
Aliphatic alcohols with more than 3-carbons cause headache, dizziness, drowsiness, muscle
weakness and delirium, central depression, coma, seizures and behavioural changes.
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 11 of 12
Section 11 - TOXICOLOGICAL INFORMATION
Secondary respiratory depression and failure, as well as low blood pressure and irregular
heart rhythms, may follow. Nausea and vomiting are seen, and liver and kidney damage is
possible as well following massive exposures. Symptoms are more acute the more carbons
there are in the alcohol.
The material is not thought to produce respiratory irritation (as classified by EC
Directives using animal models). Nevertheless inhalation of vapours, fumes or aerosols,
especially for prolonged periods, may produce respiratory discomfort and occasionally,
distress.
Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by
sleepiness, reduced alertness, loss of reflexes, lack of co-ordination, and vertigo.
CHRONIC HEALTH EFFECTS
There is limited evidence that, skin contact with this product is more likely to cause a
sensitisation reaction in some persons compared to the general population.
Propylene glycol is though, by some, to be a sensitising principal following the regular
use of topical creams by eczema patients. A study of 866 persons using a formulation
containing propylene glycol in a patch test indicated that propylene glycol caused
primary irritation in 16% of exposed individuals probably caused by dehydration.
Undiluted propylene glycol was tested on 1556 persons in a 24 hour patch test. 12.5%
showed reactions which were largely toxic (70%) or allergic in nature (30%). Reaction
responses reached their maximum on the second day or later. Reactions were seasonal in
nature ranging from 17.8% in winter to 9.2% in other seasons. In a patch-test using 25
standard allergens conducted on 500 individuals, propylene glycol ranked fourth in
sensitising response. 84 subjects were patch tested using 100% propylene glycol. as well
as 2% and 5% in water. With undiluted material, 15% demonstrated a reaction, with 40% of
the reactions being allergic in nature and 60% being irritant. In dilute solutions 5 of
248 subjects exhibited a reaction.
Undiluted propylene glycol tested on the skin of man produced no irritation under open
conditions but when applied under occlusive conditions, for 2 weeks, it produced severe
erythema, oedema and vesicles, probably due to sweat retention and weak primary
irritation.
Predictive contact skin sensitisation tests indicate that propylene glycol is an
intermediate grade sensitiser with an index of 1% of tested subjects.
Groups of cats fed 5 gm/kg/day of propylene glycol for 14 weeks showed a significant dose
-related increase in red blood cell Heinz body formation without any marked signs of
haemolytic anaemia. The no-effect-level for cats without formation of Heinz bodies is 100
-500 ml/kg. There is no evidence of anaemia or degenerative change. Groups of rats dosed
orally with 0.5 or 10 mg/kg/day for 12 weeks had lowered food intake but no adverse
effects on body weights. Erythrocytes were more fragile. Heinz bodies were not apparent.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 20000 mg/kg Skin(human):500 mg/7days Mild
Dermal (rabbit) LD50: 20800 mg/kg Skin(human):104 mg/3d Intermit Moderate
Dermal (rabbit) LD50: 11890 mg/kg Eye (rabbit): 100 mg - Mild
Eye (rabbit): 500 mg/24h - Mild
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
Section 12 - ECOLOGICAL INFORMATION
log Kow (Prager 1995): - 0.92
log Kow (Sangster 1997): - 0.92
log Pow (Verschueren 1983): 4.7
BOD5: 0.955 (2.2
BOD20: 1.225
PROPYLENE GLYCOL
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 26-Mar-2007 CHEMWATCH 10708
NC317TCP Version No:1
CD 2007/3 Page 12 of 12
Section 12 - ECOLOGICAL INFORMATION
ThOD: 1.685
DO NOT discharge into sewer or waterways.
log Kow: -1.41- -0.3
Half-life (hr) air: 32
Henry's atm m鲁 /mol: 1.20E-08
BOD 5 if unstated: 0.995,2.2%
ThOD: 1.685
BCF: <1
Bioacculmulation: not sig
processes Abiotic: photoxid
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Consult State Land Waste Authority for disposal.
路 Bury or incinerate residue at an approved site.
路 Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
propylene glycol (CAS: 57-55-6) is found on the following regulatory lists;
Australia - Australian Capital Territory - Environment Protection Regulation: Ambient environmental standards (Domestic water supply - inorganic chemicals)
Australia - Australian Capital Territory Environment Protection Regulation Pollutants entering waterways - Agricultural uses (Stock)
Australia - Australian Capital Territory Environment Protection Regulation Pollutants entering waterways - Domestic water quality
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
IMO MARPOL 73/78 (Annex II) - List of Other Liquid Substances
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 26-Mar-2007
Print Date: 4-Jan-2008
|