SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 1 of 13
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
SODIUM FLUORIDE
SYNONYMS
"Sodium Fluoride Extra Pure Ph. Eur, BP, USP, ", "Product code: 1.06441", NaF, FNa, Na
-F, "disodium difluoride", "fluoride, sodium", "natrium fluoride", "roach salt", "sodium
monofluoride", villaumite, fluorigard, fluoritab, gleem, pennwhite
PROPER SHIPPING NAME
SODIUM FLUORIDE, SOLID
PRODUCT USE
As an insecticide, used in other pesticide formulations; a constituent of vitreous enamel
and glass mixes; as a steel degreasing agent; in electroplating; in fluxes; in heat
treating salt compositions. Used in the fluoridation of drinking water; manufacture of
coated paper; frosting glass; in dental laboratories; in the removal of HF from exhaust
gases to reduce air pollution. Also used as a disinfection for fermentation apparatus in
breweries and distilleries.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 2 of 13
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
S6
RISK SAFETY
Toxic if swallowed. Keep locked up.
Contact with acids liberates very toxic gas. Do not breathe dust.
Irritating to eyes and skin. Avoid contact with eyes.
Inhalation and/or skin contact may produce Wear suitable protective clothing.
health damage*.
Cumulative effects may result following In case of insufficient ventilation wear
exposure*. suitable respiratory equipment.
May produce discomfort of the respiratory Use only in well ventilated areas.
system*.
Limited evidence of a carcinogenic effect*. Keep container in a well ventilated place.
* (limited evidence). To clean the floor and all objects contaminated
by this material use water.
This material and its container must be disposed
of in a safe way.
Keep away from food drink and animal feeding
stuffs.
Take off immediately all contaminated clothing.
In case of contact with eyes rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
sodium fluoride 7681-49-4 > 98
Section 4 - FIRST AID MEASURES
SWALLOWED
For advice, contact a Poisons Information Centre or a doctor.
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 3 of 13
Section 4 - FIRST AID MEASURES
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Seek medical advice.
EYE
If this product or its vapours come in contact with the eyes,
路 DO NOT DELAY: Immediately irrigate continuously by holding the eyelids apart and
washing with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital, eye clinic or eye specialist, ophthalmologist without delay.
SKIN
If there is evidence of severe skin irritation or skin burns:
路 Avoid further contact. Immediately remove contaminated clothing, including footwear.
路 Flush skin under running water for 15 minutes.
路 Avoiding contamination of the hands, massage calcium gluconate gel into affected areas,
pay particular attention to creases in skin.
路 Contact the Poisons Information Centre.
路 Continue gel application for at least 15 minutes after burning sensation ceases.
路 If pain recurs, repeat application of calcium gluconate gel or apply every 20 minutes.
路 If no gel is available, continue washing for at least 15 minutes, using soap if
available. If patient is conscious, give six calcium gluconate or calcium carbonate
tablets in water by mouth.
路 Transport to hospital, or doctor, urgently.
INHALED
For massive exposures:
路 If dusts, vapours, aerosols, fumes or combustion products are inhaled, remove from
contaminated area.
路 Lay patient down.
路 Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 If victim is conscious, give six calcium gluconate or calcium carbonate tablets in
water by mouth.
路 Transport to hospital, or doctor, urgently.
NOTES TO PHYSICIAN
For acute or short term repeated exposures to fluorides:
路 Fluoride absorption from gastro-intestinal tract may be retarded by calcium salts, milk
or antacids.
路 Fluoride particulates or fume may be absorbed through the respiratory tract with 20-30%
deposited at alveolar level.
路 Peak serum levels are reached 30 mins. post-exposure; 50% appears in the urine within
24 hours.
路 For acute poisoning (endotracheal intubation if inadequate tidal volume), monitor
breathing and evaluate/monitor blood pressure and pulse frequently since shock may
supervene with little warning. Monitor ECG immediately; watch for arrhythmias and
evidence of Q-T prolongation or T-wave changes. Maintain monitor. Treat shock vigorously
with isotonic saline (in 5% glucose) to restore blood volume and enhance renal excretion.
路 Where evidence of hypocalcaemic or normocalcaemic tetany exists, calcium gluconate (10
ml of a 10% solution) is injected to avoid tachycardia.
BIOLOGICAL EXPOSURE INDEX - BEI
These represent the determinants observed in specimens collected from a healthy worker
exposed at the Exposure Standard (ES or TLV):
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 4 of 13
Section 4 - FIRST AID MEASURES
Determinant Index Sampling Time Comments
Fluorides in urine 3 mg/gm creatinine Prior to shift B, NS
10mg/gm creatinine End of shift B, NS
B: Background levels occur in specimens collected from subjects NOT exposed
NS: Non-specific determinant; also observed after exposure to other exposures.
Following acute or short term repeated exposure to hydrofluoric acid:
路 Subcutaneous injections of Calcium Gluconate may be necessary around the burnt area.
Continued application of Calcium Gluconate Gel or subcutaneous Calcium Gluconate should
then continue for 3-4 days at a frequency of 4-6 times per day. If a "burning" sensation
recurs, apply more frequently.
路 Systemic effects of extensive hydrofluoric acid burns include renal damage,
hypocalcaemia and consequent cardiac arrhythmias. Monitor haematological, respiratory,
renal, cardiac and electrolyte status at least daily. Tests should include FBE, blood
gases, chest X-ray, creatinine and electrolytes, urine output, Ca ions, Mg ions and
phosphate ions. Continuous ECG monitoring may be required.
路 Where serum calcium is low, or clinical, or ECG signs of hypocalcaemia develop,
infusions of calcium gluconate, or if less serious, oral Sandocal, should be given.
Hydrocortisone 500 mg in a four to six hourly infusion may help.
路 Antibiotics should not be given as a routine, but only when indicated.
路 Eye contact pain may be excruciating and 2-3 drops of 0.05% pentocaine hydrochloride
may be instilled, followed by further irrigation
BIOLOGICAL EXPOSURE INDEX - BEI
These represent the determinants observed in specimens collected from a healthy worker
exposed at the Exposure Standard (ES or TLV):
Determinant Index Sampling Time Comments
1. Methaemoglobin in 1.5% of haemoglobin During or end of shift B, NS, SQ
blood
B: Background levels occur in specimens collected from subjects NOT exposed.
NS: Non-specific determinant; Also seen after exposure to other materials
SQ: Semi-quantitative determinant - Interpretation may be ambiguous; should be used as a
screening test or confirmatory test.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Water spray or fog.
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 5 of 13
Section 5 - FIRE FIGHTING MEASURES
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
Non combustible. Not considered to be a significant fire risk.
Decomposes on heating and produces toxic and corrosive fumes of fluorides.
FIRE INCOMPATIBILITY
Contact with acids liberates very toxic gases.
Decomposition may produce toxic fumes of: hydrogen fluoride.
HAZCHEM: 2Z
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Wear impervious gloves and safety glasses.
路 Use dry clean up procedures and avoid generating dust.
路 Sweep up or
路 Vacuum up (consider explosion-proof machines designed to be grounded during storage and
use).
路 Place spilled material in clean, dry, sealable, labelled container.
MAJOR SPILLS
路 Clear area of personnel and move upwind.
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water course.
路 Stop leak if safe to do so.
路 Contain spill with sand, earth or vermiculite.
路 Collect recoverable product into labelled containers for recycling.
路 Neutralise/decontaminate residue.
路 Collect solid residues and seal in labelled drums for disposal.
路 Wash area and prevent runoff into drains.
路 After clean up operations, decontaminate and launder all protective clothing and
equipment before storing and re-using.
路 If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 6 of 13
Section 6 - ACCIDENTAL RELEASE MEASURES
Isolation Distance 25 metres
Downwind Protection Distance 250 metres
IERG Number 37
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 154 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
sodium fluoride 75 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
sodium fluoride 5.00 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
sodium fluoride 5 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
sodium fluoride 5 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 7 of 13
Section 7 - HANDLING AND STORAGE
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Store in an isolated area away from other materials.
Plastic drum. or Steel drum with plastic liner.
Multi-ply woven plastic or paper bag with sealed plastic liner
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse.
路 Check that containers are clearly labelled.
Packaging as recommended by manufacturer.
STORAGE INCOMPATIBILITY
Segregate from. strong acids, oxidising agents.
Contact with acids produces toxic fumes., i.e hydrogen fluoride.
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
X X + X X +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
The following materials had no OELs on our records
鈥? sodium fluoride: CAS:7681- 49- 4
MATERIAL DATA
Based on a study in which the threshold for minimum increase in bone density due to
fluoride exposure was 3.38 mg/m3 (as fluoride), the present TLV-TWA has been adopted to
prevent irritant effects and disabling bone changes. There is also support for the
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 8 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
proposition that occupational exposure below the TLV will have no adverse effect on
pregnant women or off-spring. IARC has classified fluorides in drinking water as Group 3
carcinogens; i.e. Not classifiable as to its carcinogenicity to humans. Equivocal
evidence of carcinogenic activity (osteosarcoma) has been found in male rats administered
sodium fluoride in drinking water. (0-175 ppm) Evidence was not found in female rats or
in male or female mice.
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields; or as required,
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Wear chemical protective gloves, eg. PVC.
Wear safety footwear.
OTHER
路 Overalls.
路 Barrier cream
路 Eyewash unit.
Always ensure that a supply, is on hand, of calcium gluconate gel for treatment of burns
and calcium carbonate tablets for accidental ingestion.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
路 Local exhaust ventilation is required where solids are handled as powders or crystals;
even when particulates are relatively large, a certain proportion will be powdered by
mutual friction.
路 Exhaust ventilation should be designed to prevent accumulation and recirculation of
particulates in the workplace.
路 If in spite of local exhaust an adverse concentration of the substance in air could
occur, respiratory protection should be considered. Such protection might consist of:
(a): particle dust respirators, if necessary, combined with an absorption cartridge;
(b): filter respirators with absorption cartridge or canister of the right type;
(c): fresh-air hoods or masks
路 Build-up of electrostatic charge on the dust particle, may be prevented by bonding and
grounding.
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 9 of 13
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
Air contaminants generated in the workplace possess varying "escape" velocities which, in
turn, determine the "capture velocities" of fresh circulating air required to efficiently
remove the contaminant.
Type of Contaminant: Air Speed:
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 4-10
m/s (800-2000 f/min) for extraction of crusher dusts generated 2 metres distant from the
extraction point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
In confined spaces where there is inadequate ventilation, wear full-face air supplied
breathing apparatus.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White, odourless powder or crystals. Soluble in water, very slightly soluble in alcohol.
May also be available as blue tinted crystals.
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Acid.
Contact with acids liberates very toxic gas.
Molecular Weight: 42.0 Boiling Range (掳C): 1695
Melting Range (掳C): 988 Specific Gravity (water=1): 2.56- 2.79
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 10 of 13
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
pH (1% solution): 7.4 (saturated) Vapour Pressure (kPa): 0.13 @ 1077 C
Volatile Component (%vol): Not available. Evaporation Rate: Not available
Relative Vapour Density (air=1): Not available. Flash Point (掳C): Not applicable
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
Autoignition Temp (掳C): Not applicable Decomposition Temp (掳C): Not available.
State: Divided solid Viscosity: Not available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The material is. extremely discomforting and toxic if swallowed.
Considered an unlikely route of entry in commercial/industrial environments.
Fluoride causes severe loss of calcium in the blood, with symptoms appearing several
hours later including painful and rigid muscle contractions of the limbs. Cardiovascular
collapse can occur and may cause death with increased heart rate and other heart rhythm
irregularities. The brain and kidneys may be affected. Other toxic effects include
headache, increased saliva output, jerking of the eyeball and dilated pupils, lethargy,
stupor, coma and rarely, convulsions.
Ingestion of acidic corrosives may produce burns around and in the mouth, the throat and
oesophagus. Immediate pain and difficulties in swallowing and speaking may also be
evident. Swelling of the epiglottis may make it difficult to breathe which may result in
suffocation. More severe exposure may result in vomiting blood and thick mucus, shock,
abnormally low blood pressure, fluctuating pulse, shallow respiration and clammy skin,
inflammation of stomach wall, and rupture of oesophageal tissue. Untreated shock may
eventually result in kidney failure. Severe cases may result in perforation of the
stomach and abdominal cavity with consequent infection, rigidity and fever. There may be
severe narrowing of the oesophageal or pyloric sphincters; this may occur immediately or
after a delay of weeks to years. There may be coma and convulsions, followed by death due
to infection of the abdominal cavity, kidneys or lungs.
EYE
The dust is. extremely discomforting to the eyes and is capable of causing severe damage
with loss of sight.
The material may produce moderate eye irritation leading to inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
SKIN
The liquid is extremely discomforting to the skin and may cause chemical burns.
Solution of material in moisture on the skin, or perspiration, may markedly increase skin
corrosion and accelerate tissue destruction.
Toxic effects may result from skin absorption.
Fluorides are easily absorbed through the skin and cause death of soft tissue and erode
bone. Healing is delayed and death of tissue may continue to spread beneath skin.
Skin contact with acidic corrosives may result in pain and burns; these may be deep with
distinct edges and may heal slowly with the formation of scar tissue.
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 11 of 13
Section 11 - TOXICOLOGICAL INFORMATION
INHALED
The dust is. highly discomforting to the upper respiratory tract and lungs.
Persons with impaired respiratory function, airway diseases and conditions such as
emphysema or chronic bronchitis, may incur further disability if excessive concentrations
of particulate are inhaled.
Acute effects of fluoride inhalation include irritation of nose and throat, coughing and
chest discomfort. A single acute over-exposure may even cause nose bleed. Pre-existing
respiratory conditions such as emphysema, bronchitis may be aggravated by exposure.
Occupational asthma may result from exposure.
Corrosive acids can cause irritation of the respiratory tract, with coughing, choking and
mucous membrane damage. There may be dizziness, headache, nausea and weakness. Swelling
of the lungs can occur, either immediately or after a delay; symptoms of this include
chest tightness, shortness of breath, frothy phlegm and cyanosis. Lack of oxygen can
cause death hours after onset.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are by accidental skin and eye contact and inhalation of
generated dusts.
Extended exposure to inorganic fluorides causes fluorosis, which includes signs of joint
pain and stiffness, tooth discolouration, nausea and vomiting, loss of appetite,
diarrhoea or constipation, weight loss, anaemia, weakness and general unwellness. There
may also be frequent urination and thirst. Redness, itchiness and allergy-like
inflammation of the skin and mouth cavity can occur. The central nervous system may be
involved.
Repeated or prolonged exposure to acids may result in the erosion of teeth, swelling
and/or ulceration of mouth lining. Irritation of airways to lung, with cough, and
inflammation of lung tissue often occurs. Chronic exposure may inflame the skin or
conjunctiva.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (human) LDLo: 71 mg/kg Eye (rabbit): 20 mg/24h- Moderate
Oral (woman) LDLo: 90 mg/kg
Oral (human) TDLo: 0.21 mg/kg
Oral (woman) TDLo: 7 mg/kg
Oral (man) TDLo: 1662 mg/kg
Oral (rat) LD50: 52 mg/kg
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
sodium fluoride IARC:3
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: sodium fluoride
Category: 3
Section 12 - ECOLOGICAL INFORMATION
Toxicity invertebrate: LC50 (48h) 1987 ppm
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 12 of 13
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Consult State Land Waste Management Authority for disposal.
路 Treat and neutralise at an effluent treatment plant.
路 Use soda ash or slaked lime to neutralise.
路 Recycle containers, otherwise dispose of in an authorised landfill.
For small quantities:
路 Cautiously dissolve in water
路 Neutralise with sodium carbonate or if product does not dissolve completely add a small
quantity of hydrochloric acid followed by sodium carbonate
路 Add excess calcium chloride to precipitate the fluoride and/ or carbonate
路 Remove solids to site approved for hazardous waste.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: TOXIC
HAZCHEM: 2Z
UNDG:
Dangerous Goods Class: 6.1 Subrisk: None
UN Number: 1690 Packing Group: III
Shipping Name:SODIUM FLUORIDE, SOLID
Air Transport IATA:
ICAO/IATA Class: 6.1 ICAO/IATA Subrisk: None
UN/ID Number: 1690 Packing Group: III
Special provisions: None
Shipping Name: SODIUM FLUORIDE, SOLID
Maritime Transport IMDG:
IMDG Class: 6.1 IMDG Subrisk: None
UN Number: 1690 Packing Group: III
EMS Number: F- A, S- A Special provisions: None
Shipping Name: SODIUM FLUORIDE, SOLID
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: S6
REGULATIONS
sodium fluoride (CAS: 7681-49-4) is found on the following regulatory lists;
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4
International Agency for Research on Cancer (IARC) Carcinogens
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
The Australia Group Export Control List: Chemical Weapons Precursors
SODIUM FLUORIDE
Chemwatch Material Safety Data Sheet
Issue Date: 27-Oct-2006 CHEMWATCH 1690-1
NC317TCP Version No:1
CD 2007/3 Page 13 of 13
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for the reproductive no
-observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoi CR Adeq
nt TLV
sodium fluoride 2.5 mg/m3 NA NA NA Yes
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 27-Oct-2006
Print Date: 10-Jan-2008
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