SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 1 of 14
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
SODIUM METABISULFITE
SYNONYMS
Na2-S2-O5, "SBS powder", SMBS, "Food Additive 223", "disodium pyrosulphite",
"pyrosulfurous acid, disodium salt", "sodium pyrosulfite", "disodium pyrosulfite",
"sodium meta-bisulphite", "sodium meta-bisulfite", "anhydrous sodium bisulfite", "SMB
POwder", APS, FOOD00004251, AR00000487, 04506808, 015705
PRODUCT USE
Widely used in food as preservative; as Food Additive 223. Amounts in foods are subject to
regulation. Usually only 0.01 to 0.10%. Used as a reagent and as a source of sulfur
dioxide. Used to deactivate isothiazolone biocides.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 2 of 14
Section 2 - HAZARDS IDENTIFICATION
POISONS SCHEDULE
S5, NZS4
RISK SAFETY
Harmful if swallowed. Do not breathe dust.
Contact with acids liberates toxic gas. Wear suitable protective clothing.
Risk of serious damage to eyes. Use only in well ventilated areas.
Inhalation may produce health damage*. Keep container in a well ventilated place.
Cumulative effects may result following To clean the floor and all objects contaminated
exposure*. by this material use water and detergent.
Limited evidence of a carcinogenic effect*. Keep away from food drink and animal feeding
stuffs.
Possible respiratory sensitiser*. Take off immediately all contaminated clothing.
Possible skin sensitiser*. If swallowed IMMEDIATELY contact Doctor or
Poisons Information Centre (show this container
or label).
* (limited evidence).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
sodium metabisulfite 7681-57-4 >95
Slowly releases toxic
sulfur dioxide 7446-09-5
Section 4 - FIRST AID MEASURES
SWALLOWED
路 For advice, contact a Poisons Information Centre or a doctor at once.
路 Urgent hospital treatment is likely to be needed.
路 If swallowed do NOT induce vomiting.
路 If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain open airway and prevent aspiration.
路 Observe the patient carefully.
路 Never give liquid to a person showing signs of being sleepy or with reduced awareness;
i.e. becoming unconscious.
路 Give water to rinse out mouth, then provide liquid slowly and as much as casualty can
comfortably drink.
路 Transport to hospital or doctor without delay.
EYE
If this product comes in contact with the eyes:
路 Immediately hold eyelids apart and flush the eye continuously with running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital or doctor without delay.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 3 of 14
Section 4 - FIRST AID MEASURES
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Treat symptomatically.
For poisons (where specific treatment regime is absent):
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
路 Establish a patent airway with suction where necessary.
路 Watch for signs of respiratory insufficiency and assist ventilation as necessary.
路 Administer oxygen by non-rebreather mask at 10 to 15 L/min.
路 Monitor and treat, where necessary, for pulmonary oedema .
路 Monitor and treat, where necessary, for shock.
路 Anticipate seizures .
路 DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml
water (5 ml/kg recommended) for dilution where patient is able to swallow, has a strong
gag reflex and does not drool.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
路 Consider orotracheal or nasotracheal intubation for airway control in unconscious
patient or where respiratory arrest has occurred.
路 Positive-pressure ventilation using a bag-valve mask might be of use.
路 Monitor and treat, where necessary, for arrhythmias.
路 Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers
solution. Fluid overload might create complications.
路 Drug therapy should be considered for pulmonary oedema.
路 Hypotension with signs of hypovolaemia requires the cautious administration of fluids.
Fluid overload might create complications.
路 Treat seizures with diazepam.
路 Proparacaine hydrochloride should be used to assist eye irrigation.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 There is no restriction on the type of extinguisher which may be used.
路 Use extinguishing media suitable for surrounding area.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 4 of 14
Section 5 - FIRE FIGHTING MEASURES
路 Wear breathing apparatus plus protective gloves for fire only.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Non combustible.
路 Not considered a significant fire risk, however containers may burn.
Decomposition may produce toxic fumes of: sulfur oxides (SOx), sulfur dioxide (SO2).
May emit poisonous fumes.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: None
Personal Protective Equipment
Gas tight chemical resistant suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Use dry clean up procedures and avoid generating dust.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
DO NOT touch the spill material.
Moderate hazard.
路 CAUTION: Advise personnel in area.
路 Alert Emergency Services and tell them location and nature of hazard.
路 Control personal contact by wearing protective clothing.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Recover product wherever possible.
路 IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and
place in sealed plastic bags or other containers for disposal. IF WET: Vacuum/shovel up
and place in labelled containers for disposal.
路 ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise Emergency Services.
To neutralise: Add an equivalent volume of a hypochlorite solution or
diluted hydrogen peroxide. WARNING: Beware of vigorous reaction.
Neutralise oxidized solution. Collect residues and seal in drums for disposal.
Wash spill area with large quantities of water.
After clean up operations, decontaminate and launder all protective clothing
and equipment before storing and re-using.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 5 of 14
Section 6 - ACCIDENTAL RELEASE MEASURES
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
sodium metabisulfite 100 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
sodium metabisulfite 25 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
sodium metabisulfite 15 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
sodium metabisulfite 5 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Glass container.
路 Polyethylene or polypropylene container.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Contact with acids produces toxic fumes.
Keep dry.
NOTE: May develop pressure in containers; open carefully. Vent periodically.
Avoid reaction with oxidising agents.
Segregate from alcohol, water.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 6 of 14
Section 7 - HANDLING AND STORAGE
STORAGE REQUIREMENTS
路 Store in original containers.
路 Keep containers securely sealed.
路 Store in a cool, dry, well-ventilated area.
路 Store away from incompatible materials and foodstuff containers.
路 Protect containers against physical damage and check regularly for leaks.
路 Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X + X 0 +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA ppm TWA mg/m鲁 STEL ppm STEL mg/m鲁
_________ _________ _____ _____ _____ _____
Australia sodium 5
Exposure metabisulfite
Standards (Sodium
metabisulphite)
Australia sulfur dioxide 2 5.2 5 13
Exposure (Sulphur dioxide)
Standards
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
sulfur dioxide 100 [Unch]
ODOUR SAFETY FACTOR (OSF)
OSF=1.8 (SULFUR DIOXIDE)
Exposed individuals are NOT reasonably expected to be warned, by smell, that the Exposure
Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class C, D or E.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
A 550 Over 90% of exposed individuals
are aware by smell that the
Exposure Standard (TLV- TWA for
example) is being reached, even
when distracted by working
activities
B 26- 550 As " A" for 50- 90% of persons
being distracted
C 1- 26 As " A" for less than 50% of
persons being distracted
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 7 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
D 0.18- 1 10- 50% of persons aware of
being tested perceive by smell
that the Exposure Standard is
being reached
E <0.18 As " D" for less than 10% of
persons aware of being tested
.
MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
An accepted daily intake (ADI) for sodium metabisulfite is 0.7
mg/sulfite/kg body weight. The TLV-TWA is thought to be protective against
skin and eye irritation associated with exposure to higher levels.
INGREDIENT DATA
SULFUR DIOXIDE:
NOTE: Detector tubes for sulfur dioxide, measuring in excess of 0.1 ppm,
are commercially available.
Sulfur dioxide is termed a "mild" respiratory irritant.
Odour threshold (detection) is 0.5 ppm with irritation reported above
2 ppm; at 8-12 ppm eyes and nose are strongly irritated. 150 ppm is only
tolerable for about a minute because of extreme irritation. At 500 ppm
there is a sense of suffocation. Human bronchoconstriction occurs with
inhalation at 5 ppm or more and the recommended TLV-TWA is thought to
provide a reduction of significant risk of adverse respiratory effects
such as coughing, increase in sputum production and bronchoconstriction.
The reported effects of SO2 in humans exposed to levels below 2 ppm,
together with the potentiation of SO2 toxicity by soot and other
particulates, has created the need for the current review by ACGIH.
A worker inhaling 4 ppm for 8 hours and doing light-work would absorb
about 150 mg of SO2. By comparison, average dietary intake for a 70 kg man
has been established at only 50 mg.
PERSONAL PROTECTION
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 8 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Experience indicates that the following polymers are suitable as glove materials for
protection against undissolved, dry solids.
路 polychloroprene
路 nitrile rubber
路 butyl rubber
路 fluorocaoutchouc
路 polyvinyl chloride
Gloves should be examined for wear and/ or degradation constantly.
NOTE: The material may produce skin sensitisation in predisposed individuals. Care must
be taken, when removing gloves and other protective equipment, to avoid all possible skin
contact.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 9 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation usually required. If risk of overexposure exists, wear approved
respirator. Correct fit is essential to obtain adequate protection. Supplied-air type
respirator may be required in special circumstances. Correct fit is essential to ensure
adequate protection.
An approved self contained breathing apparatus (SCBA) may be required in some situations.
Provide adequate ventilation in warehouse or closed storage area. Air contaminants
generated in the workplace possess varying "escape" velocities which, in turn, determine
the "capture velocities" of fresh circulating air required to effectively remove the
contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 10 of 14
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White crystals or powder with a pungent sulfur dioxide odour. Freely soluble in water,
glycerol and slightly soluble in alcohol. The material slowly releases sulfur dioxide at
ambient temperatures. Acts as a reducing agent. Available as Technical, Pure and Food
Grades.
PHYSICAL PROPERTIES
Solid.
Contact with acids liberates toxic gas.
Molecular Weight: 190.13 pure Boiling Range (掳C): Not available
Melting Range (掳C): >300 dec.120- 150 Specific Gravity (water=1): 1.40- 1.48
Solubility in water (g/L): Reacts pH (as supplied): Not applicable
pH (1% solution): 3.5- 5.0 @ 50% Vapour Pressure (kPa): Not applicable.
Volatile Component (%vol): Not applicable. Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not applicable. Flash Point (掳C): Not applicable
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
Autoignition Temp (掳C): Not applicable Decomposition Temp (掳C): 120- 150
State: Divided solid Viscosity: Not Applicable
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be harmful; animal experiments indicate that
ingestion of less than 150 gram may be fatal or may produce serious damage to the health
of the individual.
Ingestion of sulfite salts may cause gastric irritation. Large doses may produce violent
colic, diarrhoea, circulatory disturbance, depression of vital functions and, sometimes,
death.
EYE
If applied to the eyes, this material causes severe eye damage.
SKIN
Skin contact is not thought to produce harmful health effects (as classified under EC
Directives using animal models). Systemic harm, however, has been identified following
exposure of animals by at least one other route and the material may still produce health
damage following entry through wounds, lesions or abrasions. Good hygiene practice
requires that exposure be kept to a minimum and that suitable gloves be used in an
occupational setting.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
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Section 11 - TOXICOLOGICAL INFORMATION
INHALED
Inhalation of dusts, generated by the material during the course of normal handling, may
be damaging to the health of the individual.
The material is not thought to produce respiratory irritation (as classified by EC
Directives using animal models). Nevertheless inhalation of dusts, or fumes, especially
for prolonged periods, may produce respiratory discomfort and occasionally, distress.
Sulfur dioxide is irritating. Short-term exposure causes constriction of the bronchi.
Symptoms of poisoning include throat irritation, coughing, chest tightness, difficulty
with breathing, tears, eye smarting and a suffocating feeling. Substantial exposures
directly irritate the airway, additionally causing infection of the conjunctiva,
difficulty swallowing, and redness of the pharynx. Other symptoms may include vomiting,
diarrhoea, abdominal pain, fever, headache, vertigo, agitation, tremor, convulsions, and
peripheral nerve inflammation. High concentration acute exposure may produce immediate
spasm of the bronchi and lung swelling with respiratory failure, inflammation of the
conjunctiva and the tongue. Paralysis of breathing may result. Breathing impairment due
to sulfur dioxide may be long-lasting and untreatable.
Regular exposure may reduce the sense of smell.
CHRONIC HEALTH EFFECTS
There has been some concern that this material can cause cancer or mutations but there is
not enough data to make an assessment.
Long term exposure to high dust concentrations may cause changes in lung function i.e.
pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the
lung. Prime symptom is breathlessness; lung shadows show on X-ray.
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
There is some evidence that inhaling this product is more likely to cause a sensitisation
reaction in some persons compared to the general population.
There is limited evidence that, skin contact with this product is more likely to cause a
sensitisation reaction in some persons compared to the general population.
Sulfites and bisulfites can cause narrowing of the airways, stomach upset, flushing, low
blood pressure, tingling sensation, itchy wheal, swelling and shock, and asthmatics are
especially prone. They induce allergic-like reactions which can occur on first contact
with the material.
Chronic explosure to sulfur dioxide (SO2) particle complexes in polluted air can
aggravate chronic disease, such as asthma, chronic pulmonary disease, and coronary artery
disease. It is not clear what is the concentration level required to cause these effects.
Although sulfur dioxide does not cause cancer by itself, it might act as a promotor in
tumour growth when there was simultaneous exposure to arsenic.
Animal testing showed that simultaneous exposure to benz(a)pyrene and sulfur dioxide
increases the rate of cancer development compared to exposure to only one of the above
substances.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Intravenous (rat) LD50: 115 mg/kg Eye (rabbit): Irritant *
Oral (rat) TDLo: 75 mg/kg *CCInfo. No. 1478367
[BASF]
Oral (rat) LD50: 1540 mg/kg * [ICI UK]
Oral (rat) LD50: 2480 mg/kg [Sigma/Aldrich]
Oral (rat) LD50: 500 mg/kg
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
SULFUR DIOXIDE:
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Inhalation (rat) LC50: 2520 ppm/1h Nil Reported
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
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Section 11 - TOXICOLOGICAL INFORMATION
Inhalation (human) LCLo: 1000 ppm/10m
Inhalation (human) TCLo: 3 ppm/5d
400-500 ppm - immediately dangerous to life.
NOTE: Aggravates chronic pulmonary disease and increases the risk of acute
and chronic respiratory disease - condition aggravated by smoking.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
sodium IARC:3 AFRHC AFRHC
metabisulfite
sulfur dioxide IARC:3
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: sodium
metabisulfite Category: 3
SENSITISER
AFRHC: Australia Final Report on Hazard Classification of Common Skin Sensitisers:
sodium metabisulfite
SKIN
AFRHC: Australia Final Report on Hazard Classification of Common Skin Sensitisers:
sodium metabisulfite
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: sulfur dioxide
Category: 3
Section 12 - ECOLOGICAL INFORMATION
DO NOT discharge into sewer or waterways.
log Pow (Octanol/water partition coefficient): -3.7
Risk of bioaccumulation in aquatic species is low.
Inorganic product which cannot be eliminated from effluent treatment
plants by biological purification processes. The product may lead to a
high chemical consumption of oxygen in biological sewage works or natural
waters and have a negative effect on aquatic organisms.
Toxicity to fish- LC50: 15-220 mg/L/96Hr (Salmo gairdneri)
Toxicity to bacteria- EC/LC50: 56 mg/L/17Hr (Pseudomonas putida)
COD: 165 mg O2/g product. [BASF Aust.]
Refer to data for ingredients, which follows:
SULFUR DIOXIDE:
Toxicity Fish: LC50(96)>12.5mg/L
Toxicity invertebrate: LC50(48)802-2241ppm
Section 13 - DISPOSAL CONSIDERATIONS
For small quantities:
路 Neutralise an aqueous solution of the material.
路 Filter solids for disposal to approved land fill.
路 Flush solution to sewer (subject to local regulation)
路 Heat and fumes evolved during reaction may be controlled by rate of addition.
路 Recycle wherever possible or consult manufacturer for recycling options.
路 Consult State Land Waste Management Authority for disposal.
路 Bury residue in an authorised landfill.
路 Recycle containers if possible, or dispose of in an authorised landfill.
路 Containers may still present a chemical hazard/ danger when empty.
路 Return to supplier for reuse/ recycling if possible.
Otherwise:
路 If container can not be cleaned sufficiently well to ensure that residuals do not
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 13 of 14
Section 13 - DISPOSAL CONSIDERATIONS
remain or if the container cannot be used to store the same product, then puncture
containers, to prevent re-use, and bury at an authorised landfill.
路 Where possible retain label warnings and MSDS and observe all notices pertaining to the
product.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: S5, NZS4
REGULATIONS
sodium metabisulfite (CAS: 7681-57-4) is found on the following regulatory lists;
Australia Exposure Standards
Australia Final Report on Hazard Classification of Common Skin Sensitisers
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5
International Agency for Research on Cancer (IARC) Carcinogens
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for reproductive no
-observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoi CR Adeq
nt TLV
sulfur dioxide 2.3 mg/m3 100 D NA -
These exposure guidelines have been derived from a screening level of risk assessment and
should not be construed as unequivocally safe limits. ORGS represent an 8-hour time
-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
MSDS SECTION CHANGES
The following table displays the version number of and date on which each section was last changed.
Section Name Version Date Section Name Version Date Section Name Version Date
Advice to Doctor 5 1- Oct- 2006 Storage (storage 5 1- Oct- 2006 Instability 5 1- Oct- 2006
requirement) Condition
SODIUM METABISULFITE
Chemwatch Material Safety Data Sheet
Issue Date: 28-May-2007 CHEMWATCH 21889
NC317TCP Version No:6
CD 2007/3 Page 14 of 14
Section 16 - OTHER INFORMATION
First Aid 5 1- Oct- 2006 Storage (suitable 5 1- Oct- 2006 Acute Health (eye) 5 1- Oct- 2006
(swallowed) container)
Fire Fighter 5 1- Oct- 2006 Engineering 5 1- Oct- 2006 Acute Health 5 1- Oct- 2006
(extinguishing Control (inhaled)
media)
Fire Fighter (fire 5 1- Oct- 2006 Exposure Standard 6 28- May- 2007 Acute Health 5 1- Oct- 2006
incompatibility) (skin)
Fire Fighter 5 1- Oct- 2006 Personal 5 1- Oct- 2006 Acute Health 5 1- Oct- 2006
(fire/explosion Protection (eye) (swallowed)
hazard)
Spills (major) 5 1- Oct- 2006 Personal 5 1- Oct- 2006 Chronic Health 5 1- Oct- 2006
Protection
(hands/feet)
Spills (minor) 5 1- Oct- 2006 Personal 5 1- Oct- 2006 Environmental 5 1- Oct- 2006
Protection (other)
Handling Procedure 5 1- Oct- 2006 Appearance 5 1- Oct- 2006 Disposal 5 1- Oct- 2006
Storage (storage 5 1- Oct- 2006 Physical 5 1- Oct- 2006
incompatibility) Properties
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 28-May-2007
Print Date: 10-Jan-2008
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